JP4426761B2 - ウエストナイル熱ウイルスに対するワクチン - Google Patents
ウエストナイル熱ウイルスに対するワクチン Download PDFInfo
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- JP4426761B2 JP4426761B2 JP2002579985A JP2002579985A JP4426761B2 JP 4426761 B2 JP4426761 B2 JP 4426761B2 JP 2002579985 A JP2002579985 A JP 2002579985A JP 2002579985 A JP2002579985 A JP 2002579985A JP 4426761 B2 JP4426761 B2 JP 4426761B2
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- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24171—Demonstrated in vivo effect
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| FR0104737A FR2823222B1 (fr) | 2001-04-06 | 2001-04-06 | Vaccin contre le virus de la fievre du nil |
| PCT/FR2002/001200 WO2002081621A2 (fr) | 2001-04-06 | 2002-04-05 | Vaccin contre le virus de la fievre du nil |
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| JP2004531521A JP2004531521A (ja) | 2004-10-14 |
| JP2004531521A5 JP2004531521A5 (enExample) | 2005-07-28 |
| JP4426761B2 true JP4426761B2 (ja) | 2010-03-03 |
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| JP2002579985A Expired - Lifetime JP4426761B2 (ja) | 2001-04-06 | 2002-04-05 | ウエストナイル熱ウイルスに対するワクチン |
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| JP (1) | JP4426761B2 (enExample) |
| AU (1) | AU2002307971B2 (enExample) |
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| BR (1) | BRPI0208896B1 (enExample) |
| CA (1) | CA2448796C (enExample) |
| CY (2) | CY1117676T1 (enExample) |
| DK (1) | DK1377660T3 (enExample) |
| ES (2) | ES2767413T3 (enExample) |
| FR (2) | FR2823222B1 (enExample) |
| HU (2) | HU230122B1 (enExample) |
| IL (3) | IL158204A0 (enExample) |
| LT (1) | LTC1377660I2 (enExample) |
| LU (1) | LU93048I2 (enExample) |
| MX (1) | MXPA03008998A (enExample) |
| NL (1) | NL300806I2 (enExample) |
| PL (2) | PL210306B1 (enExample) |
| RU (1) | RU2283138C2 (enExample) |
| SI (1) | SI1377660T1 (enExample) |
| WO (1) | WO2002081621A2 (enExample) |
| ZA (1) | ZA200307620B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2950109C (en) | 2000-10-27 | 2019-02-19 | John W. Hadden | Vaccine immunotherapy for immune suppressed patients |
| ES2435095T3 (es) | 2001-07-27 | 2013-12-18 | Zoetis W Llc | Vacuna del Nilo Occidental |
| AU2003296974A1 (en) * | 2002-12-13 | 2004-07-14 | Aventis Pasteur, Inc. | Production of alvac on avian embryonic stem cells |
| US8475808B2 (en) | 2003-05-23 | 2013-07-02 | Novartis Vaccines And Diagnostics, Inc. | Immunogenic reagents from west nile virus |
| US7482017B2 (en) | 2004-09-09 | 2009-01-27 | Research Development Foundation | Flavivirus variants having phenotypic variation and immunogenic compositions thereof |
| JP5603012B2 (ja) | 2005-12-02 | 2014-10-08 | トヘ モウント シナイ スクール オフ メディシネ オフ ニューヨーク ウニベルシトイ | 非天然表面タンパク質を提示するキメラウイルス及びその使用 |
| SG193821A1 (en) | 2008-08-29 | 2013-10-30 | Boehringer Ingelheim Vetmed | West nile virus vaccine |
| EP2393921B1 (en) | 2009-02-05 | 2015-07-15 | Icahn School of Medicine at Mount Sinai | Chimeric newcastle disease viruses and uses thereof |
| KR101793195B1 (ko) | 2009-03-27 | 2017-11-02 | 아카데미아 시니카 | 바이러스에 대한 면역을 위한 방법 및 조성물 |
| AU2010248761B2 (en) * | 2009-05-15 | 2016-02-11 | Irx Therapeutics, Inc. | Vaccine immunotherapy |
| TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
| RU2506093C1 (ru) * | 2012-12-06 | 2014-02-10 | Государственное научное учреждение Якутский научно-исследовательский институт сельского хозяйства Российской академии сельскохозяйственных наук | Способ специфической профилактики ринопневмонии, сальмонеллезного аборта и мыта лошадей ассоциированной вакциной в условиях табунного содержания |
