JP4414771B2 - 共焦点顕微分光装置 - Google Patents
共焦点顕微分光装置 Download PDFInfo
- Publication number
- JP4414771B2 JP4414771B2 JP2004002886A JP2004002886A JP4414771B2 JP 4414771 B2 JP4414771 B2 JP 4414771B2 JP 2004002886 A JP2004002886 A JP 2004002886A JP 2004002886 A JP2004002886 A JP 2004002886A JP 4414771 B2 JP4414771 B2 JP 4414771B2
- Authority
- JP
- Japan
- Prior art keywords
- light source
- confocal
- fluorescence
- excitation
- semiconductor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000005284 excitation Effects 0.000 claims description 87
- 239000003153 chemical reaction reagent Substances 0.000 claims description 51
- 239000004065 semiconductor Substances 0.000 claims description 47
- 238000001514 detection method Methods 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 18
- 239000013307 optical fiber Substances 0.000 claims description 18
- 230000003595 spectral effect Effects 0.000 claims description 16
- 239000000835 fiber Substances 0.000 claims description 9
- 230000001678 irradiating effect Effects 0.000 claims description 5
- 239000000758 substrate Substances 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 description 18
- 238000002189 fluorescence spectrum Methods 0.000 description 8
- 230000004888 barrier function Effects 0.000 description 4
- 239000000470 constituent Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000010287 polarization Effects 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001218 confocal laser scanning microscopy Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
- G01J3/4406—Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0256—Compact construction
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Optics & Photonics (AREA)
- Microscoopes, Condenser (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004002886A JP4414771B2 (ja) | 2004-01-08 | 2004-01-08 | 共焦点顕微分光装置 |
| US11/020,456 US7315039B2 (en) | 2004-01-08 | 2004-12-22 | Confocal microspectroscope |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004002886A JP4414771B2 (ja) | 2004-01-08 | 2004-01-08 | 共焦点顕微分光装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005195485A JP2005195485A (ja) | 2005-07-21 |
| JP2005195485A5 JP2005195485A5 (cg-RX-API-DMAC10.html) | 2007-02-22 |
| JP4414771B2 true JP4414771B2 (ja) | 2010-02-10 |
Family
ID=34737131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004002886A Expired - Fee Related JP4414771B2 (ja) | 2004-01-08 | 2004-01-08 | 共焦点顕微分光装置 |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US7315039B2 (cg-RX-API-DMAC10.html) |
| JP (1) | JP4414771B2 (cg-RX-API-DMAC10.html) |
Families Citing this family (76)
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| DE60141090D1 (de) | 2000-10-30 | 2010-03-04 | Gen Hospital Corp | Optische systeme zur gewebeanalyse |
| CA2519937C (en) | 2003-03-31 | 2012-11-20 | Guillermo J. Tearney | Speckle reduction in optical coherence tomography by path length encoded angular compounding |
| KR101204370B1 (ko) | 2003-06-06 | 2012-11-23 | 더 제너럴 하스피탈 코포레이션 | 파장 동조 소스용 방법 및 장치 |
| JP4995720B2 (ja) | 2004-07-02 | 2012-08-08 | ザ ジェネラル ホスピタル コーポレイション | ダブルクラッドファイバを有する内視鏡撮像プローブ |
| ATE538714T1 (de) | 2004-08-24 | 2012-01-15 | Gen Hospital Corp | Verfahren, system und software-anordnung zur bestimmung des elastizitätsmoduls |
| JP5324095B2 (ja) | 2004-08-24 | 2013-10-23 | ザ ジェネラル ホスピタル コーポレイション | 血管セグメントを画像化する方法および装置 |
| EP1816949A1 (en) | 2004-11-29 | 2007-08-15 | The General Hospital Corporation | Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample |
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| US7889348B2 (en) * | 2005-10-14 | 2011-02-15 | The General Hospital Corporation | Arrangements and methods for facilitating photoluminescence imaging |
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| JP2007225381A (ja) * | 2006-02-22 | 2007-09-06 | Osaka Prefecture Univ | 蛍光測定方法及び蛍光顕微鏡 |
| WO2007101026A2 (en) | 2006-02-24 | 2007-09-07 | The General Hospital Corporation | Methods and systems for performing angle-resolved fourier-domain optical coherence tomography |
| EP2015669A2 (en) | 2006-05-10 | 2009-01-21 | The General Hospital Corporation | Processes, arrangements and systems for providing frequency domain imaging of a sample |
| US7846391B2 (en) | 2006-05-22 | 2010-12-07 | Lumencor, Inc. | Bioanalytical instrumentation using a light source subsystem |
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| DE102007003134A1 (de) * | 2007-01-18 | 2008-07-24 | Carl Zeiss Microimaging Gmbh | Laserscanmikroskop und strahlvereinigende optische Baugruppe |
| US9176319B2 (en) | 2007-03-23 | 2015-11-03 | The General Hospital Corporation | Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures |
| US10534129B2 (en) | 2007-03-30 | 2020-01-14 | The General Hospital Corporation | System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque |
| US8098375B2 (en) | 2007-08-06 | 2012-01-17 | Lumencor, Inc. | Light emitting diode illumination system |
| EP2309923B1 (en) | 2008-07-14 | 2020-11-25 | The General Hospital Corporation | Apparatus and methods for color endoscopy |
| KR101018153B1 (ko) * | 2008-11-27 | 2011-02-28 | 삼성엘이디 주식회사 | Led 패키지 |
| JP5731394B2 (ja) | 2008-12-10 | 2015-06-10 | ザ ジェネラル ホスピタル コーポレイション | 光サブサンプリングを通じて、光コヒーレンストモグラヒィーのイメージング深度範囲を伸ばすためのシステム、装置及び方法 |
| US9615748B2 (en) | 2009-01-20 | 2017-04-11 | The General Hospital Corporation | Endoscopic biopsy apparatus, system and method |
| US8242462B2 (en) * | 2009-01-23 | 2012-08-14 | Lumencor, Inc. | Lighting design of high quality biomedical devices |
| WO2010091190A2 (en) | 2009-02-04 | 2010-08-12 | The General Hospital Corporation | Apparatus and method for utilization of a high-speed optical wavelength tuning source |
| CN102469943A (zh) | 2009-07-14 | 2012-05-23 | 通用医疗公司 | 用于测量脉管内流动和压力的设备、系统和方法 |
| SMT202000624T1 (it) | 2010-03-05 | 2021-01-05 | Massachusetts Gen Hospital | Apparecchio per fornire radiazione elettromagnetica a un campione |
| US9069130B2 (en) | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
| EP2575598A2 (en) | 2010-05-25 | 2013-04-10 | The General Hospital Corporation | Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images |
| US9557154B2 (en) | 2010-05-25 | 2017-01-31 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
| US10285568B2 (en) | 2010-06-03 | 2019-05-14 | The General Hospital Corporation | Apparatus and method for devices for imaging structures in or at one or more luminal organs |
| WO2012058381A2 (en) | 2010-10-27 | 2012-05-03 | The General Hospital Corporation | Apparatus, systems and methods for measuring blood pressure within at least one vessel |
| US8389957B2 (en) | 2011-01-14 | 2013-03-05 | Lumencor, Inc. | System and method for metered dosage illumination in a bioanalysis or other system |
| US8466436B2 (en) | 2011-01-14 | 2013-06-18 | Lumencor, Inc. | System and method for metered dosage illumination in a bioanalysis or other system |
| CN102175643B (zh) * | 2011-03-18 | 2013-04-10 | 苏州晓松科技开发有限公司 | 激光物证勘查仪 |
| WO2013013049A1 (en) | 2011-07-19 | 2013-01-24 | The General Hospital Corporation | Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography |
| TWI454735B (zh) * | 2011-08-19 | 2014-10-01 | Anmo Electronics Corp | 手持式螢光顯微鏡 |
| EP2769491A4 (en) | 2011-10-18 | 2015-07-22 | Gen Hospital Corp | DEVICE AND METHOD FOR PRODUCING AND / OR PROVIDING RECIRCULATING OPTICAL DELAY (DE) |
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| US9217561B2 (en) | 2012-06-15 | 2015-12-22 | Lumencor, Inc. | Solid state light source for photocuring |
| US9415550B2 (en) | 2012-08-22 | 2016-08-16 | The General Hospital Corporation | System, method, and computer-accessible medium for fabrication miniature endoscope using soft lithography |
| US10101274B2 (en) | 2012-12-05 | 2018-10-16 | Genepoc Inc. | Optical interrogation device |
