JP4361796B2 - シュードプレクタニア・ニグレラからの抗菌ポリペプチド - Google Patents
シュードプレクタニア・ニグレラからの抗菌ポリペプチド Download PDFInfo
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- JP4361796B2 JP4361796B2 JP2003545685A JP2003545685A JP4361796B2 JP 4361796 B2 JP4361796 B2 JP 4361796B2 JP 2003545685 A JP2003545685 A JP 2003545685A JP 2003545685 A JP2003545685 A JP 2003545685A JP 4361796 B2 JP4361796 B2 JP 4361796B2
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- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
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- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S426/00—Food or edible material: processes, compositions, and products
- Y10S426/807—Poultry or ruminant feed
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Fodder In General (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101732 | 2001-11-20 | ||
| DKPA200201243 | 2002-08-23 | ||
| PCT/DK2002/000781 WO2003044049A1 (en) | 2001-11-20 | 2002-11-20 | Antimicrobial polypeptides from pseudoplectania nigrella |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005533481A JP2005533481A (ja) | 2005-11-10 |
| JP2005533481A5 JP2005533481A5 (cg-RX-API-DMAC7.html) | 2006-01-12 |
| JP4361796B2 true JP4361796B2 (ja) | 2009-11-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545685A Expired - Fee Related JP4361796B2 (ja) | 2001-11-20 | 2002-11-20 | シュードプレクタニア・ニグレラからの抗菌ポリペプチド |
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| US7071293B1 (en) * | 1999-08-18 | 2006-07-04 | The University Of Iowa Research Foundation | Alpha helical peptides with broad spectrum antimicrobial activity that are insensitive to salt |
| AU2003269851A1 (en) * | 2002-10-09 | 2004-05-04 | Novozymes A/S | A method for screening for an antimicrobial polypeptide |
| ES2511292T3 (es) | 2002-10-11 | 2014-10-22 | Novozymes A/S | Método de preparación de un producto tratado con calor |
| WO2004072217A1 (en) * | 2003-02-15 | 2004-08-26 | Unilever Plc | Bleaching composition |
| CN1867668A (zh) | 2003-10-10 | 2006-11-22 | 诺维信公司 | 蛋白酶变体 |
| ES2332592T3 (es) | 2003-10-30 | 2010-02-09 | Novozymes A/S | Modulos de union a carbohidratos. |
| BRPI0507186A (pt) | 2004-01-30 | 2007-06-26 | Texas A & M Univ Sys | composição, métodos e usos para uma nova famìlia de peptìdeos |
| ES2531753T3 (es) | 2004-02-25 | 2015-03-18 | Novozymes A/S | Enzima de degradación de la pared celular fúngica |
| US7148404B2 (en) * | 2004-05-04 | 2006-12-12 | Novozymes A/S | Antimicrobial polypeptides |
| US8357408B2 (en) | 2004-06-21 | 2013-01-22 | Novozymes A/S | Proteases |
| AR050895A1 (es) | 2004-10-04 | 2006-11-29 | Novozymes As | Polipeptidos que tienen actividad de fitasa y polinucleotidos que los codifican |
| EP1809747B1 (en) | 2004-10-04 | 2016-12-14 | Novozymes A/S | Polypeptides having phytase activity and polynucleotides encoding same |
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| WO2007109750A2 (en) | 2006-03-22 | 2007-09-27 | Novozymes North America, Inc. | Fermentation processes |
| AU2007234177B2 (en) | 2006-04-04 | 2012-11-08 | Novozymes A/S | Phytase variants |
| DK2073642T3 (da) | 2006-09-29 | 2016-02-15 | Novozymes As | Xylanaser til dyrefoder |
| JP5643083B2 (ja) | 2007-03-26 | 2014-12-17 | ノボザイムス アクティーゼルスカブ | ハフニア・フィターゼ |
| CA2708712C (en) | 2007-12-11 | 2016-04-12 | Dsm Ip Assets B.V. | Use of essential oil compounds as histomonastat |
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| US8604277B2 (en) | 2009-01-28 | 2013-12-10 | Novozymes, Inc. | Polypeptides having beta-glucosidase activity and polynucleotides encoding same |
| US8563268B2 (en) | 2009-03-17 | 2013-10-22 | Novozymes A/S | Polypeptide having tyrosinase activity |
