|
DK0672145T3
(da)
|
1992-11-24 |
2003-08-11 |
Searle & Co |
Interleukin-3-(IL-3)-polypeptider med flere mutationer
|
|
GB9225453D0
(en)
|
1992-12-04 |
1993-01-27 |
Medical Res Council |
Binding proteins
|
|
ATE199392T1
(de)
|
1992-12-04 |
2001-03-15 |
Medical Res Council |
Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
|
|
DE69414870T2
(de)
|
1993-09-22 |
1999-05-12 |
Medical Research Council, London |
Antikoerper mit geaenderter zielrichtung
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6171820B1
(en)
|
1995-12-07 |
2001-01-09 |
Diversa Corporation |
Saturation mutagenesis in directed evolution
|
|
US6562594B1
(en)
|
1999-09-29 |
2003-05-13 |
Diversa Corporation |
Saturation mutagenesis in directed evolution
|
|
AU717020B2
(en)
|
1996-05-03 |
2000-03-16 |
Immunomedics Inc. |
Targeted combination immunotherapy of cancer
|
|
US7011812B1
(en)
|
1996-05-03 |
2006-03-14 |
Immunomedics, Inc. |
Targeted combination immunotherapy of cancer and infectious diseases
|
|
US5922845A
(en)
|
1996-07-11 |
1999-07-13 |
Medarex, Inc. |
Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
|
|
EP0979281B1
(en)
|
1997-05-02 |
2005-07-20 |
Genentech, Inc. |
A method for making multispecific antibodies having heteromultimeric and common components
|
|
US20030207346A1
(en)
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US7951917B1
(en)
|
1997-05-02 |
2011-05-31 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
PT1064027E
(pt)
|
1998-03-27 |
2008-09-29 |
Genentech Inc |
Sinergismo de ligando de apo-2 e anticorpo anti-her-2
|
|
US7833528B2
(en)
|
1998-06-22 |
2010-11-16 |
Immunomedics, Inc. |
Use of multispecific, non-covalent complexes for targeted delivery of therapeutics
|
|
WO2001097855A2
(en)
|
2000-06-20 |
2001-12-27 |
Immunomedics, Inc. |
Targeted combination immunotherapy of cancer and infectious diseases
|
|
US6902734B2
(en)
|
2000-08-07 |
2005-06-07 |
Centocor, Inc. |
Anti-IL-12 antibodies and compositions thereof
|
|
RU2287534C2
(ru)
|
2000-10-20 |
2006-11-20 |
Тугаи Сейяку Кабусики Кайся |
Деградированное антитело, являющееся агонистом tpo
|
|
US20020168343A1
(en)
|
2001-02-14 |
2002-11-14 |
Curiel David T. |
Combined transductional and transcriptional targeting system for improved gene delivery
|
|
DE60327199D1
(de)
|
2002-04-26 |
2009-05-28 |
Chugai Pharmaceutical Co Ltd |
Verfahren zum screening auf agonistische antikörper
|
|
AU2013200009B2
(en)
|
2002-07-18 |
2015-05-07 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
US8337841B2
(en)
|
2003-01-21 |
2012-12-25 |
Chugai Seiyaku Kabushiki Kaisha |
Methods of screening for antibody light chains
|
|
JP4794301B2
(ja)
|
2003-06-11 |
