JP4450368B2 - マイクロ流路チップの製造方法、マイクロ流路チップ、そのマイクロ流路チップを用いる生体分子の分離方法、およびそのマイクロ流路チップを有する電気泳動装置 - Google Patents

マイクロ流路チップの製造方法、マイクロ流路チップ、そのマイクロ流路チップを用いる生体分子の分離方法、およびそのマイクロ流路チップを有する電気泳動装置 Download PDF

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Publication number
JP4450368B2
JP4450368B2 JP2004060215A JP2004060215A JP4450368B2 JP 4450368 B2 JP4450368 B2 JP 4450368B2 JP 2004060215 A JP2004060215 A JP 2004060215A JP 2004060215 A JP2004060215 A JP 2004060215A JP 4450368 B2 JP4450368 B2 JP 4450368B2
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cover material
film
substrate
bonding
base material
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Expired - Fee Related
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JP2004060215A
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Japanese (ja)
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JP2005249572A5 (enExample
JP2005249572A (ja
Inventor
憲二 横山
哲 小出
幸司 坂入
和義 矢野
征夫 輕部
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National Institute of Advanced Industrial Science and Technology
Katayanagi Institute
Toppan Inc
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National Institute of Advanced Industrial Science and Technology
Katayanagi Institute
Toppan Inc
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Priority to JP2004060215A priority Critical patent/JP4450368B2/ja
Priority to US10/591,335 priority patent/US8012430B2/en
Priority to GB0619521A priority patent/GB2429428B8/en
Priority to PCT/JP2005/003604 priority patent/WO2005084794A1/ja
Publication of JP2005249572A publication Critical patent/JP2005249572A/ja
Publication of JP2005249572A5 publication Critical patent/JP2005249572A5/ja
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    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
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    • C23C14/06—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
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JP2004060215A 2004-03-04 2004-03-04 マイクロ流路チップの製造方法、マイクロ流路チップ、そのマイクロ流路チップを用いる生体分子の分離方法、およびそのマイクロ流路チップを有する電気泳動装置 Expired - Fee Related JP4450368B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2004060215A JP4450368B2 (ja) 2004-03-04 2004-03-04 マイクロ流路チップの製造方法、マイクロ流路チップ、そのマイクロ流路チップを用いる生体分子の分離方法、およびそのマイクロ流路チップを有する電気泳動装置
US10/591,335 US8012430B2 (en) 2004-03-04 2005-03-03 Methods for producing microchannel chips, microchannel chips, methods for separating biomolecules using the microchannel chips, and electrophoretic apparatus having the microchannel chips
GB0619521A GB2429428B8 (en) 2004-03-04 2005-03-03 Methods for producing microchannel chips, microchannel chips, methods for separating biomolecules using the microchannel chips and electrophoretic apparatus hav
PCT/JP2005/003604 WO2005084794A1 (ja) 2004-03-04 2005-03-03 マイクロ流路チップの製造方法、マイクロ流路チップ、そのマイクロ流路チップを用いる生体分子の分離方法、およびそのマイクロ流路チップを有する電気泳動装置

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JP2004060215A JP4450368B2 (ja) 2004-03-04 2004-03-04 マイクロ流路チップの製造方法、マイクロ流路チップ、そのマイクロ流路チップを用いる生体分子の分離方法、およびそのマイクロ流路チップを有する電気泳動装置

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JP2005249572A JP2005249572A (ja) 2005-09-15
JP2005249572A5 JP2005249572A5 (enExample) 2009-08-06
JP4450368B2 true JP4450368B2 (ja) 2010-04-14

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US (1) US8012430B2 (enExample)
JP (1) JP4450368B2 (enExample)
GB (1) GB2429428B8 (enExample)
WO (1) WO2005084794A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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JP2012047457A (ja) * 2010-08-24 2012-03-08 Shimadzu Corp マイクロ流体デバイスのクリーニング方法及びクリーニング液
US9303239B2 (en) 2013-02-27 2016-04-05 Shimadzu Corporation Method for cleaning microfluidic device and cleaning liquid

