JP2021531311A5 - - Google Patents
Info
- Publication number
- JP2021531311A5 JP2021531311A5 JP2021504235A JP2021504235A JP2021531311A5 JP 2021531311 A5 JP2021531311 A5 JP 2021531311A5 JP 2021504235 A JP2021504235 A JP 2021504235A JP 2021504235 A JP2021504235 A JP 2021504235A JP 2021531311 A5 JP2021531311 A5 JP 2021531311A5
- Authority
- JP
- Japan
- Prior art keywords
- membered
- alkyl
- cycloalkyl
- aryl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018096781 | 2018-07-24 | ||
| CNPCT/CN2018/096781 | 2018-07-24 | ||
| PCT/US2019/043112 WO2020023551A1 (en) | 2018-07-24 | 2019-07-23 | Naphthyridine compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021531311A JP2021531311A (ja) | 2021-11-18 |
| JP2021531311A5 true JP2021531311A5 (enExample) | 2022-07-22 |
| JP7386842B2 JP7386842B2 (ja) | 2023-11-27 |
Family
ID=67551416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021504235A Active JP7386842B2 (ja) | 2018-07-24 | 2019-07-23 | ナフチリジン化合物およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12297210B2 (enExample) |
| EP (1) | EP3826721B1 (enExample) |
| JP (1) | JP7386842B2 (enExample) |
| CN (1) | CN112533677A (enExample) |
| TW (1) | TW202012405A (enExample) |
| WO (1) | WO2020023551A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3856724A1 (en) * | 2018-09-30 | 2021-08-04 | F. Hoffmann-La Roche AG | Cinnoline compounds and for the treatment of hpk1-dependent disorders such as cancer |
| WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| US11203591B2 (en) | 2018-10-31 | 2021-12-21 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| TW202140473A (zh) * | 2020-01-15 | 2021-11-01 | 美商纜圖藥品公司 | Map4k1抑制劑 |
| WO2022063140A1 (en) * | 2020-09-23 | 2022-03-31 | Shenzhen Ionova Life Science Co., Ltd. | Pyrimidine and pyridine derivatives as hpk1 modulator and methods using same |
| CN114907375B (zh) * | 2021-02-07 | 2026-03-31 | 苏州信诺维医药科技股份有限公司 | 杂环化合物、其制备方法、药物组合物及应用 |
| CN114907374B (zh) * | 2021-02-07 | 2026-03-10 | 苏州信诺维医药科技股份有限公司 | 杂环化合物、其制备方法、药物组合物及应用 |
| WO2023288254A1 (en) * | 2021-07-14 | 2023-01-19 | Blueprint Medicines Corporation | Heterocyclic compounds as map4k1 inhibitors |
| US20240336630A1 (en) * | 2021-07-15 | 2024-10-10 | Blueprint Medicines Corporation | Map4k1 inhibitors |
| TW202321239A (zh) | 2021-07-20 | 2023-06-01 | 瑞典商阿斯特捷利康公司 | 作為ｈｐｋ１抑制劑用於治療癌症之經取代的吡𠯤—２—甲醯胺 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| US8088793B2 (en) | 2007-08-15 | 2012-01-03 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| JP2012500855A (ja) | 2008-08-25 | 2012-01-12 | アンプリミューン、インコーポレーテッド | Ｐｄ−１アンタゴニストおよび感染性疾患を処置するための方法 |
| EP3255060A1 (en) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| PL2504364T3 (pl) | 2009-11-24 | 2017-12-29 | Medimmune Limited | Ukierunkowane środki wiążące przeciwko B7-H1 |
| EP2770998B1 (en) | 2011-10-27 | 2020-04-29 | Merck Sharp & Dohme Corp. | Factor ixa inhibitors |
| MA42456B1 (fr) * | 2015-06-25 | 2021-06-30 | Univ Health Network | Inhibiteurs de hpk1 et leurs procédés d'utilisation |
| WO2018049214A1 (en) * | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| WO2018102366A1 (en) * | 2016-11-30 | 2018-06-07 | Ariad Pharmaceuticals, Inc. | Anilinopyrimidines as haematopoietic progenitor kinase 1 (hpk1) inhibitors |
| AU2018244935A1 (en) * | 2017-03-30 | 2019-08-15 | F. Hoffmann-La Roche Ag | Naphthyridines as inhibitors of HPK1 |
-
2019
- 2019-07-23 TW TW108126069A patent/TW202012405A/zh unknown
- 2019-07-23 WO PCT/US2019/043112 patent/WO2020023551A1/en not_active Ceased
- 2019-07-23 EP EP19750197.6A patent/EP3826721B1/en active Active
- 2019-07-23 CN CN201980049189.4A patent/CN112533677A/zh active Pending
- 2019-07-23 JP JP2021504235A patent/JP7386842B2/ja active Active
-
2021
- 2021-01-22 US US17/156,384 patent/US12297210B2/en active Active
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