DE60323210D1 - Eukaryontische signalsequenzen für polypeptid-expr - Google Patents

Eukaryontische signalsequenzen für polypeptid-expr

Info

Publication number
DE60323210D1
DE60323210D1 DE60323210T DE60323210T DE60323210D1 DE 60323210 D1 DE60323210 D1 DE 60323210D1 DE 60323210 T DE60323210 T DE 60323210T DE 60323210 T DE60323210 T DE 60323210T DE 60323210 D1 DE60323210 D1 DE 60323210D1
Authority
DE
Germany
Prior art keywords
signalsequenzen
eukaryontische
polypeptid
expr
für
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60323210T
Other languages
German (de)
English (en)
Inventor
Jeff Gray
Joe Buechler
Uday Kumar Veeramallu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xoma Technology Ltd USA
Original Assignee
Xoma Technology Ltd USA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xoma Technology Ltd USA filed Critical Xoma Technology Ltd USA
Application granted granted Critical
Publication of DE60323210D1 publication Critical patent/DE60323210D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60323210T 2002-02-13 2003-02-13 Eukaryontische signalsequenzen für polypeptid-expr Expired - Lifetime DE60323210D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/076,802 US7094579B2 (en) 2002-02-13 2002-02-13 Eukaryotic signal sequences for prokaryotic expression
PCT/US2003/004791 WO2003068956A1 (en) 2002-02-13 2003-02-13 Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries

Publications (1)

Publication Number Publication Date
DE60323210D1 true DE60323210D1 (en) 2008-10-09

Family

ID=27732544

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60323210T Expired - Lifetime DE60323210D1 (en) 2002-02-13 2003-02-13 Eukaryontische signalsequenzen für polypeptid-expr

Country Status (9)

