JP2023134618A5 - - Google Patents
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- Publication number
- JP2023134618A5 JP2023134618A5 JP2023114162A JP2023114162A JP2023134618A5 JP 2023134618 A5 JP2023134618 A5 JP 2023134618A5 JP 2023114162 A JP2023114162 A JP 2023114162A JP 2023114162 A JP2023114162 A JP 2023114162A JP 2023134618 A5 JP2023134618 A5 JP 2023134618A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cdr
- region
- antigen
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 101000960952 Homo sapiens Interleukin-1 receptor accessory protein Proteins 0.000 claims 2
- 102100039880 Interleukin-1 receptor accessory protein Human genes 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 206010000748 Acute febrile neutrophilic dermatosis Diseases 0.000 claims 1
- 208000009766 Blau syndrome Diseases 0.000 claims 1
- 241001475178 Dira Species 0.000 claims 1
- 206010018691 Granuloma Diseases 0.000 claims 1
- 206010058105 Neutrophilic dermatosis Diseases 0.000 claims 1
- 206010067115 Neutrophilic panniculitis Diseases 0.000 claims 1
- 201000008470 PAPA syndrome Diseases 0.000 claims 1
- 206010072222 Pyogenic sterile arthritis pyoderma gangrenosum and acne syndrome Diseases 0.000 claims 1
- 201000010848 Schnitzler Syndrome Diseases 0.000 claims 1
- 208000010265 Sweet syndrome Diseases 0.000 claims 1
- 206010000269 abscess Diseases 0.000 claims 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 208000020521 pyoderma gangrenosum-acne-suppurative hidradenitis syndrome Diseases 0.000 claims 1
- 208000022638 pyogenic arthritis-pyoderma gangrenosum-acne syndrome Diseases 0.000 claims 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 claims 1
- 208000026082 sterile multifocal osteomyelitis with periostitis and pustulosis Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 210000000106 sweat gland Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024216380A JP2025038044A (ja) | 2017-05-08 | 2024-12-11 | 炎症症状で使用するための抗ｉｌ－１ｒ３抗体 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17169953.1A EP3401332A1 (en) | 2017-05-08 | 2017-05-08 | Anti-il-1r3 antibodies for use in inflammatory conditions |
| EP17169953.1 | 2017-05-08 | ||
| JP2019561281A JP7315472B2 (ja) | 2017-05-08 | 2018-05-08 | 炎症症状で使用するための抗ｉｌ－１ｒ３抗体 |
| PCT/EP2018/061846 WO2018206565A1 (en) | 2017-05-08 | 2018-05-08 | Anti-il-1r3 antibodies for use in inflammatory conditions |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019561281A Division JP7315472B2 (ja) | 2017-05-08 | 2018-05-08 | 炎症症状で使用するための抗ｉｌ－１ｒ３抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024216380A Division JP2025038044A (ja) | 2017-05-08 | 2024-12-11 | 炎症症状で使用するための抗ｉｌ－１ｒ３抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023134618A JP2023134618A (ja) | 2023-09-27 |
| JP2023134618A5 true JP2023134618A5 (enExample) | 2024-04-03 |
| JP7605916B2 JP7605916B2 (ja) | 2024-12-24 |
Family
ID=58698976
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019561281A Active JP7315472B2 (ja) | 2017-05-08 | 2018-05-08 | 炎症症状で使用するための抗ｉｌ－１ｒ３抗体 |
| JP2023114162A Active JP7605916B2 (ja) | 2017-05-08 | 2023-07-12 | 炎症症状で使用するための抗ｉｌ－１ｒ３抗体 |
| JP2024216380A Pending JP2025038044A (ja) | 2017-05-08 | 2024-12-11 | 炎症症状で使用するための抗ｉｌ－１ｒ３抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019561281A Active JP7315472B2 (ja) | 2017-05-08 | 2018-05-08 | 炎症症状で使用するための抗ｉｌ－１ｒ３抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024216380A Pending JP2025038044A (ja) | 2017-05-08 | 2024-12-11 | 炎症症状で使用するための抗ｉｌ－１ｒ３抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11639392B2 (enExample) |
| EP (2) | EP3401332A1 (enExample) |
| JP (3) | JP7315472B2 (enExample) |
| CN (1) | CN110831670A (enExample) |
| AU (2) | AU2018267092B2 (enExample) |
| CA (1) | CA3062424A1 (enExample) |