2011-10-19 |
中外製薬株式会社 |
抗体の製造方法
|
|
US20090191213A9
(en)
|
2003-07-02 |
2009-07-30 |
Novo Nordisk A/S |
Compositions and methods for regulating NK cell activity
|
|
EP1631315B1
(en)
|
2003-09-24 |
2014-07-30 |
Millennium Pharmaceuticals, Inc. |
Antibodies which bind human cxcr3
|
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
GB0329825D0
(en)
|
2003-12-23 |
2004-01-28 |
Celltech R&D Ltd |
Biological products
|
|
US20050266425A1
(en)
|
2003-12-31 |
2005-12-01 |
Vaccinex, Inc. |
Methods for producing and identifying multispecific antibodies
|
|
US8420783B2
(en)
|
2004-12-08 |
2013-04-16 |
Immunomedics, Inc. |
Method and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases
|
|
WO2006074399A2
(en)
|
2005-01-05 |
2006-07-13 |
Biogen Idec Ma Inc. |
Multispecific binding molecules comprising connecting peptides
|
|
ATE423140T1
(de)
|
2005-01-05 |
2009-03-15 |
F Star Biotech Forsch & Entw |
Synthetische immunoglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften
|
|
KR101374454B1
(ko)
|
2005-03-31 |
2014-03-17 |
추가이 세이야쿠 가부시키가이샤 |
회합제어에 의한 폴리펩티드 제조방법
|
|
WO2007038392A2
(en)
|
2005-09-23 |
2007-04-05 |
Walter Reed Army Institute Of Research (Wrair) |
Antibodies with simultaneous subsite specificities to protein and lipid epitopes
|
|
US8236308B2
(en)
*
|
2005-10-11 |
2012-08-07 |
Micromet Ag |
Composition comprising cross-species-specific antibodies and uses thereof
|
|
AR060040A1
(es)
|
2006-03-21 |
2008-05-21 |
Genentech Inc |
Antagonistas de vefg y de alfa5 beta 1
|
|
EP2471816A1
(en)
|
2006-08-30 |
2012-07-04 |
Genentech, Inc. |
Multispecific antibodies
|
|
GB0620729D0
(en)
|
2006-10-18 |
2006-11-29 |
Ucb Sa |
Biological products
|
|
NZ581468A
(en)
|
2007-06-25 |
2012-09-28 |
Esbatech Alcon Biomed Res Unit |
Methods of modifying antibodies, and modified antibodies with improved functional properties
|
|
CN101952312A
(zh)
|
2007-07-31 |
2011-01-19 |
米迪缪尼有限公司 |
多特异性表位结合蛋白及其应用
|
|
CA2697922A1
(en)
|
2007-08-28 |
2009-03-12 |
Biogen Idec Ma Inc. |
Compositions that bind multiple epitopes of igf-1r
|
|
AR066170A1
(es)
|
2007-09-26 |
2009-07-29 |
Genentech Inc |
Anti integrina alfa 5 beta 1
|
|
EP2113255A1
(en)
|
2008-05-02 |
2009-11-04 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Cytotoxic immunoglobulin
|
|
RU2653753C1
(ru)
|
2008-06-25 |
2018-05-14 |
ИЭсБиЭйТЕК, ЭН АЛЬКОН БАЙОМЕДИКАЛ РИСЕРЧ ЮНИТ ЭлЭлСи |
СТАБИЛЬНЫЕ И РАСТВОРИМЫЕ АНТИТЕЛА, ИНГИБИРУЮЩИЕ TNFα
|
|
JP2011526794A
(ja)
|
2008-07-02 |
2011-10-20 |
エマージェント プロダクト デベロップメント シアトル， エルエルシー |
ＴＧＦ−βアンタゴニスト多重標的結合性分子
|
|
MX2011000071A
(es)
|
2008-07-02 |
2011-05-03 |
Emergent Product Dev Seattle |
Inmunoterapeuticos de interleucina-6 (il6).