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| US9273320B2 (en) | 2009-08-07 | 2016-03-01 | Novozymes A/S | Method of producing a sweet protein |
| EP3550016B1 (en) | 2009-11-06 | 2022-05-04 | Novozymes, Inc. | Composition for saccharification of cellulosic material |
| CN103068976A (zh) | 2009-11-06 | 2013-04-24 | 诺维信股份有限公司 | 具有纤维二糖水解酶活性的多肽和编码该多肽的多核苷酸 |
| WO2011104284A1 (en) | 2010-02-25 | 2011-09-01 | Novozymes A/S | Polypeptides having antimicrobial activity |
| CN102917600B (zh) | 2010-03-26 | 2015-07-08 | 诺维信公司 | 热稳定性肌醇六磷酸酶变体 |
| CN101845454B (zh) * | 2010-04-16 | 2012-07-04 | 刘德虎 | 在重组毕赤酵母中表达假黑盘菌素成熟多肽的方法 |
| EP2588614A1 (en) | 2010-06-30 | 2013-05-08 | DSM IP Assets B.V. | Spore surface display of bioactive molecules |
| RU2448725C2 (ru) * | 2010-07-13 | 2012-04-27 | Российская Федерация, От Имени Которой Выступает Министерство Образования И Науки Российской Федерации | Способ повышения бактерицидной активности |
| RU2434880C1 (ru) * | 2010-07-21 | 2011-11-27 | Общество С Ограниченной Ответственностью "Биохарт" | Полипептид, имеющий антибактериальную активность и пригодный для получения лекарственных средств для лечения бактериальных инфекций человека |
| CN102409003B (zh) * | 2010-09-26 | 2013-05-15 | 中国农业科学院饲料研究所 | 多拷贝高效表达重组菌丝霉素的毕赤酵母 |
| CN103945704B (zh) | 2011-06-09 | 2017-05-03 | 诺维信专利公司 | 生物活性分子的融合 |
| CN103764822B (zh) | 2011-08-19 | 2016-11-23 | 诺维信公司 | 具有蛋白酶活性的多肽 |
| JP2014530598A (ja) | 2011-09-22 | 2014-11-20 | ノボザイムスアクティーゼルスカブ | プロテアーゼ活性を有するポリペプチドおよびこれをコードするポリヌクレオチド |
| US20140342038A1 (en) | 2011-12-19 | 2014-11-20 | Novozymes A/S | Processes and Compositions For Increasing The Digestibility of Cellulosic Materials |
| ES2667318T3 (es) | 2011-12-28 | 2018-05-10 | Novozymes A/S | Polipéptidos con actividad de proteasa |
| AU2013213601B8 (en) | 2012-01-26 | 2018-01-18 | Novozymes A/S | Use of polypeptides having protease activity in animal feed and detergents |
| AU2013279440B2 (en) | 2012-06-20 | 2016-10-06 | Novozymes A/S | Use of polypeptides having protease activity in animal feed and detergents |
| ES2694765T3 (es) | 2012-09-05 | 2018-12-27 | Novozymes A/S | Polipéptidos con actividad de proteasa |
| EP2934177B1 (en) | 2012-12-21 | 2017-10-25 | Novozymes A/S | Polypeptides having protease activiy and polynucleotides encoding same |
| AU2014214032A1 (en) | 2013-02-06 | 2015-07-09 | Novozymes A/S | Use of polypeptides having protease activity in animal feed |
| EP3203858A1 (en) | 2014-10-08 | 2017-08-16 | Novozymes A/S | Bacillus strains with fast germination and antimicrobial activity against clostridium perfringens |
| WO2016060935A2 (en) | 2014-10-08 | 2016-04-21 | Novozymes A/S | Compositions and methods of improving the digestibility of animal feed |
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| EP3234143B1 (en) | 2014-12-19 | 2023-06-28 | Novozymes A/S | Compositions comprising polypeptides having xylanase activity and polypeptides having arabinofuranosidase activity |
| BR112017015623B1 (pt) | 2015-01-23 | 2022-05-31 | Novozymes A/S | Ração animal ou aditivo de ração animal ou pré-mistura de ração, método para melhora de um ou mais parâmetros de desempenho de um animal e para alimentação de um animal, e, uso de uma cepa de bacillus |
| EP3626816A1 (en) | 2015-01-23 | 2020-03-25 | Novozymes A/S | Bacillus subtilis subspecies |
| MX387681B (es) | 2015-07-02 | 2025-03-18 | Novozymes As | Composiciones de pienso para animales y uso de las mismas. |
| EP3970506A1 (en) | 2015-07-02 | 2022-03-23 | Novozymes A/S | Animal feed compositions comprising gh25 lysozyme and ec 3.1.3.26 phytase and uses thereof |
