JP2025516648A - Ｌｓｄ１阻害薬を用いるｎｆ１変異腫瘍の治療法 - Google Patents

Ｌｓｄ１阻害薬を用いるｎｆ１変異腫瘍の治療法 Download PDF

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JP2025516648A
JP2025516648A JP2024566589A JP2024566589A JP2025516648A JP 2025516648 A JP2025516648 A JP 2025516648A JP 2024566589 A JP2024566589 A JP 2024566589A JP 2024566589 A JP2024566589 A JP 2024566589A JP 2025516648 A JP2025516648 A JP 2025516648A
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mutant
use according
lsd1 inhibitor
pharmaceutical composition
cancer
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JP2025516648A5 (enExample
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ソリバ・ソリバ，ロベルト
サシロット，ナタリア
マスカーロ・クルサット，クリスティナ
ロトラント・ポソ，ダビド
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オリゾン・ゲノミクス・ソシエダッド・アノニマ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2024566589A 2022-05-09 2023-05-09 Ｌｓｄ１阻害薬を用いるｎｆ１変異腫瘍の治療法 Pending JP2025516648A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP22382443.4 2022-05-09
EP22382444.2 2022-05-09
EP22382443 2022-05-09
EP22382444 2022-05-09
PCT/EP2023/062283 WO2023217784A1 (en) 2022-05-09 2023-05-09 Methods of treating nf1-mutant tumors using lsd1 inhibitors

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JP2025516648A true JP2025516648A (ja) 2025-05-30
JP2025516648A5 JP2025516648A5 (enExample) 2026-05-19

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US (1) US20250295660A1 (enExample)
EP (1) EP4522137A1 (enExample)
JP (1) JP2025516648A (enExample)
CN (1) CN119497613A (enExample)
WO (1) WO2023217784A1 (enExample)

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CN120154611B (zh) * 2025-04-28 2025-11-18 西安交通大学医学院第一附属医院 阿昔替尼在制备丛状神经纤维瘤治疗药物中的应用

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