JP4222658B2 - 細胞支持基材、培養装置および液体処理装置 - Google Patents

細胞支持基材、培養装置および液体処理装置 Download PDF

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JP4222658B2
JP4222658B2 JP19239098A JP19239098A JP4222658B2 JP 4222658 B2 JP4222658 B2 JP 4222658B2 JP 19239098 A JP19239098 A JP 19239098A JP 19239098 A JP19239098 A JP 19239098A JP 4222658 B2 JP4222658 B2 JP 4222658B2
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cell
cell support
cells
pore diameter
support substrate
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JP2000004870A5 (cg-RX-API-DMAC10.html
JP2000004870A (ja
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哲寛 木村
則文 徳永
佳孝 大村
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Terumo Corp
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Terumo Corp
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Priority to JP19239098A priority Critical patent/JP4222658B2/ja
Priority to DE69928997T priority patent/DE69928997T2/de
Priority to US09/338,382 priority patent/US6303375B1/en
Priority to EP99401562A priority patent/EP0967273B1/en
Publication of JP2000004870A publication Critical patent/JP2000004870A/ja
Publication of JP2000004870A5 publication Critical patent/JP2000004870A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/78—Cellulose

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • External Artificial Organs (AREA)
JP19239098A 1998-06-23 1998-06-23 細胞支持基材、培養装置および液体処理装置 Expired - Fee Related JP4222658B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP19239098A JP4222658B2 (ja) 1998-06-23 1998-06-23 細胞支持基材、培養装置および液体処理装置
DE69928997T DE69928997T2 (de) 1998-06-23 1999-06-23 Zellträgermatrix, Vorrichtung für Zellkulturen und Flüssigkeitsbehandlung
US09/338,382 US6303375B1 (en) 1998-06-23 1999-06-23 Cell supporting matrix, cell culture device, and fluid treating device
EP99401562A EP0967273B1 (en) 1998-06-23 1999-06-23 Cell supporting matrix, cell culture device, and fluid treating device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19239098A JP4222658B2 (ja) 1998-06-23 1998-06-23 細胞支持基材、培養装置および液体処理装置

Publications (3)

Publication Number Publication Date
JP2000004870A JP2000004870A (ja) 2000-01-11
JP2000004870A5 JP2000004870A5 (cg-RX-API-DMAC10.html) 2005-09-29
JP4222658B2 true JP4222658B2 (ja) 2009-02-12

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JP19239098A Expired - Fee Related JP4222658B2 (ja) 1998-06-23 1998-06-23 細胞支持基材、培養装置および液体処理装置