| EP3316703B1 (en) | 2015-07-02 | 2021-11-17 | Novozymes A/S | Methods of improving animal performance |
| CN105018516B (zh) * | 2015-07-07 | 2018-02-06 | 广东海纳川生物科技股份有限公司 | 菌丝霉素蛋白的表达方法及其在抑痤疮丙酸杆菌中的应用 |
| DK3462904T3 (da) | 2016-05-24 | 2025-01-02 | Novozymes As | Polypeptider med alfa-galactosidaseaktivitet og polynukleotider, der koder for samme |
| CN109312321A (zh) | 2016-05-24 | 2019-02-05 | 诺维信公司 | 包含具有半乳聚糖酶活性的多肽和具有β-半乳糖苷酶活性的多肽的组合物 |
| US10927359B2 (en) | 2016-05-24 | 2021-02-23 | Novozymes A/S | Compositions comprising polypeptides having galactanase activity and polypeptides having beta-galactosidase activity |
| BR112018073875A2 (pt) | 2016-05-24 | 2019-02-26 | Novozymes As | polipeptídeo isolado, composição, grânulo, aditivo de ração animal, formulação líquida, ração animal, métodos para liberar galactose de material à base de planta, para melhorar um ou mais parâmetros de desempenho de um animal e o valor nutricional de uma ração animal, para preparar uma ração animal e para produzir o polipeptídeo, uso, polinucleotídeo, construto de ácido nucleico ou vetor de expressão, e, célula hospedeira recombinante. |
| BR112019000125A2 (pt) | 2016-07-08 | 2019-07-09 | Novozymes As | grânulo, polipeptídeo isolado, composição, aditivo de ração animal, ração animal peletizada, métodos de aprimoramento de um ou mais parâmetros de desempenho de um animal, de preparação de uma ração animal, para aprimorar o valor nutricional de uma ração animal, de solubilização de xilana a partir do material à base de planta e de produção do polipeptídeo, polinucleotídeo, construto de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, e, uso do grânulo |
| MX2019000140A (es) | 2016-07-08 | 2019-06-10 | Novozymes As | Variantes de xilanasa y polinucleotidos que las codifican. |
| AU2017380488B2 (en) | 2016-12-21 | 2023-09-14 | Novozymes A/S | Polypeptides having lysozyme activity, polynucleotides encoding same and uses and compositions thereof |
| WO2018177203A1 (en) | 2017-03-31 | 2018-10-04 | Novozymes A/S | Polypeptides having dnase activity |
| EP3642339B1 (en) | 2017-06-22 | 2025-09-10 | Novozymes A/S | Xylanase variants and polynucleotides encoding same |
| EP3655425B1 (en) | 2017-07-17 | 2021-10-27 | Linnane Pharma AB | Peptides with antibiotic potential against mycobacterium tuberculosis |
| WO2019020578A1 (en) | 2017-07-25 | 2019-01-31 | Dsm Ip Assets B.V. | USE OF SOPHOROLIPIDS AS ADDITIVES FOR ANIMAL FEEDING |
| WO2019043189A1 (en) | 2017-09-01 | 2019-03-07 | Novozymes A/S | ANIMAL FOOD ADDITIVES COMPRISING A POLYPEPTIDE HAVING PROTEASE ACTIVITY AND USES THEREOF |
| EP3675647B1 (en) | 2017-09-01 | 2024-10-09 | Novozymes A/S | Animal feed additives comprising a polypeptide having protease activity and uses thereof |
| WO2019096903A1 (en) | 2017-11-20 | 2019-05-23 | Novozymes A/S | New galactanases (ec 3.2.1.89) for use in soy processing |
| CN108148123B (zh) * | 2017-12-01 | 2020-11-03 | 北京生泰云科技有限公司 | 烧土火丝菌天然抗菌肽及其应用 |
| CN111491518A (zh) | 2017-12-20 | 2020-08-04 | 帝斯曼知识产权资产管理有限公司 | 包含胞壁质酶的动物饲料组合物及其用途 |
| US20210076704A1 (en) | 2017-12-20 | 2021-03-18 | Dsm Ip Assets B.V. | Animal feed compositions and uses thereof |
| US20210037856A1 (en) | 2018-03-05 | 2021-02-11 | Novozymes A/S | Ruminant Feed Composition Comprising A Muramidase |
| US12133542B2 (en) | 2018-04-25 | 2024-11-05 | Novozymes A/S | Animal feed compositions and uses thereof |
| EP3843552A1 (en) | 2018-08-31 | 2021-07-07 | Novozymes A/S | Polypeptides having protease activity and polynucleotides encoding same |
| WO2020053274A1 (en) | 2018-09-11 | 2020-03-19 | Dsm Ip Assets B.V. | Animal feed composition and use thereof |
