JP4769720B2 - Ｎ−置換ベンズイミダゾリルｃ−Ｋｉｔ阻害剤 - Google Patents

Ｎ−置換ベンズイミダゾリルｃ−Ｋｉｔ阻害剤 Download PDF

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JP4769720B2
JP4769720B2 JP2006523955A JP2006523955A JP4769720B2 JP 4769720 B2 JP4769720 B2 JP 4769720B2 JP 2006523955 A JP2006523955 A JP 2006523955A JP 2006523955 A JP2006523955 A JP 2006523955A JP 4769720 B2 JP4769720 B2 JP 4769720B2
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Prior art keywords
phenyl
benzimidazole
carboxamide
pyridin
ylmethyl
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Expired - Fee Related
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Japanese (ja)
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JP2007502821A5 (https=
JP2007502821A (ja
Inventor
ボルジヤー，ジヨシユア
カステラーノ，アルリンド・エル
クルー，アンドリユー・フイリツプ
ドン，ハン−チン
絢子 本田
ローフアー，ラドスロウ
リー，アン−フー
マルビヒル，クリステン
チユイ，リー
サンブロツク・スミス，コリン・ピーター
スン，インチユアン
ウイニー，グラハム・マイケル
チヤン，タオ
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オーエスアイ・ファーマシューテイカルズ・エル・エル・シー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
JP2006523955A 2003-08-21 2004-08-16 Ｎ−置換ベンズイミダゾリルｃ−Ｋｉｔ阻害剤 Expired - Fee Related JP4769720B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49680603P 2003-08-21 2003-08-21
US60/496,806 2003-08-21
PCT/US2004/026482 WO2005021531A1 (en) 2003-08-21 2004-08-16 N-substituted benzimidazolyl c-kit inhibitors

Publications (3)

Publication Number Publication Date
JP2007502821A JP2007502821A (ja) 2007-02-15
JP2007502821A5 JP2007502821A5 (https=) 2007-09-27
JP4769720B2 true JP4769720B2 (ja) 2011-09-07

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JP2006523955A Expired - Fee Related JP4769720B2 (ja) 2003-08-21 2004-08-16 Ｎ−置換ベンズイミダゾリルｃ−Ｋｉｔ阻害剤

Country Status (18)

Country Link
US (1) US7521448B2 (https=)
EP (1) EP1664021A1 (https=)
JP (1) JP4769720B2 (https=)
KR (1) KR20060121818A (https=)
CN (1) CN1852905A (https=)
AP (1) AP2006003549A0 (https=)
AR (1) AR045387A1 (https=)
AU (1) AU2004268949A1 (https=)
BR (1) BRPI0413746A (https=)
CA (1) CA2535896A1 (https=)
IL (1) IL173614A0 (https=)
IS (1) IS8319A (https=)
MX (1) MXPA06002018A (https=)
NO (1) NO20060664L (https=)
RU (1) RU2006108803A (https=)
TW (1) TW200524905A (https=)
UA (1) UA82395C2 (https=)
WO (1) WO2005021531A1 (https=)

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UA82395C2 (en) 2008-04-10
EP1664021A1 (en) 2006-06-07
IS8319A (is) 2006-02-21
TW200524905A (en) 2005-08-01
JP2007502821A (ja) 2007-02-15
US20060189629A1 (en) 2006-08-24
KR20060121818A (ko) 2006-11-29
CN1852905A (zh) 2006-10-25
AP2006003549A0 (en) 2006-04-30
MXPA06002018A (es) 2006-05-31
BRPI0413746A (pt) 2006-10-24
WO2005021531A1 (en) 2005-03-10
US7521448B2 (en) 2009-04-21
AU2004268949A1 (en) 2005-03-10
IL173614A0 (en) 2006-07-05

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