Country Link
US (5) US7094579B2 (https=)
EP (2) EP1481059B1 (https=)
JP (2) JP4303596B2 (https=)
AT (2) ATE406439T1 (https=)
AU (1) AU2003225578B2 (https=)
CA (1) CA2475929C (https=)
DE (1) DE60323210D1 (https=)
DK (2) DK1481059T3 (https=)
WO (1) WO2003068956A1 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
US7094579B2 (en) * 2002-02-13 2006-08-22 Xoma Technology Ltd. Eukaryotic signal sequences for prokaryotic expression
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US8293503B2 (en) 2003-10-03 2012-10-23 Promega Corporation Vectors for directional cloning
CA2541177A1 (en) * 2003-10-03 2005-09-22 Promega Corporation Vectors for directional cloning
ATE479760T1 (de) * 2004-03-24 2010-09-15 Domantis Ltd Universelles signalpeptid gas1
JP5080269B2 (ja) 2004-12-07 2012-11-21 ロンザ アーゲー メリビオースオペロン発現系
CA2589937C (en) * 2004-12-07 2014-04-22 Lonza Ag Rhamnose promoter expression system
EP2059590B1 (en) * 2006-07-14 2014-12-31 Novozymes, Inc. Methods for producing secreted polypeptides having biological activity
GB0810154D0 (en) 2008-06-04 2008-07-09 Avecia Biolog Ltd Expression vector
EP2344686B1 (en) 2008-10-03 2014-03-05 XOMA Technology Ltd. Novel triple tag sequences and methods of use thereof
JP5745432B2 (ja) * 2009-02-25 2015-07-08 ネクステラ アーエス シグナル配列非依存性ｐＩＸファージディスプレイ
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
JP2014504503A (ja) 2010-12-28 2014-02-24 ゾーマ テクノロジー リミテッド Ｐｄｚドメインを用いた細胞表面提示
AU2012212047A1 (en) 2011-02-03 2013-08-22 Xoma Technology Ltd. Methods and materials for enhancing functional protein expression in bacteria
ES3011307T3 (en) 2012-02-23 2025-04-07 Juno Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
US9803191B2 (en) 2012-07-05 2017-10-31 Genentech, Inc. Expression and secretion system
EP2877589B1 (en) 2012-07-26 2024-03-06 Momenta Pharmaceuticals, Inc. Glycoproteins with anti-inflammatory properties
MX2018004875A (es) 2015-10-22 2018-08-01 Juno Therapeutics Gmbh Metodos para cultivar celulas y kits y aparatos para ello.
EP3365453A2 (en) 2015-10-22 2018-08-29 Juno Therapeutics GmbH Methods, kits, agents and apparatuses for transduction
US10954500B2 (en) 2015-10-23 2021-03-23 Fred Hutchinson Cancer Research Center Methods to create chemically-induced dimerizing protein systems for regulation of cellular events
CN105734061B (zh) * 2016-03-25 2019-07-23 中国农业科学院生物技术研究所 从毕赤酵母中分离的鼠李糖诱导型启动子及其应用
JP7339160B2 (ja) 2017-04-27 2023-09-05 ジュノ セラピューティクス ゲーエムベーハー オリゴマー粒子試薬およびその使用方法
EP3444269A1 (en) 2017-08-17 2019-02-20 National Research Council of Canada Systems and methods for the production of diphtheria toxin polypeptides
IL275239B2 (en) 2017-12-11 2026-03-01 Abalone Bio Inc Yeast presentation of proteins in the subplasmic space
SG11202104355SA (en) 2018-10-31 2021-05-28 Juno Therapeutics Gmbh Methods for selection and stimulation of cells and apparatus for same
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
IT201900006656A1 (it) 2019-05-08 2020-11-08 Salvagnini Italia Spa Macchina piegatrice per lamiere metalliche
MX2022010467A (es) * 2020-02-25 2022-12-15 Momenta Pharmaceuticals Inc Enzimas para la sialilación de glicanos.
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins
CN116284288A (zh) * 2023-02-01 2023-06-23 深圳大学 莱茵衣藻分泌导肽和转基因莱茵衣藻及其构建方法与应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
ATE114723T1 (de) 1987-03-02 1994-12-15 Enzon Lab Inc Organismus als träger für ''single chain antibody domain (scad)''.
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9011861D0 (en) 1990-05-26 1990-07-18 Beecham Group Plc Novel compounds
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
DE4022940A1 (de) 1990-07-19 1992-01-23 Bosch Gmbh Robert Einrichtung zur temperatursteuerung eines messwiderstands
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
CA2095633C (en) 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
ATE414768T1 (de) 1991-04-10 2008-12-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
DE4122598C1 (https=) * 1991-07-08 1992-07-30 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts, 6900 Heidelberg, De
EP0605522B1 (en) 1991-09-23 1999-06-23 Medical Research Council Methods for the production of humanized antibodies
US5470997A (en) 1992-04-06 1995-11-28 Biosite Diagnostics Incorporated Amphetamine derivatives and protein and polypeptide amphetamine derivative conjugates and labels
US6555310B1 (en) * 1997-04-04 2003-04-29 Biosite Diagnostics, Inc. Polyclonal libraries
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
WO1998047343A2 (en) 1997-04-04 1998-10-29 Biosite Diagnostics, Inc. Antibodies or binding protein libraries displayed on phage, cells, or other replicatable genetic packages
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
JP3374052B2 (ja) 1997-07-28 2003-02-04 株式会社堀場製作所 オゾン測定装置
US5932445A (en) 1997-11-07 1999-08-03 Incyte Pharmaceuticals, Inc. Signal peptide-containing proteins
US6545140B1 (en) * 1998-07-13 2003-04-08 University Of Georgia Research Foundation, Inc. DNA encoding an avian beta-defensin and uses thereof
AU781460B2 (en) 1999-02-12 2005-05-26 Amgen, Inc. Glycosylated leptin compositions and related methods
US6794132B2 (en) 1999-10-02 2004-09-21 Biosite, Inc. Human antibodies
US7094579B2 (en) 2002-02-13 2006-08-22 Xoma Technology Ltd. Eukaryotic signal sequences for prokaryotic expression
DE20207301U1 (de) 2002-05-10 2002-12-19 Eichler-Stahlberg, Alke, 93059 Regensburg Expressionssystem für synthetische Gene in Mikroalgen
CN103929153B (zh) 2013-01-11 2016-12-28 北大方正集团有限公司 一种倍频处理方法和装置

