JP2025078772A5 - - Google Patents

Info

Publication number
JP2025078772A5
JP2025078772A5 JP2025034583A JP2025034583A JP2025078772A5 JP 2025078772 A5 JP2025078772 A5 JP 2025078772A5 JP 2025034583 A JP2025034583 A JP 2025034583A JP 2025034583 A JP2025034583 A JP 2025034583A JP 2025078772 A5 JP2025078772 A5 JP 2025078772A5
Authority
JP
Japan
Prior art keywords
cells
pluripotent stem
stem cells
human pluripotent
culture medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2025034583A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025078772A (ja
Filing date
Publication date
Priority claimed from JP2021009440A external-priority patent/JP7236476B2/ja
Application filed filed Critical
Publication of JP2025078772A publication Critical patent/JP2025078772A/ja
Publication of JP2025078772A5 publication Critical patent/JP2025078772A5/ja
Pending legal-status Critical Current

Links

JP2025034583A 2015-01-26 2025-03-05 造血細胞分化を誘導するための方法および組成物 Pending JP2025078772A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562107517P 2015-01-26 2015-01-26
US62/107,517 2015-01-26
US201562251016P 2015-11-04 2015-11-04
US62/251,016 2015-11-04
JP2021009440A JP7236476B2 (ja) 2015-01-26 2021-01-25 造血細胞分化を誘導するための方法および組成物
JP2023028752A JP7720337B2 (ja) 2015-01-26 2023-02-27 造血細胞分化を誘導するための方法および組成物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2023028752A Division JP7720337B2 (ja) 2015-01-26 2023-02-27 造血細胞分化を誘導するための方法および組成物

Publications (2)

Publication Number Publication Date
JP2025078772A JP2025078772A (ja) 2025-05-20
JP2025078772A5 true JP2025078772A5 (https=) 2025-10-30

Family

ID=56544232

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2017539022A Active JP6800859B2 (ja) 2015-01-26 2016-01-26 造血細胞分化を誘導するための方法および組成物
JP2019071292A Active JP6836803B2 (ja) 2015-01-26 2019-04-03 造血細胞分化を誘導するための方法および組成物
JP2021009440A Active JP7236476B2 (ja) 2015-01-26 2021-01-25 造血細胞分化を誘導するための方法および組成物
JP2023028752A Active JP7720337B2 (ja) 2015-01-26 2023-02-27 造血細胞分化を誘導するための方法および組成物
JP2025034583A Pending JP2025078772A (ja) 2015-01-26 2025-03-05 造血細胞分化を誘導するための方法および組成物

Family Applications Before (4)

Application Number Title Priority Date Filing Date
JP2017539022A Active JP6800859B2 (ja) 2015-01-26 2016-01-26 造血細胞分化を誘導するための方法および組成物
JP2019071292A Active JP6836803B2 (ja) 2015-01-26 2019-04-03 造血細胞分化を誘導するための方法および組成物
JP2021009440A Active JP7236476B2 (ja) 2015-01-26 2021-01-25 造血細胞分化を誘導するための方法および組成物
JP2023028752A Active JP7720337B2 (ja) 2015-01-26 2023-02-27 造血細胞分化を誘導するための方法および組成物

Country Status (7)

