|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
DE3034001A1
(de)
|
1980-09-10 |
1982-04-22 |
Hoechst Ag, 6000 Frankfurt |
Isochinolinderivate, verfahren zu ihrer hersellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung
|
|
PL176081B1
(pl)
|
1995-06-06 |
1999-04-30 |
Politechnika Warszawska |
Sposób wytwarzania 3-aminoizochinoliny i jej N-mono oraz N,N-dipodstawionych pochodnych
|
|
CA2374947A1
(en)
|
1999-05-24 |
2000-11-30 |
Robert M. Scarborough |
Inhibitors of factor xa
|
|
US7199149B2
(en)
|
2003-10-01 |
2007-04-03 |
Bristol Myers Squibb Company |
Monocyclic and bicyclic lactams as factor Xa inhibitors
|
|
JP2007008816A
(ja)
|
2003-10-15 |
2007-01-18 |
Ube Ind Ltd |
新規イソキノリン誘導体
|
|
EP1657241A1
(en)
|
2004-11-03 |
2006-05-17 |
Schering Aktiengesellschaft |
Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors
|
|
EP1655295A1
(en)
|
2004-11-03 |
2006-05-10 |
Schering Aktiengesellschaft |
Anthranilamide pyridinureas as VEGF receptor kinase inhibitors
|
|
US20060156485A1
(en)
|
2005-01-14 |
2006-07-20 |
The Procter & Gamble Company |
Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof
|
|
CN101213187B
(zh)
|
2005-06-28 |
2012-06-06 |
塞诺菲-安万特股份有限公司 |
作为rho-激酶抑制剂的异喹啉衍生物
|
|
PT1907424E
(pt)
|
2005-07-01 |
2015-10-09 |
Squibb & Sons Llc |
Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
|
|
TW200800194A
(en)
|
2005-10-28 |
2008-01-01 |
Lilly Co Eli |
Kinase inhibitors
|
|
US7572809B2
(en)
|
2005-12-19 |
2009-08-11 |
Hoffmann-La Roche Inc. |
Isoquinoline aminopyrazole derivatives
|
|
WO2007084391A2
(en)
|
2006-01-18 |
2007-07-26 |
Amgen Inc. |
Thiazole compounds as protein kinase b ( pkb) inhibitors
|
|
CA2651072A1
(en)
*
|
2006-05-01 |
2007-11-08 |
Pfizer Products Inc. |
Substituted 2-amino-fused heterocyclic compounds
|
|
MX2009005964A
(es)
*
|
2006-12-27 |
2009-06-15 |
Sanofi Aventis |
Derivados de isoquinolina sustituidos con cicloalquilamina.
|
|
EP1975166A1
(en)
|
2007-03-30 |
2008-10-01 |
Bayer Schering Pharma AG |
Synthesis of anthranilamides
|
|
EP2008658A1
(en)
|
2007-06-28 |
2008-12-31 |
Bayer Schering Pharma Aktiengesellschaft |
Synergistic combination of anthranilamide pyridinureas and benzamide derivatives
|
|
US8088793B2
(en)
|
2007-08-15 |
2012-01-03 |
Cytokinetics, Inc. |
Certain chemical entities, compositions, and methods
|
|
GB0803018D0
(en)
|
2008-02-19 |
2008-03-26 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
|
US8309577B2
(en)
|
2008-04-23 |
2012-11-13 |
Bristol-Myers Squibb Company |
Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands
|
|
US7863291B2
(en)
|
2008-04-23 |
2011-01-04 |
Bristol-Myers Squibb Company |
Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
|
|
GB0812969D0
(en)
|
2008-07-15 |
2008-08-20 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
|
JP2012500855A
