JP2020512974A5 - - Google Patents

Info

Publication number
JP2020512974A5
JP2020512974A5 JP2019552613A JP2019552613A JP2020512974A5 JP 2020512974 A5 JP2020512974 A5 JP 2020512974A5 JP 2019552613 A JP2019552613 A JP 2019552613A JP 2019552613 A JP2019552613 A JP 2019552613A JP 2020512974 A5 JP2020512974 A5 JP 2020512974A5
Authority
JP
Japan
Prior art keywords
alkyl
substituted
independently
pharmaceutically acceptable
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019552613A
Other languages
English (en)
Japanese (ja)
Other versions
JP7154221B2 (ja
JP2020512974A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/025562 external-priority patent/WO2018183956A1/en
Publication of JP2020512974A publication Critical patent/JP2020512974A/ja
Publication of JP2020512974A5 publication Critical patent/JP2020512974A5/ja
Application granted granted Critical
Publication of JP7154221B2 publication Critical patent/JP7154221B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019552613A 2017-03-30 2018-03-30 Hpk1の阻害剤としてのナフチリジン Active JP7154221B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2017078792 2017-03-30
CNPCT/CN2017/078792 2017-03-30
CNPCT/CN2018/076909 2018-02-15
CN2018076909 2018-02-15
PCT/US2018/025562 WO2018183956A1 (en) 2017-03-30 2018-03-30 Naphthyridines as inhibitors of hpk1

Publications (3)

Publication Number Publication Date
JP2020512974A JP2020512974A (ja) 2020-04-30
JP2020512974A5 true JP2020512974A5 (enExample) 2022-06-08
JP7154221B2 JP7154221B2 (ja) 2022-10-17

Family

ID=62223184

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019552613A Active JP7154221B2 (ja) 2017-03-30 2018-03-30 Hpk1の阻害剤としてのナフチリジン

Country Status (12)

