ES2328301T3 - Composiciones orales anticaries. - Google Patents
Composiciones orales anticaries. Download PDFInfo
- Publication number
- ES2328301T3 ES2328301T3 ES97917135T ES97917135T ES2328301T3 ES 2328301 T3 ES2328301 T3 ES 2328301T3 ES 97917135 T ES97917135 T ES 97917135T ES 97917135 T ES97917135 T ES 97917135T ES 2328301 T3 ES2328301 T3 ES 2328301T3
- Authority
- ES
- Spain
- Prior art keywords
- arginine
- oral
- calcium
- oral composition
- phytate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 138
- 230000000675 anti-caries Effects 0.000 title description 9
- 239000004475 Arginine Substances 0.000 claims abstract description 126
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 126
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims abstract description 109
- 239000011575 calcium Substances 0.000 claims abstract description 75
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 74
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 74
- 208000002925 dental caries Diseases 0.000 claims abstract description 42
- 150000001450 anions Chemical class 0.000 claims abstract description 39
- 238000000034 method Methods 0.000 claims abstract description 37
- 230000000248 cariostatic effect Effects 0.000 claims abstract description 35
- 210000000214 mouth Anatomy 0.000 claims abstract description 13
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 78
- 235000002949 phytic acid Nutrition 0.000 claims description 75
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 41
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 23
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 21
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 19
- RYJDNPSQBGFFSF-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;carbonic acid Chemical compound OC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RYJDNPSQBGFFSF-WCCKRBBISA-N 0.000 claims description 17
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 17
- 229910019142 PO4 Inorganic materials 0.000 claims description 17
- 239000010452 phosphate Substances 0.000 claims description 17
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 13
- WPEXVRDUEAJUGY-UHFFFAOYSA-B hexacalcium;(2,3,4,5,6-pentaphosphonatooxycyclohexyl) phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OC1C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C1OP([O-])([O-])=O WPEXVRDUEAJUGY-UHFFFAOYSA-B 0.000 claims description 12
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 9
- -1 inositol derivatives phosphate Chemical class 0.000 claims description 7
- 239000005022 packaging material Substances 0.000 claims description 7
- 239000001569 carbon dioxide Substances 0.000 claims description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 235000011089 carbon dioxide Nutrition 0.000 claims description 4
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 3
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 3
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 3
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical class [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 3
- 239000001506 calcium phosphate Substances 0.000 claims description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 3
- 235000011010 calcium phosphates Nutrition 0.000 claims description 3
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
- 241000628997 Flos Species 0.000 claims description 2
- INAPMGSXUVUWAF-GCVPSNMTSA-N [(2r,3s,5r,6r)-2,3,4,5,6-pentahydroxycyclohexyl] dihydrogen phosphate Chemical class OC1[C@H](O)[C@@H](O)C(OP(O)(O)=O)[C@H](O)[C@@H]1O INAPMGSXUVUWAF-GCVPSNMTSA-N 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims description 2
- 239000007937 lozenge Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 229940112822 chewing gum Drugs 0.000 claims 1
- 235000015218 chewing gum Nutrition 0.000 claims 1
- CCTIOCVIZPCTGO-BYPYZUCNSA-N phosphoarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)NP(O)(O)=O CCTIOCVIZPCTGO-BYPYZUCNSA-N 0.000 claims 1
- 239000004075 cariostatic agent Substances 0.000 abstract description 14
- 239000003795 chemical substances by application Substances 0.000 abstract description 14
- 210000003298 dental enamel Anatomy 0.000 description 45