| PE20151921A1 (es) | 2013-03-14 | 2015-12-26 | Icahn School Med Mount Sinai | Virus de la enfermedad de newcastle y usos de los mismos |
| AU2015222685A1 (en) | 2014-02-27 | 2016-09-08 | Viralytics Limited | Combination method for treatment of cancer |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| EP3837277A4 (en) | 2018-08-17 | 2022-05-11 | Icahn School of Medicine at Mount Sinai | RECOMBINANT NEWCASTLE DISEASE VIRUSES AND THEIR USES IN THE PREVENTION OF RSV DISEASE OR HUMAN METAPNEUMOVIRUS INFECTION |
| WO2021229270A1 (es) | 2020-05-13 | 2021-11-18 | Laboratorio Avi-Mex, S.A. De C.V. | Vacuna recombinante contra covid-19 en vector viral |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2909462A (en) | 1955-12-08 | 1959-10-20 | Bristol Myers Co | Acrylic acid polymer laxative compositions |
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US5505941A (en) | 1981-12-24 | 1996-04-09 | Health Research, Inc. | Recombinant avipox virus and method to induce an immune response |
| US5338683A (en) | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US5110587A (en) | 1981-12-24 | 1992-05-05 | Health Research, Incorporated | Immunogenic composition comprising synthetically modified vaccinia virus |
| US5174993A (en) | 1981-12-24 | 1992-12-29 | Health Research Inc. | Recombinant avipox virus and immunological use thereof |
| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| EP0173552B1 (en) | 1984-08-24 | 1991-10-09 | The Upjohn Company | Recombinant dna compounds and the expression of polypeptides such as tpa |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US4963481A (en) | 1985-12-18 | 1990-10-16 | Genetics Institute Inc | Promoter system |
| US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
| GB2197321B (en) | 1986-09-12 | 1990-10-03 | Genentech Inc | Method and vectors for obtaining continuous production of heterologous protein in a eukaryotic host cell line |
| DE3743138A1 (de) | 1987-12-18 | 1989-09-14 | Mayr Christian Gmbh & Co Kg | Schleifringlose, elektromagnetische ueberlastkupplung |
| MY109299A (en) * | 1990-08-15 | 1996-12-31 | Virogenetics Corp | Recombinant pox virus encoding flaviviral structural proteins |
| EP0575491B1 (en) | 1991-03-07 | 2003-08-13 | Virogenetics Corporation | Genetically engineered vaccine strain |
| US5843456A (en) | 1991-03-07 | 1998-12-01 | Virogenetics Corporation | Alvac poxvirus-rabies compositions and combination compositions and uses |
| US5382425A (en) | 1992-01-13 | 1995-01-17 | Syntro Corporation | Recombinant swinepox virus |
| FR2702373B1 (fr) | 1993-03-08 | 1996-06-07 | Rhone Merieux | Emulsions vaccinales fluides eau-dans-l'huile contenant une huile métabolisable. |
| EP0668355B1 (en) | 1993-12-20 | 1999-04-07 | Akzo Nobel N.V. | Vaccine for the protection of horses against equine herpesvirus infection |
| FR2728795B1 (fr) | 1994-12-30 | 1997-03-21 | Rhone Merieux | Vaccin vivant recombinant aviaire, utilisant comme vecteur un virus herpes aviaire |
| FR2728794B1 (fr) | 1994-12-30 | 1997-03-21 | Rhone Merieux | Vaccin recombinant aviaire a base de virus herpes aviaire, notamment contre la maladie de gumboro |
| JPH11504631A (ja) | 1995-04-25 | 1999-04-27 | バイカル インコーポレイテッド | Ｄｎａ／脂質複合体の単一バイアル製剤 |
| AU737243B2 (en) | 1996-07-03 | 2001-08-16 | Merial, Inc. | Recombinant canine adenovirus (CAV) containing exogenous DNA |
