WO2005057486A3 - Protein engineering with analogous contact environments - Google Patents

Protein engineering with analogous contact environments Download PDF

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Publication number
WO2005057486A3
WO2005057486A3 PCT/US2004/041452 US2004041452W WO2005057486A3 WO 2005057486 A3 WO2005057486 A3 WO 2005057486A3 US 2004041452 W US2004041452 W US 2004041452W WO 2005057486 A3 WO2005057486 A3 WO 2005057486A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein engineering
analogous contact
contact environments
environments
analogous
Prior art date
Application number
PCT/US2004/041452
Other languages
French (fr)
Other versions
WO2005057486A2 (en
Inventor
John R Desjarlais
Original Assignee
Xencor Inc
John R Desjarlais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc, John R Desjarlais filed Critical Xencor Inc
Priority to EP04813720A priority Critical patent/EP1695252A2/en
Priority to AU2004298058A priority patent/AU2004298058A1/en
Priority to CA002548482A priority patent/CA2548482A1/en
Publication of WO2005057486A2 publication Critical patent/WO2005057486A2/en
Publication of WO2005057486A3 publication Critical patent/WO2005057486A3/en

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Abstract

The invention relates to novel methods for engineering protein sequences using structural and homology information.
PCT/US2004/041452 2003-12-08 2004-12-08 Protein engineering with analogous contact environments WO2005057486A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP04813720A EP1695252A2 (en) 2003-12-08 2004-12-08 Protein engineering with analogous contact environments
AU2004298058A AU2004298058A1 (en) 2003-12-08 2004-12-08 Protein engineering with analogous contact environments
CA002548482A CA2548482A1 (en) 2003-12-08 2004-12-08 Protein engineering with analogous contact environments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52823003P 2003-12-08 2003-12-08
US60/528,230 2003-12-08

Publications (2)

Publication Number Publication Date
WO2005057486A2 WO2005057486A2 (en) 2005-06-23
WO2005057486A3 true WO2005057486A3 (en) 2005-08-11

Family

ID=34676831

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/041452 WO2005057486A2 (en) 2003-12-08 2004-12-08 Protein engineering with analogous contact environments

Country Status (4)

Country Link
EP (1) EP1695252A2 (en)
AU (1) AU2004298058A1 (en)
CA (1) CA2548482A1 (en)
WO (1) WO2005057486A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060003412A1 (en) * 2003-12-08 2006-01-05 Xencor, Inc. Protein engineering with analogous contact environments
JP4643713B2 (en) * 2006-11-22 2011-03-02 株式会社インシリコサイエンス Protein three-dimensional structure processing apparatus, protein three-dimensional structure processing method, and program
TW201933375A (en) * 2017-08-09 2019-08-16 美商人類長壽公司 Structural prediction of proteins
CN115458048B (en) * 2022-09-16 2023-05-26 杭州美赛生物医药科技有限公司 Antibody humanization method based on sequence coding and decoding

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003006154A2 (en) * 2001-07-10 2003-01-23 Xencor, Inc. Protein design automation for designing protein libraries with altered immunogenicity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003006154A2 (en) * 2001-07-10 2003-01-23 Xencor, Inc. Protein design automation for designing protein libraries with altered immunogenicity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LEHMANN M ET AL: "Engineering proteins for thermostability: the use of sequence alignements versus rational design and directed evolution", CURRENT OPINION IN BIOTECHNOLOGY, LONDON, GB, vol. 12, 2001, pages 371 - 375, XP002982993, ISSN: 0958-1669 *
PEI JIMIN ET AL: "Using protein design for homology detection and active site searches.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 30 SEP 2003, vol. 100, no. 20, 30 September 2003 (2003-09-30), pages 11361 - 11366, XP002331144, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
EP1695252A2 (en) 2006-08-30
AU2004298058A1 (en) 2005-06-23
CA2548482A1 (en) 2005-06-23
WO2005057486A2 (en) 2005-06-23

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