- 239000008103 glucose Substances 0.000 description 27
- 238000011534 incubation Methods 0.000 description 27
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 26
- 239000002253 acid Substances 0.000 description 26
- 238000005115 demineralization Methods 0.000 description 24
- 230000002328 demineralizing effect Effects 0.000 description 24
- 241000894006 Bacteria Species 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
- 239000013049 sediment Substances 0.000 description 20
- 230000007928 solubilization Effects 0.000 description 19
- 238000005063 solubilization Methods 0.000 description 19
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 17
- 229910052698 phosphorus Inorganic materials 0.000 description 17
- 239000011574 phosphorus Substances 0.000 description 17
- 239000000843 powder Substances 0.000 description 17
- 150000001875 compounds Chemical class 0.000 description 16
- 235000021317 phosphate Nutrition 0.000 description 15
- 230000008569 process Effects 0.000 description 14
- 238000004458 analytical method Methods 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 210000003296 saliva Anatomy 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 10
- 230000015572 biosynthetic process Effects 0.000 description 10
- 229940068041 phytic acid Drugs 0.000 description 10
- 239000000467 phytic acid Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- 230000003247 decreasing effect Effects 0.000 description 9
- 239000012153 distilled water Substances 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 238000007792 addition Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 230000001965 increasing effect Effects 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
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- 239000000872 buffer Substances 0.000 description 7
- 235000014633 carbohydrates Nutrition 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 235000000346 sugar Nutrition 0.000 description 7
- 239000006228 supernatant Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 208000002064 Dental Plaque Diseases 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 150000007513 acids Chemical class 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- DIKBFYAXUHHXCS-UHFFFAOYSA-N bromoform Chemical compound BrC(Br)Br DIKBFYAXUHHXCS-UHFFFAOYSA-N 0.000 description 6
- 150000001720 carbohydrates Chemical class 0.000 description 6
- 210000004268 dentin Anatomy 0.000 description 6
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 6
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- 150000008163 sugars Chemical class 0.000 description 6
- 229940034610 toothpaste Drugs 0.000 description 6
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- 235000011054 acetic acid Nutrition 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 230000015556 catabolic process Effects 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000002324 mouth wash Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 description 3
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- 150000001413 amino acids Chemical class 0.000 description 3
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
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- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
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- 230000005587 bubbling Effects 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Confectionery (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/611,206 US5762911A (en) | 1996-03-05 | 1996-03-05 | Anti-caries oral compositions |
| US611206 | 1996-03-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2328301T3 true ES2328301T3 (es) | 2009-11-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97917135T Expired - Lifetime ES2328301T3 (es) | 1996-03-05 | 1997-03-04 | Composiciones orales anticaries. |
Country Status (14)
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|---|---|
| US (2) | US5762911A (enExample) |
| EP (1) | EP0928184B1 (enExample) |
| JP (2) | JP3980645B2 (enExample) |
| CN (2) | CN1305530C (enExample) |
| AT (1) | ATE432685T1 (enExample) |
| AU (1) | AU719465B2 (enExample) |
| BR (1) | BR9711797B1 (enExample) |
| CA (1) | CA2252071C (enExample) |
| DE (1) | DE69739440D1 (enExample) |