| WO (1) | WO2018206565A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2990305A1 (en) | 2015-06-26 | 2016-12-29 | Mab Discovery Gmbh | Monoclonal anti-il-1racp antibodies |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| FI3592384T3 (fi) * | 2017-03-09 | 2025-09-29 | Mab Discovery Gmbh | Vasta-aineita, jotka spesifisesti sitoutuvat ihmisen IL-1R7:ään |
| EP3401332A1 (en) | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
| CN118994394A (zh) | 2017-06-12 | 2024-11-22 | 蓝鳍生物医药公司 | 抗-il1rap抗体和抗体药物缀合物 |
| JP7346390B2 (ja) | 2017-09-19 | 2023-09-19 | マブ ディスカバリー ゲゼルシャフト ミット ベシュレンクテル ハフツング | アゴニスト性ｃｄ４０抗体 |
| TW202021618A (zh) * | 2018-08-17 | 2020-06-16 | 美商２３與我有限公司 | 抗ｉｌ１ｒａｐ抗體及其使用方法 |
| SG11202106100VA (en) * | 2018-12-21 | 2021-07-29 | 23Andme Inc | Anti-il-36 antibodies and methods of use thereof |
| US20220298234A1 (en) * | 2019-05-13 | 2022-09-22 | The Johns Hopkins University | Macrophage diversity in regenerative, fibrotic biomaterial environments |
| AU2022278636A1 (en) | 2021-05-21 | 2023-11-16 | Leo Pharma A/S | Anti il-1 receptor accessory protein antibodies |
| AU2023345467A1 (en) * | 2022-09-21 | 2025-05-08 | Sanofi Biotechnology | Humanized anti-il-1r3 antibody and methods of use |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5283179A (en) | 1990-09-10 | 1994-02-01 | Promega Corporation | Luciferase assay method |
| ATE153695T1 (de) | 1990-11-26 | 1997-06-15 | Akzo Nobel Nv | Verfahren zur herstellung von antikörpern |
| PE64396A1 (es) | 1995-01-23 | 1997-01-28 | Hoffmann La Roche | Proteina accesoria del receptor de la interleucina 1 |
| US6974682B1 (en) | 1996-08-26 | 2005-12-13 | Human Genome Sciences, Inc. | Soluble interleukin-1 receptor accessory molecule |
| EP0915987A2 (en) | 1997-04-21 | 1999-05-19 | Donlar Corporation | POLY-($g(a)-L-ASPARTIC ACID), POLY-($g(a)-L-GLUTAMIC ACID) AND COPOLYMERS OF L-ASP AND L-GLU, METHOD FOR THEIR PRODUCTION AND THEIR USE |
| US6280955B1 (en) | 1997-12-16 | 2001-08-28 | Tularik Inc. | Interleukin-1 receptor accessory proteins, nucleic acids and methods |
| PT1071700E (pt) | 1998-04-20 | 2010-04-23 | Glycart Biotechnology Ag | Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
| US6541225B1 (en) | 2000-01-26 | 2003-04-01 | Raven Biotechnologies, Inc. | Methods and compositions for generating human monoclonal antibodies |
| US7449443B2 (en) | 2000-03-23 | 2008-11-11 | California Institute Of Technology | Method for stabilization of proteins using non-natural amino acids |
| US6586207B2 (en) | 2000-05-26 | 2003-07-01 | California Institute Of Technology | Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues |
| US20030026806A1 (en) | 2000-10-27 | 2003-02-06 | Amgen Inc. | Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof |
| WO2002064630A2 (en) | 2000-10-31 | 2002-08-22 | Immunex Corporation | Il-1 receptor accessory protein |
| PL374118A1 (en) | 2001-08-07 | 2005-10-03 | Immunex Corporation | Interleukin-1 receptors in the treatment of diseases |
| EP1490677A4 (en) | 2002-02-27 | 2006-01-18 | California Inst Of Techn | COMPUTER METHOD FOR DESIGNING ENZYMES FOR THE INCORPORATION OF AMINO ACID ANALOGUES INTO PROTEINS |
| US7438910B2 (en) | 2002-09-06 | 2008-10-21 | Amgen Inc. | Therapeutic human anti-IL1-R1 monoclonal antibody |
| PL222220B1 (pl) | 2003-01-22 | 2016-07-29 | Glycart Biotechnology Ag | Komórka gospodarza i sposób wytwarzania polipeptydu w komórce gospodarza |
| US20040224893A1 (en) | 2003-05-06 | 2004-11-11 | Li-Hsien Wang | Methods of using IL-1 antagonists to treat neointimal hyperplasia |
| GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| ES2737837T3 (es) | 2003-10-09 | 2020-01-16 | Ambrx Inc | Derivados poliméricos |
