JP2023520207A5 - - Google Patents
Info
- Publication number
- JP2023520207A5 JP2023520207A5 JP2022559580A JP2022559580A JP2023520207A5 JP 2023520207 A5 JP2023520207 A5 JP 2023520207A5 JP 2022559580 A JP2022559580 A JP 2022559580A JP 2022559580 A JP2022559580 A JP 2022559580A JP 2023520207 A5 JP2023520207 A5 JP 2023520207A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- tautomer
- compound
- ring
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063004713P | 2020-04-03 | 2020-04-03 | |
| US63/004,713 | 2020-04-03 | ||
| PCT/US2021/025591 WO2021203007A1 (en) | 2020-04-03 | 2021-04-02 | Substituted 5-hydroxyindole compounds as modulators of alpha-1 antitrypsin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023520207A JP2023520207A (ja) | 2023-05-16 |
| JP2023520207A5 true JP2023520207A5 (enExample) | 2024-04-10 |
| JP7733670B2 JP7733670B2 (ja) | 2025-09-03 |
Family
ID=76444526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022559580A Active JP7733670B2 (ja) | 2020-04-03 | 2021-04-02 | アルファ１－アンチトリプシンのモジュレーター |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230339915A1 (enExample) |
| EP (1) | EP4126817A1 (enExample) |
| JP (1) | JP7733670B2 (enExample) |
| CN (1) | CN115916749B (enExample) |
| AU (1) | AU2021246104A1 (enExample) |
| CA (1) | CA3177524A1 (enExample) |
| WO (1) | WO2021203007A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20210060A1 (ar) | 2018-10-05 | 2023-01-30 | Vertex Pharma | معدلات لمضاد تريبسين ألفا-1 |
| US11884672B2 (en) | 2019-05-14 | 2024-01-30 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
| CN115697969B (zh) | 2020-04-03 | 2026-08-11 | 弗特克斯药品有限公司 | α-1抗胰蛋白酶调节剂 |
| AU2021247285A1 (en) | 2020-04-03 | 2022-10-27 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
| CA3177531A1 (en) * | 2020-04-03 | 2021-10-07 | Vertex Pharmaceuticals Incorporated | Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd) |
| JP7732999B2 (ja) | 2020-04-03 | 2025-09-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | アルファ１－アンチトリプシンのモジュレーター |
| EP4188931A2 (en) | 2020-07-27 | 2023-06-07 | Vertex Pharmaceuticals Incorporated | Processes for preparing modulators of alpha-1 antitrypsin |
| WO2022104353A1 (en) | 2020-11-12 | 2022-05-19 | Vertex Pharmaceuticals Incorporated | Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat |
| CN117384133A (zh) * | 2023-10-11 | 2024-01-12 | 内蒙古益泽制药有限公司 | 一种2-溴-1-（吡啶-2-基）吲哚化合物及其制备方法 |
| WO2026136445A1 (en) | 2024-12-17 | 2026-06-25 | Sub21, Inc. | A1at modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA200700243A1 (ru) | 2004-07-14 | 2007-08-31 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы лечения гепатита с |
| US8097644B2 (en) * | 2006-03-28 | 2012-01-17 | Allergan, Inc. | Indole compounds having sphingosine-1-phosphate (S1P) receptor antagonist |
| JP5107589B2 (ja) * | 2007-02-13 | 2012-12-26 | 旭化成株式会社 | インドール誘導体 |
| RS54165B1 (sr) * | 2008-04-16 | 2015-12-31 | Karo Bio Ab | Novi ligandi za estrogenski receptor |
-
2021
- 2021-04-02 WO PCT/US2021/025591 patent/WO2021203007A1/en not_active Ceased
- 2021-04-02 US US17/916,388 patent/US20230339915A1/en active Pending
- 2021-04-02 EP EP21732608.1A patent/EP4126817A1/en active Pending
- 2021-04-02 CA CA3177524A patent/CA3177524A1/en active Pending
- 2021-04-02 JP JP2022559580A patent/JP7733670B2/ja active Active
- 2021-04-02 AU AU2021246104A patent/AU2021246104A1/en active Pending
- 2021-04-02 CN CN202180039825.2A patent/CN115916749B/zh active Active
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