Country Link
US (5) US10626372B1 (https=)
EP (1) EP3250680A4 (https=)
JP (5) JP6800859B2 (https=)
CN (2) CN107429230B (https=)
AU (3) AU2016211671B2 (https=)
SG (2) SG10202101358XA (https=)
WO (1) WO2016123100A1 (https=)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
WO2016123100A1 (en) 2015-01-26 2016-08-04 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
US20180214487A1 (en) 2015-07-21 2018-08-02 The Children's Medical Center Corporation Pd-l1 expressing hematopoietic stem cells and uses
US10947502B2 (en) * 2015-10-20 2021-03-16 FUJIFILM Cellular Dynamics, Inc. Methods for directed differentiation of pluripotent stem cells to immune cells
KR20250141836A (ko) 2015-11-04 2025-09-29 페이트 세러퓨틱스, 인코포레이티드 만능 세포의 유전자 조작
SG11201803145RA (en) 2015-11-04 2018-05-30 Fate Therapeutics Inc Methods and compositions for inducing hematopoietic cell differentiation
SG11201805186VA (en) 2016-01-20 2018-07-30 Fate Therapeutics Inc Compositions and methods for immune cell modulation in adoptive immunotherapies
JP7653759B2 (ja) 2016-01-20 2025-03-31 フェイト セラピューティクス,インコーポレイテッド 養子免疫療法における免疫細胞調節のための組成物および方法
US11525119B2 (en) 2016-09-06 2022-12-13 The Children's Medical Center Corporation Immune cells derived from induced pluripotent stem cell
EP3548049A4 (en) 2016-12-05 2020-07-22 Fate Therapeutics, Inc. COMPOSITIONS AND METHODS FOR MODULATION OF IMMUNE CELLS IN ADOPTIVE IMMUNOTHERAPIES
EP3580332B1 (en) * 2017-02-07 2026-04-15 Agency for Science, Technology And Research Methods and kits for generating mimetic innate immune cells from pluripotent stem cells
EP4272551A3 (en) * 2017-02-28 2024-03-06 The Regents of the University of California Differentiation and use of human microglia-like cells from pluripotent stem cells and hematopoietic progenitors
US12129487B2 (en) 2017-03-27 2024-10-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to obtain lymphoid progenitors
SG11201909331UA (en) 2017-04-18 2019-11-28 Fujifilm Cellular Dynamics Inc Antigen-specific immune effector cells
CA3068604A1 (en) 2017-06-13 2018-12-20 Fate Therapeutics, Inc. Compositions and methods for inducing myeloid suppressive cells and use thereof
JP2020528885A (ja) 2017-07-19 2020-10-01 フェイト セラピューティクス,インコーポレイテッド 養子免疫療法における免疫細胞調節のための組成物および方法
CN107488629A (zh) * 2017-08-14 2017-12-19 中国科学院广州生物医药与健康研究院 一种人多能干细胞的定向分化方法
US11879137B2 (en) 2017-09-22 2024-01-23 The Children's Medical Center Corporation Treatment of type 1 diabetes and autoimmune diseases or disorders
JP7257333B2 (ja) * 2017-12-28 2023-04-13 株式会社カネカ 細胞凝集抑制剤
CN112041428B (zh) 2018-01-18 2024-05-24 新加坡科技研究局 用于在悬浮培养物中分化人多能干细胞系的方法
CN108300695B (zh) * 2018-02-07 2021-08-06 清华大学 一种人类多能干细胞向造血干细胞分化的方法及培养添加剂
CA3091158A1 (en) 2018-02-14 2019-08-22 Sunnybrook Research Institute Method for generating cells of the t cell lineage
FR3079239A1 (fr) * 2018-03-23 2019-09-27 Centre National De La Recherche Scientifique Nouvelle methode d’obtention de cellules t a partir de cellules souches pluripotentes, et leurs utilisations
AU2019336221B2 (en) * 2018-09-07 2025-05-15 Wisconsin Alumni Research Foundation Generation of hematopoietic progenitor cells from human pluripotent stem cells
CN109182251A (zh) * 2018-10-08 2019-01-11 吉林大学 一种扩增内皮祖细胞数量的低血清培养基
CA3127593A1 (en) * 2019-01-22 2020-07-30 Washington University Compositions and methods for generating hematopoietic stem cells (hscs)
CN111607566B (zh) * 2019-02-22 2023-04-14 安徽中盛溯源生物科技有限公司 从人多能干细胞分化为造血祖细胞的方法及其应用
CN111154719B (zh) * 2019-02-28 2024-03-01 西湖生物医药科技(杭州)有限公司 利用外周血体外制备成熟红细胞的方法及制剂
CN110106146B (zh) * 2019-03-28 2021-04-02 中国人民解放军军事科学院军事医学研究院 化合物富马酸酮替芬在促进干细胞因子合成和分泌中的用途
EP3945815A4 (en) * 2019-04-03 2023-04-19 Akron Biotechnology, LLC CRYOPRESERVATION AND CELL CULTURE MEDIA
WO2020210429A1 (en) * 2019-04-09 2020-10-15 Rutgers, The State University Of New Jersey Methods for enriching populations of cells
CN110025014A (zh) * 2019-04-18 2019-07-19 宝康士(中国)保健食品销售有限公司 混合菌株发酵制备富含益生菌和nk细胞的基底液的方法
US11453862B2 (en) 2019-07-08 2022-09-27 Immunitybio, Inc. Mononuclear cell derived NK cells
GB201911957D0 (en) * 2019-08-20 2019-10-02 Adaptimmune Ltd Methods of producing haemogenic progenitor cells from pluripotent stem cells
