JP3980645B2 - 抗齲蝕口用組成物 - Google Patents
抗齲蝕口用組成物 Download PDFInfo
- Publication number
- JP3980645B2 JP3980645B2 JP53207497A JP53207497A JP3980645B2 JP 3980645 B2 JP3980645 B2 JP 3980645B2 JP 53207497 A JP53207497 A JP 53207497A JP 53207497 A JP53207497 A JP 53207497A JP 3980645 B2 JP3980645 B2 JP 3980645B2
- Authority
- JP
- Japan
- Prior art keywords
- arginine
- calcium
- oral composition
- phytate
- caries
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 125
- 230000000675 anti-caries Effects 0.000 title description 2
- 239000004475 Arginine Substances 0.000 claims abstract description 102
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 102
- 208000002925 dental caries Diseases 0.000 claims abstract description 73
- 239000011575 calcium Substances 0.000 claims abstract description 61
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 60
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 60
- 238000000034 method Methods 0.000 claims abstract description 37
- 150000001450 anions Chemical class 0.000 claims abstract description 36
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims abstract description 33
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 63
- 235000002949 phytic acid Nutrition 0.000 claims description 59
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 44
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 22
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 17
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 16
- RYJDNPSQBGFFSF-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;carbonic acid Chemical compound OC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RYJDNPSQBGFFSF-WCCKRBBISA-N 0.000 claims description 15
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 15
- 230000000170 anti-cariogenic effect Effects 0.000 claims description 13
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 12
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Diphosphoinositol tetrakisphosphate Chemical compound OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 12
- 229910019142 PO4 Inorganic materials 0.000 claims description 10
- 239000010452 phosphate Substances 0.000 claims description 10
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 9
- -1 inositol phosphates derivative salt Chemical class 0.000 claims description 7
- 239000005022 packaging material Substances 0.000 claims description 7
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- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical class [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 4
- KOELRIARTUZUKB-WJXVXWFNSA-L [Ca++].OC(O)=O.[O-]C([O-])=O.N[C@@H](CCCNC(N)=N)C(O)=O Chemical compound [Ca++].OC(O)=O.[O-]C([O-])=O.N[C@@H](CCCNC(N)=N)C(O)=O KOELRIARTUZUKB-WJXVXWFNSA-L 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 2
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 2
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015218 chewing gum Nutrition 0.000 claims description 2
- 229940112822 chewing gum Drugs 0.000 claims description 2
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims 1
- 229960000367 inositol Drugs 0.000 claims 1
- 235000021317 phosphate Nutrition 0.000 claims 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 11
- 239000004075 cariostatic agent Substances 0.000 abstract description 10
- 230000000248 cariostatic effect Effects 0.000 abstract 2
- 210000003298 dental enamel Anatomy 0.000 description 40
- 239000002253 acid Substances 0.000 description 27
- 238000011534 incubation Methods 0.000 description 26
- 239000008103 glucose Substances 0.000 description 25
- 241000894006 Bacteria Species 0.000 description 24
- 239000002244 precipitate Substances 0.000 description 24
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
- 210000003296 saliva Anatomy 0.000 description 20
- 238000004458 analytical method Methods 0.000 description 16
- 150000001875 compounds Chemical class 0.000 description 16
- 230000007928 solubilization Effects 0.000 description 15
- 238000005063 solubilization Methods 0.000 description 15
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 14
- 229910052698 phosphorus Inorganic materials 0.000 description 14
- 239000011574 phosphorus Substances 0.000 description 14
- 239000000843 powder Substances 0.000 description 13
- 230000008569 process Effects 0.000 description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 230000015572 biosynthetic process Effects 0.000 description 11
- 238000006298 dechlorination reaction Methods 0.000 description 11