| DK (1) | DK0928184T3 (enExample) |
| ES (1) | ES2328301T3 (enExample) |
| NZ (1) | NZ332172A (enExample) |
| PT (1) | PT928184E (enExample) |
| WO (1) | WO1997032565A1 (enExample) |
Families Citing this family (85)
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| US6436370B1 (en) * | 1999-06-23 | 2002-08-20 | The Research Foundation Of State University Of New York | Dental anti-hypersensitivity composition and method |
| WO2002045611A2 (en) * | 2000-12-08 | 2002-06-13 | Brown, Dale, G. | Biofilm therapy process and elements |
| AU2004233706A1 (en) * | 2003-04-30 | 2004-11-11 | Asahi Breweries, Ltd. | Material for inhibiting enamel decalcification |
| US8287843B2 (en) | 2003-06-23 | 2012-10-16 | Colgate-Palmolive Company | Antiplaque oral care compositions |
| US20040258629A1 (en) * | 2003-06-23 | 2004-12-23 | Boyd Thomas J. | Antiplaque confectionery dental composition |
| US8865135B2 (en) | 2003-06-23 | 2014-10-21 | Colgate-Palmolive Company | Stable dentifrice compositions |
| US7198653B2 (en) | 2003-07-31 | 2007-04-03 | Delavau Llc | Calcium carbonate granulation |
| EP1960057A4 (en) * | 2005-12-16 | 2013-03-27 | David Kannar | SURFACE ACTIVE CALCIUM PHOSPHATES |
| US20070212449A1 (en) * | 2006-03-02 | 2007-09-13 | Shamsuddin Abulkalam M | Reduction of the titratable acidity and the prevention of tooth and other bone degeneration |
| US20080274065A1 (en) * | 2006-05-09 | 2008-11-06 | Richard Scott Robinson | Oral Care Regimen |
| AU2007249542B2 (en) | 2006-05-09 | 2009-11-05 | Colgate-Palmolive Company | Oral care regimen |
| US9138414B1 (en) | 2006-09-15 | 2015-09-22 | Delavau Llc | Calcium supplement having enhanced absorption |
| EP2091505A2 (en) * | 2006-10-31 | 2009-08-26 | Oroscience, Inc | Process to form nano-sized materials, the compositions and uses thereof |
| US20080267891A1 (en) * | 2007-04-30 | 2008-10-30 | Colgate-Palmolive Company | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity |
| US20090053267A1 (en) * | 2007-08-20 | 2009-02-26 | Depierro Karen | Dentifrice composition containing silicone oil beads |
| EP2070422A1 (en) | 2007-12-05 | 2009-06-17 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Confectionery products promoting dental health |
| JP2011511667A (ja) | 2008-02-08 | 2011-04-14 | コルゲート・パーモリブ・カンパニー | デンタルフロス |
| JP5606328B2 (ja) * | 2008-02-08 | 2014-10-15 | コルゲート・パーモリブ・カンパニー | 口腔ケア歯ブラシ |
| BRPI0906465A2 (pt) * | 2008-02-08 | 2015-07-14 | Colgate Palmolive Co | Composição efervesente, e, método |
| US20090202456A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Novel salts and their uses |
| CA2710583C (en) * | 2008-02-08 | 2015-10-06 | Colgate-Palmolive Company | Compositions and devices |
| PE20130148A1 (es) * | 2008-02-08 | 2013-02-11 | Colgate Palmolive Co | Producto para el cuidado oral y metodos de uso y fabricacion de los mismos |
| US20090202452A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care regimen |
| CA2711414C (en) * | 2008-02-08 | 2013-11-19 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| MY155709A (en) * | 2008-02-08 | 2015-11-13 | Colgate Palmolive Co | Oral care regimen |
| AR070355A1 (es) * | 2008-02-08 | 2010-03-31 | Colgate Palmolive Co | Composiciones, metodos para el tratamiento de la xerostomia y uso |
| AR070357A1 (es) * | 2008-02-08 | 2010-03-31 | Colgate Palmolive Co | Producto para cuidado oral y metodos de uso y manufactura del mismo |
| AR070587A1 (es) * | 2008-02-08 | 2010-04-21 | Colgate Palmolive Co | Composiciones efervescentes de limpieza y metodos de aplicacion |
| RU2010137267A (ru) * | 2008-02-08 | 2012-03-20 | Колгейт-Палмолив Компани (US) | Дентальная салфетка |
| EP2249764B1 (en) * | 2008-02-08 | 2019-07-31 | Colgate-Palmolive Company | Tooth sealant |
| WO2009100260A2 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Compositions and methods comprising basic amino acid peptides and proteases |
| AU2015215853B2 (en) * | 2008-02-08 | 2016-11-03 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| TWI566782B (zh) * | 2008-02-08 | 2017-01-21 | 美國棕欖公司 | 口腔保健產品及其使用方法與製造 |
| RU2476890C2 (ru) * | 2008-02-08 | 2013-02-27 | Колгейт-Палмолив Компани | Способы и системы для ухода за ротовой полостью |