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JP4763443B2 (ja) * 2004-12-20 2011-08-31 東北リコー株式会社 ジケトン重合体及びその製造方法
JP2007309741A (ja) * 2006-05-17 2007-11-29 Olympus Corp 血液分離方法および血液分離装置
JP4984648B2 (ja) * 2006-05-26 2012-07-25 富士通株式会社 検出素子、その製造方法、および標的検出装置
CN101095697A (zh) * 2006-06-28 2008-01-02 李振国 水蛭和/或地龙分子量5800道尔顿以下的提取物
WO2008029685A1 (en) 2006-09-04 2008-03-13 National Institute Of Advanced Industrial Science And Technology Method for analysis of sample by capillary electrophoresis
JP2009186445A (ja) * 2008-02-08 2009-08-20 Arkray Inc キャピラリー電気泳動法によるヘモグロビンの分析方法およびそれに用いる試薬
JP4814944B2 (ja) * 2006-09-04 2011-11-16 独立行政法人産業技術総合研究所 キャピラリー電気泳動法による試料の分析方法
US20100155242A1 (en) * 2006-09-04 2010-06-24 Arkray, Inc. Method of Analyzing a Sample by Capillary Electrophoresis
JP4862115B2 (ja) * 2006-10-04 2012-01-25 国立大学法人北海道大学 マイクロチップおよびマイクロチップ電気泳動装置
CA2671750C (en) * 2006-12-14 2015-04-07 Boehringer Ingelheim Microparts Gmbh Device for the intake or manipulation of a liquid
JP2009118773A (ja) * 2007-11-14 2009-06-04 Sumitomo Bakelite Co Ltd 核酸分析法
EP2457078A4 (en) * 2009-07-23 2014-07-30 Insight Nanofluidics Inc NANOFLUIDIC CELL
EP2643695A4 (en) * 2010-11-23 2016-03-09 Univ California MULTIDIRECTIONAL MICROFLUIDIC DEVICES WITH A PAN CAPTURE BINDING REGION AND METHOD OF USE THEREOF
WO2013089887A2 (en) 2011-09-30 2013-06-20 The Regents Of The University Of California Microfluidic devices and methods for assaying a fluid sample using the same
JP6161149B2 (ja) * 2013-03-12 2017-07-12 スタンレー電気株式会社 金属被覆部材の製造方法およびその真空製造装置
KR102115548B1 (ko) 2013-12-16 2020-05-26 삼성전자주식회사 유기물 세정 조성물 및 이를 이용하는 반도체 장치의 제조 방법
JP6018237B2 (ja) 2014-02-14 2016-11-02 アークレイ株式会社 マイクロ流路を備えるチップの製造方法及びそれにより製造されるチップ
JP6441500B2 (ja) * 2014-12-15 2018-12-19 プレクセンス・インコーポレイテッド 表面プラズモン検出装置及び方法
CN108021041A (zh) * 2016-11-02 2018-05-11 中国科学院大连化学物理研究所 一种数字式微流控芯片液滴驱动控制系统及其控制方法
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
GB201815405D0 (en) * 2018-09-21 2018-11-07 Fujifilm Mfg Europe Bv Membranes suitable for detecting, filtering and/or purifying biomolecules
JP7230426B2 (ja) * 2018-10-24 2023-03-01 日本ゼオン株式会社 接合体の製造方法
JP7166889B2 (ja) * 2018-11-20 2022-11-08 ダイキン工業株式会社 1,2-ジフルオロエチレンの製造方法
CN111151313A (zh) * 2019-12-26 2020-05-15 重庆创芯生物科技有限公司 一种用于制备亲水性微流控芯片的材料及微流控芯片
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
CN113522379B (zh) * 2020-04-20 2023-04-07 中国科学院化学研究所 微墙阵列及其制备方法与应用、微通道及其制备方法、微通道反应器及其应用
WO2022064447A1 (en) 2020-09-24 2022-03-31 Waters Technologies Corporation Chromatographic hardware improvements for the separation of reactive molecules
WO2022240193A1 (ko) * 2021-05-11 2022-11-17 (주)인벤티지랩 지질 나노 입자 제조용 칩, 이를 포함하는 지질 나노 입자 제조 시스템 및 지질 나노 입자 제조 방법
DE112022002939A5 (de) * 2021-06-08 2024-04-25 Werner Döbelin Kapillarelektrophorese-apparatur

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015350A (en) 1989-11-06 1991-05-14 Applied Biosystems, Inc. Flow-rate-controlled surface-charge coating for capillary electrophoresis
US5264101A (en) 1989-11-06 1993-11-23 Applied Biosystems, Inc. Capillary electrophoresis molecular weight separation of biomolecules using a polymer-containing solution
WO1995016910A1 (en) 1993-12-17 1995-06-22 Perkin-Elmer Corporation Uncharged polymers for separation of biomolecules by capillary electrophoresis
US5989402A (en) * 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
JP4074713B2 (ja) 1998-07-29 2008-04-09 財団法人川村理化学研究所 送液デバイス及びその製造方法
US6326083B1 (en) * 1999-03-08 2001-12-04 Calipher Technologies Corp. Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety
WO2001026812A1 (en) * 1999-10-14 2001-04-19 Ce Resources Pte Ltd Microfluidic structures and methods of fabrication
JP2001252896A (ja) 2000-03-06 2001-09-18 Hitachi Ltd マイクロ流路及びそれを用いたマイクロポンプ
JP2002148236A (ja) 2000-11-08 2002-05-22 Hitachi Ltd 電気泳動装置
US6418968B1 (en) * 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
JP2003107080A (ja) 2001-09-30 2003-04-09 Jun Kikuchi 血液分析装置ならびに血液分析方法
JP2003121453A (ja) 2001-10-09 2003-04-23 Ryokusei Mes Kk Dna(デオキシリボ核酸)検査用マイクロプレート製造システム
WO2003047712A2 (en) * 2001-10-18 2003-06-12 The Board Of Trustees Of The University Of Illinois Hybrid microfluidic and nanofluidic system
US7005050B2 (en) * 2001-10-24 2006-02-28 The Regents Of The University Of Michigan Electrophoresis in microfabricated devices using photopolymerized polyacrylamide gels and electrode-defined sample injection
JP2003220330A (ja) 2002-01-31 2003-08-05 Asahi Kasei Corp 透明ポリマーチップ
JP3885674B2 (ja) 2002-06-28 2007-02-21 株式会社島津製作所 電気泳動チップとその製造方法
JPWO2004008132A1 (ja) 2002-07-11 2005-11-10 三菱電機株式会社 生体分子分離セル及びその製造方法並びにdna分取装置
JP2004061319A (ja) 2002-07-29 2004-02-26 Kawamura Inst Of Chem Res マイクロ流体デバイス及びその使用方法
US7010964B2 (en) * 2002-10-31 2006-03-14 Nanostream, Inc. Pressurized microfluidic devices with optical detection regions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012047457A (ja) * 2010-08-24 2012-03-08 Shimadzu Corp マイクロ流体デバイスのクリーニング方法及びクリーニング液
US9303239B2 (en) 2013-02-27 2016-04-05 Shimadzu Corporation Method for cleaning microfluidic device and cleaning liquid

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