JP4748911B2 - Ｎ−環状ｐ２部分を含むｃ型肝炎ウイルスの大環状ｎｓ３‐セリンプロテアーゼ阻害剤 - Google Patents

Ｎ−環状ｐ２部分を含むｃ型肝炎ウイルスの大環状ｎｓ３‐セリンプロテアーゼ阻害剤 Download PDF

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JP4748911B2
JP4748911B2 JP2001575586A JP2001575586A JP4748911B2 JP 4748911 B2 JP4748911 B2 JP 4748911B2 JP 2001575586 A JP2001575586 A JP 2001575586A JP 2001575586 A JP2001575586 A JP 2001575586A JP 4748911 B2 JP4748911 B2 JP 4748911B2
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JP2003530401A (ja
JP2003530401A5 (OSRAM
Inventor
ケビン・エックス・チェン
アショック・アラサパン
スリカント・ベンカトラマン
テジャル・エヌ・パレク
グ・ハイニン
エフ・ジョージ・ヌジョローグ
ビイヨール・エム・ギリジャバラバン
アシット・ガンガリー
アニル・サクセナ
エドウィン・ジャオ
ナンフア・エイチ・ヤオ
アンドリュー・ジェイ・プロンゲイ
ビンセント・エス・マディソン
バンチャ・ビブルバン
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2001575586A 2000-04-05 2001-04-03 Ｎ−環状ｐ２部分を含むｃ型肝炎ウイルスの大環状ｎｓ３‐セリンプロテアーゼ阻害剤 Expired - Fee Related JP4748911B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19460700P 2000-04-05 2000-04-05
US60/194,607 2000-04-05
PCT/US2001/010869 WO2001077113A2 (en) 2000-04-05 2001-04-03 Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising n-cyclic p2 moieties

Publications (3)

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JP2003530401A JP2003530401A (ja) 2003-10-14
JP2003530401A5 JP2003530401A5 (OSRAM) 2008-02-28
JP4748911B2 true JP4748911B2 (ja) 2011-08-17

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JP2001575586A Expired - Fee Related JP4748911B2 (ja) 2000-04-05 2001-04-03 Ｎ−環状ｐ２部分を含むｃ型肝炎ウイルスの大環状ｎｓ３‐セリンプロテアーゼ阻害剤

Country Status (26)

Country Link
US (1) US6846802B2 (OSRAM)
EP (1) EP1268525B1 (OSRAM)
JP (1) JP4748911B2 (OSRAM)
KR (1) KR20030036152A (OSRAM)
CN (1) CN1441806A (OSRAM)
AR (1) AR029903A1 (OSRAM)
AT (1) ATE419270T1 (OSRAM)
AU (1) AU2001253124A1 (OSRAM)
BR (1) BR0109861A (OSRAM)
CA (1) CA2405521C (OSRAM)
CZ (1) CZ20023321A3 (OSRAM)
DE (1) DE60137207D1 (OSRAM)
EC (1) ECSP014009A (OSRAM)
ES (1) ES2317900T3 (OSRAM)
HK (1) HK1047947A1 (OSRAM)
HU (1) HUP0400456A3 (OSRAM)
IL (1) IL151934A0 (OSRAM)
MX (1) MXPA02009920A (OSRAM)
NO (1) NO20024797L (OSRAM)
NZ (1) NZ521455A (OSRAM)
PE (1) PE20020188A1 (OSRAM)
PL (1) PL359359A1 (OSRAM)
RU (1) RU2002129564A (OSRAM)
SK (1) SK14192002A3 (OSRAM)
WO (1) WO2001077113A2 (OSRAM)
ZA (1) ZA200207845B (OSRAM)

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* Cited by examiner, † Cited by third party
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