| JP2014115121A (ja) * | 2012-12-06 | 2014-06-26 | Sony Corp | 微小粒子分析装置及び微小粒子分析方法 |
| WO2014117130A1 (en) | 2013-01-28 | 2014-07-31 | The General Hospital Corporation | Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging |
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| CN104089883B (zh) * | 2013-12-17 | 2017-02-01 | 浙江工商大学 | 基于激光器阵列的检测装置及小黄鱼存储时间检测方法 |
| CN104076001A (zh) * | 2013-12-17 | 2014-10-01 | 浙江工商大学 | 基于激光器阵列的检测装置及大黄鱼存储时间检测方法 |
| WO2015105870A1 (en) | 2014-01-08 | 2015-07-16 | The General Hospital Corporation | Method and apparatus for microscopic imaging |
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| LU92620B1 (de) * | 2014-12-19 | 2016-06-20 | Leica Microsystems | Rastermikroskop |
| CN104597590B (zh) * | 2014-12-30 | 2018-02-02 | 深圳先进技术研究院 | 一种超分辨荧光光谱成像显微镜 |
| CN106990519B (zh) * | 2017-05-12 | 2024-09-24 | 中国科学院苏州生物医学工程技术研究所 | 结构光照明显微成像系统 |
| JP7256207B2 (ja) * | 2018-04-20 | 2023-04-11 | ザ プロクター アンド ギャンブル カンパニー | 頭皮ケア剤の空間的イメージング |
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| EP4182747B1 (en) | 2020-07-20 | 2025-06-18 | Apple Inc. | Photonic integrated circuits with controlled collapse chip connections |
| WO2023283294A1 (en) * | 2021-07-08 | 2023-01-12 | Apple Inc. | Light source modules for noise mitigation |
| US11914201B2 (en) | 2021-09-23 | 2024-02-27 | Apple Inc. | Mechanisms that transfer light between layers of multi-chip photonic assemblies |
| US12111207B2 (en) | 2022-09-23 | 2024-10-08 | Apple Inc. | Despeckling in optical measurement systems |
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| US5239178A (en) * | 1990-11-10 | 1993-08-24 | Carl Zeiss | Optical device with an illuminating grid and detector grid arranged confocally to an object |
| JPH0894938A (ja) * | 1994-09-21 | 1996-04-12 | Sony Corp | 共焦点顕微鏡並びに光記録再生装置 |
| JP3816632B2 (ja) * | 1997-05-14 | 2006-08-30 | オリンパス株式会社 | 走査型顕微鏡 |
| US6121603A (en) * | 1997-12-01 | 2000-09-19 | Hang; Zhijiang | Optical confocal device having a common light directing means |
| US6355934B1 (en) * | 1999-02-26 | 2002-03-12 | Packard Biochip Technologies | Imaging system for an optical scanner |
| US6181474B1 (en) * | 1999-03-22 | 2001-01-30 | Kovex Corporation | Scanning confocal microscope with objective lens position tracking |
| JP2001185796A (ja) * | 1999-12-27 | 2001-07-06 | Hitachi Metals Ltd | レーザ装置、その応用装置並びにその使用方法 |
| US6423956B1 (en) * | 2000-07-28 | 2002-07-23 | Optical Biopsy Technologies | Fiber-coupled, high-speed, integrated, angled-dual-axis confocal scanning microscopes employing vertical cross-section scanning |
| DE10038526B4 (de) | 2000-08-08 | 2004-09-02 | Carl Zeiss Jena Gmbh | Verfahren und Anordnung zur Erfassung des wellenlängenabhängigen Verhaltens einer beleuchteten Probe |
| US6858852B2 (en) * | 2000-08-08 | 2005-02-22 | Carl Zeiss Jena Gmbh | Method and apparatus for rapid change of fluorescence bands in the detection of dyes in fluorescence microscopy |
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| DE10225838B4 (de) * | 2002-06-11 | 2021-10-21 | Leica Microsystems Cms Gmbh | Verfahren zur Scanmikroskopie, Scanmikroskop und Vorrichtung zum Codieren eines Beleuchtungslichtstrahles |
| US6985224B2 (en) * | 2003-03-14 | 2006-01-10 | The United States Of America As Represented By The Secretary Of The Navy | Light emitting diode (LED) array for excitation emission matrix (EEM) fluorescence spectroscopy |
| US7215468B2 (en) * | 2003-07-29 | 2007-05-08 | Olympus Corporation | Confocal microscope |
-
2004
- 2004-01-08 JP JP2004002886A patent/JP4414771B2/ja not_active Expired - Fee Related
- 2004-12-22 US US11/020,456 patent/US7315039B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7315039B2 (en) | 2008-01-01 |
| JP2005195485A (ja) | 2005-07-21 |
| US20050151094A1 (en) | 2005-07-14 |
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