| AU2019339615A1 (en) | 2018-09-11 | 2021-03-04 | Dsm Ip Assets B.V. | Animal feed composition comprising muramidase and use thereof |
| US20210337828A1 (en) | 2018-09-11 | 2021-11-04 | Dsm Ip Assets B.V. | Animal feed composition and use thereof |
| CA3108944A1 (en) | 2018-09-11 | 2020-03-19 | Dsm Ip Assets B.V. | Animal feed composition and use thereof |
| JP7484885B2 (ja) | 2018-09-11 | 2024-05-16 | ディーエスエム アイピー アセッツ ビー．ブイ． | 動物用飼料組成物及びその使用 |
| CN112752514A (zh) | 2018-09-17 | 2021-05-04 | 帝斯曼知识产权资产管理有限公司 | 动物饲料组合物及其用途 |
| US20220054600A1 (en) | 2018-09-17 | 2022-02-24 | Dsm Ip Assets B.V. | Animal feed compositions and uses thereof |
| BR112021004826A2 (pt) | 2018-09-17 | 2021-06-08 | Dsm Ip Assets B.V. | composições de ração animal e usos das mesmas |
| MX2021003040A (es) | 2018-09-17 | 2021-07-15 | Dsm Ip Assets Bv | Composiciones de alimentos animales y usos de las mismas. |
| MX2021003074A (es) | 2018-09-17 | 2021-06-23 | Dsm Ip Assets Bv | Composiciones de alimento animal y usos de las mismas. |
| EP3937652A1 (en) | 2019-03-11 | 2022-01-19 | Novozymes A/S | Fibrous maize-based animal feed with gh30 glucuronoxylan hydrolase |
| WO2021078839A1 (en) | 2019-10-22 | 2021-04-29 | Novozymes A/S | Animal feed composition |
| CN110974743B (zh) * | 2019-12-10 | 2022-03-29 | 武汉克鲁金生物科技有限公司 | 生产酵母环黄芪醇多肽混合液的方法及其抗衰老应用 |
| WO2021233937A1 (en) | 2020-05-18 | 2021-11-25 | Dsm Ip Assets B.V. | Animal feed compositions |
| US20230276828A1 (en) | 2020-05-18 | 2023-09-07 | Dsm Ip Assets B.V. | Animal feed compositions |
| EP4196575A1 (en) | 2020-08-13 | 2023-06-21 | Novozymes A/S | Phytase variants and polynucleotides encoding same |
| EP4447704A1 (en) | 2021-12-15 | 2024-10-23 | DSM IP Assets B.V. | Methods and uses for improving egg production and egg quality involving administering feed comprising muramidase (ec 3.2.1.17) |
| AU2022415276A1 (en) | 2021-12-16 | 2024-05-23 | Novozymes A/S | Protease animal feed formulation |
| WO2023131629A1 (en) | 2022-01-06 | 2023-07-13 | Novozymes A/S | Animal feed composition and use thereof |
| CA3253054A1 (en) | 2022-05-23 | 2023-11-30 | Dsm Ip Assets B.V. | METHOD FOR IMPROVING MEAT PIGMENTATION IN AN AQUATIC ANIMAL AND COMPOSITION OF ANIMAL FEED |
| BE1030801B1 (nl) | 2022-08-23 | 2024-03-26 | Nu3Guts Bv | Voederadditief voor het verhogen van de metaboliseerbare energie uit voeder in vee |
| BE1030865B1 (nl) | 2022-09-12 | 2024-04-09 | Nu3Guts Bv | Voederadditief voor het verbeteren van de darmgezondheid en/of de verteerbaarheid van voeder in vee |
| EP4629839A1 (en) | 2022-12-08 | 2025-10-15 | Novozymes A/S | Co-granulate for animal feed |
| EP4629835A1 (en) | 2022-12-08 | 2025-10-15 | Novozymes A/S | Fiber-degrading enzymes for animal feed comprising an oil seed material |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE282086T1 (de) | 1997-02-26 | 2004-11-15 | Novozymes As | Mikrobielle xyloglukanendotransglykosilase (xet) |
| FR2777568B1 (fr) * | 1998-04-15 | 2002-10-31 | Rhone Poulenc Agrochimie | Gene codant pour l'heliomicine, proteine obtenue, vecteur le contenant, organismes transformes obtenus et procede de preparation |
| US6482799B1 (en) * | 1999-05-25 | 2002-11-19 | The Regents Of The University Of California | Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial |
| IL146743A0 (en) | 1999-05-31 | 2002-07-25 | Novozymes As | Screening method for peptides |
| US6777592B2 (en) | 2000-04-14 | 2004-08-17 | E.I. Du Pont Denemours And Company | Arthropod defensins of Scolopendra canidens, Vaejovis carolinianus, and Argiope spp. |
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