UY38403A - Moduladores de la alfa-1 antitripsina - Google Patents

Moduladores de la alfa-1 antitripsina

Info

Publication number
UY38403A
UY38403A UY0001038403A UY38403A UY38403A UY 38403 A UY38403 A UY 38403A UY 0001038403 A UY0001038403 A UY 0001038403A UY 38403 A UY38403 A UY 38403A UY 38403 A UY38403 A UY 38403A
Authority
UY
Uruguay
Prior art keywords
alpha
antitrypsin
modulators
antitrypsin modulators
aatd
Prior art date
Application number
UY0001038403A
Other languages
English (en)
Inventor
Peter Jones
Philippe Marcel Nuhant
Upul Keerthi Bandarage
Cavan Mckeon Bligh
Diane M Boucher
Fanning Lev Tyler Dewey
Mary Elizabeth Eccles
Jr Robert Francis Fimognari
Kevin James Gagnon
Michael John Boyd
Barrantes Pedro M García
Simon Giroux
Jr Ronald Lee Grey
Amy Beth Hall
Sarah Carol Hood
Dennis James Hurley
Joshua Kennedy Hussey
Johnson, Jr
Sarathy Kesavan
Adam Looker
Brad D Maxwell
John Patrick Maxwell
Ales Medek
Mettachit Navamal
Setu Roday
Stefanie Roeper
Rupa Sawant
Yi Shi
Rebecca Jane Swett
Qing Tang
Timothy Lewis Tapley
Stephen A Thomson
Michael Waldo
Jinwang Xu
Veronique Damagnez
Michael Aaron Brodney
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of UY38403A publication Critical patent/UY38403A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Nuevos compuestos, composiciones y métodos de uso y preparación de los mismos, que pueden ser útiles para el tratamiento de la deficiencia de alfa-1 antitripsina (AATD).
UY0001038403A 2018-10-05 2019-10-07 Moduladores de la alfa-1 antitripsina UY38403A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862742148P 2018-10-05 2018-10-05
US201862768662P 2018-11-16 2018-11-16

Publications (1)

Publication Number Publication Date
UY38403A true UY38403A (es) 2020-04-30

Family

ID=69467663

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001038403A UY38403A (es) 2018-10-05 2019-10-07 Moduladores de la alfa-1 antitripsina

Country Status (16)

Country Link
US (2) US11623924B2 (es)
EP (1) EP3860712A1 (es)
JP (1) JP2022512588A (es)
KR (1) KR20210089656A (es)
CN (1) CN113164761A (es)
AU (1) AU2019362753A1 (es)
BR (1) BR112021006392A2 (es)
CA (1) CA3114672A1 (es)
CO (1) CO2021005884A2 (es)
IL (1) IL281884A (es)
JO (1) JOP20210060A1 (es)
MA (1) MA53827A (es)
MX (1) MX2021003819A (es)
TW (1) TW202024091A (es)
UY (1) UY38403A (es)
WO (1) WO2020081257A1 (es)