| AR072341A1 (es) | 2008-02-08 | 2010-08-25 | Colgate Palmolive Co | Metodos para la produccion de bicarbonato de arginina |
| RU2469701C2 (ru) * | 2008-02-08 | 2012-12-20 | Колгейт-Палмолив Компани | Продукт для ухода за полостью рта и способы его применения |
| AU2012211481B2 (en) * | 2008-02-08 | 2013-08-22 | Colgate-Palmolive Company | Arginine salts and their uses for the treatment of illnesses in the oral cavity |
| RU2519329C2 (ru) * | 2008-02-08 | 2014-06-10 | Колгейт-Палмолив Компани | Композиции и устройства |
| AU2013200182B2 (en) * | 2008-02-08 | 2015-05-21 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| RU2550949C2 (ru) * | 2008-02-08 | 2015-05-20 | Колгей-Палмолив Компани | Композиции, включающие основную аминокислоту и растворимую карбонатную соль |
| EP2249770A4 (en) * | 2008-02-08 | 2014-02-19 | Colgate Palmolive Co | MOUTHPACKAGE PRODUCT WITH TWO COMPONENTS |
| RU2450554C1 (ru) * | 2008-02-08 | 2012-05-20 | Колгейт-Палмолив Компани | Напиток, включающий аргинин |
| RU2481820C2 (ru) * | 2008-02-08 | 2013-05-20 | Колгейт-Палмолив Компани | Средство для ухода за полостью рта и способы его применения и изготовления |
| US20090005320A1 (en) * | 2008-09-02 | 2009-01-01 | Bruce Kneller | Compositions comprising amino acid bicarbonate and methods of use thereof |
| RU2487699C2 (ru) * | 2008-11-25 | 2013-07-20 | Дзе Проктер Энд Гэмбл Компани | КОМПОЗИЦИИ ДЛЯ УХОДА ЗА ПОЛОСТЬЮ РТА, СОДЕРЖАЩИЕ АМОРФНЫЙ КВАРЦ И ОБЛАДАЮЩИЕ НИЗКИМ ЗНАЧЕНИЕМ pH |
| BRPI0924734A2 (pt) | 2009-05-18 | 2016-01-26 | Colgate Palmolive Co | composição oral, e, métodos para preparar a composição oral, para alvejar um ingrediente ativo, para depositar um material bacteriostático ou bactericida sobre superfícies orais, para retardar ou previnir cárie dentária, método para ocluir túbulos dentinais, para tratar uma lesão por cárie, para calcificar uma polpa de dente exposta, e para calcificar a base de ou a totalidade de um buraco ou de uma fissura em um dente. |
| US8741268B2 (en) * | 2009-09-10 | 2014-06-03 | Preventive Technologies, Inc. | Dental prophylactic paste |
| TWI499430B (zh) | 2009-12-17 | 2015-09-11 | Colgate Palmolive Co | 抗侵蝕的牙膏組成物 |
| WO2011075472A1 (en) | 2009-12-18 | 2011-06-23 | Colgate-Palmolive Company | Methods for production of arginine bicarbonate at low pressure |
| US9035093B2 (en) * | 2009-12-18 | 2015-05-19 | Colgate-Palmolive Company | Methods for production of high concentration of arginine bicarbonate solution at high pressure |
| CN102844018B (zh) | 2009-12-29 | 2021-03-23 | 格雷斯公司 | 用于形成遮蔽膜的组合物及其制备和使用方法 |
| EP2528662B1 (en) | 2010-01-29 | 2018-10-17 | Colgate-Palmolive Company | Oral care product for sensitive enamel care |
| US8658139B1 (en) | 2010-02-27 | 2014-02-25 | Squigle, Inc. | Prevention and treatment of oral diseases |
| DE102010003280A1 (de) | 2010-03-25 | 2011-02-03 | Henkel Ag & Co. Kgaa | Mund- und Zahnpflege- und -reinigungsmittel mit pflanzlichen Peptiden |
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| US9717929B2 (en) * | 2010-12-07 | 2017-08-01 | Colgate-Palmolive Company | Dentifrice compositions containing calcium silicate and a basic amino acid |
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| AU2014414756B2 (en) | 2014-12-23 | 2018-04-26 | Colgate-Palmolive Company | Oral care compositions |
| WO2021067993A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and fluoride |
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| EP4216908A1 (en) | 2020-09-28 | 2023-08-02 | The Procter & Gamble Company | Array of anticavity oral care compositions |
| WO2022067142A1 (en) | 2020-09-28 | 2022-03-31 | The Procter & Gamble Company | Oral care composition comprising hops and flavor |
| WO2022067141A1 (en) | 2020-09-28 | 2022-03-31 | The Procter & Gamble Company | Aqueous compositions comprising hops-metal complex |
| EP4216920A1 (en) | 2020-09-28 | 2023-08-02 | The Procter & Gamble Company | Oral care compositions comprising prenylated flavonoids |
| EP4312956A1 (en) | 2021-03-25 | 2024-02-07 | The Procter & Gamble Company | Oral care compositions comprising hops and sweetener |
| WO2022204715A1 (en) | 2021-03-25 | 2022-09-29 | The Procter & Gamble Company | Edible oral compositions comprising hops |
