JP2021534104A5 - - Google Patents
Info
- Publication number
- JP2021534104A5 JP2021534104A5 JP2021506660A JP2021506660A JP2021534104A5 JP 2021534104 A5 JP2021534104 A5 JP 2021534104A5 JP 2021506660 A JP2021506660 A JP 2021506660A JP 2021506660 A JP2021506660 A JP 2021506660A JP 2021534104 A5 JP2021534104 A5 JP 2021534104A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- independently selected
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862715845P | 2018-08-08 | 2018-08-08 | |
| US62/715,845 | 2018-08-08 | ||
| PCT/US2019/045459 WO2020033514A1 (en) | 2018-08-08 | 2019-08-07 | Benzimidazole inhibitors of pad enzymes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021534104A JP2021534104A (ja) | 2021-12-09 |
| JP2021534104A5 true JP2021534104A5 (enExample) | 2022-08-16 |
| JP7434281B2 JP7434281B2 (ja) | 2024-02-20 |
Family
ID=67766305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021506660A Active JP7434281B2 (ja) | 2018-08-08 | 2019-08-07 | Ｐａｄ酵素のベンズイミダゾール阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220348562A1 (enExample) |
| EP (1) | EP3833439B1 (enExample) |
| JP (1) | JP7434281B2 (enExample) |
| KR (1) | KR20210042933A (enExample) |
| CN (1) | CN112789087B (enExample) |
| ES (1) | ES2956090T3 (enExample) |
| WO (1) | WO2020033514A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7447080B2 (ja) | 2018-08-08 | 2024-03-11 | ブリストル－マイヤーズ スクイブ カンパニー | Ｐａｄ４阻害剤としての置換チエノピロール |
| MX2021001565A (es) | 2018-08-08 | 2021-04-19 | Bristol Myers Squibb Co | Inhibidores tipo indol y azaindol de enzimas peptidil arginina deiminasas (pad). |
| WO2021158840A1 (en) | 2020-02-06 | 2021-08-12 | Bristol-Myers Squibb Company | Macrocyclic pad4 inhibitors useful as immunosuppressant |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| WO2021222353A1 (en) | 2020-04-30 | 2021-11-04 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
| TW202233174A (zh) | 2020-12-22 | 2022-09-01 | 美商基利科學股份有限公司 | 肽基精胺酸去亞胺酶之抑制劑 |
| WO2022140390A1 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
| KR20260041867A (ko) | 2023-07-21 | 2026-03-27 | 브리스톨-마이어스 스큅 컴퍼니 | Pad4 조정제의 시트룰린화 및 활성을 평가하는 방법 |
| WO2026020127A2 (en) | 2024-07-19 | 2026-01-22 | Bristol-Myers Squibb Company | Methods of assessing citrullination and activity of pad2 modulators |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1214330A1 (en) * | 1999-09-21 | 2002-06-19 | LION Bioscience AG | Benzimidazole derivatives and combinatorial libraries thereof |
| WO2010051245A1 (en) * | 2008-11-03 | 2010-05-06 | Merck Sharp & Dohme Corp. | Benzimidazole and aza-benzimidazole carboxamides |
| KR101916443B1 (ko) * | 2012-07-26 | 2018-11-08 | 글락소 그룹 리미티드 | Pad4 억제제로서의 2-(아자인돌-2-일) 벤즈이미다졸 |
| KR20180005250A (ko) * | 2015-05-21 | 2018-01-15 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Pad4 억제제로서의 벤조이미다졸 유도체 |
| AR107032A1 (es) * | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores bicíclicos de pad4 |
| AR107030A1 (es) * | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
| CA3015482A1 (en) * | 2016-02-23 | 2017-08-31 | Padlock Therapeutics, Inc. | Heteroaryl inhibitors of pad4 |
| WO2018022897A1 (en) * | 2016-07-27 | 2018-02-01 | Padlock Therapeutics, Inc. | Covalent inhibitors of pad4 |
| CN107311933B (zh) * | 2017-06-28 | 2020-12-22 | 中国人民解放军军事医学科学院毒物药物研究所 | 一类苯并咪唑衍生物，及其制备方法和用途 |
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2019
- 2019-08-07 US US17/265,840 patent/US20220348562A1/en active Pending
- 2019-08-07 KR KR1020217006470A patent/KR20210042933A/ko active Pending
- 2019-08-07 JP JP2021506660A patent/JP7434281B2/ja active Active
- 2019-08-07 ES ES19759140T patent/ES2956090T3/es active Active
- 2019-08-07 EP EP19759140.7A patent/EP3833439B1/en active Active
- 2019-08-07 WO PCT/US2019/045459 patent/WO2020033514A1/en not_active Ceased
- 2019-08-07 CN CN201980064964.3A patent/CN112789087B/zh active Active