EP4017969A1 (en) * 2019-08-20 2022-06-29 Adaptimmune Limited Culture medium for haematopoietic induction
CN115003800A (zh) * 2019-08-28 2022-09-02 安斯泰来再生医药协会 治疗血管疾病的方法
EP4065690A4 (en) 2019-11-29 2022-10-05 Rutgers, the State University of New Jersey METHODS OF ISOLATING UMBRELLA PLASMA PRODUCTS, TISSUE AND CELL EXOSOMES AND COMPOSITIONS AND METHODS OF USE THEREOF
KR20220113349A (ko) * 2019-12-11 2022-08-12 리페아론 게엠베하 생물반응기의 현탁액에서 줄기세포의 확장
EP4081035A4 (en) 2019-12-23 2024-03-27 Boston Medical Center Corporation HUMAN IPSC-BASED DERIVATION OF NK AND T CELLS USING EARLY NOTCH INDUCTION
WO2021173458A1 (en) * 2020-02-28 2021-09-02 Purdue Research Foundation Generating aorta-gonad-mesonephros-like hematopoietic cells from human pluripotent stem cells under a defined condition
US12351824B2 (en) 2020-02-28 2025-07-08 Takeda Pharmaceutical Company Limited Method for producing natural killer cells from pluripotent stem cells
EP4138893A4 (en) * 2020-04-21 2024-06-12 Intima Bioscience, Inc. CELLULAR VACCINE PLATFORM AND METHODS OF USE THEREOF
CN111808812B (zh) * 2020-08-31 2020-12-15 首都医科大学附属北京友谊医院 一种用于多能干细胞向造血干细胞分化的材料和方法
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
US20240043800A1 (en) * 2021-02-05 2024-02-08 Sungkwang Medical Foundation Method for differentiating pluripotent stem cell-derived hemogenic endothelial cells into lymphoid lineage cells
GB202102297D0 (en) * 2021-02-18 2021-04-07 Adaptimmune Ltd Methods of Producing Haemogenic Endothelial Cells from Pluripotent Stem Cells
JP2024512327A (ja) * 2021-03-05 2024-03-19 ザ チルドレンズ メディカル センター コーポレーション ヒト多能性幹細胞からのストロマフリーnk細胞分化法
JP2024514091A (ja) * 2021-03-31 2024-03-28 ガルーダ セラピューティクス インコーポレイテッド 多能性幹細胞由来の造血系統
CA3215311A1 (en) 2021-04-01 2022-10-06 The Regents Of The University Of California Genetic modification of mammalian cells to confer resistance to csf1r antagonists
CN113215086A (zh) * 2021-05-26 2021-08-06 杭州原生生物科技有限公司 一种多能干细胞诱导分化成造血干细胞的培养基及方法
CA3222770A1 (en) * 2021-06-15 2022-12-22 Takeda Pharmaceutical Company Limited Method for producing natural killer cells from pluripotent stem cells
EP4373920A1 (en) * 2021-07-19 2024-05-29 Repairon Immuno GmbH Method of producing a population of immune cells from pluripotent stem cells
KR102595504B1 (ko) * 2021-10-13 2023-10-30 랩인큐브 주식회사 줄기세포의 분화가 가능한 나노 플랫폼 및 이의 제조방법
MX2024007261A (es) 2021-12-17 2024-08-06 Umoja Biopharma Inc Celula linfoide innata citotoxica y usos de la misma.
CN118829724A (zh) * 2022-01-20 2024-10-22 科济生物医药(上海)有限公司 诱导细胞分化的方法
TW202346574A (zh) * 2022-01-31 2023-12-01 日商希里歐斯股份有限公司 自然殺手細胞之製造方法
WO2023156774A1 (en) * 2022-02-15 2023-08-24 The University Of Birmingham Generating bone marrow organoids
WO2023191597A1 (ko) * 2022-04-01 2023-10-05 (주) 테라베스트 유도만능줄기세포로부터 생산된 자연살해세포, 이의 제조 방법 및 이의 용도
CN114752548B (zh) * 2022-04-28 2025-01-21 澳门大学 一种诱导干细胞分化为角质细胞的方法
CN114774365B (zh) * 2022-06-16 2022-08-23 呈诺再生医学科技(北京)有限公司 一种诱导iPSC分化获得CD34+细胞和NK细胞的方法及其应用
CN114958771B (zh) * 2022-06-27 2023-12-05 广东康盾创新产业集团股份公司 一种ipsc-car-nk细胞的制备方法
EP4577641A1 (en) * 2022-08-25 2025-07-02 Trailhead Biosystems Inc. Methods and compositions for generating hemogenic endothelial cells from pluripotent stem cells
WO2024064642A2 (en) 2022-09-19 2024-03-28 Tune Therapeutics, Inc. Compositions, systems, and methods for modulating t cell function
EP4671365A1 (en) 2023-02-24 2025-12-31 Xellsmart Biomedical (Suzhou) Co., Ltd Kit for inducing stem cells to differentiate into NK cells, use of the kit, and use of the combination of NK cells and TMZ in the treatment of drug-resistant GBM.
WO2025029840A1 (en) 2023-07-31 2025-02-06 Tune Therapeutics, Inc. Compositions and methods for multiplexed activation and repression of t cell gene expression
CN121909284A (zh) 2023-07-31 2026-04-21 图恩疗法股份有限公司 用于调节il-2基因表达的组合物和方法
WO2025125560A1 (en) * 2023-12-15 2025-06-19 Institut National de la Santé et de la Recherche Médicale Methods for generating myeloid cells
CN117757625B (zh) * 2023-12-20 2026-03-27 中国医学科学院输血研究所 基于一种多孔材料的诱导nk细胞的方法
WO2025219552A1 (en) * 2024-04-17 2025-10-23 Assitance Publique Hopitaux De Paris Method for producing t cell progenitors from human pluripotent stem cells
GB202405750D0 (en) * 2024-04-24 2024-06-05 Plasticell Ltd Therapy