(ja)
|
2008-08-25 |
2012-01-12 |
アンプリミューン、インコーポレーテッド |
Pd−1アンタゴニストおよび感染性疾患を処置するための方法
|
|
EP3255060A1
(en)
|
2008-12-09 |
2017-12-13 |
F. Hoffmann-La Roche AG |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
PL2504364T3
(pl)
|
2009-11-24 |
2017-12-29 |
Medimmune Limited |
Ukierunkowane środki wiążące przeciwko B7-H1
|
|
WO2011066342A2
(en)
|
2009-11-24 |
2011-06-03 |
Amplimmune, Inc. |
Simultaneous inhibition of pd-l1/pd-l2
|
|
WO2011073845A1
(en)
|
2009-12-16 |
2011-06-23 |
Pfizer Inc. |
N-linked hydroxamic acid derivatives useful as antibacterial agents
|
|
US20110152246A1
(en)
|
2009-12-18 |
2011-06-23 |
Intermune, Inc. |
Novel inhibitors of hepatitis c virus replication
|
|
RU2012146246A
(ru)
|
2010-03-31 |
2014-05-10 |
Актелион Фармасьютиклз Лтд |
Антибактериальные производные изохинолин-3-илмочевины
|
|
ES2546465T3
(es)
|
2010-10-29 |
2015-09-23 |
Pfizer Inc |
Inhibidores de N1/N2-lactama acetil-CoA carboxilasa
|
|
EA026115B1
(ru)
|
2010-12-17 |
2017-03-31 |
Ф. Хоффманн-Ля Рош Аг |
Замещенные 6,6-конденсированные азотсодержащие гетероциклические соединения и их применение
|
|
CA2830866A1
(en)
|
2011-04-08 |
2012-10-11 |
Pfizer Inc. |
Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
|
|
US8940735B2
(en)
|
2011-06-23 |
2015-01-27 |
Viamet Pharmaceuticals, Inc. |
Metalloenzyme inhibitor compounds
|
|
WO2013003315A2
(en)
|
2011-06-26 |
2013-01-03 |
President And Fellows Of Harvard College |
Methods for preparing isoquinolines
|
|
WO2013169793A2
(en)
|
2012-05-09 |
2013-11-14 |
Ipierian, Inc. |
Methods and compositions for tdp-43 proteinopathies
|
|
TW201408658A
(zh)
|
2012-08-27 |
2014-03-01 |
Array Biopharma Inc |
絲胺酸/酥胺酸激酶抑制劑
|
|
GB201216018D0
(en)
*
|
2012-09-07 |
2012-10-24 |
Cancer Rec Tech Ltd |
Pharmacologically active compounds
|
|
RU2015113597A
(ru)
|
2012-09-14 |
2016-11-10 |
Итернити Байосайенс Инк. |
Производные аминоизохинолина в качестве ингибиторов протеинкиназы
|
|
WO2014123900A1
(en)
|
2013-02-05 |
2014-08-14 |
Sirenas Marine Discovery |
Anti-cancer and anti-hiv compounds
|
|
DK3016946T3
(da)
|
2013-07-03 |
2023-01-09 |
Karyopharm Therapeutics Inc |
Substituerede benzofuranyl- og benzoxazolylforbindelser og anvendelser deraf
|
|
US10130625B2
(en)
|
2014-07-22 |
2018-11-20 |
University Of Maryland, College Park |
Linked diaryl compounds with anticancer properties and methods of using the same
|
|
GB201416754D0
(en)
|
2014-09-23 |
2014-11-05 |
Mission Therapeutics Ltd |
Novel compounds
|
|
MA42456B1
(fr)
*
|
2015-06-25 |
2021-06-30 |
Univ Health Network |
Inhibiteurs de hpk1 et leurs procédés d'utilisation
|
|
US20170247393A1
(en)
|
2015-10-20 |
2017-08-31 |
Forum Pharmaceuticals, Inc. |
Aminoisoxazoline Compounds as Agonists of Alpha7-Nicotinic Acetylcholine Receptors
|
|
CU20180059A7
(es)
|
2015-12-17 |
