JP2009543802A5 - - Google Patents
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- JP2009543802A5 JP2009543802A5 JP2009519653A JP2009519653A JP2009543802A5 JP 2009543802 A5 JP2009543802 A5 JP 2009543802A5 JP 2009519653 A JP2009519653 A JP 2009519653A JP 2009519653 A JP2009519653 A JP 2009519653A JP 2009543802 A5 JP2009543802 A5 JP 2009543802A5
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- JP
- Japan
- Prior art keywords
- nrr
- nhr
- acyl
- independently
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 27
- 125000002252 acyl group Chemical group 0.000 claims 20
- 125000003710 aryl alkyl group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 125000004404 heteroalkyl group Chemical group 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000000304 alkynyl group Chemical group 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000030507 AIDS Diseases 0.000 claims 3
- 208000031886 HIV Infections Diseases 0.000 claims 3
- 208000037357 HIV infectious disease Diseases 0.000 claims 3
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 206010027476 Metastases Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- -1 arylheteroaryl Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 208000037819 metastatic cancer Diseases 0.000 claims 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83000606P | 2006-07-11 | 2006-07-11 | |
| US81999706P | 2006-07-11 | 2006-07-11 | |
| PCT/US2007/073285 WO2008008854A2 (en) | 2006-07-11 | 2007-07-11 | Cxcr4 antagonists including diazine and triazine structures for the treatment of medical disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009543802A JP2009543802A (ja) | 2009-12-10 |
| JP2009543802A5 true JP2009543802A5 (enExample) | 2011-09-01 |
Family
ID=38924159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009519653A Pending JP2009543802A (ja) | 2006-07-11 | 2007-07-11 | 医学的疾患の治療のためのジアジン及びトリアジン構造を含むｃｘｃｒ４アンタゴニスト |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8080659B2 (enExample) |
| EP (1) | EP2041067A4 (enExample) |
| JP (1) | JP2009543802A (enExample) |
| WO (1) | WO2008008854A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1838321A4 (en) * | 2005-01-07 | 2009-03-18 | Univ Emory | CXCR4 ANTAGONISTS FOR THE TREATMENT OF HIV INFECTION |
| US8338448B2 (en) | 2008-03-28 | 2012-12-25 | Altiris Therapeutics, Inc. | Chemokine receptor modulators |
| US20120294803A1 (en) * | 2010-01-27 | 2012-11-22 | Emory University | Cxcr4 antagonists for imaging of cancer and inflammatory disorders |
| EP2380596A1 (en) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopentapeptide derivatives and uses thereof |
| EP2380597A1 (en) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopeptide derivatives and uses thereof |
| US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
| MX365242B (es) | 2011-05-16 | 2019-05-28 | Genzyme Corp | El uso del antagonista cxcr4: 1,1´-[1,4-fenileno-bis-(metileno)-bi s-1, 4, 8, 11-tetraazaciclotetradecano (plerixaflor) para el tratamiento del síndrome de whim. |
| WO2013060865A1 (en) | 2011-10-28 | 2013-05-02 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| ES2634939T3 (es) | 2011-11-07 | 2017-09-29 | Emory University | Compuestos que contienen aminas tricíclicas para el tratamiento o prevención de síntomas asociados con la disfunción endocrina |
| EP3296310A1 (en) | 2011-12-22 | 2018-03-21 | GlycoMimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
| JP6392773B2 (ja) | 2012-12-07 | 2018-09-19 | グリコミメティクス， インコーポレイテッド | 造血細胞の動員のためにｅ−セレクチンアンタゴニストを使用する化合物、組成物および方法 |
| HUE044571T2 (hu) | 2014-06-06 | 2019-11-28 | Univ Muenchen Tech | Módosított ciklopentapeptidek és alkalmazásaik |
| HUE045542T2 (hu) | 2014-12-03 | 2019-12-30 | Glycomimetics Inc | E-szelektinek és CXCR4 kemokin receptorok heterobifunkcionális inhibitorai |
| US10434195B2 (en) * | 2015-08-03 | 2019-10-08 | Emory University | Methylsulfonamide derivatives and uses related thereto |
| US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
| JP2019524791A (ja) | 2016-08-08 | 2019-09-05 | グリコミメティクス， インコーポレイテッド | Ｅ−セレクチンの阻害剤もしくはｃｘｃｒ４の阻害剤との、またはｅ−セレクチンおよびｃｘｃｒ４両方のヘテロ二機能性阻害剤とのｔ細胞チェックポイント阻害剤の組み合わせ |
| WO2018068010A1 (en) | 2016-10-07 | 2018-04-12 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
| MA46589A (fr) | 2016-10-24 | 2019-08-28 | Yumanity Therapeutics Inc | Composés et utilisations de ces derniers |
| MA47212A (fr) | 2017-01-06 | 2019-11-13 | Yumanity Therapeutics Inc | Méthodes de traitement de troubles neurologiques |
| US11197877B2 (en) | 2017-03-15 | 2021-12-14 | Glycomimetics. Inc. | Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists |
| CN109553604B (zh) * | 2017-09-25 | 2021-08-27 | 盛世泰科生物医药技术(苏州)有限公司 | 4-氨基嘧啶衍生物作cxcr4抑制剂及其应用 |
| WO2019084157A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | COMPOUNDS AND USES THEREOF |
| EP3717013A1 (en) | 2017-11-30 | 2020-10-07 | GlycoMimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| KR20200104889A (ko) | 2017-12-29 | 2020-09-04 | 글리코미메틱스, 인크. | E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제 |
| AU2019230013A1 (en) | 2018-03-05 | 2020-09-10 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
| CN112312913B (zh) | 2018-03-23 | 2024-03-08 | 詹森药业有限公司 | 化合物和其用途 |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| MX2021008903A (es) | 2019-01-24 | 2021-11-04 | Yumanity Therapeutics Inc | Compuestos y usos de los mismos. |
| JP2022526890A (ja) * | 2019-03-22 | 2022-05-27 | ユマニティ セラピューティクス，インコーポレーテッド | 化合物及びその使用 |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US776465A (en) * | 1904-04-15 | 1904-11-29 | Charles A Gildemeyer | Spigot. |
| US5993817A (en) | 1995-01-23 | 1999-11-30 | Xenotech | Method to ameliorate osteolysis and metastasis |
| US6358915B1 (en) | 1995-03-07 | 2002-03-19 | George Washington University | Methods for inhibiting metastasis |
| AU6390696A (en) | 1995-06-20 | 1997-01-22 | Trustees Of Boston University | Hypoxia-responsive adhesion molecules, specific antibodies, nd their uses |
| US6344545B1 (en) | 1996-06-14 | 2002-02-05 | Progenics Pharmaceuticals, Inc. | Method for preventing HIV-1 infection of CD4+ cells |
| US5922676A (en) | 1996-09-20 | 1999-07-13 | The Burnham Institute | Methods of inhibiting cancer by using superfibronectin |
| US5874438A (en) | 1996-10-11 | 1999-02-23 | Bayer Aktiengesellschaft | 2,2'-bridged bis-2,4-diaminoquinazolines |
| US6534626B1 (en) | 1997-12-01 | 2003-03-18 | The United States Of America As Represented By The Department Of Health & Human Services | Chemokine variants |
| AU762472B2 (en) | 1998-03-13 | 2003-06-26 | University Of British Columbia, The | Therapeutic chemokine receptor antagonists |
| CA2327530A1 (en) | 1998-05-05 | 1999-11-11 | Adherex Technologies, Inc. | Compounds and methods for modulating nonclassical cadherin-mediated functions |
| CA2319153A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Novel sodium channel drugs and uses |
| US6420354B1 (en) * | 1998-06-08 | 2002-07-16 | Advanced Medicine, Inc. | Sodium channel drugs and uses |
| EP1050583A4 (en) | 1998-11-24 | 2005-02-02 | Hisamitsu Pharmaceutical Co | INHIBITORS OF HIV INFECTIONS |
| US6750348B1 (en) | 1999-03-24 | 2004-06-15 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds |
| IL145401A0 (en) | 1999-03-24 | 2002-06-30 | Anormed Inc | Chemokine receptor binding heterocyclic compounds |
| EP2275447A1 (en) | 1999-11-24 | 2011-01-19 | Schering Corporation | Methods of inhibiting metastasis |
| US20030220482A1 (en) | 2000-02-03 | 2003-11-27 | Ziwei Huang | Novel peptide antagonist of CXCR4 derived from the N-terminus of the viral chemokine vMIP-II |
| WO2001070727A1 (en) * | 2000-03-23 | 2001-09-27 | Sanofi-Synthelabo | 2-(arylalkylamino)pyrimidone derivatives and 2-(heteroarylalkylamino)pyrimidone derivatives |
| AU5811001A (en) | 2000-05-09 | 2001-11-20 | Univ British Columbia | Cxcr4 antagonist treatment of hematopoietic cells |
| WO2002002516A2 (en) * | 2000-06-30 | 2002-01-10 | Thomas Jefferson University | Inhibitors of hiv integrase |
| CN1630517A (zh) | 2001-05-24 | 2005-06-22 | 吴羽化学工业株式会社 | 包含含氮化合物的具有cxcr4拮抗作用的药物 |
| WO2003029218A1 (en) | 2001-09-28 | 2003-04-10 | Kureha Chemical Industry Company, Limited | Novel nitrogenous compound and use thereof |
| US7354932B2 (en) | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| WO2004020462A1 (ja) | 2002-08-27 | 2004-03-11 | Fujii, Nobutaka | Ｃｘｃｒ４拮抗薬およびその用途 |
| DE10240064A1 (de) | 2002-08-30 | 2004-03-11 | Universitätsklinikum Freiburg | CXCR4-Rezeptor-Antagonisten |
| US20040132642A1 (en) | 2002-11-12 | 2004-07-08 | Government Of The U.S.A., Represented By The Secretary, Dept. Of Health & Human Services | Methods of inhibiting metastasis or growth of a tumor cell |
| US20050002939A1 (en) | 2002-12-23 | 2005-01-06 | Albert Zlotnik | Tumor killing/tumor regression using CXCR4 antagonists |
| CA2520406A1 (en) | 2003-03-27 | 2004-10-14 | Emory University | Cxcr4 antagonists and methods of their use |
| WO2004091518A2 (en) | 2003-04-11 | 2004-10-28 | Anormed Inc. | Cxcr4 chemokine receptor binding compounds |
| AU2004232361A1 (en) | 2003-04-22 | 2004-11-04 | Anormed Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| DK1687297T3 (da) * | 2003-11-24 | 2014-09-22 | Prometic Biosciences Inc | Triazindimerer til behandling af autoimmunsygdomme |
| GB0405193D0 (en) * | 2004-03-08 | 2004-04-21 | Medical Res Council | Compounds |
| RU2007130077A (ru) * | 2005-01-07 | 2009-02-20 | Эмори Юниверсити (Us) | Антагонисты cxcr4 и их применение для лечения вич-инфекции |
| EP1838321A4 (en) | 2005-01-07 | 2009-03-18 | Univ Emory | CXCR4 ANTAGONISTS FOR THE TREATMENT OF HIV INFECTION |
| US20080227799A1 (en) | 2006-07-11 | 2008-09-18 | Liotta Dennis C | CXCR4 Antagonists Including Heteroatoms for the Treatment of Medical Disorders |
-
2007
- 2007-07-11 JP JP2009519653A patent/JP2009543802A/ja active Pending
- 2007-07-11 US US11/776,476 patent/US8080659B2/en active Active
- 2007-07-11 EP EP07812814A patent/EP2041067A4/en not_active Withdrawn
- 2007-07-11 WO PCT/US2007/073285 patent/WO2008008854A2/en not_active Ceased