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US5780300A (en) 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
GB9710807D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
AU749465B2 (en) 1997-06-13 2002-06-27 Japanese Foundation For Cancer Research Smad6 and uses thereof
NZ501276A (en) 1997-07-01 2000-10-27 Warner Lambert Co 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors in treating proliferative disorders
US6140081A (en) 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
KR20030032922A (ko) 2000-02-24 2003-04-26 싸이트 테라피스 인코포레이티드 세포의 동시 자극 및 농축
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
JP3811775B2 (ja) 2000-07-19 2006-08-23 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー 4−ヨードフェニルアミノベンズヒドロキサム酸の酸素化エステル
JP2002060786A (ja) 2000-08-23 2002-02-26 Kao Corp 硬質表面用殺菌防汚剤
US6689744B2 (en) 2000-09-22 2004-02-10 Genentech, Inc. Notch receptor agonists and uses
WO2002059285A1 (en) 2000-10-27 2002-08-01 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
JP2005500061A (ja) 2001-08-20 2005-01-06 ザ スクリップス リサーチ インスティテュート Cnnについての亜鉛フィンガー結合ドメイン
EP1456380B1 (en) 2001-11-02 2012-04-18 Giuliani International Limited Smad7 inhibitors for the treatment of cns diseases
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
KR100984595B1 (ko) 2002-03-13 2010-09-30 어레이 바이오파마 인크. Mek 억제제로서의 n3 알킬화 벤즈이미다졸 유도체
US7575925B2 (en) 2002-12-10 2009-08-18 Sunnybrook Health Sciences Centre Cell preparations comprising cells of the T cell lineage and methods of making and using them
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
CN1905873A (zh) 2003-11-19 2007-01-31 阵列生物制药公司 Mek的杂环抑制剂及其使用方法
US7972854B2 (en) 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
WO2005118788A2 (en) 2004-05-27 2005-12-15 The Trustees Of The University Of Pennsylvania Novel artificial antigen presenting cells and uses therefor
US20070036769A9 (en) 2004-06-03 2007-02-15 Linheng Li BMP pathway methods and compositions
ES2405785T3 (es) 2005-05-18 2013-06-03 Array Biopharma Inc. Inhibidores heterocíclicos de MEK y métodos de uso de los mismos
EP1992360A4 (en) 2006-02-01 2010-02-17 Univ Tokyo COMMON USE OF A TGF BETA SIGNAL HEMMER AND AN ANTITUMORAL AGENT
RU2425876C2 (ru) 2006-03-24 2011-08-10 Чилдрен'З Медикал Сентер Корпорейшн Способ модулирования роста гематопоэтических стволовых клеток
PL2044056T3 (pl) 2006-07-14 2013-01-31 Novartis Ag Pochodne pirymidyny jako inhibitory ALK-5
CA2676044C (en) 2007-01-30 2019-10-22 University Of Georgia Research Foundation, Inc. Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc)
SI2856876T1 (en) 2007-03-30 2018-04-30 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
WO2009091826A2 (en) 2008-01-14 2009-07-23 The Board Of Regents Of The University Of Texas System Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car)
WO2009097140A1 (en) 2008-01-30 2009-08-06 Memorial Sloan-Kettering Cancer Center Methods for off -the -shelf tumor immunotherapy using allogeneic t-cell precursors
WO2009104825A1 (en) * 2008-02-18 2009-08-27 Kaist Method for inducing the defferentiation of embryonic stem cells into hemangioblast
CA3186451A1 (en) 2008-05-06 2009-11-12 Astellas Institute For Regenerative Medicine Hemangio colony forming cells and non-engrafting hemangio cells
EP3623374B1 (en) 2008-12-03 2021-09-08 The Scripps Research Institute Stem cell cultures
WO2010087594A2 (ko) 2009-01-28 2010-08-05 한국생명공학연구원 시디93 또는 이의 가용성 단편의 용도
WO2010096746A1 (en) * 2009-02-20 2010-08-26 Cellular Dynamics International, Inc. Methods and compositions for the differentiation of stem cells
KR101720961B1 (ko) 2009-02-27 2017-03-29 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 다능성 세포의 분화