Also Published As

Publication number Publication date
DK1481059T3 (da) 2009-01-12
AU2003225578A1 (en) 2003-09-04
US8476040B2 (en) 2013-07-02
CA2475929A1 (en) 2003-08-21
JP2009131286A (ja) 2009-06-18
US7094579B2 (en) 2006-08-22
US20030228660A1 (en) 2003-12-11
US20030162249A1 (en) 2003-08-28
AU2003225578B2 (en) 2008-04-03
CA2475929C (en) 2013-01-15
US20080214411A1 (en) 2008-09-04
EP1481059A1 (en) 2004-12-01
EP2060628B1 (en) 2011-11-16
US20110224102A1 (en) 2011-09-15
JP4303596B2 (ja) 2009-07-29
JP5190963B2 (ja) 2013-04-24
US7396661B2 (en) 2008-07-08
US7977068B2 (en) 2011-07-12
ATE533845T1 (de) 2011-12-15
ATE406439T1 (de) 2008-09-15
US7972811B2 (en) 2011-07-05
US20100009857A1 (en) 2010-01-14
DK2060628T3 (da) 2012-01-23
JP2005517407A (ja) 2005-06-16
EP1481059A4 (en) 2006-02-01
EP2060628A1 (en) 2009-05-20
EP1481059B1 (en) 2008-08-27
WO2003068956A1 (en) 2003-08-21

Similar Documents

Publication Publication Date Title
DE60323210D1 (en) Eukaryontische signalsequenzen für polypeptid-expr
IL161016A (en) Polypeptides capable of ang-2 binding
WO2002085923A3 (en) In vivo incorporation of unnatural amino acids
TW200611910A (en) Interferon-alpha polypeptides and conjugates
AU2002304814A1 (en) Protein-protein interactions in adipocytes
WO2002066653A3 (en) Procaryotic libraries and uses
WO2004087874A3 (en) Novel nucleic acids and polypeptides
WO2004039834A3 (en) Recombinant protein variants
AU2002365269A8 (en) Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses
EP1978994A4 (en) BMP-7 VARIANTS COMPOSITIONS, METHODS AND USES
SG161106A1 (en) Inhibitor proteins of a protease and use thereof
WO2005086654A3 (en) Self-cleaving affinity tags and methods of use
WO2003091447A3 (en) D1-1 nucleic acids, polypeptides and related methods
MY142798A (en) Methods for preventing glyconoylation of proteins
AU2003297670A8 (en) P53-associated parkin-like cytoplasmic protein, and related compositions and methods
EP1639109A4 (en) DNA VECTORS
WO2005057486A3 (en) Protein engineering with analogous contact environments
ATE397079T1 (de) Verfahren zur klonierung mittels doppelter selektion und vektoren dafür
AU2001229990A1 (en) Novel polypeptide---human protein phosphatase 2c26 and polynucleotide encoding it
AU2003902414A0 (en) Flowering induction
BR0315222A (pt) Promotor de il-18bp, sua preparação e uso
WO2002046417A3 (en) Adipocyte complement related protein zacrp3x2
WO2001057187A3 (en) Novel bone marrow nucleic acids and polypeptides
WO2003091414A3 (en) Adipocyte complement related protein zacrp8
WO2004019883A3 (en) Tick polypeptides as anticoagulants and vaccines

Legal Events

Date Code Title Description
8364 No opposition during term of opposition