CY1117676T1 - Εμβολιο κατα του ιου του δυτικου νειλου - Google Patents

Εμβολιο κατα του ιου του δυτικου νειλου

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Publication number
CY1117676T1
CY1117676T1 CY20161100275T CY161100275T CY1117676T1 CY 1117676 T1 CY1117676 T1 CY 1117676T1 CY 20161100275 T CY20161100275 T CY 20161100275T CY 161100275 T CY161100275 T CY 161100275T CY 1117676 T1 CY1117676 T1 CY 1117676T1
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CY
Cyprus
Prior art keywords
expression vectors
west nile
virus
nile virus
vivo
Prior art date
Application number
CY20161100275T
Other languages
English (en)
Inventor
Sheena May Loosmore
Jean-Christophe Francis Audonnet
Jules Maarten Minke
Original Assignee
Merial
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial filed Critical Merial
Publication of CY1117676T1 publication Critical patent/CY1117676T1/el

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24171—Demonstrated in vivo effect

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση αφορά φορείς έκφρασης in vivo και in vitro που περιλαμβάνουν ένα πολυνουκλεοτίδιο που κωδικοποιεί τη δομική πρωτεΐνη Ε του ιού του Δυτικού Νείλου ή ιού WN, που προαιρετικά συνδέεται με ένα πολυνουκλεοτίδιο που κωδικοποιεί την προμεμβρανώδη πρωτεΐνη prM και/ή τη μεμβρανική πρωτεΐνη Μ, ιδίως υπό τη μορφή που κωδικοποιεί την prM-M-E. Οι εν λόγω in vivo φορείς έκφρασης ενσωματώνονται σε ζωντανά εμβόλια. Οι φορείς έκφρασης in vivo χρησιμοποιούνται για την παραγωγή πρωτεϊνών in vitro που μπορούν στη συνέχεια να χρησιμοποιηθούν σε εμβόλια υπομονάδων. Η εφεύρεση αφορά επίσης πολυδύναμα εμβόλια που περιλαμβάνουν ένα στοιχείο εμβολίου κατά του ιού του ΔΝ και ένα στοιχείο εμβολίου κατά ενός άλλου παθογόνου παράγοντα. Η εφεύρεση είναι σχεδιασμένη ιδίως για ιπποειδή, κυνοειδή, αιλουροειδή, βοοειδή, χοίρους και πουλιά.
CY20161100275T 2001-04-06 2016-04-06 Εμβολιο κατα του ιου του δυτικου νειλου CY1117676T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0104737A FR2823222B1 (fr) 2001-04-06 2001-04-06 Vaccin contre le virus de la fievre du nil
EP02759818.4A EP1377660B1 (fr) 2001-04-06 2002-04-05 Vaccin contre le virus de la fievre du nil

Publications (1)

Publication Number Publication Date
CY1117676T1 true CY1117676T1 (el) 2016-12-14

Family

ID=8862055

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20161100275T CY1117676T1 (el) 2001-04-06 2016-04-06 Εμβολιο κατα του ιου του δυτικου νειλου
CY2016018C CY2016018I2 (el) 2001-04-06 2016-05-20 Εμβολιο κατα του ιου του δυτικου νειλου

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2016018C CY2016018I2 (el) 2001-04-06 2016-05-20 Εμβολιο κατα του ιου του δυτικου νειλου

Country Status (22)

Country Link
EP (2) EP1377660B1 (el)
JP (1) JP4426761B2 (el)
AU (1) AU2002307971B2 (el)
BE (1) BE2016C021I2 (el)
BR (1) BRPI0208896B1 (el)
CA (1) CA2448796C (el)
CY (2) CY1117676T1 (el)
DK (1) DK1377660T3 (el)
ES (2) ES2566044T3 (el)
FR (2) FR2823222B1 (el)
HK (2) HK1219412A1 (el)
HU (2) HU230122B1 (el)
IL (3) IL158204A0 (el)
LT (1) LTC1377660I2 (el)
LU (1) LU93048I2 (el)
MX (1) MXPA03008998A (el)
NL (1) NL300806I2 (el)
PL (2) PL210306B1 (el)
RU (1) RU2283138C2 (el)
SI (1) SI1377660T1 (el)
WO (1) WO2002081621A2 (el)
ZA (1) ZA200307620B (el)

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Also Published As

Publication number Publication date
FR16C0014I2 (fr) 2016-09-09
AU2002307971B2 (en) 2008-01-17
HUP0401868A2 (hu) 2004-12-28
EP2979705A1 (fr) 2016-02-03
EP1377660A2 (fr) 2004-01-07
MXPA03008998A (es) 2004-10-15
NL300806I2 (el) 2016-06-09
JP4426761B2 (ja) 2010-03-03
FR2823222B1 (fr) 2004-02-06
BRPI0208896B1 (pt) 2016-06-07
ZA200307620B (en) 2005-07-27
SI1377660T1 (sl) 2016-05-31
RU2283138C2 (ru) 2006-09-10
HUS1500047I1 (hu) 2017-03-28
HK1219412A1 (zh) 2017-04-07
RU2003132455A (ru) 2005-04-27
CA2448796A1 (en) 2002-10-17
CY2016018I1 (el) 2016-12-14
HUP0401868A3 (en) 2011-06-28
WO2002081621A3 (fr) 2003-02-20
IL158204A0 (en) 2004-05-12
DK1377660T3 (en) 2016-03-29
ES2767413T3 (es) 2020-06-17
LTC1377660I2 (lt) 2017-04-25
BE2016C021I2 (el) 2021-03-23
CA2448796C (en) 2012-11-20
LU93048I2 (fr) 2016-06-27
PL207584B1 (pl) 2011-01-31
PL210306B1 (pl) 2011-12-30
ES2566044T3 (es) 2016-04-08
JP2004531521A (ja) 2004-10-14
FR2823222A1 (fr) 2002-10-11
IL158204A (en) 2013-03-24
IL185263A0 (en) 2008-01-06
HU230122B1 (hu) 2015-08-28
HK1061868A1 (zh) 2004-10-08
WO2002081621A2 (fr) 2002-10-17
BR0208896A (pt) 2004-07-20
CY2016018I2 (el) 2016-12-14
EP2979705B1 (fr) 2019-10-23
EP1377660B1 (fr) 2016-01-13
FR16C0014I1 (el) 2016-05-27
PL365210A1 (en) 2004-12-27

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