EP2419511B1 (en) 2009-04-09 2018-01-17 Sangamo Therapeutics, Inc. Targeted integration into stem cells
CA2777720C (en) 2009-10-16 2020-10-06 The Scripps Research Institute Induction of pluripotent cells
WO2011072246A2 (en) 2009-12-10 2011-06-16 Regents Of The University Of Minnesota Tal effector-mediated dna modification
US9206394B2 (en) 2010-02-03 2015-12-08 The University Of Tokyo Method for reconstructing immune function using pluripotent stem cells
JPWO2011096482A1 (ja) * 2010-02-03 2013-06-13 国立大学法人 東京大学 多能性幹細胞を用いた免疫機能再建法
US8652845B2 (en) 2010-03-18 2014-02-18 Kyoto University Method for producing mesodermal cells by culturing under adherent conditions and without co-culture with cells from a different species in a serum-free medium
WO2011159726A2 (en) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
WO2011159684A2 (en) * 2010-06-15 2011-12-22 Cellular Dynamics International, Inc. Generation of induced pluripotent stem cells from small volumes of peripheral blood
AU2011281062B2 (en) 2010-07-21 2015-01-22 Board Of Regents, The University Of Texas System Methods and compositions for modification of a HLA locus
US9279103B2 (en) 2010-08-05 2016-03-08 Wisconsin Alumni Research Foundation Simplified basic media for human pluripotent cell culture
ES2654994T3 (es) 2010-08-12 2018-02-15 Fate Therapeutics, Inc. Terapia mejorada con células madre y precursoras hematopoyéticas
US9181529B2 (en) * 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
BR112013014527A2 (pt) 2010-12-20 2017-03-07 Genentech Inc anticorpo isolado, ácido nucleico isolado, célula hospedeira, método para produzir um anticorpo, imunoconjugado, formulação farmacêutica, uso do imunoconjugado, método para tratamento de um indivíduo que tem um câncer positivo para mesotelina, para inibição de proliferação de uma célula positiva para mesotelina, para detecção de mesotelina humana em uma amostra biológica e para detectar um câncer positivo para mesotelina
EP2655601A4 (en) 2010-12-22 2014-09-10 Fate Therapeutics Inc CELL CULTURAL PLATFORM FOR INDIVIDUAL CELL SIZING AND IMPROVED RESOLUTION OF IPSCS
EP2658965B1 (en) 2010-12-31 2016-03-02 Universität für Bodenkultur Wien Method of generating induced pluripotent stem cells and differentiated cells
US8700106B2 (en) 2011-03-09 2014-04-15 Universal Electronics Inc. System and method for provision of infrared signalling in smart phone devices
CN102732483B (zh) 2011-03-31 2014-12-03 北京大学 造血祖细胞的制备方法及其专用培养基
US20130071414A1 (en) 2011-04-27 2013-03-21 Gianpietro Dotti Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies
JP2014520551A (ja) 2011-07-11 2014-08-25 セルラー ダイナミクス インターナショナル, インコーポレイテッド 細胞のリプログラミング方法およびゲノムの改変方法
JP5872041B2 (ja) 2011-08-16 2016-03-01 サムスン ライフ パブリック ウェルフェア ファンデーション 幹細胞由来微小胞を含む神経生成促進用組成物
CN102329769B (zh) 2011-09-28 2013-07-31 浙江大学 一种获得造血干细胞的方法
US10391126B2 (en) 2011-11-18 2019-08-27 Board Of Regents, The University Of Texas System CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA
SG11201402502RA (en) 2011-11-21 2015-01-29 Sunnybrook Res Inst Populations of hematopoietic progenitors and methods of enriching stem cells therefor
JP6220791B2 (ja) 2011-12-02 2017-10-25 フェイト セラピューティクス,インコーポレイテッド 増強された幹細胞組成物
WO2013086029A1 (en) 2011-12-05 2013-06-13 Primorigen Biosciences Inc. Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
EP2788476B1 (en) 2011-12-08 2019-05-22 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
EP2606884A1 (en) 2011-12-21 2013-06-26 Ecole Polytechnique Fédérale de Lausanne (EPFL) Inhibitors of notch signaling pathway and use thereof in treatment of cancers
US20150166969A1 (en) 2012-02-24 2015-06-18 Fred Hutchinson Cancer Research Center Compositions and methods for the treatment of hemoglobinopathies
