JP4342797B2 - 新世代三重照準、キラル、広域スペクトラム抗菌、７位置換ピペリジノ−キノロンカルボン酸誘導体の調製、組成、および薬剤としての使用 - Google Patents

新世代三重照準、キラル、広域スペクトラム抗菌、７位置換ピペリジノ−キノロンカルボン酸誘導体の調製、組成、および薬剤としての使用 Download PDF

Info

Publication number
JP4342797B2
JP4342797B2 JP2002583413A JP2002583413A JP4342797B2 JP 4342797 B2 JP4342797 B2 JP 4342797B2 JP 2002583413 A JP2002583413 A JP 2002583413A JP 2002583413 A JP2002583413 A JP 2002583413A JP 4342797 B2 JP4342797 B2 JP 4342797B2
Authority
JP
Japan
Prior art keywords
amino
dihydro
fluoro
piperidinyl
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2002583413A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005504729A (ja
JP2005504729A5 (enExample
Inventor
ノエル、ジェイ．デ、ソウザ
マヘシ、ブイ．パテル
プラサド、ケイ．デシュパンデ
シュリカント、ブイ．グプト
サティシュ、ビー．バウサー
ミリンド、シー．シュクラ
ワイ．チューグ
ニチン、シュティー
ラビンドラ、ディー．ヨール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wockhardt Ltd
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Publication of JP2005504729A publication Critical patent/JP2005504729A/ja
Publication of JP2005504729A5 publication Critical patent/JP2005504729A5/ja
Application granted granted Critical
Publication of JP4342797B2 publication Critical patent/JP4342797B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2002583413A 2001-04-25 2002-04-24 新世代三重照準、キラル、広域スペクトラム抗菌、７位置換ピペリジノ−キノロンカルボン酸誘導体の調製、組成、および薬剤としての使用 Expired - Fee Related JP4342797B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28629101P 2001-04-25 2001-04-25
US28710401P 2001-04-27 2001-04-27
US34116501P 2001-12-13 2001-12-13
PCT/IN2002/000111 WO2002085886A2 (en) 2001-04-25 2002-04-24 Chiral, broad-spectrum antibacterial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation and compositions

Publications (3)

Publication Number Publication Date
JP2005504729A JP2005504729A (ja) 2005-02-17
JP2005504729A5 JP2005504729A5 (enExample) 2006-01-05
JP4342797B2 true JP4342797B2 (ja) 2009-10-14

Family

ID=27403606

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002583413A Expired - Fee Related JP4342797B2 (ja) 2001-04-25 2002-04-24 新世代三重照準、キラル、広域スペクトラム抗菌、７位置換ピペリジノ−キノロンカルボン酸誘導体の調製、組成、および薬剤としての使用

Country Status (6)

Country Link
US (1) US6964966B2 (enExample)
EP (1) EP1392677A2 (enExample)
JP (1) JP4342797B2 (enExample)
AU (1) AU2002302963A1 (enExample)
CA (1) CA2445888A1 (enExample)
WO (1) WO2002085886A2 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8163769B2 (en) 2002-03-12 2012-04-24 Abbott Laboratories Antibacterial compounds
EP1631570A1 (en) * 2003-03-12 2006-03-08 Abbott Laboratories Naphthyridine derivatives as antibacterial agents
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
TW200526626A (en) 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
GB0321509D0 (en) * 2003-09-13 2003-10-15 Astrazeneca Ab Chemical compounds
SI1675852T1 (sl) * 2003-09-22 2009-06-30 Janssen Pharmaceutica Nv 7-amino alkilidenil-heterociklični kinoloni in naftiridoni
EP1694667A2 (en) * 2003-11-20 2006-08-30 Wockhardt Limited Polymorphs of 1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3, 3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid hydrochloride and mesalyte salts
DE102004035203A1 (de) 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
US7732612B2 (en) 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
WO2006087543A1 (en) 2005-02-18 2006-08-24 Astrazeneca Ab Antibacterial piperidine derivatives
DE102005030524A1 (de) * 2005-06-30 2007-01-18 Aicuris Gmbh & Co. Kg Substituierte Chinolone II
DE102006005861A1 (de) 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
WO2008038122A2 (en) * 2006-09-29 2008-04-03 Wockhardt Research Centre Processes for the preparation of 7-substituted 3,3-dimethyl-4-amino-piperidino-quinolone carboxylic acid derivatives
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
US20100331546A1 (en) * 2008-02-27 2010-12-30 Sumitomo Chemical Company, Limited Method for optical resolution of alkyl piperidin-3-yl carbamate and intermediate therefor
EP2379505A4 (en) 2008-12-05 2012-10-17 Designmedix Inc CHLOROQUINES MODIFIED BY A MONOCYCLIC GROUP OR A FUSED CYCLE GROUP
WO2011034971A1 (en) * 2009-09-15 2011-03-24 Designmedix, Inc. Modified fluoroquinolone compounds and methods of using the same
KR20180016485A (ko) 2015-06-09 2018-02-14 바이엘 파마 악티엔게젤샤프트 무스카린성 m2 수용체의 양성 알로스테릭 조정제
WO2018011017A1 (de) 2016-07-11 2018-01-18 Bayer Pharma Aktiengesellschaft 7-substituierte 1-pyridyl-naphthyridin-3-carbonsäureamide und ihre verwendung
JOP20190045A1 (ar) 2016-09-14 2019-03-14 Bayer Ag مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها.
EP3296298A1 (de) 2016-09-14 2018-03-21 Bayer Pharma Aktiengesellschaft 7-substituierte 1-aryl-naphthyridin-3-carbonsäureamide und ihre verwendung