| BR112023019587A2 (pt) | 2021-03-25 | 2024-02-06 | Procter & Gamble | Composições para tratamento bucal que compreendem lúpulo |
| CN115572309B (zh) * | 2022-09-20 | 2024-05-03 | 浙江工业大学 | 一种高效阻燃、抗熔滴的环境友好型阻燃剂 |
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| US20250120890A1 (en) | 2023-09-14 | 2025-04-17 | The Procter & Gamble Company | Oral Care Compositions Comprising Hops Beta Acids And Tin |
| WO2025080747A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| US20250120891A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025080746A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| US20250120897A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025080743A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025076709A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932608A (en) * | 1971-08-30 | 1976-01-13 | General Mills, Inc. | Food composition |
| US3943241A (en) * | 1971-08-30 | 1976-03-09 | General Mills, Inc. | Cariostatic composition |
| US4064138A (en) * | 1975-11-12 | 1977-12-20 | General Mills, Inc. | Amino acid derivatives |
| USRE31181E (en) * | 1976-06-18 | 1983-03-15 | Means and method for improving natural defenses against caries | |
| ZA773318B (en) * | 1976-06-18 | 1978-04-26 | I Kleinberg | Means and method for improving natural defenses against caries |
| GB1573727A (en) * | 1978-05-19 | 1980-08-28 | Colgate Palmolive Co | Dentifrices |
| US4225579A (en) * | 1979-02-27 | 1980-09-30 | Israel Kleinberg | Means and method for improving defenses against caries |
| JPS5835965B2 (ja) * | 1979-07-31 | 1983-08-05 | ライオン株式会社 | 口腔用組成物 |
| US4367218A (en) * | 1979-09-06 | 1983-01-04 | Jacobson Jerry I | Anti-caries oral rinse |
| US4528181A (en) * | 1984-02-01 | 1985-07-09 | Colgate-Palmolive Company | Dentifrice containing dual sources of fluoride |
| JPS61233612A (ja) * | 1985-04-10 | 1986-10-17 | Kao Corp | チユ−インガム |
| US5370865A (en) * | 1992-05-15 | 1994-12-06 | Kao Corporation | Composition for use in oral cavity |
| CN1094309A (zh) * | 1993-04-27 | 1994-11-02 | 李颖 | 一种矿质吸收因子肽钙及其制剂的制备方法 |
-
1996
- 1996-03-05 US US08/611,206 patent/US5762911A/en not_active Expired - Lifetime
-
1997
- 1997-03-04 BR BRPI9711797-8A patent/BR9711797B1/pt not_active IP Right Cessation
- 1997-03-04 CN CNB2005100727356A patent/CN1305530C/zh not_active Expired - Lifetime
- 1997-03-04 NZ NZ332172A patent/NZ332172A/xx not_active IP Right Cessation
- 1997-03-04 JP JP53207497A patent/JP3980645B2/ja not_active Expired - Lifetime
- 1997-03-04 EP EP97917135A patent/EP0928184B1/en not_active Expired - Lifetime
- 1997-03-04 CA CA002252071A patent/CA2252071C/en not_active Expired - Lifetime
- 1997-03-04 AU AU25563/97A patent/AU719465B2/en not_active Expired
- 1997-03-04 CN CNB971969965A patent/CN1206978C/zh not_active Expired - Lifetime
- 1997-03-04 ES ES97917135T patent/ES2328301T3/es not_active Expired - Lifetime
- 1997-03-04 PT PT97917135T patent/PT928184E/pt unknown
- 1997-03-04 DK DK97917135T patent/DK0928184T3/da active
- 1997-03-04 WO PCT/US1997/005273 patent/WO1997032565A1/en not_active Ceased
- 1997-03-04 AT AT97917135T patent/ATE432685T1/de active
- 1997-03-04 DE DE69739440T patent/DE69739440D1/de not_active Expired - Lifetime
-
1998
- 1998-02-19 US US09/026,132 patent/US6217851B1/en not_active Expired - Lifetime
-
2006
- 2006-06-26 JP JP2006175656A patent/JP2006265268A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DK0928184T3 (da) | 2009-09-28 |
| BR9711797B1 (pt) | 2010-12-14 |
| JP3980645B2 (ja) | 2007-09-26 |
| CN1206978C (zh) | 2005-06-22 |
| WO1997032565A1 (en) | 1997-09-12 |
| AU719465B2 (en) | 2000-05-11 |
| ATE432685T1 (de) | 2009-06-15 |
| CN1305530C (zh) | 2007-03-21 |
| EP0928184A4 (en) | 1999-10-20 |
| BR9711797A (pt) | 2000-01-18 |
| CN1701815A (zh) | 2005-11-30 |
| PT928184E (pt) | 2009-09-09 |
| JP2001504083A (ja) | 2001-03-27 |
| NZ332172A (en) | 2000-11-24 |
| AU2556397A (en) | 1997-09-22 |
| JP2006265268A (ja) | 2006-10-05 |
| DE69739440D1 (de) | 2009-07-16 |
| EP0928184A1 (en) | 1999-07-14 |
| EP0928184B1 (en) | 2009-06-03 |
| US6217851B1 (en) | 2001-04-17 |
| CA2252071C (en) | 2004-12-21 |
| CA2252071A1 (en) | 1997-09-12 |
| US5762911A (en) | 1998-06-09 |
| CN1227483A (zh) | 1999-09-01 |
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