FI2838548T3 (fi) 2012-04-17 2023-10-02 Univ Washington Through Its Center For Commercialization HLA:n luokan II puutteelliset solut, HLA:n luokan II puutteelliset solut, jotka kykenevät ilmentämään HLA:n luokan II proteiineja, ja niiden käytöt
EP2839013B1 (en) 2012-04-18 2020-08-26 The Board of Trustees of the Leland Stanford Junior University Non-disruptive gene targeting
WO2013163171A1 (en) 2012-04-24 2013-10-31 Kaufman Dan S Method for developing natural killer cells from stem cells
JP6164746B2 (ja) 2012-05-22 2017-07-19 国立大学法人 東京大学 抗原特異的t細胞の製造方法
BR112014029417B1 (pt) 2012-05-25 2023-03-07 Cellectis Método ex vivo para a preparação de células t para imunoterapia
WO2014011540A1 (en) 2012-07-09 2014-01-16 Emory University Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto
MX370148B (es) 2012-10-02 2019-12-03 Memorial Sloan Kettering Cancer Center Composiciones y su uso para inmunoterapia.
US20150329821A1 (en) 2012-10-19 2015-11-19 Agency For Science, Technology And Research Methods of differentiating stem cells into one or more cell lineages
US9382531B2 (en) 2012-10-22 2016-07-05 Wisconsin Alumni Research Foundation Induction of hemogenic endothelium from pluripotent stem cells
US9255250B2 (en) 2012-12-05 2016-02-09 Sangamo Bioscience, Inc. Isolated mouse or human cell having an exogenous transgene in an endogenous albumin gene
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
HUE043785T2 (hu) 2013-03-13 2019-09-30 Wisconsin Alumni Res Found Módszerek és anyagok humán pluripotens õssejtek hematoendothelialis differenciálására meghatározott körülmények között
IL311390A (en) 2013-03-15 2024-05-01 Memorial Sloan Kettering Cancer Center Preparations and methods for immunotherapy
US9943545B2 (en) 2013-03-15 2018-04-17 Fate Therapeutics, Inc. Stem cell culture media and methods of enhancing cell survival
WO2014165707A2 (en) 2013-04-03 2014-10-09 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted t-cells derived from pluripotent stem cells
EP4286517A3 (en) 2013-04-04 2024-03-13 President and Fellows of Harvard College Therapeutic uses of genome editing with crispr/cas systems
US10117899B2 (en) 2013-10-17 2018-11-06 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
US9932607B2 (en) 2013-11-15 2018-04-03 The Board Of Trustees Of The Leland Stanford Junior University Site-specific integration of transgenes into human cells
CA2941004A1 (en) 2014-03-04 2015-09-11 Peter Flynn Improved reprogramming methods and cell culture platforms
PT3122769T (pt) 2014-03-28 2023-04-24 Univ Minnesota Polipéptidos, células e métodos que envolvem cd16 manipulado
KR20200138445A (ko) 2014-04-24 2020-12-09 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 입양 세포 요법 생성물을 생성하기 위한 유도 만능 줄기 세포의 응용
CN103937743B (zh) 2014-04-27 2017-12-01 浙江大学 一种利用三维诱导系统获得造血干细胞的方法
WO2016123100A1 (en) 2015-01-26 2016-08-04 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
US20180112180A1 (en) 2015-01-26 2018-04-26 Fate Therapeutics, Inc. Cells with increased immuno-regulatory properties and methods for their use and manufacture
US20170020922A1 (en) 2015-07-16 2017-01-26 Batu Biologics Inc. Gene editing for immunological destruction of neoplasia
JP6816133B2 (ja) 2015-10-05 2021-01-20 プレシジョン バイオサイエンシズ,インク. 改変ヒトt細胞受容体アルファ定常領域遺伝子を含む遺伝子改変細胞
SG11201803145RA (en) 2015-11-04 2018-05-30 Fate Therapeutics Inc Methods and compositions for inducing hematopoietic cell differentiation
KR20250141836A (ko) 2015-11-04 2025-09-29 페이트 세러퓨틱스, 인코포레이티드 만능 세포의 유전자 조작
WO2017164257A1 (ja) 2016-03-23 2017-09-28 国立大学法人京都大学 血球分化能の高い中胚葉誘導方法
EP4628587A3 (en) 2016-04-15 2026-02-25 Memorial Sloan Kettering Cancer Center Transgenic t cell and chimeric antigen receptor t cell compositions and related methods