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3984403A (en) 1972-06-30 1976-10-05 Takeda Chemical Industries, Ltd. Arginine and lysine salts of acid cephalosporins
US3985882A (en) 1972-11-02 1976-10-12 Riker Laboratories, Inc. Substituted benzo[ij]quinolinzine-2-carboxylic acids and derivatives thereof as bactericidal agents
US3924042A (en) 1973-03-26 1975-12-02 Minnesota Mining & Mfg Method for treatment of bacterial plant disease
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4051247A (en) 1975-04-14 1977-09-27 Riker Laboratories, Inc. Method of using 7-hydroxy-benzo[ij]quinolizine-2-carboxylic acid derivatives
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4416884A (en) 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
JPS5746986A (en) 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS57176987A (en) 1981-04-24 1982-10-30 Otsuka Pharmaceut Co Ltd Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative
NO156828C (no) 1980-11-10 1987-12-02 Otsuka Pharma Co Ltd Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser.
JPS5781486A (en) 1980-11-10 1982-05-21 Otsuka Pharmaceut Co Ltd Benzo(ij)quinolidine-2-carboxylic acid derivative
US4404207A (en) 1981-11-06 1983-09-13 Riker Laboratories, Inc. Antimicrobial 8-substituted benzo [IJ]quinolizines
JPS5890511A (ja) 1981-11-25 1983-05-30 Otsuka Pharmaceut Co Ltd 抗菌剤
JPS59106488A (ja) 1982-12-10 1984-06-20 Dai Ichi Seiyaku Co Ltd ベンゾキノリジン誘導体
US4777175A (en) 1982-09-09 1988-10-11 Warner-Lambert Company Antibacterial agents
US4665079A (en) 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US4638067A (en) 1982-09-09 1987-01-20 Warner-Lambert Co. Antibacterial agents
US4443447A (en) 1982-10-25 1984-04-17 Riker Laboratories, Inc. Phenyl-substituted tricyclic antibacterial agents
US4472406A (en) 1982-11-12 1984-09-18 Riker Laboratories, Inc. Antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo [ij]quinolizine-2-carboxylic acids and derivatives
DE3248507A1 (de) 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
JPS59137482A (ja) 1983-01-26 1984-08-07 Otsuka Pharmaceut Co Ltd ピロロ〔３，２，１，−ｉｊ〕キノリン−５−カルボン酸誘導体
JPS59155381A (ja) 1983-02-22 1984-09-04 Kyorin Pharmaceut Co Ltd ベンゾキノリジンカルボン酸誘導体及びその製造法
US4472407A (en) 1983-03-17 1984-09-18 Riker Laboratories, Inc. Antimicrobial 8-alkoxy-6,7-dihydro-5-methyl-9-fluoro-1-oxo-1H,5H-benzo[ij]qu
US4642355A (en) 1984-02-24 1987-02-10 Otsuka Pharmaceutical Factory, Inc. Proline derivatives
US5097032A (en) 1984-07-20 1992-03-17 Warner-Lambert Company Antibacterial agents - II
US4822801A (en) 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
JPH089597B2 (ja) 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62215572A (ja) 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPS63198664A (ja) * 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
CN1019114B (zh) 1986-03-31 1992-11-18 三共株式会社 喹啉-3-羟酸衍生物的制备方法
JPS63192753A (ja) 1987-02-05 1988-08-10 Otsuka Pharmaceut Co Ltd テトラヒドロキノリン誘導体の光学分割法
US5290934A (en) * 1987-04-16 1994-03-01 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US5591744A (en) 1987-04-16 1997-01-07 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
HU200917B (en) 1987-07-20 1990-09-28 Chinoin Gyogyszer Es Vegyeszet Process for producing pharmaceutical compositions comprising quinoline or naphthyridinecarboxylic acid and tetracycline derivatives as active ingredient
US4851418A (en) 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
EP0342675B1 (en) 1988-05-19 1995-01-25 Chugai Seiyaku Kabushiki Kaisha Novel quinolonecarboxylic acid derivatives
