WO2009016812A1 - ２－フェニルキノリン－４－カルボン酸誘導体を有効成分とする貧血の予防及び／又は治療剤 - Google Patents

２－フェニルキノリン－４－カルボン酸誘導体を有効成分とする貧血の予防及び／又は治療剤 Download PDF

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Publication number
WO2009016812A1
WO2009016812A1 PCT/JP2008/001986 JP2008001986W WO2009016812A1 WO 2009016812 A1 WO2009016812 A1 WO 2009016812A1 JP 2008001986 W JP2008001986 W JP 2008001986W WO 2009016812 A1 WO2009016812 A1 WO 2009016812A1
Authority
WO
WIPO (PCT)
Prior art keywords
anemia
substituents
phenylquinoline
prophylactic
carboxylic acid
Prior art date
Application number
PCT/JP2008/001986
Other languages
English (en)
French (fr)
Inventor
Masanori Ashikawa
Junya Tagashira
Akiyasu Koketsu
Tatsuaki Nishiyama
Satoshi Goda
Masaki Yamabi
Takeshi Doi
Hiroyuki Ishiwata
Original Assignee
Kowa Company, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Company, Ltd. filed Critical Kowa Company, Ltd.
Publication of WO2009016812A1 publication Critical patent/WO2009016812A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　本発明は、ＥＰＯ産生促進作用を有し、貧血の予防及び／又は治療に有用な医薬を提供する。 　本発明は、下記の一般式（１）： 〔式中、Ｒ１、Ｒ２、Ｒ３、Ｒ４、Ｒ５、Ｒ６、Ｒ７、Ｒ８、Ｒ９、及びＲ１０は、それぞれ独立して、水素原子、ハロゲン原子、１～３の置換基を有してもよいＣ１－６アルキル基、１～３の置換基を有してもよいＣ３－８シクロアルキル基又は１～３の置換基を有してもよいＣ１－６アルコキシ基を示し、Ｒ１１は水素原子又は１～３の置換基を有してもよいＣ１－６アルキル基を示す。〕 で表される２－フェニルキノリン－４－カルボン酸誘導体若しくはその塩、又はそれらの溶媒和物を含有してなるＥＰＯ産生促進剤、及びＥＰＯ産生を促進することにより症状が改善される疾患（特に貧血）の予防及び／又は治療薬に関する。
PCT/JP2008/001986 2007-07-27 2008-07-25 ２－フェニルキノリン－４－カルボン酸誘導体を有効成分とする貧血の予防及び／又は治療剤 WO2009016812A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-196778 2007-07-27
JP2007196778 2007-07-27

Publications (1)

Publication Number Publication Date
WO2009016812A1 true WO2009016812A1 (ja) 2009-02-05

Family

ID=40304056

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/001986 WO2009016812A1 (ja) 2007-07-27 2008-07-25 ２－フェニルキノリン－４－カルボン酸誘導体を有効成分とする貧血の予防及び／又は治療剤

Country Status (1)

Country Link
WO (1) WO2009016812A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010113498A1 (ja) 2009-03-31 2010-10-07 興和株式会社 テトラヒドロキノリン化合物を有効成分とする貧血の予防及び／又は治療剤
WO2012110789A1 (en) 2011-02-15 2012-08-23 Isis Innovation Limited Method for assaying ogfod1 activity
WO2013014449A1 (en) 2011-07-28 2013-01-31 Isis Innovation Limited Assay for histidinyl hydroxylase activity

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6042367A (ja) * 1983-07-22 1985-03-06 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー 抗腫瘍剤としてのフエニルキノリンカルボン酸および誘導体
JPH01110673A (ja) * 1987-08-31 1989-04-27 American Cyanamid Co 置換２−フエニル−４−キノリンカルボン酸
JPH08500338A (ja) * 1992-06-10 1996-01-16 藤沢薬品工業株式会社 貧血治療のためのピラゾロピリジン化合物
WO2001024785A2 (en) * 1999-10-01 2001-04-12 Institute Of Molecular And Cell Biology Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases
WO2002036568A1 (en) * 2000-11-06 2002-05-10 Astrazeneca Ab N-type calcium channel antagonists for the treatment of pain
WO2004052859A1 (ja) * 2002-12-06 2004-06-24 Kowa Co., Ltd. エリスロポエチン産生促進剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6042367A (ja) * 1983-07-22 1985-03-06 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー 抗腫瘍剤としてのフエニルキノリンカルボン酸および誘導体
JPH01110673A (ja) * 1987-08-31 1989-04-27 American Cyanamid Co 置換２−フエニル−４−キノリンカルボン酸
JPH08500338A (ja) * 1992-06-10 1996-01-16 藤沢薬品工業株式会社 貧血治療のためのピラゾロピリジン化合物
WO2001024785A2 (en) * 1999-10-01 2001-04-12 Institute Of Molecular And Cell Biology Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases
WO2002036568A1 (en) * 2000-11-06 2002-05-10 Astrazeneca Ab N-type calcium channel antagonists for the treatment of pain
WO2004052859A1 (ja) * 2002-12-06 2004-06-24 Kowa Co., Ltd. エリスロポエチン産生促進剤

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010113498A1 (ja) 2009-03-31 2010-10-07 興和株式会社 テトラヒドロキノリン化合物を有効成分とする貧血の予防及び／又は治療剤
US8791090B2 (en) 2009-03-31 2014-07-29 Kowa Company, Ltd. Prophylactic and/or therapeutic agent for anemia comprising tetrahydroquinoline compound as active ingredient
JP5572154B2 (ja) * 2009-03-31 2014-08-13 興和株式会社 テトラヒドロキノリン化合物を有効成分とする貧血の予防及び／又は治療剤
US9045423B2 (en) 2009-03-31 2015-06-02 Kowa Company, Ltd. Prophylactic and/or therapeutic agent for anemia comprising tetrahydroquinoline compound as active ingredient
WO2012110789A1 (en) 2011-02-15 2012-08-23 Isis Innovation Limited Method for assaying ogfod1 activity
WO2013014449A1 (en) 2011-07-28 2013-01-31 Isis Innovation Limited Assay for histidinyl hydroxylase activity

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