JOP20210060A1 - معدلات لمضاد تريبسين ألفا-1 - Google Patents

معدلات لمضاد تريبسين ألفا-1

Info

Publication number
JOP20210060A1
JOP20210060A1 JOP/2021/0060A JOP20210060A JOP20210060A1 JO P20210060 A1 JOP20210060 A1 JO P20210060A1 JO P20210060 A JOP20210060 A JO P20210060A JO P20210060 A1 JOP20210060 A1 JO P20210060A1
Authority
JO
Jordan
Prior art keywords
alpha
antitrypsin
modulators
aatd
compositions
Prior art date
Application number
JOP/2021/0060A
Other languages
English (en)
Inventor
Yi Shi
Mary Elizabeth Eccles
Upul Keerthi Bandarage
Michael Aaron Brodney
Cavan Mckeon Bligh
Diane M Boucher
Michael John Boyd
Timothy Lewis Tapley
Qing Tang
Stephen A Thomson
Peter Jones
Jr Mac Arthur Johnson
Veronique Damagnez
Fanning Lev Tyler Dewey
Stefanie Roeper
Setu Roday
Rupa Sawant
Rebecca Jane Swett
Jinwang Xu
Barrantes Pedro M Garcia
Kevin James Gagnon
Jr Ronald Lee Grey
Simon Giroux
Jr Robert Francis Fimognari
Kevin Michael Cottrell
Sarathy Kesavan
Adam Looker
Brad D Maxwell
John Patrick Maxwell
Ales Medek
Mettachit Navamal
Philippe Marcel Nuhant
Joshua Kennedy Hussey
Amy Beth Hall
Sarah Carol Hood
Dennis James Hurley
Michael Waldo
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of JOP20210060A1 publication Critical patent/JOP20210060A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

غير متوفر
JOP/2021/0060A 2018-10-05 2019-10-04 معدلات لمضاد تريبسين ألفا-1 JOP20210060A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862742148P 2018-10-05 2018-10-05
US201862768662P 2018-11-16 2018-11-16
PCT/US2019/054681 WO2020081257A1 (en) 2018-10-05 2019-10-04 Modulators of alpha-1 antitrypsin

Publications (1)

Publication Number Publication Date
JOP20210060A1 true JOP20210060A1 (ar) 2023-01-30

Family

ID=69467663

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0060A JOP20210060A1 (ar) 2018-10-05 2019-10-04 معدلات لمضاد تريبسين ألفا-1

Country Status (16)

