JP4560998B2 - 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌 - Google Patents

発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌 Download PDF

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Publication number
JP4560998B2
JP4560998B2 JP2001162806A JP2001162806A JP4560998B2 JP 4560998 B2 JP4560998 B2 JP 4560998B2 JP 2001162806 A JP2001162806 A JP 2001162806A JP 2001162806 A JP2001162806 A JP 2001162806A JP 4560998 B2 JP4560998 B2 JP 4560998B2
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glutamine
gene
activity
dna
strain
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Expired - Lifetime
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Japanese (ja)
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JP2002300887A5 (enExample
JP2002300887A (ja
Inventor
純 中村
嘉代 森口
裕 泉井
伸樹 川嶋
亘 中松
修 倉橋
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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Priority to JP2001162806A priority Critical patent/JP4560998B2/ja
Priority to BRPI0200320A priority patent/BRPI0200320B1/pt
Priority to US10/062,458 priority patent/US7262035B2/en
Priority to DE60208450T priority patent/DE60208450T2/de
Priority to EP02001993A priority patent/EP1229121B1/en
Priority to EP04000167A priority patent/EP1424398A3/en
Priority to CNB021205817A priority patent/CN100457894C/zh
Publication of JP2002300887A publication Critical patent/JP2002300887A/ja
Priority to US11/616,463 priority patent/US20070092953A1/en
Publication of JP2002300887A5 publication Critical patent/JP2002300887A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2001162806A 2001-02-05 2001-05-30 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌 Expired - Lifetime JP4560998B2 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2001162806A JP4560998B2 (ja) 2001-02-05 2001-05-30 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌
BRPI0200320A BRPI0200320B1 (pt) 2001-02-05 2002-02-04 bactéria corineforme transgênica, e, método para produzir l-glutamina
DE60208450T DE60208450T2 (de) 2001-02-05 2002-02-05 Verfahren zur Herstellung von L-Glutamin mittels Fermentation und ein L-Glutamin produzierendes Bakterium
EP02001993A EP1229121B1 (en) 2001-02-05 2002-02-05 Method for producing L-glutamine by fermentation and L-glutamine producing bacterium
US10/062,458 US7262035B2 (en) 2001-02-05 2002-02-05 Method for producing L-glutamine by fermentation and L-glutamine producing bacterium
EP04000167A EP1424398A3 (en) 2001-02-05 2002-02-05 Method for producing L-glutamine by fermentation and L-glutamine producing bacterium
CNB021205817A CN100457894C (zh) 2001-02-05 2002-02-05 通过发酵生产l-谷氨酰胺的方法和产生l-谷氨酰胺的细菌
US11/616,463 US20070092953A1 (en) 2001-02-05 2006-12-27 Method for producing l-glutamine by fermentation and l-glutamine producing bacterium

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001028163 2001-02-05
JP2001-28163 2001-02-05
JP2001162806A JP4560998B2 (ja) 2001-02-05 2001-05-30 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌

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JP2002300887A JP2002300887A (ja) 2002-10-15
JP2002300887A5 JP2002300887A5 (enExample) 2007-07-05
JP4560998B2 true JP4560998B2 (ja) 2010-10-13

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US (2) US7262035B2 (enExample)
EP (2) EP1229121B1 (enExample)
JP (1) JP4560998B2 (enExample)
CN (1) CN100457894C (enExample)
BR (1) BRPI0200320B1 (enExample)
DE (1) DE60208450T2 (enExample)

