AU2003225578B2 - Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries - Google Patents

Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries Download PDF

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Publication number
AU2003225578B2
AU2003225578B2 AU2003225578A AU2003225578A AU2003225578B2 AU 2003225578 B2 AU2003225578 B2 AU 2003225578B2 AU 2003225578 A AU2003225578 A AU 2003225578A AU 2003225578 A AU2003225578 A AU 2003225578A AU 2003225578 B2 AU2003225578 B2 AU 2003225578B2
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Australia
Prior art keywords
polypeptide
vector
promoter
seq
antibody
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Expired
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AU2003225578A
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AU2003225578A1 (en
Inventor
Joe Buechler
Jeff Gray
Uday Kumar Veeramallu
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Xoma Technology Ltd USA
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Xoma Technology Ltd USA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2003225578A 2002-02-13 2003-02-13 Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries Expired AU2003225578B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/076,802 US7094579B2 (en) 2002-02-13 2002-02-13 Eukaryotic signal sequences for prokaryotic expression
US10/076,802 2002-02-13
PCT/US2003/004791 WO2003068956A1 (en) 2002-02-13 2003-02-13 Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries

Publications (2)

Publication Number Publication Date
AU2003225578A1 AU2003225578A1 (en) 2003-09-04
AU2003225578B2 true AU2003225578B2 (en) 2008-04-03

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Family Applications (1)

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AU2003225578A Expired AU2003225578B2 (en) 2002-02-13 2003-02-13 Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries

Country Status (9)

Country Link
US (5) US7094579B2 (https=)
EP (2) EP1481059B1 (https=)
JP (2) JP4303596B2 (https=)
AT (2) ATE406439T1 (https=)
AU (1) AU2003225578B2 (https=)
CA (1) CA2475929C (https=)
DE (1) DE60323210D1 (https=)
DK (2) DK1481059T3 (https=)
WO (1) WO2003068956A1 (https=)

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JP5745432B2 (ja) * 2009-02-25 2015-07-08 ネクステラ アーエス シグナル配列非依存性ｐＩＸファージディスプレイ
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
JP2014504503A (ja) 2010-12-28 2014-02-24 ゾーマ テクノロジー リミテッド Ｐｄｚドメインを用いた細胞表面提示
AU2012212047A1 (en) 2011-02-03 2013-08-22 Xoma Technology Ltd. Methods and materials for enhancing functional protein expression in bacteria
ES3011307T3 (en) 2012-02-23 2025-04-07 Juno Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
US9803191B2 (en) 2012-07-05 2017-10-31 Genentech, Inc. Expression and secretion system
EP2877589B1 (en) 2012-07-26 2024-03-06 Momenta Pharmaceuticals, Inc. Glycoproteins with anti-inflammatory properties
MX2018004875A (es) 2015-10-22 2018-08-01 Juno Therapeutics Gmbh Metodos para cultivar celulas y kits y aparatos para ello.
EP3365453A2 (en) 2015-10-22 2018-08-29 Juno Therapeutics GmbH Methods, kits, agents and apparatuses for transduction
US10954500B2 (en) 2015-10-23 2021-03-23 Fred Hutchinson Cancer Research Center Methods to create chemically-induced dimerizing protein systems for regulation of cellular events
CN105734061B (zh) * 2016-03-25 2019-07-23 中国农业科学院生物技术研究所 从毕赤酵母中分离的鼠李糖诱导型启动子及其应用
JP7339160B2 (ja) 2017-04-27 2023-09-05 ジュノ セラピューティクス ゲーエムベーハー オリゴマー粒子試薬およびその使用方法
EP3444269A1 (en) 2017-08-17 2019-02-20 National Research Council of Canada Systems and methods for the production of diphtheria toxin polypeptides
IL275239B2 (en) 2017-12-11 2026-03-01 Abalone Bio Inc Yeast presentation of proteins in the subplasmic space
SG11202104355SA (en) 2018-10-31 2021-05-28 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
IT201900006656A1 (it) 2019-05-08 2020-11-08 Salvagnini Italia Spa Macchina piegatrice per lamiere metalliche
MX2022010467A (es) * 2020-02-25 2022-12-15 Momenta Pharmaceuticals Inc Enzimas para la sialilación de glicanos.
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins
CN116284288A (zh) * 2023-02-01 2023-06-23 深圳大学 莱茵衣藻分泌导肽和转基因莱茵衣藻及其构建方法与应用

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Also Published As

Publication number Publication date
DK1481059T3 (da) 2009-01-12
AU2003225578A1 (en) 2003-09-04
US8476040B2 (en) 2013-07-02
CA2475929A1 (en) 2003-08-21
JP2009131286A (ja) 2009-06-18
US7094579B2 (en) 2006-08-22
US20030228660A1 (en) 2003-12-11
US20030162249A1 (en) 2003-08-28
CA2475929C (en) 2013-01-15
US20080214411A1 (en) 2008-09-04
EP1481059A1 (en) 2004-12-01
EP2060628B1 (en) 2011-11-16
US20110224102A1 (en) 2011-09-15
JP4303596B2 (ja) 2009-07-29
JP5190963B2 (ja) 2013-04-24
US7396661B2 (en) 2008-07-08
US7977068B2 (en) 2011-07-12
ATE533845T1 (de) 2011-12-15
ATE406439T1 (de) 2008-09-15
US7972811B2 (en) 2011-07-05
US20100009857A1 (en) 2010-01-14
DE60323210D1 (en) 2008-10-09
DK2060628T3 (da) 2012-01-23
JP2005517407A (ja) 2005-06-16
EP1481059A4 (en) 2006-02-01
EP2060628A1 (en) 2009-05-20
EP1481059B1 (en) 2008-08-27
WO2003068956A1 (en) 2003-08-21

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired