JP3135672B2 - マクロライド抗生物質の結晶及び溶媒和物 - Google Patents

マクロライド抗生物質の結晶及び溶媒和物

Info

Publication number
JP3135672B2
JP3135672B2 JP04107514A JP10751492A JP3135672B2 JP 3135672 B2 JP3135672 B2 JP 3135672B2 JP 04107514 A JP04107514 A JP 04107514A JP 10751492 A JP10751492 A JP 10751492A JP 3135672 B2 JP3135672 B2 JP 3135672B2
Authority
JP
Japan
Prior art keywords
dirithromycin
solvate
type
water
solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP04107514A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05117289A (ja
Inventor
ジェームズ・マイケル・グリーン
ホリー・マリー・ハンキンス
グレゴリー・アラン・スティーブンソン
デイビッド・デイル・ワース
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPH05117289A publication Critical patent/JPH05117289A/ja
Application granted granted Critical
Publication of JP3135672B2 publication Critical patent/JP3135672B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Formation And Processing Of Food Products (AREA)
JP04107514A 1991-04-29 1992-04-27 マクロライド抗生物質の結晶及び溶媒和物 Expired - Fee Related JP3135672B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69284291A 1991-04-29 1991-04-29
US692842 1991-04-29

Publications (2)

Publication Number Publication Date
JPH05117289A JPH05117289A (ja) 1993-05-14
JP3135672B2 true JP3135672B2 (ja) 2001-02-19

Family

ID=24782254

Family Applications (2)

Application Number Title Priority Date Filing Date
JP04107514A Expired - Fee Related JP3135672B2 (ja) 1991-04-29 1992-04-27 マクロライド抗生物質の結晶及び溶媒和物
JP10732592A Expired - Fee Related JP3333545B2 (ja) 1991-04-29 1992-04-27 ジリスロマイシンを含有する医薬製剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP10732592A Expired - Fee Related JP3333545B2 (ja) 1991-04-29 1992-04-27 ジリスロマイシンを含有する医薬製剤

Country Status (27)

