JP4560411B2 - 炎症性疾患の治療のためのｐ２ｘ７阻害剤としての３−（３，５−ジオキソ−４，５−ジヒドロ−３ｈ−（１，２，４）トリアジン−２−イル）−ベンズアミド誘導体 - Google Patents

炎症性疾患の治療のためのｐ２ｘ７阻害剤としての３−（３，５−ジオキソ−４，５−ジヒドロ−３ｈ−（１，２，４）トリアジン−２−イル）−ベンズアミド誘導体 Download PDF

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JP4560411B2
JP4560411B2 JP2004563515A JP2004563515A JP4560411B2 JP 4560411 B2 JP4560411 B2 JP 4560411B2 JP 2004563515 A JP2004563515 A JP 2004563515A JP 2004563515 A JP2004563515 A JP 2004563515A JP 4560411 B2 JP4560411 B2 JP 4560411B2
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hydroxy
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chloro
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アンソニー ドムブロスキ，マーク
ジェイコブ デュプランティエ，アレン
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ファイザー・プロダクツ・インク
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JP2004563515A 2002-12-31 2003-12-19 炎症性疾患の治療のためのｐ２ｘ７阻害剤としての３−（３，５−ジオキソ−４，５−ジヒドロ−３ｈ−（１，２，４）トリアジン−２−イル）−ベンズアミド誘導体 Expired - Lifetime JP4560411B2 (ja)

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US43750502P 2002-12-31 2002-12-31
PCT/IB2003/006254 WO2004058270A1 (en) 2002-12-31 2003-12-19 3-(3,5-dioxo-4,5-dihydro-3h-(1,2,4)triazin-2-yl)-benzamide derivatives as p2x7-inhibitors for the treatment of inflammatory diseases

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JP2006513206A JP2006513206A (ja) 2006-04-20
JP2006513206A5 JP2006513206A5 (https=) 2007-02-08
JP4560411B2 true JP4560411B2 (ja) 2010-10-13

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JP2008504362A (ja) 2004-06-29 2008-02-14 ファイザー・プロダクツ・インク Ｐ２ｘ７阻害活性をもつ５−［４−（２−ヒドロキシ−エチル）−３，５−ジオキソ−４，５−ジヒドロ−３ｈ−［１，２，４］トリアジン−２−イル］−ベンズアミド誘導体を、トリアジンの４−位において置換されていない誘導体とオキシランをルイス酸の存在下で反応させることにより製造する方法
WO2006003500A1 (en) 2004-06-29 2006-01-12 Pfizer Products Inc. Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h`1,2,4!triazin-2-yl!-benzamide derivatives by deprotecting the hydroxyl-protected precursers

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MXPA05006749A (es) 2005-09-08
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WO2004058270A1 (en) 2004-07-15
EP1581232A1 (en) 2005-10-05
ES2464350T3 (es) 2014-06-02
UY28153A1 (es) 2004-07-30
US7671053B2 (en) 2010-03-02
AR042673A1 (es) 2005-06-29
US6974812B2 (en) 2005-12-13
CO5580749A2 (es) 2005-11-30
TNSN05174A1 (fr) 2007-05-14
IS7840A (is) 2005-05-09
BR0317803A (pt) 2005-11-29
NI200500118A (es) 2006-05-19
EA200500777A1 (ru) 2005-12-29
OA12978A (en) 2006-10-13
AP1997A (en) 2009-04-22
NL1025148C2 (nl) 2007-09-28
CA2512193A1 (en) 2004-07-15
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CR7884A (es) 2005-08-05
PA8591801A1 (es) 2004-07-26
PL378251A1 (pl) 2006-03-20
TWI288133B (en) 2007-10-11
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ZA200503912B (en) 2006-07-26
EA008591B1 (ru) 2007-06-29
PY0333692A (es) 2010-05-03
KR100689138B1 (ko) 2007-03-08
GEP20084304B (en) 2008-02-11
IL212241A0 (en) 2011-06-30
CN1732006A (zh) 2006-02-08
CL2003002765A1 (es) 2005-01-07
AU2003285716A1 (en) 2004-07-22
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US20070281939A1 (en) 2007-12-06
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