2018-10-04 |
Gilead Sciences Inc |
Compuestos inhibidores de la quinasa de unión a tank
|
|
CN107163022B
(zh)
|
2016-03-07 |
2021-07-16 |
上海如絮生物科技有限公司 |
一种异喹啉类化合物、其中间体、制备方法和应用
|
|
CA3016341A1
(en)
|
2016-03-07 |
2017-09-14 |
Merck Sharp & Dohme Corp. |
Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections
|
|
GB201604647D0
(en)
|
2016-03-18 |
2016-05-04 |
Mission Therapeutics Ltd |
Novel compounds
|
|
CN107266421B
(zh)
|
2016-04-08 |
2020-12-04 |
正大天晴药业集团股份有限公司 |
取代的苯并咪唑类衍生物
|
|
AR108326A1
(es)
|
2016-04-27 |
2018-08-08 |
Samumed Llc |
Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
|
|
AR108325A1
(es)
|
2016-04-27 |
2018-08-08 |
Samumed Llc |
Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
|
|
US10280164B2
(en)
*
|
2016-09-09 |
2019-05-07 |
Incyte Corporation |
Pyrazolopyridone compounds and uses thereof
|
|
CN115819417A
(zh)
*
|
2016-09-09 |
2023-03-21 |
因赛特公司 |
作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途
|
|
TWI771327B
(zh)
|
2016-10-05 |
2022-07-21 |
英商使命醫療公司 |
新穎化合物
|
|
WO2018102366A1
(en)
*
|
2016-11-30 |
2018-06-07 |
Ariad Pharmaceuticals, Inc. |
Anilinopyrimidines as haematopoietic progenitor kinase 1 (hpk1) inhibitors
|
|
WO2018119263A1
(en)
|
2016-12-22 |
2018-06-28 |
Incyte Corporation |
Heterocyclic compounds derivatives as pd-l1 internalization inducers
|
|
HUE064141T2
(hu)
|
2017-01-20 |
2024-02-28 |
Arcus Biosciences Inc |
Azolopirimidin rákkal összefüggõ rendellenességek kezelésére
|
|
JP6453507B2
(ja)
|
2017-03-30 |
2019-01-16 |
アムジエン・インコーポレーテツド |
Mcl−1タンパク質を阻害する化合物
|
|
EP3601259B1
(en)
|
2017-03-30 |
2022-02-23 |
F. Hoffmann-La Roche AG |
Isoquinolines as inhibitors of hpk1
|
|
AR111307A1
(es)
|
2017-03-30 |
2019-06-26 |
Takeda Pharmaceuticals Co |
Derivados de 1,2-dihidroespiro[ciclohexan-1,3-indol] o 1,2-dihidroespiro[ciclohexan-1,3-pirrolo[3,2-b]piridina] como inhibidores de hexakisfosfato quinasa
|
|
JP7252908B2
(ja)
|
2017-06-14 |
2023-04-05 |
トレベナ・インコーポレイテッド |
S1p1活性を調節するための化合物およびその使用法
|
|
US10604514B2
(en)
|
2017-10-19 |
2020-03-31 |
Samumed, Llc |
6-(5-membered heteroaryl)isoquinolin-3-yl carboxamides and preparation and use thereof
|
|
WO2019084497A1
(en)
|
2017-10-27 |
2019-05-02 |
Samumed, Llc |
6- (HETEROARYL AND ARYL WITH 6 CHAINS) ISOQUINOLIN-3-YL CARBOXAMIDES, THEIR PREPARATION AND THEIR USE
|
|
WO2019155066A1
(en)
|
2018-02-12 |
2019-08-15 |
Bayer Aktiengesellschaft |
Fungicidal oxadiazoles
|
|
TW202019905A
(zh)
|
2018-07-24 |
2020-06-01 |
瑞士商赫孚孟拉羅股份公司 |
異喹啉化合物及其用途
|
|
TW202024053A
(zh)
|
2018-10-02 |
2020-07-01 |
美商建南德克公司 |
異喹啉化合物及其用途
|
|
US11612606B2
(en)
|
2018-10-03 |
2023-03-28 |
Genentech, Inc. |
8-aminoisoquinoline compounds and uses thereof
|
|
WO2020072695A1
(en)
|
2018-10-03 |
2020-04-09 |
Genentech, Inc. |
8-aminoisoquinoline compounds and uses thereof
|