| FR2751226B1 (fr) | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique contre les pathologies du cheval |
| FR2751227B1 (fr) | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique contre les pathologies canines, notamment les pathologies respiratoires et digestives |
| FR2751225B1 (fr) | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique aviaire |
| WO1998016247A1 (en) | 1996-10-11 | 1998-04-23 | The Regents Of The University Of California | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
| ES2345614T3 (es) * | 1997-02-28 | 2010-09-28 | Sanofi Pasteur Biologics Co. | Vacunas quimericas de flavivirus. |
| US7227011B2 (en) * | 1998-06-04 | 2007-06-05 | United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Nucleic acid vaccines for prevention of flavivirus infection |
| US6294176B1 (en) | 1998-07-10 | 2001-09-25 | Schering-Plough Veterinary Corp. | Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species |
| US6416763B1 (en) * | 1998-08-28 | 2002-07-09 | Hawaii Biotechnology Group, Inc. | Recombinant nonstructural protein subunit vaccine against flaviviral infection |
| US6645740B1 (en) | 1999-06-10 | 2003-11-11 | Merial Limited | Nucleic acids encodings equine GM-CSF |
| BR0011732B1 (pt) | 1999-06-10 | 2014-02-04 | Vacinas de dna para animais de companhia e de esporte | |
| FR2796397B1 (fr) | 1999-07-16 | 2006-09-01 | Merial Sas | Genes de calicivirus felin et vaccins notamment vaccins recombines |
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2001
- 2001-04-06 FR FR0104737A patent/FR2823222B1/fr not_active Expired - Lifetime
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- 2002-04-05 ES ES15162832T patent/ES2767413T3/es not_active Expired - Lifetime
- 2002-04-05 AU AU2002307971A patent/AU2002307971B2/en not_active Expired
- 2002-04-05 WO PCT/FR2002/001200 patent/WO2002081621A2/fr not_active Ceased
- 2002-04-05 ES ES02759818.4T patent/ES2566044T3/es not_active Expired - Lifetime
- 2002-04-05 CA CA2448796A patent/CA2448796C/en not_active Expired - Lifetime
- 2002-04-05 EP EP15162832.8A patent/EP2979705B1/fr not_active Expired - Lifetime
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- 2002-04-05 RU RU2003132455/13A patent/RU2283138C2/ru active
- 2002-04-05 EP EP02759818.4A patent/EP1377660B1/fr not_active Expired - Lifetime
- 2002-04-05 PL PL391444A patent/PL210306B1/pl unknown
- 2002-04-05 IL IL15820402A patent/IL158204A0/xx unknown
- 2002-04-05 SI SI200231069A patent/SI1377660T1/sl unknown
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- 2002-04-05 PL PL365210A patent/PL207584B1/pl unknown
- 2002-04-05 JP JP2002579985A patent/JP4426761B2/ja not_active Expired - Lifetime
- 2002-04-05 DK DK02759818.4T patent/DK1377660T3/en active
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- 2007-08-14 IL IL185263A patent/IL185263A0/en active IP Right Grant
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2015
- 2015-09-18 HU HUS1500047C patent/HUS1500047I1/hu unknown
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2016
- 2016-04-06 CY CY20161100275T patent/CY1117676T1/el unknown
- 2016-04-19 FR FR16C0014C patent/FR16C0014I2/fr active Active
- 2016-04-20 NL NL300806C patent/NL300806I2/nl unknown
- 2016-04-20 LT LTPA2016011C patent/LTC1377660I2/lt unknown
- 2016-04-26 LU LU93048C patent/LU93048I2/xx unknown
- 2016-04-26 BE BE2016C021C patent/BE2016C021I2/fr unknown
- 2016-05-20 CY CY2016018C patent/CY2016018I2/el unknown
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