JP2023520395A5 - - Google Patents

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Publication number
JP2023520395A5
JP2023520395A5 JP2022559581A JP2022559581A JP2023520395A5 JP 2023520395 A5 JP2023520395 A5 JP 2023520395A5 JP 2022559581 A JP2022559581 A JP 2022559581A JP 2022559581 A JP2022559581 A JP 2022559581A JP 2023520395 A5 JP2023520395 A5 JP 2023520395A5
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tautomer
compound
alkyl
pharmaceutically acceptable
acceptable salt
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JP2022559581A
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JP2023520395A (ja
JP7803872B2 (ja
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Priority claimed from PCT/US2021/025616 external-priority patent/WO2021203025A1/en
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JP2022559581A 2020-04-03 2021-04-02 アルファ1-アンチトリプシンのモジュレーター Active JP7803872B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063004719P 2020-04-03 2020-04-03
US63/004,719 2020-04-03
PCT/US2021/025616 WO2021203025A1 (en) 2020-04-03 2021-04-02 1 h-pyrazolo[4,3-g]isoquinoline and 1 h-pyrazolo[4,3-g]quinoline derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)

Publications (3)

Publication Number Publication Date
JP2023520395A JP2023520395A (ja) 2023-05-17
JP2023520395A5 true JP2023520395A5 (enExample) 2024-04-10
JP7803872B2 JP7803872B2 (ja) 2026-01-21

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JP2022559581A Active JP7803872B2 (ja) 2020-04-03 2021-04-02 アルファ1-アンチトリプシンのモジュレーター

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US (1) US12624028B2 (enExample)
EP (1) EP4126863B1 (enExample)
JP (1) JP7803872B2 (enExample)
CN (1) CN115715292B (enExample)
AU (1) AU2021247285A1 (enExample)
CA (1) CA3179333A1 (enExample)
WO (1) WO2021203025A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20210060A1 (ar) 2018-10-05 2023-01-30 Vertex Pharma معدلات لمضاد تريبسين ألفا-1
US11884672B2 (en) 2019-05-14 2024-01-30 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
CN115697969B (zh) 2020-04-03 2026-08-11 弗特克斯药品有限公司 α-1抗胰蛋白酶调节剂
AU2021247285A1 (en) 2020-04-03 2022-10-27 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
JP7732999B2 (ja) 2020-04-03 2025-09-02 バーテックス ファーマシューティカルズ インコーポレイテッド アルファ1-アンチトリプシンのモジュレーター
EP4188931A2 (en) 2020-07-27 2023-06-07 Vertex Pharmaceuticals Incorporated Processes for preparing modulators of alpha-1 antitrypsin
WO2022104353A1 (en) 2020-11-12 2022-05-19 Vertex Pharmaceuticals Incorporated Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat
WO2025090827A1 (en) * 2023-10-27 2025-05-01 Sub21, Inc. A1at modulators
WO2025236095A1 (en) * 2024-05-17 2025-11-20 Congruence Therapeutics Inc. Modulators of alpha-1 antitrypsin
WO2026136445A1 (en) 2024-12-17 2026-06-25 Sub21, Inc. A1at modulators

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CA3177531A1 (en) 2020-04-03 2021-10-07 Vertex Pharmaceuticals Incorporated Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)
CN115697969B (zh) 2020-04-03 2026-08-11 弗特克斯药品有限公司 α-1抗胰蛋白酶调节剂
AU2021247282A1 (en) 2020-04-03 2022-10-27 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
JP7732999B2 (ja) 2020-04-03 2025-09-02 バーテックス ファーマシューティカルズ インコーポレイテッド アルファ1-アンチトリプシンのモジュレーター
AU2021247285A1 (en) 2020-04-03 2022-10-27 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
WO2021203007A1 (en) 2020-04-03 2021-10-07 Vertex Pharmaceuticals Incorporated Substituted 5-hydroxyindole compounds as modulators of alpha-1 antitrypsin
EP4188931A2 (en) 2020-07-27 2023-06-07 Vertex Pharmaceuticals Incorporated Processes for preparing modulators of alpha-1 antitrypsin
WO2022104353A1 (en) 2020-11-12 2022-05-19 Vertex Pharmaceuticals Incorporated Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat
US20240002386A1 (en) 2020-11-17 2024-01-04 Vertex Pharmaceuticals Incorporated Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2h-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid
TW202421121A (zh) 2022-09-09 2024-06-01 美商維泰克斯製藥公司 α-1抗胰蛋白酶之調節劑

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