|
IL73534A
(en)
|
1983-11-18 |
1990-12-23 |
Riker Laboratories Inc |
1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
|
|
US5658592A
(en)
|
1994-05-13 |
1997-08-19 |
Kuraray Co., Ltd. |
Medical crosslinked polymer gel of carboxylic polysaccharide and diaminoalkane
|
|
US7662368B2
(en)
|
1999-07-16 |
2010-02-16 |
Institut Pasteur |
Method of inducing SHC phosphorylation of inducing the SHC/MAPK pathway by administering a peptide of IL-2
|
|
US20030191291A1
(en)
|
2000-09-08 |
2003-10-09 |
Kochendoerfer Gerd G. |
Synthetic erythropoiesis stimulating proteins
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
CA2447594A1
(en)
|
2001-06-21 |
2003-01-03 |
Clontech Laboratories, Inc. |
Water-soluble polymeric metal ion affinity compositions and methods for using the same
|
|
AU2003221078A1
(en)
|
2002-04-08 |
2003-10-20 |
Denki Kagaku Kogyo Kabushiki Kaisha |
Therapeutic composition for bone infectious disease
|
|
US7445894B2
(en)
|
2002-05-03 |
2008-11-04 |
Molecular Probes, Inc. |
Compositions and methods for detection and isolation of phosphorylated molecules
|
|
EP1651162B1
(en)
|
2003-05-20 |
2015-10-21 |
ImmunoGen, Inc. |
Improved cytotoxic agents comprising new maytansinoids
|
|
WO2007052267A2
(en)
|
2005-11-01 |
2007-05-10 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Biodegradable composite for internal local radiotherapy
|
|
US7919079B2
(en)
|
2006-03-31 |
2011-04-05 |
Biosante Pharmaceuticals, Inc. |
Cancer immunotherapy compositions and methods of use
|
|
EP2017281A4
(en)
|
2006-04-14 |
2012-03-14 |
Kyowa Hakko Kirin Co Ltd |
AGONISTS AT TOLL-LIKE RECEPTOR 9
|
|
EP1867638A1
(de)
|
2006-06-16 |
2007-12-19 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Verfahren zur kovalenten Verknüpfung zweier Moleküle mittels Diels-Alder-Reaktion mit inversem Elektronenbedarf
|
|
US8398956B2
(en)
|
2007-01-11 |
2013-03-19 |
Immunomedics, Inc. |
In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
|
|
US8236949B2
(en)
|
2007-07-17 |
2012-08-07 |
University Of Delaware |
Tetrazine-based bio-orthogonal coupling reagents and methods
|
|
CA2693266C
(en)
|
2007-08-01 |
2015-06-30 |
Idera Pharmaceuticals, Inc. |
Novel synthetic agonists of tlr9
|
|
WO2009064738A2
(en)
|
2007-11-12 |
2009-05-22 |
Bipar Sciences, Inc. |
Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents
|
|
WO2011127149A1
(en)
|
2010-04-06 |
2011-10-13 |
University Of Utah Research Foundation |
Controlled release combination biomaterials
|
|
JP5574083B2
(ja)
|
2008-08-01 |
2014-08-20 |
アンタイス エス.エイ. |
高い残留性及び容量を与える高い能力を有する注入可能なヒドロゲル
|
|
CN102271712B
(zh)
|
2008-10-31 |
2015-11-25 |
通用医疗公司 |
用于将物质递送至生物靶标的组合物和方法
|
|
US20110223257A1
(en)
|
2008-11-17 |
2011-09-15 |
Enzon Pharmaceuticals, Inc. |
Releasable fusogenic lipids for nucleic acids delivery systems
|
|
JP2012516352A
(ja)
|
2009-01-30 |
2012-07-19 |
イデラ ファーマシューティカルズ インコーポレイテッド |
Tlr9の合成アゴニスト
|
|
WO2010119389A2
(en)
|
2009-04-16 |
2010-10-21 |
Koninklijke Philips Electronics N.V. |
Pretargeting kit, method and agents used therein
|
|
EP2360167A1
(en)
|
2010-02-03 |
2011-08-24 |
Deutsches Krebsforschungszentrum |
Post-synthetic modification of nucleic acids by inverse Diels-Alder reaction
|
|
CN103221398B
(zh)
|
2010-07-23 |
2016-03-23 |
特拉华大学 |
用于快速构建放射性核素标记探针的四嗪-反式环辛烯连接反应
|
|
WO2012049624A1
(en)
|
2010-10-14 |
2012-04-19 |
Koninklijke Philips Electronics N.V. |
Pretargeting kit, method and agents used therein
|
|
WO2012074840A2
(en)
|
2010-11-22 |
2012-06-07 |
The General Hospital Corporation |
Compositions and methods for in vivo imaging
|
|
JP5992435B2
(ja)
|
2010-12-21 |
2016-09-14 |
コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. |
循環からの生体分子の除去剤
|
|
EP2522369A1
(en)
|
2011-05-09 |
2012-11-14 |
Koninklijke Philips Electronics N.V. |
Pretargeting kit, method and agents used therein
|
|
EP2709666B1
(en)
*
|
2011-05-16 |
2021-07-14 |
Koninklijke Philips N.V. |
Bio-orthogonal drug activation
|
|
US20140256831A1
(en)
|
2011-05-31 |
2014-09-11 |
The University Of Tokyo |
Hydrogel and method for producing same
|
|
ES2393602B1
(es)
|
2011-06-09 |
2013-10-02 |
Universidad Complutense De Madrid |
Materiales biocerámicos para el tratamiento de la osteomielitis.