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Publication number Priority date Publication date Assignee Title
JP2022512588A (ja) 2018-10-05 2022-02-07 バーテックス ファーマシューティカルズ インコーポレイテッド アルファ１アンチトリプシンのモジュレーター
US11884672B2 (en) 2019-05-14 2024-01-30 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
TW202116303A (zh) * 2019-10-02 2021-05-01 美商維泰克斯製藥公司 α—１抗胰蛋白酶缺乏症之治療方法
GB201918404D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of aplha1-antitrypsin deficiency
GB201918416D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency
GB201918410D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of alpha1-antitrypsin deficiency
GB201918414D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency
GB201918413D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of alpha1-antitrypsin deficiency
KR20220163429A (ko) * 2020-04-03 2022-12-09 버텍스 파마슈티칼스 인코포레이티드 알파-1-항트립신 결핍증(aatd) 치료를 위한 알파-1-항트립신 조절제로서의 피롤로[2,3-f]인다졸 유도체 및 2,4,5,10-테트라아자트리시클로[7.3.0.03,7]도데카-1,3(7),5,8,11-펜타엔 유도체
GB202009074D0 (en) 2020-06-15 2020-07-29 Z Factor Ltd Compound
AU2021318940A1 (en) 2020-07-27 2023-03-16 Vertex Pharmaceuticals Incorporated Processes for preparing modulators of alpha-1 antitrypsin
WO2022104353A1 (en) 2020-11-12 2022-05-19 Vertex Pharmaceuticals Incorporated Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat
IL302872A (en) * 2020-11-17 2023-07-01 Vertex Pharma Solid forms of 4-(5-(4-FLUOROPHENYL)-6-TETRAHYDRO-2H-PYRAN-4-YL)- 1,5-DIHYDROPYRROLO[2,3-F]INDAZOL-7-YL)Benzoic acid
GB202108523D0 (en) 2021-06-15 2021-07-28 Z Factor Ltd Compositions and their use for the treatment of alpha1-antitrypsin deficiency
CN114605385B (zh) * 2022-03-25 2023-09-08 河南大学 吲哚哌啶脲类trpv1拮抗/faah抑制双靶点药物及制备方法和应用

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US11884672B2 (en) 2019-05-14 2024-01-30 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
TW202116303A (zh) 2019-10-02 2021-05-01 美商維泰克斯製藥公司 α—１抗胰蛋白酶缺乏症之治療方法
CA3168807A1 (en) 2020-01-30 2021-08-05 Vertex Pharmaceuticals Incorporated Methods of treatment for alpha-1 antitrypsin deficiency
CA3177524A1 (en) 2020-04-03 2021-10-07 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
KR20220163429A (ko) 2020-04-03 2022-12-09 버텍스 파마슈티칼스 인코포레이티드 알파-1-항트립신 결핍증(aatd) 치료를 위한 알파-1-항트립신 조절제로서의 피롤로[2,3-f]인다졸 유도체 및 2,4,5,10-테트라아자트리시클로[7.3.0.03,7]도데카-1,3(7),5,8,11-펜타엔 유도체
CN115768772A (zh) 2020-04-03 2023-03-07 弗特克斯药品有限公司 作为用于治疗α-1抗胰蛋白酶缺乏症(AATD)的α-1抗胰蛋白酶调节剂的吡喃并[4,3-b]L吲哚衍生物
AU2021246527A1 (en) 2020-04-03 2022-10-27 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
WO2021203023A1 (en) 2020-04-03 2021-10-07 Vertex Pharmaceuticals Incorporated Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)
CN115715292A (zh) 2020-04-03 2023-02-24 弗特克斯药品有限公司 作为用于治疗α-1-抗胰蛋白酶缺乏症(AATD)的α-1-抗胰蛋白酶调节剂的1H-吡唑并[4,3-g]异喹啉和1H-吡唑并[4,3-g]喹啉衍生物
AU2021318940A1 (en) 2020-07-27 2023-03-16 Vertex Pharmaceuticals Incorporated Processes for preparing modulators of alpha-1 antitrypsin

Also Published As

Publication number Publication date
US20230265080A1 (en) 2023-08-24
CO2021005884A2 (es) 2021-05-20
CA3114672A1 (en) 2020-04-23
TW202024091A (zh) 2020-07-01
IL281884A (en) 2021-05-31
KR20210089656A (ko) 2021-07-16
JOP20210060A1 (ar) 2023-01-30
MA53827A (fr) 2021-09-15
EP3860712A1 (en) 2021-08-11
CN113164761A (zh) 2021-07-23
JP2022512588A (ja) 2022-02-07
BR112021006392A2 (pt) 2021-07-06
US11623924B2 (en) 2023-04-11
AU2019362753A1 (en) 2021-05-20
US20210179587A1 (en) 2021-06-17
WO2020081257A1 (en) 2020-04-23
MX2021003819A (es) 2021-06-23

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