JP2024521895A5 - - Google Patents
Info
- Publication number
- JP2024521895A5 JP2024521895A5 JP2023574337A JP2023574337A JP2024521895A5 JP 2024521895 A5 JP2024521895 A5 JP 2024521895A5 JP 2023574337 A JP2023574337 A JP 2023574337A JP 2023574337 A JP2023574337 A JP 2023574337A JP 2024521895 A5 JP2024521895 A5 JP 2024521895A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- nhr
- formula
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/PL2021/000030 WO2022255888A1 (en) | 2021-06-01 | 2021-06-01 | Targeted protein degradation using bifunctional compounds that bind ubiquitin ligase and target mcl-1 protein |
| PLPCT/PL2021/000030 | 2021-06-01 | ||
| PCT/EP2022/064481 WO2022253713A1 (en) | 2021-06-01 | 2022-05-27 | Targeted protein degradation using bifunctional compounds that bind ubiquitin ligase and target mcl-1 protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024521895A JP2024521895A (ja) | 2024-06-04 |
| JP2024521895A5 true JP2024521895A5 (enExample) | 2025-07-07 |
Family
ID=77168359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023574337A Pending JP2024521895A (ja) | 2021-06-01 | 2022-05-27 | ユビキチンリガーゼに結合しｍｃｌ－１タンパク質を標的とする二官能性化合物を用いた標的タンパク質分解 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240294499A1 (enExample) |
| EP (1) | EP4347579A1 (enExample) |
| JP (1) | JP2024521895A (enExample) |
| KR (1) | KR20240029561A (enExample) |
| CN (1) | CN117957218A (enExample) |
| AU (1) | AU2022284249A1 (enExample) |
| BR (1) | BR112023025067A2 (enExample) |
| CA (1) | CA3218442A1 (enExample) |
| IL (1) | IL308676A (enExample) |
| MX (1) | MX2023014331A (enExample) |
| WO (2) | WO2022255888A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022146151A1 (en) * | 2020-12-30 | 2022-07-07 | Captor Therapeutics S.A. | Novel compounds which bind to cereblon, and methods of use thereof |
| WO2023049919A1 (en) * | 2021-09-27 | 2023-03-30 | The Trustees Of The University Of Pennsylvania | Inhibitors of molluscum contagiosum infection and methods using the same |
| WO2024015340A1 (en) * | 2022-07-12 | 2024-01-18 | Regents Of The University Of Michigan | Cereblon ligands and uses thereof |
| JP2025540970A (ja) * | 2022-12-06 | 2025-12-17 | キャプター セラピューティクス エス．エー． | ユビキチンリガーゼ及びターゲットｍｃｌ－１タンパク質に結合する二機能性化合物を使用するターゲティングされたタンパク質分解 |
| WO2024123195A1 (en) * | 2022-12-06 | 2024-06-13 | Captor Therapeutics S.A. | Targeted protein degradation using prodrugs of bifunctional compounds that bind ubiquitin ligase and target mcl-1 protein |
| WO2024167423A1 (en) | 2023-02-07 | 2024-08-15 | Captor Therapeutics S.A. | Gspt1 degrader compounds |
| AU2023477303A1 (en) * | 2023-12-22 | 2026-06-04 | Captor Therapeutics S.A. | Targeted protein degradation using bifunctional compounds that bind ubiquitin ligase and target protein kinase c |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306663B1 (en) | 1999-02-12 | 2001-10-23 | Proteinex, Inc. | Controlling protein levels in eucaryotic organisms |
| KR101511074B1 (ko) * | 2007-04-16 | 2015-04-13 | 애브비 인코포레이티드 | 7-치환된 인돌 Ｍｃｌ-1 억제제 |
| WO2015031608A1 (en) * | 2013-08-28 | 2015-03-05 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP6815318B2 (ja) * | 2014-12-23 | 2021-01-20 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | 二官能性分子によって標的化タンパク質分解を誘導する方法 |
| CN109153644B (zh) * | 2016-03-16 | 2022-10-21 | H·李·莫菲特癌症中心研究有限公司 | 用以增强效应t细胞功能的针对cereblon的小分子 |
| CN109152933B (zh) * | 2016-04-21 | 2022-12-02 | 生物风险投资有限责任公司 | 诱导抗细胞凋亡bcl-2家族蛋白的降解的化合物及其用途 |
| SI3526202T1 (sl) * | 2016-10-11 | 2025-04-30 | Arvinas Operations, Inc. | Spojine in postopki za ciljno razgradnjo androgenskih receptorjev |
| IL325835A (en) * | 2016-12-23 | 2026-03-01 | Univ Yale | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides |
| IL319363A (en) * | 2017-01-31 | 2025-05-01 | Arvinas Operations Inc | Cervalon ligands and bifunctional compounds containing them |
| CN107382862A (zh) * | 2017-07-17 | 2017-11-24 | 大连理工大学 | 硫/氧代萘酰亚胺类化合物及其应用 |
| CN118108706A (zh) * | 2017-09-04 | 2024-05-31 | C4医药公司 | 戊二酰亚胺 |
| WO2021105335A1 (en) * | 2019-11-27 | 2021-06-03 | Captor Therapeutics S.A. | Piperidine-2, 6-dione derivatives which bind to cereblon, and methods of use thereof |
| JP7852923B2 (ja) * | 2019-11-27 | 2026-04-28 | キャプター セラピューティクス エス．エー． | セレブロンに結合するピペリジン－２，６－ジオン誘導体、及びその使用方法 |
-
2021
- 2021-06-01 WO PCT/PL2021/000030 patent/WO2022255888A1/en not_active Ceased
-
2022
- 2022-05-27 WO PCT/EP2022/064481 patent/WO2022253713A1/en not_active Ceased
- 2022-05-27 BR BR112023025067A patent/BR112023025067A2/pt unknown
- 2022-05-27 AU AU2022284249A patent/AU2022284249A1/en active Pending
- 2022-05-27 US US18/565,630 patent/US20240294499A1/en active Pending
- 2022-05-27 IL IL308676A patent/IL308676A/en unknown
- 2022-05-27 JP JP2023574337A patent/JP2024521895A/ja active Pending
- 2022-05-27 EP EP22731153.7A patent/EP4347579A1/en active Pending
- 2022-05-27 KR KR1020237045449A patent/KR20240029561A/ko active Pending
- 2022-05-27 CN CN202280053420.9A patent/CN117957218A/zh active Pending
- 2022-05-27 MX MX2023014331A patent/MX2023014331A/es unknown
- 2022-05-27 CA CA3218442A patent/CA3218442A1/en active Pending