JP2760379B2 - 置換2−フエニル−4−キノリンカルボン酸 - Google Patents

置換2−フエニル−4−キノリンカルボン酸

Info

Publication number
JP2760379B2
JP2760379B2 JP63213853A JP21385388A JP2760379B2 JP 2760379 B2 JP2760379 B2 JP 2760379B2 JP 63213853 A JP63213853 A JP 63213853A JP 21385388 A JP21385388 A JP 21385388A JP 2760379 B2 JP2760379 B2 JP 2760379B2
Authority
JP
Japan
Prior art keywords
hydroxy
biphenyl
water
halogen
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP63213853A
Other languages
English (en)
Japanese (ja)
Other versions
JPH01110673A (ja
Inventor
レスリー・エイチ・サザーランド
アドルフ・イー・スロボダ
ラルフ・グラツシング・チヤイルド
ジヨン・エフ・ポレツト
デニス・ダブリユー・パウエル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AMERIKAN SAIANAMITSUDO CO
Original Assignee
AMERIKAN SAIANAMITSUDO CO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AMERIKAN SAIANAMITSUDO CO filed Critical AMERIKAN SAIANAMITSUDO CO
Publication of JPH01110673A publication Critical patent/JPH01110673A/ja
Application granted granted Critical
Publication of JP2760379B2 publication Critical patent/JP2760379B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
JP63213853A 1987-08-31 1988-08-30 置換2−フエニル−4−キノリンカルボン酸 Expired - Lifetime JP2760379B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US090996 1987-08-31
US90996 1987-08-31
US07/090,996 US4847381A (en) 1987-08-31 1987-08-31 2-Phenyl-4-quinoline carboxylic acids

Publications (2)

Publication Number Publication Date
JPH01110673A JPH01110673A (ja) 1989-04-27
JP2760379B2 true JP2760379B2 (ja) 1998-05-28

Family

ID=22225261

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63213853A Expired - Lifetime JP2760379B2 (ja) 1987-08-31 1988-08-30 置換2−フエニル−4−キノリンカルボン酸

Country Status (24)

Country Link
US (1) US4847381A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0305952B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2760379B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR970005909B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR245698A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE90079T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU613661B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1333606C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (1) CS274434B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD282225A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3881456T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK169473B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2058191T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI92692C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3008033T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU202498B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE65148B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL87457A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO174961C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ225924A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH26258A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL156232B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT88365B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA886443B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968701A (en) * 1988-04-26 1990-11-06 E. I. Du Pont De Nemours And Company 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents
US4918077A (en) * 1989-01-25 1990-04-17 E. I. Du Pont De Nemours & Co., Inc. 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents
US5204329A (en) * 1990-06-11 1993-04-20 Du Pont Merck Pharmaceutical Company Treatment of organ transplantation rejection
US5135934A (en) * 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
US5409886A (en) * 1993-02-18 1995-04-25 Mitsui Toatsu Chemicals, Incorporated 3-pyrroline-2-one derivatives and herbicidal compositions containing same
US5428040A (en) * 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
US5578609A (en) * 1994-03-25 1996-11-26 The Dupont Merck Pharmaceutical Company 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents
ID18663A (id) * 1996-04-12 1998-04-30 Novartis Ag Komposisi farmasi berlapis enterik
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
JP2002505689A (ja) 1997-06-19 2002-02-19 セプレイコー インコーポレイテッド キノリン−インドール抗菌剤、それらに関する用途及び組成物
US6376670B1 (en) 1997-06-19 2002-04-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
WO1999038846A1 (en) * 1998-01-30 1999-08-05 Procept, Inc. Immunosuppressive agents
SE9901366D0 (sv) * 1999-04-16 1999-04-16 Pharmacia & Upjohn Ab Injector device and method for its operation
US20020121638A1 (en) * 2000-06-30 2002-09-05 Vladimir Grushin Electroluminescent iridium compounds with fluorinated phenylpyridines, phenylpyrimidines, and phenylquinolines and devices made with such compounds
WO2009016812A1 (ja) * 2007-07-27 2009-02-05 Kowa Company, Ltd. 2-フェニルキノリン-4-カルボン酸誘導体を有効成分とする貧血の予防及び/又は治療剤
KR20160079123A (ko) 2013-11-22 2016-07-05 젠자임 코포레이션 신경변성 질병을 치료하기 위한 신규한 방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776290A (en) * 1957-01-01 Hydroxy cevchoninates and carboxylic
US2008923A (en) * 1931-07-09 1935-07-23 Graham Patmore L Cinchoninic acid salts of piperazines
US2077903A (en) * 1933-12-15 1937-04-20 Gen Aniline Works Inc Process of preparing 3-amino-quinolines
US2486440A (en) * 1946-01-10 1949-11-01 Gen Aniline & Film Corp Production of phenazonium dyestuff images
BE502610A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1950-04-18
US2888346A (en) * 1955-08-22 1959-05-26 Gen Aniline & Film Corp Ultra-violet absorbing compounds
DE1049701B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1957-02-21
FR6592M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1967-10-31 1968-12-30
BE794945A (fr) * 1972-02-04 1973-08-02 Sandoz Sa Application de derives de la quinoleine pour stabiliser des matieres organiques contre les effets de la lumiere ultraviolette
US4009020A (en) * 1975-05-06 1977-02-22 Amchem Products, Inc. Method of regulating plant growth
SU1109402A1 (ru) * 1982-10-12 1984-08-23 Предприятие П/Я Р-6496 Способ получени производных 2-(хинолил-4)-5-арилоксазола
US4680299A (en) * 1984-04-30 1987-07-14 E.I. Du Pont De Nemours And Company 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof
ZA845594B (en) * 1983-07-22 1986-03-26 Du Pont Phenylquinolinecarboxylic acids and derivatives as antitumor agents

Also Published As

Publication number Publication date
NO174961C (no) 1994-08-10
ZA886443B (en) 1989-04-26
NO883865L (no) 1989-03-01
IE65148B1 (en) 1995-10-04
EP0305952B1 (en) 1993-06-02
GR3008033T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-09-30
FI92692B (fi) 1994-09-15
HUT48597A (en) 1989-06-28
NZ225924A (en) 1991-07-26
US4847381A (en) 1989-07-11
ATE90079T1 (de) 1993-06-15
CS274434B2 (en) 1991-04-11
PH26258A (en) 1992-04-01
DK482688D0 (da) 1988-08-30
NO883865D0 (no) 1988-08-30
FI92692C (fi) 1994-12-27
ES2058191T3 (es) 1994-11-01
PT88365A (pt) 1989-06-30
PT88365B (pt) 1995-03-31
EP0305952A1 (en) 1989-03-08
DE3881456D1 (de) 1993-07-08
CS587588A2 (en) 1990-06-13
AU613661B2 (en) 1991-08-08
DD282225A5 (de) 1990-09-05
PL274471A1 (en) 1989-05-02
CA1333606C (en) 1994-12-20
FI883997L (fi) 1989-03-01
HU202498B (en) 1991-03-28
AR245698A1 (es) 1994-02-28
KR970005909B1 (ko) 1997-04-22
FI883997A0 (fi) 1988-08-30
AU2167888A (en) 1989-03-02
DE3881456T2 (de) 1994-01-13
PL156232B1 (en) 1992-02-28
DK482688A (da) 1989-03-01
DK169473B1 (da) 1994-11-07
IL87457A (en) 1994-08-26
IL87457A0 (en) 1989-01-31
JPH01110673A (ja) 1989-04-27
KR890003703A (ko) 1989-04-17
NO174961B (no) 1994-05-02
IE882628L (en) 1989-02-28

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