WO2018206565A1 - Anti-il-1r3 antibodies for use in inflammatory conditions - Google Patents

Anti-il-1r3 antibodies for use in inflammatory conditions Download PDF

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Publication number
WO2018206565A1
WO2018206565A1 PCT/EP2018/061846 EP2018061846W WO2018206565A1 WO 2018206565 A1 WO2018206565 A1 WO 2018206565A1 EP 2018061846 W EP2018061846 W EP 2018061846W WO 2018206565 A1 WO2018206565 A1 WO 2018206565A1
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WO
WIPO (PCT)
Prior art keywords
antibody
seq
cdr
region
mab
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2018/061846
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English (en)
French (fr)
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WO2018206565A9 (en
Inventor
Stephan Fischer
Karsten Beckmann
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MAB Discovery GmbH
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MAB Discovery GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN201880045411.9A priority Critical patent/CN110831670A/zh
Priority to CA3062424A priority patent/CA3062424A1/en
Priority to JP2019561281A priority patent/JP7315472B2/ja
Priority to US16/612,052 priority patent/US11639392B2/en
Priority to EP18724816.6A priority patent/EP3621693B1/en
Priority to AU2018267092A priority patent/AU2018267092B2/en
Application filed by MAB Discovery GmbH filed Critical MAB Discovery GmbH
Publication of WO2018206565A1 publication Critical patent/WO2018206565A1/en
Anticipated expiration legal-status Critical
Publication of WO2018206565A9 publication Critical patent/WO2018206565A9/en
Priority to US18/184,759 priority patent/US12698334B2/en
Priority to JP2023114162A priority patent/JP7605916B2/ja
Priority to AU2024202910A priority patent/AU2024202910A1/en
Priority to JP2024216380A priority patent/JP7825695B2/ja
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Definitions

  • the present invention relates to methods for treating medical conditions and/or disorders characterized by uncontrolled or abnormal expression of members of the IL1R3 signaling pathway such as IL-lct, IL- ⁇ , IL-33, I L-36, I LIRA and/or I L1R3, as well as variants thereof.
  • members of the IL1R3 signaling pathway such as IL-lct, IL- ⁇ , IL-33, I L-36, I LIRA and/or I L1R3, as well as variants thereof.
  • the term also includes the neonatal receptor, FcRn, which is responsible for the transfer of materna l IgGs to the fetus (Guyer et al, J. I mmunol. 117:587 (1976) and Kim et al, J. I mmunol. 24:249 (1994)) and mediates slower catabolism, thus longer half-life.
  • FcRn neonatal receptor
  • Fc region-containing polypeptide refers to a polypeptide, such as an antibody or immunoadhesin (see definitions below), which comprises an Fc region.
  • the invention encompasses anti-ILlR3 antibody for use in the treatment of an IL1R3- mediated inflammatory condition and/or disorder in a subject.
  • the subject is a mouse and the antibody comprises a heavy chain variable (VH) region that is at least 90 % identical to the VH region of SEQ ID NO: 176, and a light chain variable (VL) region that is at least 90% identical to the VL region of SEQ I D NO: 177.
  • VH heavy chain variable
  • VL light chain variable
  • substitutions, insertions, or deletions occur in regions outside the CDRs (i.e., in the FRs).
  • the antibody that specifically binds to I L-1R3 or a fragment or derivative thereof that contains at least a portion of said antibody that is sufficient to confer I L-1R3 binding specificity binds to the same epitope as an antibody selected from the group of antibodies MAB-
  • the antibodies according to the invention have the advantage to be very potent when it comes to binding to their target. They exhibit a strong binding capacity to their antigen, IL1R3, but not to other receptors.
  • the binding properties of the antibodies were studied in biochemical enzyme- linked immunosorbent assays (ELISA) and cell binding analysis (flow cytometry) and are exemplified in Figures 2, 6 and 7.
  • the antibodies according to the invention do not only inhibit the functional activation of cytokine release in different cell lines as described above, but also in PMBCs or whole blood cells from donors. They inhibit cytokine release mediated by different specific or complex stimuli. For example, they inhibit activation of PBMCs stimulated with LPS, heat-inactivated Candida albicans, IL-12/IL-33 or anti-CD3/CD28 antibodies (cf. Fig. 14 and 15).
  • Such a pharmaceutically composition may comprise a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody that specifically binds to the IL-1R3 or a fragment or derivative thereof that contains at least a portion of said antibody that is sufficient to confer IL-1R3 binding specificity, according to the invention.
  • pharmaceutical carrier includes any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like that are physiologically compatible.
  • the carrier is suitable for intravenous, intramuscular, subcutaneous, parenteral, spinal or epidermal administration (e.g. by injection or infusion).
  • said antibody comprises a heavy chain variable region (VH) sequence having at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to an amino acid sequence selected from the group of VH sequences according to the invention.
  • VH heavy chain variable region
  • Example 13 Functional blockage of immune cells in whole blood
  • MSU Intraperitoneal injection
  • MAB-16-0531, 500 ⁇ g/mouse anti-I L-l 3
  • I L-IRa I L-IRa
  • Saline was used both as control for stimulation and inhibition.
  • the four groups were comprised of 4 mice as control of stimuli (Saline (inhib.) + Saline(stimuli)), 8 mice with MSU alone (Saline+MSU), 8 mice with MAB- 16-0531 + MSU) and 8 mice with I L-IRa (lOmg/kg + MSU).
  • MAB-16-0531 and I L-IRa were injected LP.
  • Fig. 22 Imiquimod psoriasis in vivo model

