JP4791968B2 - アミドメチル置換２−（４−スルホニルアミノ）−３−ヒドロキシ−３，４−ジヒドロ−２ｈ−クロメン−６−イル誘導体、該誘導体を製造するための方法及び中間生成物並びにこれらの化合物を含有する医薬品 - Google Patents
アミドメチル置換２−（４−スルホニルアミノ）−３−ヒドロキシ−３，４−ジヒドロ−２ｈ−クロメン−６−イル誘導体、該誘導体を製造するための方法及び中間生成物並びにこれらの化合物を含有する医薬品 Download PDFInfo
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- JP4791968B2 JP4791968B2 JP2006534762A JP2006534762A JP4791968B2 JP 4791968 B2 JP4791968 B2 JP 4791968B2 JP 2006534762 A JP2006534762 A JP 2006534762A JP 2006534762 A JP2006534762 A JP 2006534762A JP 4791968 B2 JP4791968 B2 JP 4791968B2
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- alkyl
- formula
- chromen
- phenyl
- dimethyl
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10348298A DE10348298A1 (de) | 2003-10-17 | 2003-10-17 | Amidomethyl-substituierte 2-(4-Sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-ylderivade, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE10348298.9 | 2003-10-17 | ||
| PCT/EP2004/052539 WO2005037780A2 (de) | 2003-10-17 | 2004-10-14 | Amidomethyl-substituierte 2-(4-sulfonilamino)-3-hidroxy-3,4-dihydro-2h-chromen-6-yl-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007516235A JP2007516235A (ja) | 2007-06-21 |
| JP2007516235A5 JP2007516235A5 (uk) | 2008-07-24 |
| JP4791968B2 true JP4791968B2 (ja) | 2011-10-12 |
Family
ID=34442032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006534762A Expired - Fee Related JP4791968B2 (ja) | 2003-10-17 | 2004-10-14 | アミドメチル置換２−（４−スルホニルアミノ）−３−ヒドロキシ−３，４−ジヒドロ−２ｈ−クロメン−６−イル誘導体、該誘導体を製造するための方法及び中間生成物並びにこれらの化合物を含有する医薬品 |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1678130B1 (uk) |
| JP (1) | JP4791968B2 (uk) |
| KR (1) | KR20060129170A (uk) |
| CN (1) | CN100532375C (uk) |
| AR (1) | AR046106A1 (uk) |
| AT (1) | ATE405547T1 (uk) |
| AU (1) | AU2004281195B2 (uk) |
| BR (1) | BRPI0415523A (uk) |
| CA (1) | CA2542813C (uk) |
| DE (3) | DE10348298A1 (uk) |
| DK (1) | DK1678130T3 (uk) |
| ES (1) | ES2313126T3 (uk) |
| HK (1) | HK1096960A1 (uk) |
| HR (1) | HRP20080602T3 (uk) |
| IL (1) | IL174950A (uk) |
| MX (1) | MXPA06003958A (uk) |
| NO (1) | NO20062202L (uk) |
| PL (1) | PL1678130T3 (uk) |
| PT (1) | PT1678130E (uk) |
| RU (1) | RU2355685C2 (uk) |
| SI (1) | SI1678130T1 (uk) |
| TW (1) | TWI321564B (uk) |
| UA (1) | UA82907C2 (uk) |
| WO (1) | WO2005037780A2 (uk) |
| ZA (1) | ZA200602788B (uk) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006016420D1 (de) * | 2005-04-12 | 2010-10-07 | Abbott Products Gmbh | Aminoalkylamidomethylsubstituierte 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2h-cromen-6-yl derivate und ihre verwendung als kaliumkanalblocker |
| US7714150B2 (en) | 2005-04-12 | 2010-05-11 | Solvay Pharmaceuticals Gmbh | Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H-chroman-6-yl derivatives |
| CA2615440A1 (en) * | 2005-07-22 | 2007-02-08 | Merck & Co., Inc. | Potassium channel inhibitors |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| NO3175985T3 (uk) | 2011-07-01 | 2018-04-28 | ||
| US20150045305A1 (en) | 2012-01-27 | 2015-02-12 | Gilead Sciences, Inc. | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
| WO2014134419A1 (en) | 2013-03-01 | 2014-09-04 | Gilead Sciences, Inc. | Use of ikach blockers for the treatment of cardiac diseases |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994012173A1 (en) * | 1992-11-30 | 1994-06-09 | Smithkline Beecham Plc | Benzopyron analogues for the treatment of anxiety, mania, depression or withdrawal symptoms |
