JP3251587B2 - 炎症疾患の治療および腫瘍壊死因子の産生阻害に有用な化合物 - Google Patents
炎症疾患の治療および腫瘍壊死因子の産生阻害に有用な化合物Info
- Publication number
- JP3251587B2 JP3251587B2 JP51749193A JP51749193A JP3251587B2 JP 3251587 B2 JP3251587 B2 JP 3251587B2 JP 51749193 A JP51749193 A JP 51749193A JP 51749193 A JP51749193 A JP 51749193A JP 3251587 B2 JP3251587 B2 JP 3251587B2
- Authority
- JP
- Japan
- Prior art keywords
- cyano
- methoxyphenyl
- cis
- trans
- cyclopentyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US862,111 | 1986-05-12 | ||
| US86211192A | 1992-04-02 | 1992-04-02 | |
| US96876192A | 1992-10-30 | 1992-10-30 | |
| US968,761 | 1992-10-30 | ||
| PCT/US1993/002516 WO1993019751A1 (en) | 1992-04-02 | 1993-03-05 | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH07508263A JPH07508263A (ja) | 1995-09-14 |
| JP3251587B2 true JP3251587B2 (ja) | 2002-01-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP51749193A Expired - Lifetime JP3251587B2 (ja) | 1992-04-02 | 1993-03-05 | 炎症疾患の治療および腫瘍壊死因子の産生阻害に有用な化合物 |
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|---|---|
| US (1) | US5605923A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0636026B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP3251587B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN1094031A (cg-RX-API-DMAC10.html) |
| AU (1) | AU3924993A (cg-RX-API-DMAC10.html) |
| DE (1) | DE69331265T2 (cg-RX-API-DMAC10.html) |
| IL (1) | IL105220A0 (cg-RX-API-DMAC10.html) |
| MA (1) | MA22922A1 (cg-RX-API-DMAC10.html) |
| MX (1) | MX9301942A (cg-RX-API-DMAC10.html) |
| WO (1) | WO1993019751A1 (cg-RX-API-DMAC10.html) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6572794B1 (en) | 2000-07-24 | 2003-06-03 | Essilor International Compagnie Generale D'optique | Method of manufacturing a photochromic molded article |
| US6740699B2 (en) | 2001-01-11 | 2004-05-25 | Essilor International Compagnie Generale D'optique | Method for obtaining a stabilized photochromic latex, latex obtained, and application to ophthalmic optics |
| US6770710B2 (en) | 2000-11-17 | 2004-08-03 | Essilor International Compagnie Generale D'optique | Process for obtaining a photochromic latex |
| WO2023208941A1 (en) | 2022-04-26 | 2023-11-02 | Essilor International | Photochromic optical article having a mirror coating |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0919544T3 (da) * | 1992-04-02 | 2003-09-15 | Smithkline Beecham Corp | Forbindelser egnede til behandling af allergiske og inflammatoriske sygdomme |
| AU7174794A (en) * | 1993-06-18 | 1995-01-17 | Smithkline Beecham Corporation | Compounds |
| US5780667A (en) * | 1993-10-01 | 1998-07-14 | Smithkline Beecham Corporation | Compounds, compositions and treatment of allergies and inflammation therewith |
| US6013827A (en) * | 1994-03-11 | 2000-01-11 | Smithkline Beecham Corporation | Compounds |
| GB9404706D0 (en) * | 1994-03-11 | 1994-04-27 | Smithkline Beecham Corp | Compounds |
| US5998428A (en) * | 1995-05-31 | 1999-12-07 | Smithkline Beecham Corporation | Compounds and methods for treating PDE IV-related diseases |
| EP0799182A4 (en) * | 1994-12-23 | 1998-03-25 | Smithkline Beecham Corp | DIMERES 3.3- (DISUBSTITUTED) CYCLOHEXAN-1-OL AND RELATED COMPOUNDS |
| ATE306260T1 (de) * | 1994-12-23 | 2005-10-15 | Smithkline Beecham Corp | Monomere der 4,4-(disubstituierten)cyclohexan-1- ole und verwandte verbindungen |
| ZA9510826B (en) * | 1994-12-23 | 1996-06-20 | Smithkline Beecham Corp | 3,3-(disubstituted)cyclohexan-1-ol monomers and related compounds |
| EP0799204A4 (en) * | 1994-12-23 | 1998-03-25 | Smithkline Beecham Corp | MONOMERS OF 1,3,3- (TRISUBSTITUE) CYCLOHEXANE AND RELATED COMPOUNDS |
| WO1996020161A1 (en) * | 1994-12-23 | 1996-07-04 | Smithkline Beecham Corporation | 4,4-(disubstituted)cyclohexan-1-ol dimers and related compounds |
| US5777160A (en) * | 1994-12-23 | 1998-07-07 | Smithkline Beecham Corporation | 1, 4, 4-(trisubstituted) cyclohex-1-ene dimers and related compounds |
| DK0828728T3 (da) * | 1995-05-18 | 2003-05-19 | Altana Pharma Ag | Phenyldihydrobenzofuraner |
| JPH11505539A (ja) * | 1995-05-18 | 1999-05-21 | ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング | シクロヘキシルジヒドロベンゾフラン |