DE3906365A1 (de) 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
FI95130C (fi) * 1988-07-20 1995-12-27 Sankyo Co Menetelmä lääkeaineena käyttökelpoisten 4-oksokinoliini-3-karboksyylihapon johdannaisten valmistamiseksi
JP2688711B2 (ja) 1988-11-10 1997-12-10 大塚製薬株式会社 ベンゾヘテロ環化合物
JP2731853B2 (ja) 1989-01-17 1998-03-25 大塚製薬株式会社 トリ低級アルカノイルオキシホウ素の製造法
JP2688712B2 (ja) 1989-01-17 1997-12-10 大塚製薬株式会社 ハロゲン置換キノリン誘導体の製造法
US5185337A (en) 1989-03-29 1993-02-09 Otsuka Pharmaceutical Co., Ltd. Pyrroloquinoline derivatives and pharmaceutical compositions for antimicrobial use
DK545889D0 (da) 1989-04-28 1989-11-02 Daiichi Seiyaku Co Anti-human-immundefektvirus-praeparat
FR2675144B1 (fr) * 1991-04-10 1995-06-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
US5869661A (en) 1991-07-16 1999-02-09 Chugai Seiyaku Kabushiki Kaisha Method of producing a quinolonecarboxylic acid derivative
EP0541086A1 (en) 1991-11-08 1993-05-12 Kaken Pharmaceutical Co., Ltd. Antibacterial 6-fluoro-quinolones having an oxime group on the substituent in position 7
NO304832B1 (no) 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
JPH05339238A (ja) 1992-06-10 1993-12-21 Otsuka Pharmaceut Co Ltd テトラヒドロキノリン誘導体のラセミ化方法
JPH06145167A (ja) 1992-11-06 1994-05-24 Hokuriku Seiyaku Co Ltd ８−メトキシ−５−メチルキノリン−３−カルボン酸誘導体
WO1994014794A1 (fr) 1992-12-28 1994-07-07 Yoshitomi Pharmaceutical Industries, Ltd. Derive d'acide 8-methoxyquinolonecarboxylique
KR0148277B1 (ko) 1993-01-18 1998-11-02 채영복 신규한 플루오르퀴놀론계 유도체 및 그의 제조방법
TW301607B (enExample) 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd
WO1994020105A1 (en) 1993-03-10 1994-09-15 Otsuka Pharmaceutical Company, Limited Interleukin-1 inhibitor
US6034100A (en) 1993-03-10 2000-03-07 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting cytokine secretion
CA2152828A1 (en) 1993-03-16 1994-07-07 Shin-Ichi Uesato 8-methoxy-quinolonecarboxylic acid derivatives
DE4342186A1 (de) 1993-12-10 1995-06-14 Bayer Ag Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten
WO1996022988A1 (en) 1995-01-24 1996-08-01 Hokuriku Seiyaku Co., Ltd. Quinolinecarboxylic acid derivatives
US6121285A (en) 1995-11-22 2000-09-19 Daiichi Pharmaceutical Co., Ltd. Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives
US5753269A (en) 1995-12-27 1998-05-19 Bayer Corporation Otic microbial combinations
WO1997031000A1 (en) 1996-02-21 1997-08-28 Darwin Discovery Limited Quinolones and their therapeutic use
WO1997044034A1 (en) 1996-05-20 1997-11-27 Otsuka Pharmaceutical Co., Ltd. Remedy for rosacea
AU3459797A (en) 1996-07-12 1998-02-09 Daiichi Pharmaceutical Co., Ltd. Cis-substituted aminocyclopropane derivatives
KR20010014209A (ko) 1997-06-24 2001-02-26 스즈키 다다시 시스-치환된 플루오로메틸피롤리딘 유도체
EP1015445B1 (en) 1997-09-15 2009-02-25 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
DE19751948A1 (de) 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
WO2000018404A1 (en) 1998-09-30 2000-04-06 Alcon Laboratories, Inc. Antibiotic compositions for treatment of the eye, ear and nose
US7247642B2 (en) 1999-05-07 2007-07-24 Wockhardt Limited Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
US6514986B2 (en) 2000-11-22 2003-02-04 Wockhardt Limited Chiral fluoroquinolone arginine salt forms
ATE378335T1 (de) 2000-05-08 2007-11-15 Wockhardt Ltd Chirale fluorochinolizinon arginine salze
WO2001085728A2 (en) 2000-05-08 2001-11-15 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i, j] quinolizines, processes, compositions and methods of treatment
AU2001280091A1 (en) 2000-08-01 2002-02-13 Wockhardt Limited Inhibitors of cellular efflux pumps of microbes