- 239000012153 distilled water Substances 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 150000001720 carbohydrates Chemical class 0.000 description 10
- 238000005115 demineralization Methods 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- 230000002401 inhibitory effect Effects 0.000 description 10
- 229940068041 phytic acid Drugs 0.000 description 10
- 239000000467 phytic acid Substances 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- 235000014633 carbohydrates Nutrition 0.000 description 9
- 230000002328 demineralizing effect Effects 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 239000004091 cariogenic agent Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 239000006228 supernatant Substances 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- DIKBFYAXUHHXCS-UHFFFAOYSA-N bromoform Chemical compound BrC(Br)Br DIKBFYAXUHHXCS-UHFFFAOYSA-N 0.000 description 6
- 210000004268 dentin Anatomy 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 239000000606 toothpaste Substances 0.000 description 6
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
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- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 229940083982 sodium phytate Drugs 0.000 description 5
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- 229940034610 toothpaste Drugs 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- 239000001506 calcium phosphate Substances 0.000 description 4
- 229910000389 calcium phosphate Inorganic materials 0.000 description 4
- 235000011010 calcium phosphates Nutrition 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 4
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- 239000002324 mouth wash Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000004278 EU approved seasoning Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
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- 238000005119 centrifugation Methods 0.000 description 3
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- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
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- A61K33/10—Carbonates; Bicarbonates
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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Landscapes
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| US6436370B1 (en) * | 1999-06-23 | 2002-08-20 | The Research Foundation Of State University Of New York | Dental anti-hypersensitivity composition and method |
| AU2002227247A1 (en) * | 2000-12-08 | 2002-06-18 | Brown, Dale G. | Biofilm therapy process and elements |
| CA2524087A1 (en) * | 2003-04-30 | 2004-11-11 | Asahi Breweries, Ltd. | Material for inhibiting enamel decalcification |
| US20040258629A1 (en) * | 2003-06-23 | 2004-12-23 | Boyd Thomas J. | Antiplaque confectionery dental composition |
| US8287843B2 (en) | 2003-06-23 | 2012-10-16 | Colgate-Palmolive Company | Antiplaque oral care compositions |
| PL1635774T5 (pl) | 2003-06-23 | 2011-06-30 | Colgate Palmolive Co | Trwałe kompozycje do czyszczenia zębów |
| US7198653B2 (en) | 2003-07-31 | 2007-04-03 | Delavau Llc | Calcium carbonate granulation |
| EP1960057A4 (en) * | 2005-12-16 | 2013-03-27 | David Kannar | SURFACE ACTIVE CALCIUM PHOSPHATES |
| US20070212449A1 (en) * | 2006-03-02 | 2007-09-13 | Shamsuddin Abulkalam M | Reduction of the titratable acidity and the prevention of tooth and other bone degeneration |
| US20080274065A1 (en) * | 2006-05-09 | 2008-11-06 | Richard Scott Robinson | Oral Care Regimen |
| BRPI0711271A2 (pt) | 2006-05-09 | 2011-11-08 | Colgate Palmolive Co | método de limpeza de uma superfìcie oral, de manutenção da saúde oral e/ou de aumento da saúde oral |
| US9138414B1 (en) | 2006-09-15 | 2015-09-22 | Delavau Llc | Calcium supplement having enhanced absorption |
| EP2091505A2 (en) * | 2006-10-31 | 2009-08-26 | Oroscience, Inc | Process to form nano-sized materials, the compositions and uses thereof |
| US20080267891A1 (en) * | 2007-04-30 | 2008-10-30 | Colgate-Palmolive Company | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity |
| US20090053267A1 (en) * | 2007-08-20 | 2009-02-26 | Depierro Karen | Dentifrice composition containing silicone oil beads |
| EP2070422A1 (en) | 2007-12-05 | 2009-06-17 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Confectionery products promoting dental health |
| EP3943064A1 (en) * | 2008-02-08 | 2022-01-26 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| BRPI0822121A2 (pt) * | 2008-02-08 | 2014-09-30 | Colgate Palmolive Co | Composição para cuidado oral, e uso da mesma |