| TR201809892T4 (tr) | 2003-11-05 | 2018-07-23 | Roche Glycart Ag | Fc reseptörüne bağlanma afinitesi ve artırılmış efektör fonksiyonu bulunan antijen bağlayan moleküller. |
| EP1718602A4 (en) | 2004-01-30 | 2007-12-12 | Peplin Biolipids Pty Ltd | THERAPEUTIC AND CARRIER MOLECULES |
| NZ548255A (en) | 2004-02-02 | 2010-10-29 | Ambrx Inc | Modified human interferon polypeptides and their uses |
| US8945857B2 (en) | 2005-07-01 | 2015-02-03 | John Schrader | Methods of isolating cells and generating monoclonal antibodies |
| NO345919B1 (no) | 2005-08-26 | 2021-10-18 | Roche Glycart Ag | Modifiserte antigen-bindende molekyler med endret celle-signaliseringsaktivitet |
| AU2007307324B2 (en) | 2006-05-19 | 2013-08-15 | Alder Biopharmaceuticals, Inc. | Culture method for obtaining a clonal population of antigen-specific B cells |
| JP2011515497A (ja) | 2008-03-26 | 2011-05-19 | セレラント セラピューティクス インコーポレイテッド | 骨髄性血液学的増殖性疾患と関連する免疫グロブリンおよび／またはＴｏｌｌ様受容体タンパク質ならびにその使用 |
| AR075896A1 (es) | 2009-03-20 | 2011-05-04 | Genentech Inc | Anticuerpos anti-her (factor de crecimiento epidermico) |
| GB2472856B (en) | 2009-08-21 | 2012-07-11 | Cantargia Ab | IL1-RAP modulators and uses thereof |
| WO2011124718A1 (en) | 2010-04-09 | 2011-10-13 | Novozymes A/S | Albumin derivatives and variants |
| SI2400298T1 (sl) | 2010-05-28 | 2013-11-29 | F. Hoffmann-La Roche Ag | Postopek kultivacije posamezne B-celice in izdelava specifičnih protiteles |
| EP3508498A1 (en) * | 2011-01-19 | 2019-07-10 | Cantargia AB | Novel agents and uses thereof |
| SI2691417T2 (sl) | 2011-03-29 | 2025-05-30 | Roche Glycart Ag | FC variante protitelesa |
| AU2012242666A1 (en) * | 2011-04-15 | 2013-11-28 | Merck Patent Gmbh | Anti- IL-1R1 inhibitors for use in cancer |
| CN103608030A (zh) | 2011-06-21 | 2014-02-26 | 昂科发克特公司 | 用于治疗和诊断癌症的组合物和方法 |
| WO2013023015A2 (en) | 2011-08-11 | 2013-02-14 | Albert Einstein College Of Medicine Of Yeshiva University | Targets for diagnosis, prognosis and therapy of acute myeloid leukemia and myelodysplastic syndromes |
| US9212227B2 (en) | 2012-04-30 | 2015-12-15 | Janssen Biotech, Inc. | ST2L antibody antagonists for the treatment of ST2L-mediated inflammatory pulmonary conditions |
| US20150315279A1 (en) * | 2012-12-21 | 2015-11-05 | Cellerant Therapeutics, Inc. | Antibodies that bind membrane-bound il1rap |
| US10126304B2 (en) | 2013-01-16 | 2018-11-13 | George Mason Research Foundation, Inc. | Binding domain mapping |
| GB201403875D0 (en) | 2014-03-05 | 2014-04-16 | Cantargia Ab | Novel antibodies and uses thereof |
| GB201413913D0 (en) * | 2014-08-06 | 2014-09-17 | Cantargia Ab | Novel antibodies and uses thereof |
| CA2990305A1 (en) | 2015-06-26 | 2016-12-29 | Mab Discovery Gmbh | Monoclonal anti-il-1racp antibodies |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| EP3401332A1 (en) * | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
-
2017
- 2017-05-08 EP EP17169953.1A patent/EP3401332A1/en not_active Withdrawn
-
2018
- 2018-05-08 JP JP2019561281A patent/JP7315472B2/ja active Active
- 2018-05-08 EP EP18724816.6A patent/EP3621693A1/en active Pending
- 2018-05-08 AU AU2018267092A patent/AU2018267092B2/en active Active
- 2018-05-08 CN CN201880045411.9A patent/CN110831670A/zh active Pending
- 2018-05-08 US US16/612,052 patent/US11639392B2/en active Active
- 2018-05-08 WO PCT/EP2018/061846 patent/WO2018206565A1/en not_active Ceased
- 2018-05-08 CA CA3062424A patent/CA3062424A1/en active Pending
-
2023
- 2023-03-16 US US18/184,759 patent/US20230383000A1/en active Pending
- 2023-07-12 JP JP2023114162A patent/JP7605916B2/ja active Active
-
2024
- 2024-05-02 AU AU2024202910A patent/AU2024202910A1/en active Pending
- 2024-12-11 JP JP2024216380A patent/JP2025038044A/ja active Pending
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