Country Link
US (2) US10407424B2 (enExample)
EP (1) EP3601284B1 (enExample)
JP (1) JP7154221B2 (enExample)
KR (1) KR20190136028A (enExample)
CN (1) CN110678466B (enExample)
AU (1) AU2018244935A1 (enExample)
BR (1) BR112019018093A2 (enExample)
CA (1) CA3052492A1 (enExample)
IL (1) IL268262A (enExample)
MX (1) MX2019011511A (enExample)
TW (1) TW201904964A (enExample)
WO (1) WO2018183956A1 (enExample)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019018093A2 (pt) * 2017-03-30 2020-06-16 F. Hoffmann-La Roche Ag Compostos, composição, método de inibição de hpk1, métodos para melhorar uma resposta imune e para tratar um distúrbio e usos do composto
AU2018341781B2 (en) * 2017-09-28 2023-03-30 Cstone Pharmaceuticals Fused ring derivative as A2A receptor inhibitor
WO2019090198A1 (en) 2017-11-06 2019-05-09 Bristol-Myers Squibb Company Isofuranone compounds useful as hpk1 inhibitors
KR102708681B1 (ko) 2018-02-13 2024-09-26 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
WO2019178129A1 (en) 2018-03-13 2019-09-19 Shire Human Genetic Therapies, Inc. Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof
EP4600247A3 (en) 2018-04-19 2025-11-19 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
UA126421C2 (uk) 2018-07-13 2022-09-28 Гіліад Сайєнсіз, Інк. Інгібітори pd-1/pd-l1
TW202012405A (zh) * 2018-07-24 2020-04-01 瑞士商赫孚孟拉羅股份公司 萘啶化合物及其用途
CN113454070A (zh) * 2018-09-30 2021-09-28 豪夫迈·罗氏有限公司 噌啉化合物及用于hpk1依赖性疾患诸如癌症的治疗
WO2020092528A1 (en) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
PE20211655A1 (es) 2018-10-31 2021-08-24 Gilead Sciences Inc Compuestos de 6-azabencimidazol sustituidos como inhibidores de hpk1
US20220047603A1 (en) 2018-12-11 2022-02-17 Bayer Aktiengesellschaft Substituted pyrrolopyridine-derivatives
US12492194B2 (en) 2019-03-26 2025-12-09 Janssen Pharmaceutica Nv HPK1 inhibitors
CA3129772A1 (en) 2019-03-26 2020-10-01 Janssen Pharmaceutica Nv Bicyclic hpk1 inhibitors
TWI826690B (zh) 2019-05-23 2023-12-21 美商基利科學股份有限公司 經取代之烯吲哚酮化物及其用途
AU2020301161B2 (en) 2019-06-25 2023-10-26 Gilead Sciences, Inc. FLT3L-Fc fusion proteins and methods of use
TWI848141B (zh) 2019-07-04 2024-07-11 英屬開曼群島商百濟神州有限公司 及其用途
TW202116753A (zh) * 2019-07-11 2021-05-01 大陸商南京征祥醫藥有限公司 以噌啉作為hpk1的抑制劑
CN112239473B (zh) 2019-07-17 2023-12-08 百济神州(北京)生物科技有限公司 作为hpk1抑制剂的三环化合物的制备方法
CN110483402B (zh) * 2019-08-12 2021-07-23 上海毕得医药科技股份有限公司 一种3-溴-5-苯基-1h-吡唑的合成方法
WO2021032148A1 (en) * 2019-08-21 2021-02-25 Beigene, Ltd. Aminopyrazine compounds as hpk1 inhibitor and the use thereof
PH12022550605A1 (en) * 2019-09-13 2023-09-25 Nimbus Saturn Inc Hpk1 antagonists and uses thereof
US11370803B2 (en) 2019-09-18 2022-06-28 Takeda Pharmaceutical Company Limited Heteroaryl plasma kallikrein inhibitors
PT4031547T (pt) 2019-09-18 2024-08-27 Takeda Pharmaceuticals Co Inibidores de calicreína plasmática e utilizações dos mesmos
KR102902719B1 (ko) 2019-10-18 2025-12-24 포티 세븐, 엘엘씨 골수이형성 증후군 및 급성 골수성 백혈병을 치료하기 위한 조합 치료
CA3153636A1 (en) 2019-10-31 2021-05-06 Forty Seven, Inc. Anti-cd47 and anti-cd20 based treatment of blood cancer
TWI778443B (zh) 2019-11-12 2022-09-21 美商基利科學股份有限公司 Mcl1抑制劑
EP4445902A3 (en) 2019-12-24 2024-12-18 Carna Biosciences, Inc. Diacylglycerol kinase modulating compounds
TW202140473A (zh) * 2020-01-15 2021-11-01 美商纜圖藥品公司 Map4k1抑制劑
CN117964757A (zh) 2020-02-14 2024-05-03 吉利德科学公司 与ccr8结合的抗体和融合蛋白及其用途
CN113336747A (zh) * 2020-03-03 2021-09-03 轶诺(浙江)药业有限公司 新型hpk1抑制剂及其制备方法和应用
US12110294B2 (en) 2020-05-01 2024-10-08 Gilead Sciences, Inc. CD73 compounds
WO2021249913A1 (en) 2020-06-09 2021-12-16 Bayer Aktiengesellschaft 2'-(quinolin-3-yl)-5',6'-dihydrospiro[azetidine-3,4'-pyrrolo[1,2-b]pyrazole]-1-carboxylate derivatives and related compounds as map4k1 (hpk1) inhibitors for the treatment of cancer
CN111965367A (zh) * 2020-07-23 2020-11-20 北京大学第三医院(北京大学第三临床医学院) Hip-55在作为gpcr偏向药物靶点中的应用
TWI908894B (zh) * 2020-09-28 2025-12-21 南韓商福斯特生物股份有限公司 作為造血前驅細胞激酶1(hpk1)抑制劑的吲唑及其用途
US20240174683A1 (en) 2021-02-05 2024-05-30 Bayer Aktiengesellschaft Map4k1 inhibitors
CN114907375B (zh) * 2021-02-07 2026-03-31 苏州信诺维医药科技股份有限公司 杂环化合物、其制备方法、药物组合物及应用
CN114907374B (zh) * 2021-02-07 2026-03-10 苏州信诺维医药科技股份有限公司 杂环化合物、其制备方法、药物组合物及应用
WO2022174253A1 (en) 2021-02-12 2022-08-18 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
CN117295737A (zh) 2021-03-05 2023-12-26 林伯士萨顿公司 Hpk1拮抗剂和其用途
CN115073308A (zh) * 2021-03-15 2022-09-20 苏州信礼发医药技术有限公司 1-氨甲基-1-环丙醇的合成方法
CN117396469A (zh) * 2021-03-17 2024-01-12 武田药品工业株式会社 血浆激肽释放酶的抑制剂
WO2022213062A1 (en) 2021-03-29 2022-10-06 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
WO2022214009A1 (zh) * 2021-04-08 2022-10-13 杭州阿诺生物医药科技有限公司 一种高活性的hpk1激酶抑制剂
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 CD47/SIRPα結合及NEDD8活化酶E1調節次單元之共抑制以用於治療癌症
CN117136190A (zh) * 2021-04-22 2023-11-28 浙江海正药业股份有限公司 芳香稠合环类衍生物及其制备方法和用途
TW202313094A (zh) 2021-05-18 2023-04-01 美商基利科學股份有限公司 使用FLT3L—Fc融合蛋白之方法
EP4359415A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271650A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
US11932634B2 (en) 2021-06-23 2024-03-19 Gilead Sciences, Inc. Diacylglycerol kinase modulating compounds
WO2022271659A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
MX2024000751A (es) 2021-07-14 2024-03-25 Blueprint Medicines Corp Compuestos heterociclicos como inhibidores de map4k1.
AU2022375782B2 (en) 2021-10-28 2026-02-26 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
AU2022376954B2 (en) 2021-10-29 2026-04-23 Gilead Sciences, Inc. Cd73 compounds
US20230220106A1 (en) 2021-12-08 2023-07-13 Dragonfly Therapeutics, Inc. Antibodies targeting 5t4 and uses thereof
WO2023107956A1 (en) 2021-12-08 2023-06-15 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and 5t4
AU2022419982B2 (en) 2021-12-22 2026-04-16 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
CA3237577A1 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
EP4493554A1 (en) 2022-03-17 2025-01-22 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
WO2023183817A1 (en) 2022-03-24 2023-09-28 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
TWI876305B (zh) 2022-04-05 2025-03-11 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
WO2023193759A1 (en) * 2022-04-07 2023-10-12 Insilico Medicine Ip Limited Hpk1 antagonists and uses thereof
CR20240451A (es) 2022-04-21 2024-12-04 Gilead Sciences Inc Compuestos de modulación de kras g12d
JP2025520511A (ja) * 2022-06-17 2025-07-03 ニューロン23, インコーポレイテッド キナーゼモジュレーターおよびその使用方法
WO2024003773A1 (en) * 2022-07-01 2024-01-04 Pfizer Inc. 2,7-naphthyridine compounds as mastl inhibitors
PE20250758A1 (es) 2022-07-01 2025-03-13 Gilead Sciences Inc Compuestos de cd73
WO2024064668A1 (en) 2022-09-21 2024-03-28 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY
WO2024064214A2 (en) * 2022-09-21 2024-03-28 Takeda Pharmaceutical Company Limited Synthesis of cyclopropane carboxylic acids
CN119894905A (zh) * 2022-09-23 2025-04-25 广州威诺森医药科技有限公司 一种骈环吡啶类甾体合成酶抑制剂及其制备方法和应用
CN120225509A (zh) 2022-12-22 2025-06-27 吉利德科学公司 Prmt5抑制剂及其用途
AU2024252725A1 (en) 2023-04-11 2025-11-06 Gilead Sciences, Inc. Kras modulating compounds
PE20260121A1 (es) 2023-04-21 2026-01-16 Gilead Sciences Inc Inhibidores de prmt5 y usos de los mismos
WO2024243025A1 (en) * 2023-05-19 2024-11-28 Ikena Oncology, Inc. Naphthyl-substituted pyrido[4,3-d]pyrimidines and related compounds and their use in treating medical conditions
AU2024306338A1 (en) 2023-06-30 2026-01-08 Gilead Sciences, Inc. Kras modulating compounds
KR20260046403A (ko) 2023-07-26 2026-04-07 길리애드 사이언시즈, 인코포레이티드 Parp7 저해제
WO2025024811A1 (en) 2023-07-26 2025-01-30 Gilead Sciences, Inc. Parp7 inhibitors
US20250101042A1 (en) 2023-09-08 2025-03-27 Gilead Sciences, Inc. Kras g12d modulating compounds
AU2024337913A1 (en) 2023-09-08 2026-03-26 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
US20250154172A1 (en) 2023-11-03 2025-05-15 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors
WO2025245003A1 (en) 2024-05-21 2025-11-27 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2026039365A1 (en) 2024-08-12 2026-02-19 Gilead Sciences, Inc. Kras modulating compounds
WO2026089992A1 (en) 2024-10-21 2026-04-30 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
CA2612241C (en) 2005-07-01 2018-11-06 Medarex, Inc. Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
KR20100044251A (ko) 2007-08-15 2010-04-29 싸이토키네틱스, 인코포레이티드 특정 화학 물질, 조성물 및 방법
JP2012500652A (ja) 2008-08-25 2012-01-12 アンプリミューン、インコーポレーテッド 標的化共刺激ポリペプチドおよび癌を処置するための使用方法
EP4209510B1 (en) 2008-12-09 2024-01-31 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
NO2504364T3 (enExample) 2009-11-24 2018-01-06
US20130017199A1 (en) 2009-11-24 2013-01-17 AMPLIMMUNE ,Inc. a corporation Simultaneous inhibition of pd-l1/pd-l2
EP2770998B1 (en) 2011-10-27 2020-04-29 Merck Sharp & Dohme Corp. Factor ixa inhibitors
US9556144B2 (en) * 2012-06-15 2017-01-31 Curegenix, Inc. Compound as WNT signaling inhibitor, composition, and use thereof
CA2905830C (en) * 2013-03-12 2022-01-18 Curegenix Inc. Quinazoline and naphthyridine derivatives useful in the treatment of cancer
ES2872555T3 (es) * 2015-06-25 2021-11-02 Univ Health Network Inhibidores de HPK1 y métodos de uso de los mismos
BR112019018093A2 (pt) * 2017-03-30 2020-06-16 F. Hoffmann-La Roche Ag Compostos, composição, método de inibição de hpk1, métodos para melhorar uma resposta imune e para tratar um distúrbio e usos do composto

