JP4303596B2 - ポリペプチドを発現させるための真核生物シグナル配列およびポリペプチド提示ライブラリー - Google Patents

ポリペプチドを発現させるための真核生物シグナル配列およびポリペプチド提示ライブラリー Download PDF

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JP4303596B2
JP4303596B2 JP2003568071A JP2003568071A JP4303596B2 JP 4303596 B2 JP4303596 B2 JP 4303596B2 JP 2003568071 A JP2003568071 A JP 2003568071A JP 2003568071 A JP2003568071 A JP 2003568071A JP 4303596 B2 JP4303596 B2 JP 4303596B2
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seq
sequence
antibody
operably linked
signal
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ジェフ グレイ，
ジョー ベックラー，
ウデイ クマール ヴェーラマッル，
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ゾーマ テクノロジー リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2003568071A 2002-02-13 2003-02-13 ポリペプチドを発現させるための真核生物シグナル配列およびポリペプチド提示ライブラリー Expired - Lifetime JP4303596B2 (ja)

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Application Number Priority Date Filing Date Title
US10/076,802 US7094579B2 (en) 2002-02-13 2002-02-13 Eukaryotic signal sequences for prokaryotic expression
PCT/US2003/004791 WO2003068956A1 (en) 2002-02-13 2003-02-13 Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries

Related Child Applications (1)

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JP2009065285A Division JP5190963B2 (ja) 2002-02-13 2009-03-17 ポリペプチドを発現させるための真核生物シグナル配列およびポリペプチド提示ライブラリー

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JP2005517407A JP2005517407A (ja) 2005-06-16
JP2005517407A5 JP2005517407A5 (https=) 2006-03-30
JP4303596B2 true JP4303596B2 (ja) 2009-07-29

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JP2009065285A Expired - Fee Related JP5190963B2 (ja) 2002-02-13 2009-03-17 ポリペプチドを発現させるための真核生物シグナル配列およびポリペプチド提示ライブラリー

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US (5) US7094579B2 (https=)
EP (2) EP1481059B1 (https=)
JP (2) JP4303596B2 (https=)
AT (2) ATE406439T1 (https=)
AU (1) AU2003225578B2 (https=)
CA (1) CA2475929C (https=)
DE (1) DE60323210D1 (https=)
DK (2) DK1481059T3 (https=)
WO (1) WO2003068956A1 (https=)

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US10954500B2 (en) 2015-10-23 2021-03-23 Fred Hutchinson Cancer Research Center Methods to create chemically-induced dimerizing protein systems for regulation of cellular events
CN105734061B (zh) * 2016-03-25 2019-07-23 中国农业科学院生物技术研究所 从毕赤酵母中分离的鼠李糖诱导型启动子及其应用
JP7339160B2 (ja) 2017-04-27 2023-09-05 ジュノ セラピューティクス ゲーエムベーハー オリゴマー粒子試薬およびその使用方法
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MX2022010467A (es) * 2020-02-25 2022-12-15 Momenta Pharmaceuticals Inc Enzimas para la sialilación de glicanos.
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
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CN116284288A (zh) * 2023-02-01 2023-06-23 深圳大学 莱茵衣藻分泌导肽和转基因莱茵衣藻及其构建方法与应用

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Publication number Publication date
DK1481059T3 (da) 2009-01-12
AU2003225578A1 (en) 2003-09-04
US8476040B2 (en) 2013-07-02
CA2475929A1 (en) 2003-08-21
JP2009131286A (ja) 2009-06-18
US7094579B2 (en) 2006-08-22
US20030228660A1 (en) 2003-12-11
US20030162249A1 (en) 2003-08-28
AU2003225578B2 (en) 2008-04-03
CA2475929C (en) 2013-01-15
US20080214411A1 (en) 2008-09-04
EP1481059A1 (en) 2004-12-01
EP2060628B1 (en) 2011-11-16
US20110224102A1 (en) 2011-09-15
JP5190963B2 (ja) 2013-04-24
US7396661B2 (en) 2008-07-08
US7977068B2 (en) 2011-07-12
ATE533845T1 (de) 2011-12-15
ATE406439T1 (de) 2008-09-15
US7972811B2 (en) 2011-07-05
US20100009857A1 (en) 2010-01-14
DE60323210D1 (en) 2008-10-09
DK2060628T3 (da) 2012-01-23
JP2005517407A (ja) 2005-06-16
EP1481059A4 (en) 2006-02-01
EP2060628A1 (en) 2009-05-20
EP1481059B1 (en) 2008-08-27
WO2003068956A1 (en) 2003-08-21

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