Also Published As

Publication number Publication date
EP1392677A2 (en) 2004-03-03
CA2445888A1 (en) 2002-10-31
WO2002085886A2 (en) 2002-10-31
US20030096812A1 (en) 2003-05-22
AU2002302963A1 (en) 2002-11-05
JP2005504729A (ja) 2005-02-17
US6964966B2 (en) 2005-11-15
WO2002085886A3 (en) 2003-05-22
AU2002302963A8 (en) 2005-10-13

Similar Documents

Publication Publication Date Title
JP4342797B2 (ja) 新世代三重照準、キラル、広域スペクトラム抗菌、７位置換ピペリジノ−キノロンカルボン酸誘導体の調製、組成、および薬剤としての使用
US7626032B2 (en) Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
ES2321042T3 (es) Quinolonas antimicrobianas, composiciones y usos de las mismas.
JP5816629B2 (ja) 新規の複素環式アクリルアミド及び医薬としてのその使用
JP2005511743A (ja) 新世代の三重標的化したキラルな広域スペクトラム抗菌性の７位置換ピペリジノ−キノロンカルボン酸誘導体、その調製方法、組成物、および医薬としての使用
CA2417799A1 (en) Inhibitors of cellular efflux pumps of microbes
TWI484959B (zh) 抗細菌之喹啉衍生物（一）
EP1262477B1 (en) Anti-acid-fast bacterial agents containing pyridonecarboxylic acids as the active ingredient
TWI444380B (zh) ７-胺基亞烷基-雜環喹諾酮及啶酮
TWI396536B (zh) 抗細菌之喹啉衍生物（三）
JP2004515549A (ja) 抗微生物２−ピリドン類、その組成物と使用
TWI487526B (zh) 抗細菌之喹啉衍生物
KR102110366B1 (ko) 항균성 퀴놀린 유도체
US7098219B2 (en) Inhibitors of cellular efflux pumps of microbes
CA2468190A1 (en) New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US7723524B2 (en) 8-cyanoquinolonecarboxylic acid derivative
WO2010012138A1 (zh) 7-[4-(胺甲基)-4-氟-3-(烷氧亚氨基)吡咯烷-1-基]取代的喹啉羧酸衍生物及其制备方法
CN101107241A (zh) 氟烷基吡咯烷衍生物
HK1030415B (en) Antimicrobial quinolones, their compositions and uses

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050422

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050422

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050511

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20081118

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090218

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090225

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090318

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090326

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090420

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090427

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090513

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090612

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090708

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120717

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees