|
CN110678466B
(zh)
*
|
2017-03-30 |
2023-01-31 |
豪夫迈·罗氏有限公司 |
作为hpk1抑制剂的二氮杂萘类
|
|
WO2019062803A1
(zh)
*
|
2017-09-28 |
2019-04-04 |
基石药业 |
作为a2a受体抑制剂的并环类衍生物
|
|
WO2019090198A1
(en)
|
2017-11-06 |
2019-05-09 |
Bristol-Myers Squibb Company |
Isofuranone compounds useful as hpk1 inhibitors
|
|
WO2019160882A1
(en)
|
2018-02-13 |
2019-08-22 |
Gilead Sciences, Inc. |
Pd-1/pd-l1 inhibitors
|
|
CN112135825A
(zh)
|
2018-03-13 |
2020-12-25 |
夏尔人类遗传性治疗公司 |
血浆激肽释放酶抑制剂及其用途
|
|
KR102591947B1
(ko)
|
2018-04-19 |
2023-10-25 |
길리애드 사이언시즈, 인코포레이티드 |
Pd-1/pd-l1 억제제
|
|
PE20210642A1
(es)
|
2018-07-13 |
2021-03-23 |
Gilead Sciences Inc |
Inhibidores de pd-1/pd-l1
|
|
JP7386842B2
(ja)
*
|
2018-07-24 |
2023-11-27 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
ナフチリジン化合物およびその使用
|
|
WO2020069402A1
(en)
*
|
2018-09-30 |
2020-04-02 |
Genentech, Inc. |
Cinnoline compounds and for the treatment of hpk1-dependent disorders such as cancer
|
|
EP3873608A1
(en)
|
2018-10-31 |
2021-09-08 |
Gilead Sciences, Inc. |
Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
|
|
EP4371987B9
(en)
*
|
2018-10-31 |
2025-11-26 |
Gilead Sciences, Inc. |
Substituted 6-azabenzimidazole compounds as hpk1 inhibitors
|
|
US20220047603A1
(en)
|
2018-12-11 |
2022-02-17 |
Bayer Aktiengesellschaft |
Substituted pyrrolopyridine-derivatives
|
|
TW202102488A
(zh)
|
2019-03-26 |
2021-01-16 |
比利時商健生藥品公司 |
Hpk1抑制劑
|
|
MA55478A
(fr)
|
2019-03-26 |
2022-02-09 |
Janssen Pharmaceutica Nv |
Inhibiteurs bicycliques de hpk1
|
|
US11453681B2
(en)
|
2019-05-23 |
2022-09-27 |
Gilead Sciences, Inc. |
Substituted eneoxindoles and uses thereof
|
|
CN114245807B
(zh)
|
2019-06-25 |
2025-05-02 |
吉利德科学公司 |
Flt3l-fc融合蛋白和使用方法
|
|
TWI848141B
(zh)
|
2019-07-04 |
2024-07-11 |
英屬開曼群島商百濟神州有限公司 |
及其用途
|
|
WO2021004535A1
(en)
*
|
2019-07-11 |
2021-01-14 |
Nanjing Zhengxiang Pharmaceuticals Co., Ltd. |
Cinnolines as inhibitors of hpk 1
|
|
US12459958B2
(en)
|
2019-07-17 |
2025-11-04 |
Beone Medicines I Gmbh |
Tricyclic compounds as HPK1 inhibitor and the use thereof
|
|
CN110483402B
(zh)
*
|
2019-08-12 |
2021-07-23 |
上海毕得医药科技股份有限公司 |
一种3-溴-5-苯基-1h-吡唑的合成方法
|
|
US12673933B2
(en)
|
2019-08-21 |
2026-07-07 |
Beone Medicines I Gmbh |
Aminopyrazine compounds as HPK1 inhibitor and the use thereof
|
|
US12215105B2
(en)
*
|
2019-09-13 |
2025-02-04 |
Nimbus Saturn, Inc. |
HPK1 antagonists and uses thereof
|
|
WO2021055589A1
(en)
|
2019-09-18 |
2021-03-25 |
Shire Human Genetic Therapies, Inc. |
Heteroaryl plasma kallikrein inhibitors
|
|
CN114728962B
(zh)
|
2019-09-18 |
2025-09-19 |
武田药品工业有限公司 |
血浆激肽释放酶抑制剂及其用途
|
|
PH12022550835A1
(en)
|
2019-10-18 |
2023-07-03 |
Forty Seven Inc |
Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia
|
|
NZ786589A
(en)
|
2019-10-31 |
2025-03-28 |
Forty Seven Llc |
Anti-cd47 and anti-cd20 based treatment of blood cancer
|
|
TWI778443B
(zh)
|
2019-11-12 |
2022-09-21 |
美商基利科學股份有限公司 |
Mcl1抑制劑
|
|
CN115362003B
(zh)
|
2019-12-24 |
2024-03-22 |
卡尔那生物科学株式会社 |
二酰基甘油激酶调节化合物
|
|
EP4090663A1
(en)
|
2020-01-15 |
2022-11-23 |
Blueprint Medicines Corporation |
Map4k1 inhibitors
|
|
TWI890283B
(zh)
|
2020-02-14 |
2025-07-11 |
美商基利科學股份有限公司 |
結合ccr8之抗體及融合蛋白及其用途
|
|
CN113336747A
(zh)
*
|
2020-03-03 |
2021-09-03 |
轶诺(浙江)药业有限公司 |
新型hpk1抑制剂及其制备方法和应用
|
|
JP7564888B2
(ja)
|
2020-05-01 |
2024-10-09 |
ギリアード サイエンシーズ, インコーポレイテッド |
Cd73阻害性2,4-ジオキソピリミジン化合物
|
|
WO2021249913A1
(en)
|
2020-06-09 |
2021-12-16 |
Bayer Aktiengesellschaft |
2'-(quinolin-3-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxylate derivatives and related compounds as map4k1 (hpk1) inhibitors for the treatment of cancer
|
|
CN111965367A
(zh)
*
|
2020-07-23 |
2020-11-20 |
北京大学第三医院(北京大学第三临床医学院) |
Hip-55在作为gpcr偏向药物靶点中的应用
|
|
WO2022064458A1
(en)
*
|
2020-09-28 |
2022-03-31 |
1ST Biotherapeutics, Inc. |
Indazoles as hematopoietic progenitor kinase 1 (hpk1) inhibitors and methods of using same
|
|
WO2022167627A1
(en)
|
2021-02-05 |
2022-08-11 |
Bayer Aktiengesellschaft |
Map4k1 inhibitors
|
|
CN114907375B
(zh)
*
|
2021-02-07 |
2026-03-31 |
苏州信诺维医药科技股份有限公司 |
杂环化合物、其制备方法、药物组合物及应用
|
|
CN114907374B
(zh)
*
|
2021-02-07 |
2026-03-10 |
苏州信诺维医药科技股份有限公司 |
杂环化合物、其制备方法、药物组合物及应用
|
|
WO2022174253A1
(en)
|
2021-02-12 |
2022-08-18 |
Nimbus Saturn, Inc. |
Hpk1 antagonists and uses thereof
|
|
CN117295737A
(zh)
|
2021-03-05 |
2023-12-26 |
林伯士萨顿公司 |
Hpk1拮抗剂和其用途
|
|
CN115073308A
(zh)
*
|
2021-03-15 |
2022-09-20 |
苏州信礼发医药技术有限公司 |
1-氨甲基-1-环丙醇的合成方法
|
|
US20240226106A1
(en)
*
|
2021-03-17 |
2024-07-11 |
Shire Human Genetic Therapies, Inc. |
Inhibitors of plasma kallikrein
|
|
WO2022213062A1
(en)
|
2021-03-29 |
2022-10-06 |
Nimbus Saturn, Inc. |
Hpk1 antagonists and uses thereof
|
|
TW202304434A
(zh)
*
|
2021-04-08 |
2023-02-01 |
大陸商杭州阿諾生物醫藥科技有限公司 |
一種高活性的hpk1激酶抑制劑
|
|
TW202302145A
(zh)
|
2021-04-14 |
2023-01-16 |
美商基利科學股份有限公司 |
CD47/SIRPα結合及NEDD8活化酶E1調節次單元之共抑制以用於治療癌症
|
|
WO2022222951A1
(zh)
*
|
2021-04-22 |
2022-10-27 |
浙江海正药业股份有限公司 |
芳香稠合环类衍生物及其制备方法和用途
|
|
WO2022245671A1
(en)
|
2021-05-18 |
2022-11-24 |
Gilead Sciences, Inc. |
Methods of using flt3l-fc fusion proteins
|
|
CN117355531A
(zh)
|
2021-06-23 |
2024-01-05 |
吉利德科学公司 |
二酰基甘油激酶调节化合物
|
|
MX2023014762A
(es)
|
2021-06-23 |
2024-01-15 |
Gilead Sciences Inc |
Compuestos moduladores de diacilglicerol quinasa.
|
|
JP7651018B2
(ja)
|
2021-06-23 |
2025-03-25 |
ギリアード サイエンシーズ, インコーポレイテッド |
ジアシルグリセロールキナーゼ調節化合物
|
|
EP4359413A1
(en)
|
2021-06-23 |
2024-05-01 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
MX2024000751A
(es)
*
|
2021-07-14 |
2024-03-25 |
Blueprint Medicines Corp |
Compuestos heterociclicos como inhibidores de map4k1.
|
|
EP4423078A1
(en)
|
2021-10-28 |
2024-09-04 |
Gilead Sciences, Inc. |
Pyridizin-3(2h)-one derivatives
|
|
PE20241186A1
(es)
|
2021-10-29 |
2024-06-03 |
Gilead Sciences Inc |
Compuestos de cd73
|
|
WO2023107954A1
(en)
|
2021-12-08 |
2023-06-15 |
Dragonfly Therapeutics, Inc. |
Antibodies targeting 5t4 and uses thereof
|
|
US20230203202A1
(en)
|
2021-12-08 |
2023-06-29 |
Dragonfly Therapeutics, Inc. |
Proteins binding nkg2d, cd16 and 5t4
|
|
US20240124412A1
(en)
|
2021-12-22 |
2024-04-18 |
Gilead Sciences, Inc. |
Ikaros zinc finger family degraders and uses thereof
|
|
CN118488948A
(zh)
|
2021-12-22 |
2024-08-13 |
吉利德科学公司 |
Ikaros锌指家族降解剂及其用途
|
|
CA3248911A1
(en)
|
2022-01-28 |
2023-08-03 |
Gilead Sciences, Inc. |
POLY(ADENOSINE DIPHOSPHATE-RIBOSE) POLYMERASE 7 INHIBITORS
|
|
PL4245756T3
(pl)
|
2022-03-17 |
2025-02-17 |
Gilead Sciences, Inc. |
Środki degradujące palec cynkowy z rodziny ikaros i ich zastosowania
|
|
AU2023240346A1
(en)
|
2022-03-24 |
2024-09-19 |
Gilead Sciences, Inc. |
Combination therapy for treating trop-2 expressing cancers
|
|
TWI876305B
(zh)
|
2022-04-05 |
2025-03-11 |
美商基利科學股份有限公司 |
用於治療結腸直腸癌之組合療法
|
|
WO2023193759A1
(en)
*
|
2022-04-07 |
2023-10-12 |
Insilico Medicine Ip Limited |
Hpk1 antagonists and uses thereof
|
|
EP4511127A1
(en)
|
2022-04-21 |
2025-02-26 |
Gilead Sciences, Inc. |
Kras g12d modulating compounds
|
|
AU2023294765A1
(en)
*
|
2022-06-17 |
2024-12-12 |
Sundance Biosciences, Inc. |
Kinase modulators and methods of use thereof
|
|
WO2024006929A1
(en)
|
2022-07-01 |
2024-01-04 |
Gilead Sciences, Inc. |
Cd73 compounds
|
|
WO2024003773A1
(en)
*
|
2022-07-01 |
2024-01-04 |
Pfizer Inc. |
2,7-naphthyridine compounds as mastl inhibitors
|
|
US20240091351A1
(en)
|
2022-09-21 |
2024-03-21 |
Gilead Sciences, Inc. |
FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY
|
|
JP2025531158A
(ja)
*
|
2022-09-21 |
2025-09-19 |
武田薬品工業株式会社 |
シクロプロパンカルボン酸の合成
|
|
CN119894905A
(zh)
*
|
2022-09-23 |
2025-04-25 |
广州威诺森医药科技有限公司 |
一种骈环吡啶类甾体合成酶抑制剂及其制备方法和应用
|
|
EP4638436A1
(en)
|
2022-12-22 |
2025-10-29 |
Gilead Sciences, Inc. |
Prmt5 inhibitors and uses thereof
|
|
WO2024215754A1
(en)
|
2023-04-11 |
2024-10-17 |
Gilead Sciences, Inc. |
Kras modulating compounds
|
|
PE20260121A1
(es)
|
2023-04-21 |
2026-01-16 |
Gilead Sciences Inc |
Inhibidores de prmt5 y usos de los mismos
|
|
WO2024243025A1
(en)
*
|
2023-05-19 |
2024-11-28 |
Ikena Oncology, Inc. |
Naphthyl-substituted pyrido[4,3-d]pyrimidines and related compounds and their use in treating medical conditions
|
|
JP2026522894A
(ja)
|
2023-06-30 |
2026-07-09 |
ギリアード サイエンシーズ, インコーポレイテッド |
Kras調節化合物
|
|
CN121568935A
(zh)
|
2023-07-26 |
2026-02-24 |
吉利德科学公司 |
Parp7抑制剂
|
|
AU2024297978A1
(en)
|
2023-07-26 |
2026-02-05 |
Gilead Sciences, Inc. |
Parp7 inhibitors
|
|
US20250109147A1
(en)
|
2023-09-08 |
2025-04-03 |
Gilead Sciences, Inc. |
Kras g12d modulating compounds
|
|
EP4774280A1
(en)
|
2023-09-08 |
2026-07-15 |
Gilead Sciences, Inc. |
Kras g12d modulating compounds
|
|
WO2025096589A1
(en)
|
2023-11-03 |
2025-05-08 |
Gilead Sciences, Inc. |
Prmt5 inhibitors and uses thereof
|
|
US20250230168A1
(en)
|
2023-12-22 |
2025-07-17 |
Gilead Sciences, Inc. |
Azaspiro wrn inhibitors
|
|
WO2025245003A1
(en)
|
2024-05-21 |
2025-11-27 |
Gilead Sciences, Inc. |
Prmt5 inhibitors and uses thereof
|
|
US20260098049A1
(en)
|
2024-08-12 |
2026-04-09 |
Gilead Sciences, Inc. |
Kras modulating compounds
|
|
US20260130893A1
(en)
|
2024-10-21 |
2026-05-14 |
Gilead Sciences, Inc. |
Prmt5 inhibitors and uses thereof
|
|
WO2026136515A1
(en)
|
2024-12-19 |
2026-06-25 |
Gilead Sciences, Inc. |
Parp7 inhibitors
|