Similar Documents

Publication Publication Date Title
ES2761406T3 (es) Protección transitoria de células normales durante una quimioterapia
RU2468021C2 (ru) Гетероциклические соединения и их применение
JP2024532733A5 (enExample)
JP2020007311A5 (enExample)
JP2026000916A5 (enExample)
JP2021523099A5 (enExample)
JP2016513737A5 (enExample)
JP2019510798A5 (enExample)
RU2014130125A (ru) Новые пиррольные соединения, способ их получения и фармацевтические композиции, содержащие их
RU2019102647A (ru) Антипролиферационные средства на основе пиримидина
RU2021102253A (ru) Деструкторы белка mdm2
JP2021532162A5 (enExample)
JP2022507065A5 (enExample)
JP2011251990A5 (enExample)
JP2015520143A5 (enExample)
RU2014115847A (ru) Пирролопиримидиновые соединения для лечения злокачественной опухоли
RU2020118594A (ru) Противораковые агенты
RU2012144844A (ru) Комплексные соединения железа(iii) для лечения и профилактики симптомов железодефицита и железодефицитной анемии
JP2012158602A5 (enExample)
RU2018122864A (ru) Ингибиторы протеинкиназ, их способ получения и медицинское применение
JP2008506644A5 (enExample)
UA129653C2 (uk) Макроциклічна сполука як агоніст sting, спосіб з її застосуванням і шлях її застосування
JP2019514955A (ja) 選択的エストロゲン受容体ダウンレギュレーター(serds)
JP2024505562A (ja) 選択的bcl-xl protac化合物及び使用の方法
JP2021522197A5 (enExample)