| WO2000058300A1 (fr) * | 1999-03-25 | 2000-10-05 | Nissan Chemical Industries, Ltd. | Derives du chroman |
| JP2002523451A (ja) * | 1998-09-01 | 2002-07-30 | ブリストル−マイヤーズ スクイブ カンパニー | カリウムチャネル抑制剤および方法 |
| JP2003518101A (ja) * | 1999-12-21 | 2003-06-03 | アイカゲン インコーポレイテッド | カリウムチャネル阻害剤 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19546736A1 (de) * | 1995-12-14 | 1997-06-19 | Hoechst Ag | Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate |
| JP2000336085A (ja) * | 1999-03-25 | 2000-12-05 | Nissan Chem Ind Ltd | クロマン誘導体 |
-
2003
- 2003-10-17 DE DE10348298A patent/DE10348298A1/de not_active Withdrawn
-
2004
- 2004-10-13 AR ARP040103705A patent/AR046106A1/es not_active Application Discontinuation
- 2004-10-13 TW TW093130943A patent/TWI321564B/zh not_active IP Right Cessation
- 2004-10-14 EP EP04817204A patent/EP1678130B1/de not_active Expired - Lifetime
- 2004-10-14 RU RU2006116629/04A patent/RU2355685C2/ru not_active IP Right Cessation
- 2004-10-14 KR KR1020067006939A patent/KR20060129170A/ko not_active Application Discontinuation
- 2004-10-14 PL PL04817204T patent/PL1678130T3/pl unknown
- 2004-10-14 JP JP2006534762A patent/JP4791968B2/ja not_active Expired - Fee Related
- 2004-10-14 CA CA2542813A patent/CA2542813C/en not_active Expired - Fee Related
- 2004-10-14 AU AU2004281195A patent/AU2004281195B2/en not_active Ceased
- 2004-10-14 DK DK04817204T patent/DK1678130T3/da active
- 2004-10-14 PT PT04817204T patent/PT1678130E/pt unknown
- 2004-10-14 DE DE112004001659T patent/DE112004001659D2/de not_active Expired - Fee Related
- 2004-10-14 ES ES04817204T patent/ES2313126T3/es not_active Expired - Lifetime
- 2004-10-14 AT AT04817204T patent/ATE405547T1/de active
- 2004-10-14 CN CNB2004800283503A patent/CN100532375C/zh not_active Expired - Fee Related
- 2004-10-14 BR BRPI0415523-8A patent/BRPI0415523A/pt not_active IP Right Cessation
- 2004-10-14 ZA ZA200602788A patent/ZA200602788B/xx unknown
- 2004-10-14 SI SI200430848T patent/SI1678130T1/sl unknown
- 2004-10-14 WO PCT/EP2004/052539 patent/WO2005037780A2/de active IP Right Grant
- 2004-10-14 MX MXPA06003958A patent/MXPA06003958A/es active IP Right Grant
- 2004-10-14 UA UAA200605330A patent/UA82907C2/uk unknown
- 2004-10-14 DE DE502004007916T patent/DE502004007916D1/de not_active Expired - Lifetime
-
2006
- 2006-04-11 IL IL174950A patent/IL174950A/en not_active IP Right Cessation
- 2006-05-16 NO NO20062202A patent/NO20062202L/no not_active Application Discontinuation
-
2007
- 2007-02-23 HK HK07102051.5A patent/HK1096960A1/xx not_active IP Right Cessation
-
2008
- 2008-11-20 HR HR20080602T patent/HRP20080602T3/xx unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994012173A1 (en) * | 1992-11-30 | 1994-06-09 | Smithkline Beecham Plc | Benzopyron analogues for the treatment of anxiety, mania, depression or withdrawal symptoms |
| JP2002523451A (ja) * | 1998-09-01 | 2002-07-30 | ブリストル−マイヤーズ スクイブ カンパニー | カリウムチャネル抑制剤および方法 |
| WO2000058300A1 (fr) * | 1999-03-25 | 2000-10-05 | Nissan Chemical Industries, Ltd. | Derives du chroman |
| JP2003518101A (ja) * | 1999-12-21 | 2003-06-03 | アイカゲン インコーポレイテッド | カリウムチャネル阻害剤 |
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