JP2021534097A5 - - Google Patents
Info
- Publication number
- JP2021534097A5 JP2021534097A5 JP2021506621A JP2021506621A JP2021534097A5 JP 2021534097 A5 JP2021534097 A5 JP 2021534097A5 JP 2021506621 A JP2021506621 A JP 2021506621A JP 2021506621 A JP2021506621 A JP 2021506621A JP 2021534097 A5 JP2021534097 A5 JP 2021534097A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- independently selected
- cycloalkyl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862715858P | 2018-08-08 | 2018-08-08 | |
| US62/715,858 | 2018-08-08 | ||
| PCT/US2019/045424 WO2020033488A1 (en) | 2018-08-08 | 2019-08-07 | Substituted benzimidazoles as pad4 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021534097A JP2021534097A (ja) | 2021-12-09 |
| JP2021534097A5 true JP2021534097A5 (enExample) | 2022-08-08 |
| JP7483678B2 JP7483678B2 (ja) | 2024-05-15 |
Family
ID=67766299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021506621A Active JP7483678B2 (ja) | 2018-08-08 | 2019-08-07 | Ｐａｄ４阻害剤としての置換ベンズイミダゾール |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20220402950A1 (enExample) |
| EP (1) | EP3833438B1 (enExample) |
| JP (1) | JP7483678B2 (enExample) |
| KR (1) | KR102825194B1 (enExample) |
| CN (1) | CN112805066A (enExample) |
| AU (1) | AU2019318415A1 (enExample) |
| BR (1) | BR112021002089A2 (enExample) |
| CA (1) | CA3108871A1 (enExample) |
| CL (1) | CL2021000292A1 (enExample) |
| CO (1) | CO2021001219A2 (enExample) |
| EA (1) | EA202190464A1 (enExample) |
| ES (1) | ES2973714T3 (enExample) |
| IL (1) | IL280641A (enExample) |
| MX (1) | MX2021001471A (enExample) |
| PE (1) | PE20211067A1 (enExample) |
| SG (1) | SG11202101176YA (enExample) |
| TW (1) | TW202019411A (enExample) |
| WO (1) | WO2020033488A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7447080B2 (ja) * | 2018-08-08 | 2024-03-11 | ブリストル－マイヤーズ スクイブ カンパニー | Ｐａｄ４阻害剤としての置換チエノピロール |
| MX2021001565A (es) | 2018-08-08 | 2021-04-19 | Bristol Myers Squibb Co | Inhibidores tipo indol y azaindol de enzimas peptidil arginina deiminasas (pad). |
| WO2021158840A1 (en) | 2020-02-06 | 2021-08-12 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| WO2021222353A1 (en) | 2020-04-30 | 2021-11-04 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| TW202233174A (zh) | 2020-12-22 | 2022-09-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| WO2022140390A1 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| CN116492462B (zh) * | 2023-02-03 | 2023-09-22 | 山东第一医科大学附属眼科医院(山东省眼科医院) | Pad4抑制剂在防治角膜移植术后免疫排斥反应中的应用 |
| KR20260041867A (ko) | 2023-07-21 | 2026-03-27 | 브리스톨-마이어스 스큅 컴퍼니 | Pad4 조정제의 시트룰린화 및 활성을 평가하는 방법 |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101916443B1 (ko) | 2012-07-26 | 2018-11-08 | 글락소 그룹 리미티드 | Pad4 억제제로서의 2-(아자인돌-2-일) 벤즈이미다졸 |
| KR20180005250A (ko) * | 2015-05-21 | 2018-01-15 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Pad4 억제제로서의 벤조이미다졸 유도체 |
| AR107032A1 (es) * | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| AR107030A1 (es) * | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
| WO2018022897A1 (en) * | 2016-07-27 | 2018-02-01 | Padlock Therapeutics, Inc. | Covalent inhibitors of pad4 |
-
2019
- 2019-08-07 MX MX2021001471A patent/MX2021001471A/es unknown
- 2019-08-07 US US17/265,844 patent/US20220402950A1/en active Pending
- 2019-08-07 EP EP19759133.2A patent/EP3833438B1/en active Active
- 2019-08-07 PE PE2021000170A patent/PE20211067A1/es unknown
- 2019-08-07 TW TW108128157A patent/TW202019411A/zh unknown
- 2019-08-07 CA CA3108871A patent/CA3108871A1/en active Pending
- 2019-08-07 KR KR1020217006450A patent/KR102825194B1/ko active Active
- 2019-08-07 SG SG11202101176YA patent/SG11202101176YA/en unknown
- 2019-08-07 JP JP2021506621A patent/JP7483678B2/ja active Active
- 2019-08-07 AU AU2019318415A patent/AU2019318415A1/en not_active Abandoned
- 2019-08-07 ES ES19759133T patent/ES2973714T3/es active Active
- 2019-08-07 BR BR112021002089-6A patent/BR112021002089A2/pt not_active Application Discontinuation
- 2019-08-07 EA EA202190464A patent/EA202190464A1/ru unknown
- 2019-08-07 WO PCT/US2019/045424 patent/WO2020033488A1/en not_active Ceased
- 2019-08-07 CN CN201980064958.8A patent/CN112805066A/zh active Pending
-
2021
- 2021-02-03 CL CL2021000292A patent/CL2021000292A1/es unknown
- 2021-02-03 CO CONC2021/0001219A patent/CO2021001219A2/es unknown
- 2021-02-04 IL IL280641A patent/IL280641A/en unknown