Similar Documents

Publication Publication Date Title
JP2025078772A5 (https=)
JP2023058748A5 (https=)
JP2019103521A5 (https=)
CN107429230B (zh) 用于诱导造血细胞分化的方法和组合物
JP6647864B2 (ja) 赤血球の産生
JP2022105220A5 (https=)
JP2020517237A5 (https=)
EP2277993A1 (en) Method for producing endothelial cells (variants)
CA2363851A1 (en) Use of collagenase in the preparation of neural stem cell cultures
JP2024153768A5 (https=)
CN108570448B (zh) 一种高效的hPSCs向MSCs分化的方法
WO2023138680A9 (zh) 诱导细胞分化的方法
RU2006110203A (ru) Получение гамкергических нейронов in vitro из эмбриональных стволовых клеток и их применение при лечении неврологических расстройств
Zambidis et al. Emergence of human angiohematopoietic cells in normal development and from cultured embryonic stem cells
CN117683713A (zh) 利用人多潜能干细胞体外制备t淋巴细胞和nk细胞
US11814647B2 (en) Methods of modulating cell phenotype by way of regulating the gaseous environment
CN116769695A (zh) 从畸胎瘤、类器官和拟胚体中产生人细胞和组织的培养基和方法
Lu et al. GeneChip analysis of human embryonic stem cell differentiation into hemangioblasts: an in silico dissection of mixed phenotypes
CN119432720B (zh) 猪胚胎干细胞诱导形成猪类囊胚的方法及培养基
Denker Induced pluripotent stem cells: how to deal with the developmental potential
CN116751738B (zh) 一种信号巢细胞以及类胚胎的制备方法
JP2024523332A5 (https=)
CN117757743A (zh) 一种使人诱导多能干细胞分化为自然杀伤细胞的培养基及方法
JP2024546108A5 (https=)
HK40061773A (en) Methods and compositions for inducing hematopoietic cell differentiation