Country Link
US (2) US11623924B2 (ar)
EP (1) EP3860712A1 (ar)
JP (1) JP2022512588A (ar)
KR (1) KR20210089656A (ar)
CN (1) CN113164761A (ar)
AU (1) AU2019362753A1 (ar)
BR (1) BR112021006392A2 (ar)
CA (1) CA3114672A1 (ar)
CO (1) CO2021005884A2 (ar)
IL (1) IL281884A (ar)
JO (1) JOP20210060A1 (ar)
MA (1) MA53827A (ar)
MX (1) MX2021003819A (ar)
TW (1) TW202024091A (ar)
UY (1) UY38403A (ar)
WO (1) WO2020081257A1 (ar)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11623924B2 (en) 2018-10-05 2023-04-11 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
UY38696A (es) * 2019-05-14 2020-11-30 Vertex Pharma Moduladores de alfa-1 antitripsina
TW202116303A (zh) * 2019-10-02 2021-05-01 美商維泰克斯製藥公司 α—１抗胰蛋白酶缺乏症之治療方法
GB201918416D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency
GB201918414D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency
GB201918410D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of alpha1-antitrypsin deficiency
GB201918413D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of alpha1-antitrypsin deficiency
GB201918404D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of aplha1-antitrypsin deficiency
EP4126877A1 (en) * 2020-04-03 2023-02-08 Vertex Pharmaceuticals Incorporated Pyrrolo[2,3-f]indazole and 2,4,5,10-tetrazatricyclo[7.3.0.03,7]dodeca-1,3(7),5,8,11-pentaene derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (aatd)
GB202009074D0 (en) 2020-06-15 2020-07-29 Z Factor Ltd Compound
KR20230044478A (ko) 2020-07-27 2023-04-04 버텍스 파마슈티칼스 인코포레이티드 Alpha-1 항트립신 조절제 제조 방법
US20240012010A1 (en) 2020-11-12 2024-01-11 Vertex Pharmaceuticals Incorporated Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat
KR20230110313A (ko) * 2020-11-17 2023-07-21 버텍스 파마슈티칼스 인코포레이티드 4-(5-(4-플루오로페닐)-6-(테트라하이드로-2H-피란-4-일)-1,5-디하이드로피롤로[2,3-f]인다졸-7-일)벤조산의 고형분 형태
GB202108523D0 (en) 2021-06-15 2021-07-28 Z Factor Ltd Compositions and their use for the treatment of alpha1-antitrypsin deficiency
CN114605385B (zh) * 2022-03-25 2023-09-08 河南大学 吲哚哌啶脲类trpv1拮抗/faah抑制双靶点药物及制备方法和应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790679A (fr) * 1971-11-03 1973-04-27 Ici Ltd Derives de l'indole
DK158590D0 (da) 1990-07-02 1990-07-02 Lundbeck & Co As H Indolderivater
JP2000072751A (ja) 1998-08-26 2000-03-07 Tanabe Seiyaku Co Ltd イソキノリノン誘導体
JP2000281654A (ja) 1999-03-26 2000-10-10 Tanabe Seiyaku Co Ltd イソキノリン誘導体
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
FR2802532A1 (fr) 1999-12-17 2001-06-22 Sanofi Synthelabo Derives de 2-phenyl-quinoleine, leur preparation et leur application en therapeutique
US6638929B2 (en) 1999-12-29 2003-10-28 Wyeth Tricyclic protein kinase inhibitors
EP1305308B1 (en) 2000-07-26 2006-12-20 Smithkline Beecham Plc Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
WO2002094790A1 (fr) 2001-05-23 2002-11-28 Mitsubishi Pharma Corporation Compose heterocyclique condense et son utilisation medicale
CA2465597A1 (en) 2001-11-14 2003-06-12 Ben Zion Dolitzky Amorphous and crystalline forms of losartan potassium and process for their preparation
US7208601B2 (en) 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
WO2011056222A1 (en) * 2009-11-05 2011-05-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods of treating disorders associated with protein aggregation
US20110224229A1 (en) 2010-03-10 2011-09-15 Astrazeneca Ab Novel Crystalline Form
US9572794B2 (en) 2014-08-06 2017-02-21 Vanderbilt University Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists
WO2016154051A1 (en) 2015-03-20 2016-09-29 University Of Florida Research Foundation, Inc. Combination therapy for treating infections diseases
JP2019516700A (ja) 2016-05-12 2019-06-20 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Ａｓｈ１ｌ阻害剤及びそれを用いた治療方法
WO2019076336A1 (zh) 2017-10-19 2019-04-25 江苏豪森药业集团有限公司 含吡唑基的三并环类衍生物、其制备方法和应用
ES2964964T3 (es) 2017-11-01 2024-04-10 Bristol Myers Squibb Co Compuestos bicíclicos puenteados como moduladores del receptor X farnesoide
CN107698505A (zh) 2017-11-20 2018-02-16 孙婷婷 一种诺得司他的制备方法
PE20211444A1 (es) 2017-12-13 2021-08-05 Lupin Ltd Componentes heterociclicos biciclicos sustituidos como inhibidores de prmt5
CA3088766A1 (en) 2018-01-31 2019-08-08 Merck Patent Gmbh Quinoline compounds as irak inhibitors and uses thereof
WO2019243841A1 (en) 2018-06-22 2019-12-26 Ucl Business Ltd Novel compounds
BR112021002267A8 (pt) 2018-08-07 2023-02-07 Merck Sharp & Dohme Inibidores de prmt5
US11623924B2 (en) 2018-10-05 2023-04-11 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
CN110776459B (zh) 2019-03-19 2023-01-24 江苏知原药业股份有限公司 7-羟基-2-喹诺酮-二硫代氨基甲酸酯类胆碱酯酶抑制剂
UY38696A (es) 2019-05-14 2020-11-30 Vertex Pharma Moduladores de alfa-1 antitripsina
TW202116303A (zh) 2019-10-02 2021-05-01 美商維泰克斯製藥公司 α—１抗胰蛋白酶缺乏症之治療方法
BR112022014861A2 (pt) 2020-01-30 2022-09-20 Vertex Pharma Métodos de tratamento para deficiência de alfa-1 antittripsina
US20230157999A1 (en) 2020-04-03 2023-05-25 Vertex Pharmaceuticals Incorporated Pyrano[4,3-b]indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (aatd)
IL296920A (en) 2020-04-03 2022-12-01 Vertex Pharma Indole derivatives as alpha-1-antitrypsin modulators for the treatment of alpha-1-antitrypsin deficiency (aatd)
WO2021203025A1 (en) 2020-04-03 2021-10-07 Vertex Pharmaceuticals Incorporated 1 h-pyrazolo[4,3-g]isoquinoline and 1 h-pyrazolo[4,3-g]quinoline derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)
JP2023520207A (ja) 2020-04-03 2023-05-16 バーテックス ファーマシューティカルズ インコーポレイテッド アルファ１－アンチトリプシンのモジュレーター
EP4126877A1 (en) 2020-04-03 2023-02-08 Vertex Pharmaceuticals Incorporated Pyrrolo[2,3-f]indazole and 2,4,5,10-tetrazatricyclo[7.3.0.03,7]dodeca-1,3(7),5,8,11-pentaene derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (aatd)
US20230159504A1 (en) 2020-04-03 2023-05-25 Vertex Pharmaceuticals Incorporated 7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (aatd)
KR20230044478A (ko) 2020-07-27 2023-04-04 버텍스 파마슈티칼스 인코포레이티드 Alpha-1 항트립신 조절제 제조 방법

Also Published As

Publication number Publication date
US20230265080A1 (en) 2023-08-24
EP3860712A1 (en) 2021-08-11
AU2019362753A1 (en) 2021-05-20
KR20210089656A (ko) 2021-07-16
CA3114672A1 (en) 2020-04-23
JP2022512588A (ja) 2022-02-07
UY38403A (es) 2020-04-30
MA53827A (fr) 2021-09-15
US11623924B2 (en) 2023-04-11
BR112021006392A2 (pt) 2021-07-06
CN113164761A (zh) 2021-07-23
TW202024091A (zh) 2020-07-01
WO2020081257A1 (en) 2020-04-23
CO2021005884A2 (es) 2021-05-20
MX2021003819A (es) 2021-06-23
IL281884A (en) 2021-05-31
US20210179587A1 (en) 2021-06-17

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