|
|
WO2013115885A2
(en)
|
2011-11-22 |
2013-08-08 |
The Regents Of The University Of Michigan |
Synthesizing functionalized dendrimers within biological settings
|
|
CN104302408B
(zh)
|
2012-02-27 |
2016-12-14 |
阿穆尼克斯运营公司 |
Xten缀合组合物和制造其的方法
|
|
US9206271B2
(en)
|
2012-03-25 |
2015-12-08 |
Wisconsin Alumni Research Foundation |
Fully backbone degradable and functionalizable polymers derived from the ring-opening metathesis polymerization (ROMP)
|
|
US10274490B2
(en)
|
2012-06-12 |
2019-04-30 |
The General Hospital Corporation |
Magnetic labeling of bacteria
|
|
WO2014065860A1
(en)
|
2012-10-24 |
2014-05-01 |
The General Hospital Corporation |
Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
|
|
US10927139B2
(en)
|
2012-11-22 |
2021-02-23 |
Tagworks Pharmaceuticals B.V. |
Chemically cleavable group
|
|
US20150297741A1
(en)
|
2012-11-22 |
2015-10-22 |
Tagworks Pharmaceuticals B.V. |
Bio-orthogonal drug activation
|
|
WO2014081299A1
(en)
|
2012-11-22 |
2014-05-30 |
Tagworks Pharmaceuticals B.V. |
Activatable liposomes
|
|
WO2014081300A1
(en)
|
2012-11-22 |
2014-05-30 |
Tagworks Pharmaceuticals B.V. |
Channel protein activatable liposomes
|
|
SG11201502796RA
(en)
|
2012-12-13 |
2015-05-28 |
Aduro Biotech Inc |
Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
|
|
US20150359913A1
(en)
|
2013-01-25 |
2015-12-17 |
Memorial Sloan-Kettering Cancer Center |
Tetrazines/trans-cyclooctenes in solid phase synthesis of labeled peptides
|
|
WO2014138186A1
(en)
|
2013-03-05 |
2014-09-12 |
The Johns Hopkins University |
Bioorthogonal two-component delivery systems for enhanced internalization of nanotherapeutics
|
|
FI2964224T3
(fi)
|
2013-03-08 |
2024-09-27 |
Polyactiva Pty Ltd |
Polymeerikonjugaatti bioaktiivisen aineen annostelemiseksi
|
|
CU24377B1
(es)
|
2013-05-18 |
2018-12-05 |
Aduro Biotech Inc |
Dinucléotidos de purina cíclicos y composiciones de los mismos útiles para inducir la producción de interferón de tipo i dependientes de sting
|
|
EP2996472B1
(en)
|
2013-05-18 |
2019-03-27 |
Aduro Biotech, Inc. |
Compositions and methods for inhibiting "stimulator of interferon gene" dependent signalling
|
|
JP6600302B2
(ja)
|
2013-06-12 |
2019-10-30 |
ザ ジェネラル ホスピタル コーポレイション |
標的分子のマルチプレックス検出のための方法、キット、およびシステム、ならびにそれらの使用
|
|
EP3010486B1
(en)
|
2013-06-19 |
2023-11-22 |
The Regents of The University of California |
Chemical structures for localized delivery of therapeutic agents
|
|
US10046002B2
(en)
|
2013-08-02 |
2018-08-14 |
Syntrix Biosystems Inc. |
Method for treating cancer using chemokine antagonists
|
|
JP2016538344A
(ja)
|
2013-11-19 |
2016-12-08 |
ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago |
癌処置としてのstingアゴニストの使用
|
|
PL3099717T3
(pl)
|
2014-01-31 |
2019-10-31 |
Novartis Ag |
Cząsteczki przeciwciała dla TIM-3 i ich zastosowanie
|
|
WO2015117235A1
(en)
|
2014-02-10 |
2015-08-13 |
Mcmaster University |
Targeted molecular imaging contrast agents
|
|
EA201691765A1
(ru)
|
2014-03-14 |
2016-12-30 |
Новартис Аг |