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AU756507B2 (en) * 1998-03-18 2003-01-16 Ajinomoto Co., Inc. L-glutamic acid-producing bacterium and method for producing L-glutamic acid
JP4427878B2 (ja) 1999-08-20 2010-03-10 味の素株式会社 析出を伴う発酵法によるｌ−グルタミン酸の製造法
JP4560998B2 (ja) * 2001-02-05 2010-10-13 味の素株式会社 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌
JP4599726B2 (ja) 2001-02-20 2010-12-15 味の素株式会社 Ｌ−グルタミン酸の製造法
DE60335774D1 (de) * 2002-11-26 2011-03-03 Ajinomoto Kk Methode für die Produktion von L-Glutamin und L-Glutamin-produzierendes Bakterium
JP2004187684A (ja) * 2002-11-26 2004-07-08 Ajinomoto Co Inc Ｌ−グルタミンの製造法及びｌ−グルタミン生産菌
JP4576850B2 (ja) * 2003-03-03 2010-11-10 味の素株式会社 発酵法によるｌ−アルギニン又はｌ−リジンの製造法
US20050014236A1 (en) * 2003-03-03 2005-01-20 Yumi Matsuzaki Method for producing L-arginine or L-lysine by fermentation
JP5325372B2 (ja) * 2003-05-07 2013-10-23 味の素株式会社 Ｌ−グルタミン酸の製造法
DE10344739A1 (de) * 2003-09-26 2005-04-14 Degussa Ag Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
DE602005019063D1 (de) 2004-06-25 2010-03-11 Kyowa Hakko Bio Co Ltd Verfahren zur herstellung von substanzen
WO2007074857A1 (ja) 2005-12-27 2007-07-05 Kyowa Hakko Kogyo Co., Ltd. Ｌ－グルタミンの製造法
EP2612915B1 (en) 2006-09-01 2015-04-08 Kyowa Hakko Bio Co., Ltd. Method for production of L-Glutamine
JP2010041920A (ja) 2006-12-19 2010-02-25 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010110216A (ja) 2007-02-20 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸または核酸の製造方法
JP2010130899A (ja) * 2007-03-14 2010-06-17 Ajinomoto Co Inc Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法
JP2011512144A (ja) * 2008-02-21 2011-04-21 ビーエーエスエフ ソシエタス・ヨーロピア γ−アミノ酪酸の生産方法
RU2418064C2 (ru) * 2009-01-23 2011-05-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ СЕМЕЙСТВА ГЛУТАМАТА ИЛИ L-ВАЛИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia
RU2420586C2 (ru) * 2009-01-23 2011-06-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Способ получения l-аминокислоты семейства глутамата с использованием бактерии, принадлежащей к роду escherichia
JP2012223091A (ja) 2009-08-25 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
WO2011083859A1 (ja) 2010-01-08 2011-07-14 協和発酵バイオ株式会社 Ｌ－グルタミンまたはｌ－グルタミン酸の製造法
US8859241B2 (en) 2010-01-08 2014-10-14 Kyowa Hakko Bio Co., Ltd. Process for production of L-amino acid
RU2496867C2 (ru) * 2011-04-25 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Способ получения l-аминокислоты семейства глутамата с использованием коринеформной бактерии
US9822387B2 (en) 2011-07-29 2017-11-21 Mitsui Chemicals, Inc. Microorganism having carbon dioxide fixation pathway introduced thereinto
PE20141569A1 (es) 2011-11-11 2014-11-08 Ajinomoto Kk Metodo para producir una sustancia diana mediante fermentacion
US9828618B2 (en) 2013-01-24 2017-11-28 Mitsui Chemicals, Inc. Microorganism having carbon dioxide fixation cycle introduced thereinto
KR101773755B1 (ko) 2013-05-13 2017-09-01 아지노모토 가부시키가이샤 Ｌ-아미노산의 제조법
JP2016165225A (ja) 2013-07-09 2016-09-15 味の素株式会社 有用物質の製造方法
JP2016192903A (ja) 2013-09-17 2016-11-17 味の素株式会社 海藻由来バイオマスからのｌ−アミノ酸の製造方法
ES2694011T3 (es) 2013-10-21 2018-12-17 Ajinomoto Co., Inc. Método para producir L-aminoácido
EP3061828B1 (en) 2013-10-23 2024-08-28 Ajinomoto Co., Inc. Method for producing target substance
CN103695491B (zh) * 2013-12-24 2016-08-24 山东民强生物科技股份有限公司 L-谷氨酰胺的精制方法
CN103695492B (zh) * 2013-12-24 2016-04-06 山东民强生物科技股份有限公司 一种提高l-谷氨酰胺收率的方法
CN103667382B (zh) * 2013-12-24 2015-09-02 山东民强生物科技股份有限公司 一种微生物发酵生产l-谷氨酰胺的方法
CN105054068A (zh) * 2014-01-25 2015-11-18 北京凯因科技股份有限公司 一种酵母谷胱甘肽营养配制品
JP6623690B2 (ja) 2015-10-30 2019-12-25 味の素株式会社 グルタミン酸系ｌ−アミノ酸の製造法
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
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CN113025542B (zh) * 2019-12-25 2022-09-16 中国科学院微生物研究所 产l-谷氨酰胺的重组大肠杆菌及其构建方法与应用
KR102198072B1 (ko) * 2020-03-04 2021-01-04 씨제이제일제당 주식회사 글루타민 신테타아제 변이형 폴리펩티드 및 이를 이용한 l-글루타민 생산 방법
CN113444655B (zh) * 2020-03-26 2023-05-16 吉林中粮生化有限公司 谷氨酸棒状杆菌、高谷氨酸产量的温度敏感型菌株及其获得方法、应用以及谷氨酸发酵方法
KR102216450B1 (ko) * 2020-03-30 2021-02-17 대상 주식회사 글루타민 생산능을 향상시키는 형질전환용 재조합 벡터 및 이를 도입한 균주
CN113201535B (zh) * 2020-07-20 2022-02-08 中国科学院天津工业生物技术研究所 谷氨酸脱氢酶基因启动子的突变体及其应用
EP4239070A4 (en) 2020-10-28 2025-09-10 Ajinomoto Kk PROCESS FOR THE PRODUCTION OF L-AMINO ACID
EP4230743A4 (en) 2020-11-20 2024-04-17 CJ Cheiljedang Corporation MICROORGANISM WITH IMPROVED L-GLUTAMINE PRODUCTION CAPABILITY AND L-GLUTAMINE PRODUCTION PROCESS THEREFOR
CN112646766B (zh) * 2020-12-30 2023-08-18 内蒙古伊品生物科技有限公司 一种改造基因bbd29_04920的产l-谷氨酸的重组菌株及其构建方法与应用
CN113817627B (zh) * 2021-07-15 2023-04-28 大连医诺生物股份有限公司 一种嗜乙酰乙酸棒杆菌及以氨态氮浓度控制进行谷氨酰胺发酵的方法
CN113684165B (zh) * 2021-08-12 2023-07-25 江南大学 一种重组谷氨酸棒杆菌及其在生产l-谷氨酰胺中的应用
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Also Published As

Publication number Publication date
EP1424398A3 (en) 2004-09-22
BRPI0200320B1 (pt) 2016-07-26
US7262035B2 (en) 2007-08-28
US20070092953A1 (en) 2007-04-26
CN100457894C (zh) 2009-02-04
DE60208450D1 (de) 2006-03-30
BR0200320A (pt) 2002-10-29
EP1424398A2 (en) 2004-06-02
CN1384190A (zh) 2002-12-11
DE60208450T2 (de) 2006-08-24
US20030003550A1 (en) 2003-01-02
EP1229121B1 (en) 2006-01-04
EP1229121A2 (en) 2002-08-07
EP1229121A3 (en) 2003-03-12
JP2002300887A (ja) 2002-10-15

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