|
|
KR20110044991A
(ko)
|
2008-07-02 |
2011-05-03 |
이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 |
ＴＮＦ-α 길항제 다-표적 결합 단백질
|
|
WO2010008690A1
(en)
|
2008-07-14 |
2010-01-21 |
Uchicago Argonne, Llc |
Methods for systematic control of protein stability
|
|
EP2321345A1
(en)
|
2008-07-28 |
2011-05-18 |
Emergent Product Development Seattle, LLC |
Multi-specific binding proteins targeting b cell disorders
|
|
AU2009298131B2
(en)
|
2008-10-02 |
2016-07-14 |
Aptevo Research And Development Llc |
CD86 antagonist multi-target binding proteins
|
|
KR20150036824A
(ko)
|
2009-03-20 |
2015-04-07 |
제넨테크, 인크. |
이중특이적 항-ｈｅｒ 항체
|
|
BRPI1014089A2
(pt)
|
2009-04-02 |
2016-04-19 |
Roche Glycart Ag |
anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples
|
|
PL2483310T3
(pl)
|
2009-09-29 |
2015-01-30 |
Roche Glycart Ag |
Bispecyficzne przeciwciała agonistyczne dla receptora śmierci
|
|
KR20120093312A
(ko)
|
2009-10-30 |
2012-08-22 |
바이엘 헬스케어 엘엘씨 |
항체 모방체 스캐폴드
|
|
CA2781682A1
(en)
|
2009-12-04 |
2011-06-09 |
Genentech, Inc. |
Multispecific antibodies, antibody analogs, compositions, and methods
|
|
US20130089554A1
(en)
|
2009-12-29 |
2013-04-11 |
Emergent Product Development Seattle, Llc |
RON Binding Constructs and Methods of Use Thereof
|
|
SG183149A1
(en)
|
2010-02-08 |
2012-09-27 |
Regeneron Pharma |
Common light chain mouse
|
|
WO2011109726A2
(en)
|
2010-03-05 |
2011-09-09 |
Bioatla Llc |
Homologous multi-specific antibodies
|
|
WO2011133886A2
(en)
|
2010-04-23 |
2011-10-27 |
Genentech, Inc. |
Production of heteromultimeric proteins
|
|
DK2593797T3
(da)
|
2010-07-16 |
2019-08-05 |
Bioatla Llc |
Hidtil ukendte fremgangsmåder til proteinevolution
|
|
WO2012023053A2
(en)
|
2010-08-16 |
2012-02-23 |
Novimmune S.A. |
Methods for the generation of multispecific and multivalent antibodies
|
|
KR20130096731A
(ko)
|
2010-09-08 |
2013-08-30 |
할로자임, 아이엔씨 |
조건부 활성 치료적 단백질을 평가，확인 또는 진화시키는 방법
|
|
CN105859889B
(zh)
|
2010-11-17 |
2020-01-07 |
中外制药株式会社 |
具有代替凝血因子viii的功能的功能的多特异性抗原结合分子
|
|
PH12013501435B1
(en)
|
2011-01-14 |
2019-02-01 |
UCB Biopharma SRL |
Antibody molecules which bind il-17a and il-17f
|
|
EP2500073A1
(en)
|
2011-03-17 |
2012-09-19 |
ChromaCon AG |
Method for identification and purification of multi-specific polypeptides
|
|
JP6400470B2
(ja)
|
2011-05-16 |
2018-10-03 |
ジェネロン（シャンハイ）コーポレイション リミテッド |
多重特異性Ｆａｂ融合タンパク質および使用法
|
|
WO2012162067A2
(en)
*
|
2011-05-21 |
2012-11-29 |
Macrogenics, Inc. |
Cd3-binding molecules capable of binding to human and non-human cd3
|
|
US20150045540A1
(en)
|
2011-06-28 |
2015-02-12 |
Sea Lane Biotechnologies, Llc |
Multispecific stacked variable domain binding proteins
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
EP2543680A1
(en)
|
2011-07-07 |
2013-01-09 |
Centre National de la Recherche Scientifique |
Multispecific mutated antibody Fab fragments
|
|
EP2760891B1
(en)
|
2011-09-26 |
2018-11-07 |
JN Biosciences LLC |
Hybrid constant regions
|
|
CN104203981A
(zh)
*
|
2011-12-19 |
2014-12-10 |
合成免疫股份有限公司 |
双特异性抗体分子
|
|
SG10201704846VA
(en)
|
2012-03-14 |
2017-07-28 |
Regeneron Pharma |
Multispecific antigen-binding molecules and uses thereof
|
|
US20150086584A1
(en)
|
2012-03-22 |
2015-03-26 |
University Of Miami |
Multi-specific binding agents
|
|
EP3553089A1
(en)
|
2012-05-10 |
2019-10-16 |
Bioatla, LLC |
Multi-specific monoclonal antibodies
|
|
MX2014014162A
(es)
|
2012-05-24 |
2015-02-04 |
Hoffmann La Roche |
Anticuerpos multiespecificos.