| AU2013200182B2 (en) * | 2008-02-08 | 2015-05-21 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| PA8774301A1 (es) * | 2008-02-08 | 2009-09-17 | Colgate Palmolive Co | Regimen de cuidado bucal |
| MX2010005190A (es) * | 2008-02-08 | 2010-06-03 | Colgate Palmolive Co | Hilo dental. |
| CA2705299C (en) * | 2008-02-08 | 2016-12-06 | Richard Scott Robinson | Dental wipe |
| AU2015215853B2 (en) * | 2008-02-08 | 2016-11-03 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| MY157021A (en) * | 2008-02-08 | 2016-04-15 | Colgate Palmolive Co | Oral care product and methods of use thereof |
| EP2247278A4 (en) * | 2008-02-08 | 2014-02-19 | Colgate Palmolive Co | COMPOSITIONS AND METHODS OF CLEANING |
| MX2010005004A (es) * | 2008-02-08 | 2010-05-27 | Colgate Palmolive Co | Composiciones y dispositivos. |
| AU2008349847C1 (en) * | 2008-02-08 | 2012-12-13 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| BRPI0907106A2 (pt) * | 2008-02-08 | 2016-05-03 | Colgate Palmolive Co | bebida, e, método para melhorar a saúde oral. |
| AR070592A1 (es) * | 2008-02-08 | 2010-04-21 | Colgate Palmolive Co | Composiciones para el blanqueamiento dental |
| CN102215811A (zh) * | 2008-02-08 | 2011-10-12 | 高露洁-棕榄公司 | 泡腾组合物 |
| AU2012211481B2 (en) * | 2008-02-08 | 2013-08-22 | Colgate-Palmolive Company | Arginine salts and their uses for the treatment of illnesses in the oral cavity |
| BRPI0907102A2 (pt) | 2008-02-08 | 2016-05-03 | Colgate Palmolive Co | composição dental, e, método para eliminar ou reduzir o desconforto e a dor associados com a hipersensibilidade da dentina |
| TWI374756B (en) * | 2008-02-08 | 2012-10-21 | Colgate Palmolive Co | Compositions and methods comprising basic amino acid peptides and proteases |
| CN101938982B (zh) * | 2008-02-08 | 2014-06-04 | 高露洁-棕榄公司 | 口腔护理产品和其使用和制备方法 |
| TWI389876B (zh) * | 2008-02-08 | 2013-03-21 | Colgate Palmolive Co | 鹽的製造方法 |
| RU2010137265A (ru) * | 2008-02-08 | 2012-03-20 | Колгейт-Палмолив Компани (US) | Новые соли и их применение |
| CN102037360B (zh) * | 2008-02-08 | 2016-10-05 | 高露洁-棕榄公司 | 口腔护理方法和系统 |
| BRPI0906462A2 (pt) * | 2008-02-08 | 2015-07-14 | Colgate Palmolive Co | Método para tratar, melhorar, inibir ou evitar boca seca, saliva artificial, uso de um aminoácido básico em forma livre ou de sal, e, aminoácido básico em forma livre ou de sal |
| BRPI0906466A2 (pt) * | 2008-02-08 | 2015-07-14 | Colgate Palmolive Co | Composição para cuidado oral, e, métodos para preparar uma composição oral, e para aplicar uma quantidade eficaz da composição oral |
| RU2481820C2 (ru) * | 2008-02-08 | 2013-05-20 | Колгейт-Палмолив Компани | Средство для ухода за полостью рта и способы его применения и изготовления |
| JP2011510095A (ja) * | 2008-02-08 | 2011-03-31 | コルゲート・パーモリブ・カンパニー | 歯用シーラント［０００１］この出願は２００８年２月８日に出願された米国一連番号６１／０２７，４２５の利益を主張し、その内容を本明細書に援用する。 |
| US20090202452A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care regimen |
| MX2010005002A (es) * | 2008-02-08 | 2010-05-24 | Colgate Palmolive Co | Cepillo de dientes para el cuidado oral. |
| US20090005320A1 (en) * | 2008-09-02 | 2009-01-01 | Bruce Kneller | Compositions comprising amino acid bicarbonate and methods of use thereof |
| US8216552B2 (en) * | 2008-11-25 | 2012-07-10 | The Procter & Gamble Company | Oral care compositions containing gel networks and fused silica |
| CN102427795A (zh) | 2009-05-18 | 2012-04-25 | 高露洁-棕榄公司 | 含有聚胍*化合物的口腔组合物及其制备和使用方法 |
| US8741268B2 (en) * | 2009-09-10 | 2014-06-03 | Preventive Technologies, Inc. | Dental prophylactic paste |
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| EP2513048B1 (en) * | 2009-12-18 | 2016-11-16 | Colgate-Palmolive Company | Methods for production of high concentration of arginine bicarbonate solution at high pressure |
| KR20170134772A (ko) | 2009-12-29 | 2017-12-06 | 더블유.알. 그레이스 앤드 캄파니-콘. | 은폐 막을 형성하기 위한 조성물, 및 이의 제조 및 사용 방법 |
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| WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
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| US20220096362A1 (en) | 2020-09-28 | 2022-03-31 | The Procter & Gamble Company | Aqueous Compositions Comprising Hops-Metal Complex |
| BR112023002883A2 (pt) | 2020-09-28 | 2023-04-04 | Procter & Gamble | Conjunto de composições para tratamento bucal anticárie |
| BR112023019585A2 (pt) | 2021-03-25 | 2024-02-06 | Procter & Gamble | Composições para tratamento bucal que compreendem lúpulo e adoçante |
| US20220313595A1 (en) | 2021-03-25 | 2022-10-06 | The Procter & Gamble Company | Oral Care Compositions Comprising Hops |