Country Link
EP (2) EP0511799B1 (OSRAM)
JP (2) JP3135672B2 (OSRAM)
KR (2) KR100194307B1 (OSRAM)
CN (2) CN1069197C (OSRAM)
AT (2) ATE144425T1 (OSRAM)
AU (2) AU655978B2 (OSRAM)
BR (2) BR9201540A (OSRAM)
CA (2) CA2067275C (OSRAM)
CY (2) CY1946A (OSRAM)
CZ (2) CZ282218B6 (OSRAM)
DE (2) DE69211220T2 (OSRAM)
DK (2) DK0511799T3 (OSRAM)
ES (2) ES2093779T3 (OSRAM)
FI (2) FI101795B (OSRAM)
GR (2) GR3020439T3 (OSRAM)
HK (2) HK153696A (OSRAM)
HU (2) HU215917B (OSRAM)
IE (2) IE76296B1 (OSRAM)
IL (2) IL101705A (OSRAM)
MX (2) MX9201946A (OSRAM)
MY (2) MY109498A (OSRAM)
NO (2) NO180450C (OSRAM)
NZ (2) NZ242506A (OSRAM)
RU (2) RU2045953C1 (OSRAM)
TW (2) TW315371B (OSRAM)
YU (2) YU44492A (OSRAM)
ZA (2) ZA922776B (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW271400B (OSRAM) * 1992-07-30 1996-03-01 Pfizer
CR5278A (es) * 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
DE69730138T2 (de) * 1996-07-29 2005-03-03 Abbott Laboratories, Abbott Park Herstellung von kristallinen form ii von clarithromycin
IL128845A0 (en) * 1996-09-24 2000-01-31 Lilly Co Eli Coated particle formulation
RU2147234C1 (ru) * 1999-03-09 2000-04-10 Жемчугов Владислав Евгеньевич Препарат для профилактики и лечения особо опасных инфекционных заболеваний
US6390690B1 (en) 2000-05-17 2002-05-21 3M Innovative Properties Company Fiber optic connector for coupling devices on intersecting planes
RU2212242C1 (ru) * 2001-12-24 2003-09-20 Закрытое акционерное общество "Брынцалов-А" Антибиотик сумазид
CA2670482C (en) * 2006-12-05 2011-10-11 Pfizer Inc. Motilide polymorphs
CN102145008B (zh) * 2010-12-29 2013-06-05 辰欣药业股份有限公司 一种地红霉素药物组合物及其制备方法
CN107151261B (zh) * 2017-06-09 2020-06-12 广州大光制药有限公司 一种地红霉素化合物的晶型及其结晶制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2515075C2 (de) * 1975-04-07 1985-10-24 Dr. Karl Thomae Gmbh, 7950 Biberach Erythromycinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0184921A3 (en) * 1984-12-08 1986-10-29 Beecham Group Plc Erythromycin derivatives
DE3524572A1 (de) * 1985-07-10 1987-01-15 Thomae Gmbh Dr K Feste arzneimittelformen zur peroralen anwendung enthaltend 9-deoxo-11-deoxy-9,11-(imino(2-(2-methoxyethoxy)ethyliden)-oxy)-(9s)-erythromycin und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
HU9201398D0 (en) 1992-07-28
IL101704A0 (en) 1992-12-30
IE74885B1 (en) 1997-08-13
NO179504B (no) 1996-07-15
MY114226A (en) 2002-09-30
CA2067274C (en) 2002-10-15
NZ242505A (en) 1993-06-25
IE76296B1 (en) 1997-10-08
HUT62595A (en) 1993-05-28
MX9201944A (es) 1992-11-01
NO921616D0 (no) 1992-04-27
FI101795B1 (fi) 1998-08-31
TW216399B (OSRAM) 1993-11-21
NZ242506A (en) 1993-09-27
DK0511799T3 (da) 1996-06-24
HU215917B (hu) 1999-03-29
DE69211220D1 (de) 1996-07-11
DE69214710D1 (de) 1996-11-28
FI101795B (fi) 1998-08-31
HU213613B (en) 1997-08-28
CA2067275C (en) 2002-11-26
CS127692A3 (en) 1992-11-18
AU655978B2 (en) 1995-01-19
IL101705A (en) 1996-01-31
HK153696A (en) 1996-08-16
AU1525592A (en) 1992-11-05
TW315371B (OSRAM) 1997-09-11
CN1030611C (zh) 1996-01-03
GR3020439T3 (en) 1996-10-31
CN1066186A (zh) 1992-11-18
AU1525792A (en) 1992-11-05
NO180450B (no) 1997-01-13
JPH05117289A (ja) 1993-05-14
HU9203168D0 (en) 1992-12-28
IE921346A1 (en) 1992-11-04
AU646734B2 (en) 1994-03-03
RU2045953C1 (ru) 1995-10-20
JP3333545B2 (ja) 2002-10-15
HK215096A (en) 1996-12-13
KR100194307B1 (ko) 1999-06-15
BR9201541A (pt) 1992-12-01
GR3021706T3 (en) 1997-02-28
IL101704A (en) 1998-02-22
IL101705A0 (en) 1992-12-30
MY109498A (en) 1997-02-28
YU44392A (sh) 1994-12-28
ZA922777B (en) 1993-10-15
NO921616L (no) 1992-10-30
CN1066270A (zh) 1992-11-18
CZ282021B6 (cs) 1997-04-16
CY1946A (en) 1992-04-27
KR920019365A (ko) 1992-11-19
JPH05117154A (ja) 1993-05-14
YU44492A (sh) 1994-06-24
ES2093779T3 (es) 1997-01-01
CY1975A (en) 1997-09-05
DE69211220T2 (de) 1996-11-07
EP0511799A1 (en) 1992-11-04
MX9201946A (es) 1992-11-01
KR920019364A (ko) 1992-11-19
BR9201540A (pt) 1992-12-01
KR100193742B1 (ko) 1999-06-15
ES2088098T3 (es) 1996-08-01
NO921617L (no) 1992-10-30
ZA922776B (en) 1993-10-15
EP0511799B1 (en) 1996-06-05
EP0511800A1 (en) 1992-11-04
FI921876A0 (fi) 1992-04-27
FI921877L (fi) 1992-10-30
CS127792A3 (en) 1992-11-18
CA2067274A1 (en) 1992-10-30
IE921345A1 (en) 1992-11-04
CN1069197C (zh) 2001-08-08
ATE144425T1 (de) 1996-11-15
DE69214710T2 (de) 1997-03-13
NO180450C (no) 1997-04-23
HUT63956A (en) 1993-11-29
NO179504C (no) 1996-10-23
NO921617D0 (no) 1992-04-27
CA2067275A1 (en) 1992-10-30
FI921877A0 (fi) 1992-04-27
RU2070203C1 (ru) 1996-12-10
FI921876A7 (fi) 1992-10-30
FI921876L (fi) 1992-10-30
ATE138924T1 (de) 1996-06-15
CZ282218B6 (cs) 1997-06-11
DK0511800T3 (da) 1997-04-21
EP0511800B1 (en) 1996-10-23

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