|
|
CA2879814A1
(en)
|
2012-08-02 |
2014-02-06 |
Jn Biosciences Llc |
Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece
|
|
KR20140036905A
(ko)
|
2012-09-18 |
2014-03-26 |
삼성전자주식회사 |
이중특이 항체를 포함하는 단백질 복합체
|
|
GB201223276D0
(en)
|
2012-12-21 |
2013-02-06 |
Ucb Pharma Sa |
Antibodies and methods of producing same
|
|
JP6693872B2
(ja)
|
2013-07-25 |
2020-05-13 |
シトムクス セラピューティクス，インコーポレイティド |
多重特異性抗体、多重特異性活性化可能抗体、及びそれらの使用方法
|
|
EP2840091A1
(en)
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof
|
|
CA2955947A1
(en)
*
|
2014-07-25 |
2016-01-28 |
Cytomx Therapeutics, Inc. |
Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same
|
|
MX386342B
(es)
*
|
2014-07-25 |
2025-03-18 |
Memorial Sloan Kettering Cancer Center |
Móleculas de unión a her2 y cd3 biespecíficas.
|
|
WO2016077505A2
(en)
|
2014-11-11 |
2016-05-19 |
Amunix Operating Inc. |
Targeted xten conjugate compositions and methods of making same
|
|
US20170369592A1
(en)
*
|
2015-01-09 |
2017-12-28 |
Mabimmune Diagostics AG |
Novel anti-fibroblast activation protein (fap) antibodies and uses derived thereof
|
|
SG11201705988UA
(en)
*
|
2015-02-24 |
2017-08-30 |
Bioatla Llc |
Conditionally active biological proteins
|
|
CA3003399A1
(en)
*
|
2015-11-02 |
2017-05-11 |
Bioatla, Llc |
Conditionally active polypeptides
|
|
CN108602889A
(zh)
*
|
2015-12-22 |
2018-09-28 |
瑞泽恩制药公司 |
医治急性成淋巴细胞性白血病的双特异性抗cd20/抗cd3抗体
|
|
AU2017222461A1
(en)
|
2016-02-22 |
2018-08-30 |
Oceanside Biotechnology |
Neoantigen compositions and methods of using the same in immunooncotherapy
|
|
WO2017167350A1
(en)
|
2016-03-30 |
2017-10-05 |
Horst Lindhofer |
Multispecific antibodies for use in the treatment of a neoplasm of the urinary tract
|
|
EP4656204A3
(en)
|
2016-04-15 |
2026-06-03 |
BioAtla, Inc. |
Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof
|
|
WO2017201731A1
(en)
*
|
2016-05-27 |
2017-11-30 |
Beijing Vdjbio Co., Ltd. |
Antibodies, composition and kits comprising same, and methods of use thereof
|
|
US9567399B1
(en)
|
2016-06-20 |
2017-02-14 |
Kymab Limited |
Antibodies and immunocytokines
|
|
MX2019002199A
(es)
|
2016-08-31 |
2019-05-16 |
Bioatla Llc |
Polipeptidos condicionalmente activos y métodos para generarlos.
|
|
CN112513081A
(zh)
|
2018-06-14 |
2021-03-16 |
生物蛋白有限公司 |
多重特异性抗体构建体
|
|
WO2023230626A2
(en)
*
|
2022-05-27 |
2023-11-30 |
Bighat Biosciences, Inc. |
Ph-selective anti-cd3 antibodies and use of the same
|