| AR004471A1 (es) * | 1995-05-31 | 1998-12-16 | Smithkline Beecham Corp | Compuestos de ciclohexan-1-ol-4,4-disustituidos, utiles en el tratamiento de enfermedades alergicas e inflamatorias y composiciones farmaceuticas que lascontienen |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| US5891883A (en) * | 1995-12-21 | 1999-04-06 | Smithkline Beecham Corporation | 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds |
| US6235786B1 (en) | 1997-08-06 | 2001-05-22 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
| US6294573B1 (en) | 1997-08-06 | 2001-09-25 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
| US6288261B1 (en) | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
| DZ3019A1 (fr) * | 1999-03-01 | 2005-05-20 | Smithkline Beecham Corp | Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd. |
| US20020077276A1 (en) * | 1999-04-27 | 2002-06-20 | Fredeking Terry M. | Compositions and methods for treating hemorrhagic virus infections and other disorders |
| US20040220424A1 (en) * | 1999-08-06 | 2004-11-04 | Smithkline Beecham Corporation | Process for preparing acids via alpha-chloroepoxy esters |
| UY26268A1 (es) * | 1999-08-06 | 2001-01-31 | Smithkline Beecham Corp | Procedimiento para preparar acidos a traves de alfa-cloroep xi- esteres ley 17164 art 127 |
| EP1671651B1 (en) | 1999-08-21 | 2009-11-11 | Nycomed GmbH | Synergistic combination of pumafentrine and salmeterol |
| CA2817619A1 (en) | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
| US20030206898A1 (en) | 2002-04-26 | 2003-11-06 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| CA2800126A1 (en) | 2002-07-19 | 2004-01-29 | Abbott Biotechnology Ltd. | Treatment of tnf.alpha. related disorders |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| MY150740A (en) | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
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1993
- 1993-03-05 AU AU39249/93A patent/AU3924993A/en not_active Abandoned
- 1993-03-05 JP JP51749193A patent/JP3251587B2/ja not_active Expired - Lifetime
- 1993-03-05 MX MX9301942A patent/MX9301942A/es unknown
- 1993-03-05 WO PCT/US1993/002516 patent/WO1993019751A1/en not_active Ceased
- 1993-03-05 DE DE69331265T patent/DE69331265T2/de not_active Expired - Lifetime
- 1993-03-05 US US08/313,093 patent/US5605923A/en not_active Expired - Lifetime
- 1993-03-05 EP EP93908421A patent/EP0636026B1/en not_active Expired - Lifetime
- 1993-03-30 IL IL10522093A patent/IL105220A0/xx unknown
- 1993-04-01 MA MA23148A patent/MA22922A1/fr unknown
- 1993-04-02 CN CN93105214A patent/CN1094031A/zh active Pending
Non-Patent Citations (3)
| Title |
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| Ａｒｍｙａｎｓｋｉｊ Ｋｈｉｍ．Ｚｈ．，Ｖｏｌ．３１，Ｎｏ．９（１９７８）ｐ．６８９−ｐ．６９３ |
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| 名古屋市立大学薬学部研究年報、第２０号（１９７２）ｐ．３６−ｐ．３９ |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6572794B1 (en) | 2000-07-24 | 2003-06-03 | Essilor International Compagnie Generale D'optique | Method of manufacturing a photochromic molded article |
| US6770710B2 (en) | 2000-11-17 | 2004-08-03 | Essilor International Compagnie Generale D'optique | Process for obtaining a photochromic latex |
| US6740699B2 (en) | 2001-01-11 | 2004-05-25 | Essilor International Compagnie Generale D'optique | Method for obtaining a stabilized photochromic latex, latex obtained, and application to ophthalmic optics |
| WO2023208941A1 (en) | 2022-04-26 | 2023-11-02 | Essilor International | Photochromic optical article having a mirror coating |
Also Published As
| Publication number | Publication date |
|---|---|
| MA22922A1 (fr) | 1994-04-01 |
| CN1094031A (zh) | 1994-10-26 |
| EP0636026A1 (en) | 1995-02-01 |
| US5605923A (en) | 1997-02-25 |
| DE69331265D1 (de) | 2002-01-17 |
| MX9301942A (es) | 1994-08-31 |
| WO1993019751A1 (en) | 1993-10-14 |
| IL105220A0 (en) | 1994-08-26 |
| EP0636026B1 (en) | 2001-12-05 |
| JPH07508263A (ja) | 1995-09-14 |
| EP0636026A4 (cg-RX-API-DMAC10.html) | 1995-02-22 |
| AU3924993A (en) | 1993-11-08 |
| DE69331265T2 (de) | 2002-08-08 |
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