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PCT/EP2018/061846 2017-05-08 2018-05-08 Anti-il-1r3 antibodies for use in inflammatory conditions Ceased WO2018206565A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AU2018267092A AU2018267092B2 (en) 2017-05-08 2018-05-08 Anti-IL-1R3 antibodies for use in inflammatory conditions
CA3062424A CA3062424A1 (en) 2017-05-08 2018-05-08 Anti-il-1r3 antibodies for use in inflammatory conditions
JP2019561281A JP7315472B2 (ja) 2017-05-08 2018-05-08 炎症症状で使用するための抗ｉｌ－１ｒ３抗体
US16/612,052 US11639392B2 (en) 2017-05-08 2018-05-08 Anti-IL-1R3 antibodies for use in inflammatory conditions
EP18724816.6A EP3621693B1 (en) 2017-05-08 2018-05-08 Anti-il-1r3 antibodies for use in inflammatory conditions
CN201880045411.9A CN110831670A (zh) 2017-05-08 2018-05-08 用于炎性病症的抗il-1r3抗体
US18/184,759 US12698334B2 (en) 2017-05-08 2023-03-16 Anti-IL-1R3 antibodies for use in inflammatory conditions
JP2023114162A JP7605916B2 (ja) 2017-05-08 2023-07-12 炎症症状で使用するための抗ｉｌ－１ｒ３抗体
AU2024202910A AU2024202910A1 (en) 2017-05-08 2024-05-02 Anti-IL-1R3 antibodies for use in inflammatory conditions
JP2024216380A JP7825695B2 (ja) 2017-05-08 2024-12-11 炎症症状で使用するための抗ｉｌ－１ｒ３抗体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17169953.1A EP3401332A1 (en) 2017-05-08 2017-05-08 Anti-il-1r3 antibodies for use in inflammatory conditions
EP17169953.1 2017-05-08

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US16/612,052 A-371-Of-International US11639392B2 (en) 2017-05-08 2018-05-08 Anti-IL-1R3 antibodies for use in inflammatory conditions
US18/184,759 Continuation US12698334B2 (en) 2017-05-08 2023-03-16 Anti-IL-1R3 antibodies for use in inflammatory conditions

Publications (2)

Publication Number Publication Date
WO2018206565A1 true WO2018206565A1 (en) 2018-11-15
WO2018206565A9 WO2018206565A9 (en) 2019-12-26

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PCT/EP2018/061846 Ceased WO2018206565A1 (en) 2017-05-08 2018-05-08 Anti-il-1r3 antibodies for use in inflammatory conditions

Country Status (7)

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US (2) US11639392B2 (enExample)
EP (2) EP3401332A1 (enExample)
JP (3) JP7315472B2 (enExample)
CN (1) CN110831670A (enExample)
AU (2) AU2018267092B2 (enExample)
CA (1) CA3062424A1 (enExample)
WO (1) WO2018206565A1 (enExample)

Cited By (7)

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EP3592384A1 (en) * 2017-03-09 2020-01-15 MAB Discovery GmbH Antibodies specifically binding to human il-1r7
WO2020037154A1 (en) * 2018-08-17 2020-02-20 23Andme, Inc. Anti-il1rap antibodies and methods of use thereof
WO2020232148A1 (en) * 2019-05-13 2020-11-19 The Johns Hopkins University Macrophage diversity in regenerative, fibrotic biomaterial environments
US12043669B2 (en) 2021-05-21 2024-07-23 Leo Pharma A/S IL-1 receptor accessory protein-inhibiting antibodies and antigen-binding fragments thereof
US12502352B1 (en) 2024-06-25 2025-12-23 Kiniksa Pharmaceuticals, Gmbh Formulations of anti-interleukin 1 receptor 1 antibodies
WO2026022232A1 (en) 2024-07-24 2026-01-29 Almirall, S.A. Il-1rap inhibitor for treating or preventing hidradenitis suppurativa
US12655224B2 (en) 2024-06-25 2026-06-16 Kiniksa Pharmaceuticals, Gmbh Compositions of IL-1R1 antibodies and methods of producing and using the same

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CN108026172B (zh) 2015-06-26 2022-04-29 赛诺菲生物技术公司 单克隆抗il-1racp抗体
EP3241845A1 (en) 2016-05-06 2017-11-08 MAB Discovery GmbH Humanized anti-il-1r3 antibodies
EP3401332A1 (en) 2017-05-08 2018-11-14 MAB Discovery GmbH Anti-il-1r3 antibodies for use in inflammatory conditions
WO2018231827A1 (en) 2017-06-12 2018-12-20 Bluefin Biomedicine, Inc. Anti-il1rap antibodies and antibody drug conjugates
WO2019057792A1 (en) * 2017-09-19 2019-03-28 Mab Discovery Gmbh CD40 ANTIBODY AGONISTS
MX2021007589A (es) * 2018-12-21 2021-12-10 23Andme Inc Anticuerpos anti il-36 y procedimientos de uso de estos.
KR20230077722A (ko) * 2020-08-10 2023-06-01 지브이20 테라퓨틱스 엘엘씨 Igsf8을 표적화하여 자가면역 질환 및 암을 치료하기 위한 조성물 및 방법
CN112358539A (zh) * 2020-11-16 2021-02-12 桂林医学院附属医院 一种小鼠截短IL-36γ蛋白及其制备方法
US12054552B2 (en) * 2022-09-21 2024-08-06 Sanofi Biotechnology Humanized anti-IL-1R3 antibody and methods of use

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