Молекулы антител против lag-3 и их применения
|
|
AU2015229014B2
(en)
|
2014-03-14 |
2019-07-25 |
The Regents Of The University Of California |
TCO conjugates and methods for delivery of therapeutic agents
|
|
JP6787789B2
(ja)
|
2014-04-04 |
2020-11-18 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
詰め替え可能な薬物送達デバイスおよびその使用方法
|
|
EP3125960B1
(en)
|
2014-04-04 |
2020-06-03 |
President and Fellows of Harvard College |
Click-crosslinked hydrogels and methods of use
|
|
EP3152217B1
(en)
|
2014-06-04 |
2018-08-01 |
GlaxoSmithKline Intellectual Property Development Limited |
Cyclic di-nucleotides as modulators of sting
|
|
WO2016014799A1
(en)
|
2014-07-23 |
2016-01-28 |
University Of Iowa Research Foundation |
Epidermal growth factor and blockade of immune checkpoints in cancer immunotherapy
|
|
GB201501462D0
(en)
|
2015-01-29 |
2015-03-18 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
TWI706958B
(zh)
|
2015-03-10 |
2020-10-11 |
美商艾杜諾生物科技公司 |
活化「干擾素基因刺激因子」依賴性訊息傳導之組合物及方法
|
|
KR102779525B1
(ko)
|
2015-05-29 |
2025-03-12 |
다이나박스 테크놀로지 코퍼레이션 |
폐암을 치료하기 위한 폴리뉴클레오티드 Toll-유사 수용체 9 아고니스트의 폐내 투여
|
|
EA201890161A1
(ru)
|
2015-06-29 |
2018-06-29 |
Верастэм, Инк. |
Терапевтические композиции, комбинации и способы применения
|
|
CN108137641B
(zh)
|
2015-08-13 |
2022-04-01 |
默沙东公司 |
作为sting激动剂的环状双核苷酸化合物
|
|
CN108135857A
(zh)
|
2015-09-10 |
2018-06-08 |
沙思奇公司 |
生物正交组合物
|
|
KR20180066241A
(ko)
|
2015-10-28 |
2018-06-18 |
아두로 바이오테크, 인코포레이티드 |
“인터페론 유전자의 자극제”-의존성 신호전달을 활성화시키기 위한 조성물 및 방법
|
|
JP6411676B2
(ja)
|
2015-12-03 |
2018-10-24 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited |
Stingの調節因子としての環状プリンジヌクレオチド
|
|
SMT202500412T1
(it)
|
2016-01-11 |
2025-11-10 |
Innate Tumor Immunity Inc |
Dinucleotidi ciclici per il trattamento di condizioni associate all’attività di sting quali il cancro
|
|
KR102775461B1
(ko)
|
2016-04-01 |
2025-02-28 |
어비디티 바이오사이언시스 인크. |
핵산-폴리펩타이드 조성물 및 이의 용도
|
|
RU2725292C2
(ru)
*
|
2016-04-27 |
2020-06-30 |
Иммьюномедикс, Инк. |
Эффективность конъюгатов антитела против trop-2 с лекарственным средством sn-38 для терапии рецидивирующих/рефрактерных к ингибиторам контрольной точки опухолей
|
|
EP3507367A4
(en)
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
|
WO2018009652A1
(en)
|
2016-07-06 |
2018-01-11 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
CA3029644A1
(en)
|
2016-07-06 |
2018-01-11 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
WO2018013887A1
(en)
|
2016-07-15 |
2018-01-18 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
SG11201900154VA
(en)
|
2016-07-15 |
2019-02-27 |
Sperovie Biosciences Inc |
Compounds, compositions, and methods for the treatment of disease
|
|
US10537590B2
(en)
|
2016-09-30 |
2020-01-21 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds
|
|
JP6636673B2
(ja)
|
2016-10-04 |
2020-01-29 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
STINGアゴニストとしてのベンゾ[b]チオフェン化合物
|
|
JOP20170188A1
(ar)
|
2016-11-25 |
2019-01-30 |
Janssen Biotech Inc |
ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
|
|
WO2018100558A2
(en)
|
2016-12-01 |
2018-06-07 |
Takeda Pharmaceutical Company Limited |
Cyclic dinucleotide
|
|
RU2019122598A
(ru)
|
2016-12-20 |
2021-01-22 |
Мерк Шарп И Доум Корп. |
Циклические динуклеотидные агонисты sting для лечения рака
|
|
ES2924186T3
(es)
|
2017-01-27 |
2022-10-05 |
Janssen Biotech Inc |
Dinucleótidos cíclicos como agonistas de STING
|
|
ES2891326T3
(es)
|
2017-01-27 |
2022-01-27 |
Janssen Biotech Inc |
Dinucleótidos cíclicos como agonistas de la STING
|
|
JOP20190218A1
(ar)
|
2017-03-22 |
2019-09-22 |
Boehringer Ingelheim Int |
مركبات ثنائية النيوكليوتيدات حلقية معدلة
|
|
AU2018250312C1
(en)
*
|
2017-04-07 |
2024-08-22 |
Tambo, Inc. |
Bioorthogonal compositions
|
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
|
US11466047B2
(en)
|
2017-05-12 |
2022-10-11 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
|
US20200138827A1
(en)
|
2017-06-22 |
2020-05-07 |
Curadev Pharma Limited |
Small molecule modulators of human sting
|
|
JP2020524718A
(ja)
|
2017-06-22 |
2020-08-20 |
キュラデブ・ファーマ・リミテッドCuradev Pharma Limited |
ヒトstingの複素環式小分子調節因子
|
|
CN111132972B
(zh)
|
2017-06-22 |
2024-07-12 |
克拉德夫制药有限公司 |
人sting的小分子调节剂
|
|
MA49772A
(fr)
|
2017-08-04 |
2021-04-21 |
Merck Sharp & Dohme |
Agonistes benzo[b]thiophène de sting pour le traitement du cancer
|
|
EP3675859A4
(en)
|
2017-08-31 |
2021-06-30 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND PROCEDURES FOR TREATMENT OF DISEASES
|
|
US11707531B2
(en)
|
2017-09-11 |
2023-07-25 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
WO2019051488A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
CN111601900A
(zh)
|
2017-11-02 |
2020-08-28 |
詹森生物制药有限公司 |
寡核苷酸构建体及其用途
|
|
PH12020550585A1
(en)
|
2017-11-10 |
2021-04-19 |
Takeda Pharmaceuticals Co |
Sting modulator compounds, and methods of making and using
|
|
MX2020006290A
(es)
|
2017-12-15 |
2020-12-03 |
Janssen Biotech Inc |
Dinucleotidos ciclicos como agonistas de sting.
|
|
PL3700564T3
(pl)
|
2017-12-15 |
2026-02-23 |
Elanco Animal Health Gmbh |
Kompozycje immunostymulujące
|
|
WO2019123338A1
(en)
|
2017-12-20 |
2019-06-27 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'2' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
WO2019125974A1
(en)
|
2017-12-20 |
2019-06-27 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
|
US11203610B2
(en)
|
2017-12-20 |
2021-12-21 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
JP7037667B2
(ja)
|
2017-12-20 |
2022-03-16 |
インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール,ヴイ.ヴイ.アイ. |
Stingアダプタータンパク質を活性化するホスホン酸結合を有する3’3’環状ジヌクレオチド
|
|
AU2019262521B2
(en)
*
|
2018-05-04 |
2024-04-18 |
Tagworks Pharmaceuticals B.V. |
Compounds comprising a linker for increasing transcyclooctene stability
|
|
WO2021007160A1
(en)
|
2019-07-05 |
2021-01-14 |
Tambo, Inc. |
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
|
|
CN110496233B
(zh)
*
|
2019-09-05 |
2022-07-19 |
复旦大学附属中山医院 |
一种spect显像剂及其标记前体及其制备方法、组合物和用途
|