JP2021531311A5 - - Google Patents
Info
- Publication number
- JP2021531311A5 JP2021531311A5 JP2021504235A JP2021504235A JP2021531311A5 JP 2021531311 A5 JP2021531311 A5 JP 2021531311A5 JP 2021504235 A JP2021504235 A JP 2021504235A JP 2021504235 A JP2021504235 A JP 2021504235A JP 2021531311 A5 JP2021531311 A5 JP 2021531311A5
- Authority
- JP
- Japan
- Prior art keywords
- membered
- alkyl
- cycloalkyl
- aryl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018096781 | 2018-07-24 | ||
| CNPCT/CN2018/096781 | 2018-07-24 | ||
| PCT/US2019/043112 WO2020023551A1 (en) | 2018-07-24 | 2019-07-23 | Naphthyridine compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021531311A JP2021531311A (ja) | 2021-11-18 |
| JP2021531311A5 true JP2021531311A5 (enExample) | 2022-07-22 |
| JP7386842B2 JP7386842B2 (ja) | 2023-11-27 |
Family
ID=67551416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021504235A Active JP7386842B2 (ja) | 2018-07-24 | 2019-07-23 | ナフチリジン化合物およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12297210B2 (enExample) |
| EP (1) | EP3826721B1 (enExample) |
| JP (1) | JP7386842B2 (enExample) |
| CN (1) | CN112533677A (enExample) |
| TW (1) | TW202012405A (enExample) |
| WO (1) | WO2020023551A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113454070A (zh) * | 2018-09-30 | 2021-09-28 | 豪夫迈·罗氏有限公司 | 噌啉化合物及用于hpk1依赖性疾患诸如癌症的治疗 |
| PE20211655A1 (es) | 2018-10-31 | 2021-08-24 | Gilead Sciences Inc | Compuestos de 6-azabencimidazol sustituidos como inhibidores de hpk1 |
| WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| TWI826690B (zh) | 2019-05-23 | 2023-12-21 | 美商基利科學股份有限公司 | 經取代之烯吲哚酮化物及其用途 |
| TW202140473A (zh) | 2020-01-15 | 2021-11-01 | 美商纜圖藥品公司 | Map4k1抑制劑 |
| WO2022063140A1 (en) * | 2020-09-23 | 2022-03-31 | Shenzhen Ionova Life Science Co., Ltd. | Pyrimidine and pyridine derivatives as hpk1 modulator and methods using same |
| CN114907375B (zh) * | 2021-02-07 | 2026-03-31 | 苏州信诺维医药科技股份有限公司 | 杂环化合物、其制备方法、药物组合物及应用 |
| CN114907374B (zh) * | 2021-02-07 | 2026-03-10 | 苏州信诺维医药科技股份有限公司 | 杂环化合物、其制备方法、药物组合物及应用 |
| MX2024000751A (es) | 2021-07-14 | 2024-03-25 | Blueprint Medicines Corp | Compuestos heterociclicos como inhibidores de map4k1. |
| CN117940406A (zh) * | 2021-07-15 | 2024-04-26 | 缆图药品公司 | Map4k1抑制剂 |
| EP4373817B1 (en) | 2021-07-20 | 2025-05-21 | Astrazeneca AB | Substituted pyrazine-2-carboxamides as hpk1 inhibitors for the treatment of cancer |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| CA2612241C (en) | 2005-07-01 | 2018-11-06 | Medarex, Inc. | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
| KR20100044251A (ko) | 2007-08-15 | 2010-04-29 | 싸이토키네틱스, 인코포레이티드 | 특정 화학 물질, 조성물 및 방법 |
| JP2012500652A (ja) | 2008-08-25 | 2012-01-12 | アンプリミューン、インコーポレーテッド | 標的化共刺激ポリペプチドおよび癌を処置するための使用方法 |
| EP4209510B1 (en) | 2008-12-09 | 2024-01-31 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| NO2504364T3 (enExample) | 2009-11-24 | 2018-01-06 | ||
| US20130017199A1 (en) | 2009-11-24 | 2013-01-17 | AMPLIMMUNE ,Inc. a corporation | Simultaneous inhibition of pd-l1/pd-l2 |
| EP2770998B1 (en) | 2011-10-27 | 2020-04-29 | Merck Sharp & Dohme Corp. | Factor ixa inhibitors |
| ES2872555T3 (es) * | 2015-06-25 | 2021-11-02 | Univ Health Network | Inhibidores de HPK1 y métodos de uso de los mismos |
| US20180072718A1 (en) * | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| JP7025426B2 (ja) * | 2016-11-30 | 2022-02-24 | アリアド ファーマシューティカルズ， インコーポレイテッド | 造血前駆体キナーゼ１（ｈｐｋ１）阻害剤としてのアニリノピリミジンａｓ |
| BR112019018093A2 (pt) * | 2017-03-30 | 2020-06-16 | F. Hoffmann-La Roche Ag | Compostos, composição, método de inibição de hpk1, métodos para melhorar uma resposta imune e para tratar um distúrbio e usos do composto |
-
2019
- 2019-07-23 TW TW108126069A patent/TW202012405A/zh unknown
- 2019-07-23 CN CN201980049189.4A patent/CN112533677A/zh active Pending
- 2019-07-23 WO PCT/US2019/043112 patent/WO2020023551A1/en not_active Ceased
- 2019-07-23 JP JP2021504235A patent/JP7386842B2/ja active Active
- 2019-07-23 EP EP19750197.6A patent/EP3826721B1/en active Active
-
2021
- 2021-01-22 US US17/156,384 patent/US12297210B2/en active Active
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