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US (1) US6303375B1 (cg-RX-API-DMAC10.html)
EP (1) EP0967273B1 (cg-RX-API-DMAC10.html)
JP (1) JP4222658B2 (cg-RX-API-DMAC10.html)
DE (1) DE69928997T2 (cg-RX-API-DMAC10.html)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541243B1 (en) * 2000-06-05 2003-04-01 Axon Instruments, Inc. Perfusion chamber for electrophysiological testing of oocytes
US20020045260A1 (en) * 2000-10-17 2002-04-18 Shih-Chieh Hung Method of isolating mesenchymal stem cells
US20040029266A1 (en) * 2002-08-09 2004-02-12 Emilio Barbera-Guillem Cell and tissue culture device
JP4555773B2 (ja) * 2003-03-24 2010-10-06 独立行政法人国立環境研究所 細胞培養基質および細胞接着蛋白質またはペプチドの固相化標品
EP1475434A1 (en) * 2003-05-09 2004-11-10 Oncoscience AG Method for storing tumor cells
GB2401612A (en) * 2003-05-13 2004-11-17 Univ Manchester Method and device for culturing tissue
JP2006025635A (ja) * 2004-07-13 2006-02-02 Kaneka Corp 多孔質の支持体に細胞を内在化させる方法、器具または装置
US7514256B2 (en) * 2005-02-11 2009-04-07 Emilio Barbera-Guillem Bioreactor for selectively controlling the molecular diffusion between fluids
US8865460B2 (en) 2005-08-12 2014-10-21 Clemson University Research Foundation Co-culture bioreactor system
EP2965769B1 (en) 2005-08-26 2018-12-26 Regents of the University of Minnesota Decellularization and recellularization of organs and tissues
DE102005058187A1 (de) 2005-12-01 2007-06-14 Carl Zeiss Jena Gmbh Anordnung zur Fokussierung von Beleuchtungseinrichtung für Mikroskope
US20090215176A1 (en) * 2008-02-25 2009-08-27 Clemson University Differential Pressure Pump System
RU2011143730A (ru) * 2009-03-31 2013-05-10 Риджентс Оф Дзе Юниверсити Оф Миннесота Децеллюляризации и рецеллюляризация органов и тканей
US10233420B2 (en) 2010-09-01 2019-03-19 Regents Of The University Of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
US9969966B2 (en) 2011-05-30 2018-05-15 Atech Partners Limited Bioreactor system for continuous cell cultivation
RS53886B1 (sr) * 2012-09-06 2015-08-31 Pluristem Ltd. Uređaji i postupci za kultivaciju ćelija
BR112015023642A2 (pt) 2013-03-15 2017-07-18 Miromatrix Medical Inc uso de perfusão de fígado descelularizado para permitir recelularização de célula
WO2014186411A1 (en) 2013-05-17 2014-11-20 Siemens Healthcare Diagnostics Inc. Particle release and collection
FR3017877A1 (fr) * 2014-02-24 2015-08-28 Univ Rouen Materiau pour la culture des cellules, procedes de preparation et ses utilisations
WO2017158791A1 (ja) * 2016-03-17 2017-09-21 富士機械製造株式会社 人工臓器用のセルチャンバー
WO2018048899A1 (en) 2016-09-06 2018-03-15 Micromatrix Medical Inc. Use of resected liver serum for whole liver engineering
KR101856379B1 (ko) * 2016-11-04 2018-05-09 단국대학교 천안캠퍼스 산학협력단 세포 시딩방법
KR101846732B1 (ko) * 2016-11-04 2018-04-06 단국대학교 천안캠퍼스 산학협력단 신경세포 in vitro 배양방법
CN112154201B (zh) * 2018-05-22 2024-12-27 形态细胞科技公司 灌注生物反应器、灌注器件、人造肝脏系统及相关方法
WO2019241499A1 (en) 2018-06-13 2019-12-19 Miromatrix Medical Inc. Fistula filler and deployment system
EP3921405A1 (en) 2019-02-05 2021-12-15 Corning Incorporated Woven cell culture substrates
CN110556046B (zh) * 2019-08-09 2021-05-28 西安交通大学 一种双网络结构三维组织模型及其灌流一体化制备方法
US11118151B2 (en) 2019-11-05 2021-09-14 Corning Incorporated Fixed bed bioreactor and methods of using the same
CN116529353A (zh) * 2020-11-30 2023-08-01 康宁股份有限公司 具有受控的分区孔隙度的填装床生物反应器

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4440853A (en) * 1980-08-21 1984-04-03 Board Of Trustees Of The Leland Stanford Junior University Microbiological methods using hollow fiber membrane reactor
JPH0746988B2 (ja) 1986-03-14 1995-05-24 日東電工株式会社 付着性動物細胞の培養法および培養装置
GB8729889D0 (en) * 1987-12-22 1988-02-03 Unilever Plc Bio-catalysts support systems
US5595909A (en) 1988-05-23 1997-01-21 Regents Of The University Of Minnesota Filter device
DE69020248T2 (de) 1989-07-14 1996-01-25 Terumo Corp Filtermaterial zum Abscheiden von Leukozyten und Verfahren zu seiner Herstellung.
JPH0825886B2 (ja) 1989-07-14 1996-03-13 テルモ株式会社 白血球捕捉用フィルター材およびその製造方法
JPH0576364A (ja) 1991-09-20 1993-03-30 Kanegafuchi Chem Ind Co Ltd 動物遊離細胞の固定化物、固定化方法および培養方法
ES2090963T3 (es) 1992-02-07 1996-10-16 Monsanto Co Higado biologico artificial.
JPH06284883A (ja) 1992-07-10 1994-10-11 Sanyo Chem Ind Ltd 肝細胞培養方法
JPH06153905A (ja) 1992-11-24 1994-06-03 Sanyo Chem Ind Ltd 細胞培養基材および細胞培養方法
JPH06277050A (ja) 1993-03-26 1994-10-04 Kanegafuchi Chem Ind Co Ltd 動物細胞の固定化物および培養方法
JP3511399B2 (ja) 1993-03-31 2004-03-29 株式会社三菱化学ヤトロン 細胞培養基材及び細胞培養方法
CA2244659C (en) * 1995-10-06 2007-05-01 Leonardus Marcus Flendrig Biological reactor for the cultivation of cells
JPH1146759A (ja) 1997-08-06 1999-02-23 Terumo Corp 細胞培養液

Also Published As

Publication number Publication date
EP0967273A1 (en) 1999-12-29
DE69928997D1 (de) 2006-01-26
US6303375B1 (en) 2001-10-16
JP2000004870A (ja) 2000-01-11
EP0967273B1 (en) 2005-12-21
DE69928997T2 (de) 2006-09-21

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