| CN117083053A (zh) | 2021-03-25 | 2023-11-17 | 宝洁公司 | 包含啤酒花的可食口腔组合物 |
| CN115572309B (zh) * | 2022-09-20 | 2024-05-03 | 浙江工业大学 | 一种高效阻燃、抗熔滴的环境友好型阻燃剂 |
| WO2025000250A1 (en) | 2023-06-28 | 2025-01-02 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids |
| AU2024306065A1 (en) | 2023-06-28 | 2025-11-27 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids and tin |
| WO2025006671A2 (en) | 2023-06-28 | 2025-01-02 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids |
| US20250120890A1 (en) | 2023-09-14 | 2025-04-17 | The Procter & Gamble Company | Oral Care Compositions Comprising Hops Beta Acids And Tin |
| US20250120893A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025080746A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| US20250120896A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| US20250120897A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025076709A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025080742A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3943241A (en) * | 1971-08-30 | 1976-03-09 | General Mills, Inc. | Cariostatic composition |
| US3932608A (en) * | 1971-08-30 | 1976-01-13 | General Mills, Inc. | Food composition |
| US4064138A (en) * | 1975-11-12 | 1977-12-20 | General Mills, Inc. | Amino acid derivatives |
| USRE31181E (en) * | 1976-06-18 | 1983-03-15 | Means and method for improving natural defenses against caries | |
| ZA773318B (en) * | 1976-06-18 | 1978-04-26 | I Kleinberg | Means and method for improving natural defenses against caries |
| GB1573727A (en) * | 1978-05-19 | 1980-08-28 | Colgate Palmolive Co | Dentifrices |
| US4225579A (en) * | 1979-02-27 | 1980-09-30 | Israel Kleinberg | Means and method for improving defenses against caries |
| JPS5835965B2 (ja) * | 1979-07-31 | 1983-08-05 | ライオン株式会社 | 口腔用組成物 |
| US4367218A (en) * | 1979-09-06 | 1983-01-04 | Jacobson Jerry I | Anti-caries oral rinse |
| US4528181A (en) * | 1984-02-01 | 1985-07-09 | Colgate-Palmolive Company | Dentifrice containing dual sources of fluoride |
| JPS61233612A (ja) * | 1985-04-10 | 1986-10-17 | Kao Corp | チユ−インガム |
| US5370865A (en) * | 1992-05-15 | 1994-12-06 | Kao Corporation | Composition for use in oral cavity |
| CN1094309A (zh) * | 1993-04-27 | 1994-11-02 | 李颖 | 一种矿质吸收因子肽钙及其制剂的制备方法 |
-
1996
- 1996-03-05 US US08/611,206 patent/US5762911A/en not_active Expired - Lifetime
-
1997
- 1997-03-04 AT AT97917135T patent/ATE432685T1/de active
- 1997-03-04 NZ NZ332172A patent/NZ332172A/xx not_active IP Right Cessation
- 1997-03-04 CN CNB971969965A patent/CN1206978C/zh not_active Expired - Lifetime
- 1997-03-04 AU AU25563/97A patent/AU719465B2/en not_active Expired
- 1997-03-04 EP EP97917135A patent/EP0928184B1/en not_active Expired - Lifetime
- 1997-03-04 JP JP53207497A patent/JP3980645B2/ja not_active Expired - Lifetime
- 1997-03-04 BR BRPI9711797-8A patent/BR9711797B1/pt not_active IP Right Cessation
- 1997-03-04 ES ES97917135T patent/ES2328301T3/es not_active Expired - Lifetime
- 1997-03-04 CN CNB2005100727356A patent/CN1305530C/zh not_active Expired - Lifetime
- 1997-03-04 DK DK97917135T patent/DK0928184T3/da active
- 1997-03-04 CA CA002252071A patent/CA2252071C/en not_active Expired - Lifetime
- 1997-03-04 PT PT97917135T patent/PT928184E/pt unknown
- 1997-03-04 WO PCT/US1997/005273 patent/WO1997032565A1/en not_active Ceased
- 1997-03-04 DE DE69739440T patent/DE69739440D1/de not_active Expired - Lifetime
-
1998
- 1998-02-19 US US09/026,132 patent/US6217851B1/en not_active Expired - Lifetime
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2006
- 2006-06-26 JP JP2006175656A patent/JP2006265268A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2252071A1 (en) | 1997-09-12 |
| WO1997032565A1 (en) | 1997-09-12 |
| EP0928184A1 (en) | 1999-07-14 |
| JP2006265268A (ja) | 2006-10-05 |
| ES2328301T3 (es) | 2009-11-11 |
| BR9711797A (pt) | 2000-01-18 |
| CA2252071C (en) | 2004-12-21 |
| CN1305530C (zh) | 2007-03-21 |
| EP0928184B1 (en) | 2009-06-03 |
| PT928184E (pt) | 2009-09-09 |
| US5762911A (en) | 1998-06-09 |
| US6217851B1 (en) | 2001-04-17 |
| EP0928184A4 (en) | 1999-10-20 |
| DE69739440D1 (de) | 2009-07-16 |
| BR9711797B1 (pt) | 2010-12-14 |
| CN1206978C (zh) | 2005-06-22 |
| AU719465B2 (en) | 2000-05-11 |
| AU2556397A (en) | 1997-09-22 |
| DK0928184T3 (da) | 2009-09-28 |
| NZ332172A (en) | 2000-11-24 |
| JP2001504083A (ja) | 2001-03-27 |
| ATE432685T1 (de) | 2009-06-15 |
| CN1701815A (zh) | 2005-11-30 |
| CN1227483A (zh) | 1999-09-01 |
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