|
US5844092A
(en)
|
1994-03-18 |
1998-12-01 |
Genentech, Inc. |
Human TRK receptors and neurotrophic factor inhibitors
|
|
US5877016A
(en)
|
1994-03-18 |
1999-03-02 |
Genentech, Inc. |
Human trk receptors and neurotrophic factor inhibitors
|
|
DK1292680T3
(da)
|
2000-06-22 |
2010-03-08 |
Genentech Inc |
Agonist-anti-TrkC monoklonale antistoffer
|
|
EP1597251B1
(en)
|
2003-02-20 |
2009-06-10 |
SmithKline Beecham Corporation |
Pyrimidine compounds
|
|
MY141220A
(en)
|
2003-11-17 |
2010-03-31 |
Astrazeneca Ab |
Pyrazole derivatives as inhibitors of receptor tyrosine kinases
|
|
GB0512324D0
(en)
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
|
PE20060664A1
(es)
|
2004-09-15 |
2006-08-04 |
Novartis Ag |
Amidas biciclicas como inhibidores de cinasa
|
|
DE102005003687A1
(de)
|
2005-01-26 |
2006-07-27 |
Sphingo Tec Gmbh |
Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation
|
|
US20080287437A1
(en)
|
2005-05-16 |
2008-11-20 |
Astrazeneca Ab |
Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors
|
|
ITRM20050290A1
(it)
|
2005-06-07 |
2006-12-08 |
Lay Line Genomics Spa |
Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
|
|
UA95244C2
(ru)
|
2005-06-22 |
2011-07-25 |
Плексикон, Инк. |
Соединения и способ модулирования активности киназ, и показания для их применения
|
|
HRP20140218T4
(hr)
|
2005-08-25 |
2017-06-16 |
Creabilis Therapeutics S.P.A. |
Polimerni konjugati k-252a i njihovi derivati
|
|
WO2007026720A1
(ja)
|
2005-08-31 |
2007-03-08 |
Taisho Pharmaceutical Co., Ltd. |
縮環ピラゾール誘導体
|
|
DK3184526T3
(en)
|
2005-12-13 |
2019-01-14 |
Incyte Holdings Corp |
PYRROLO [2,3-D] PYRIMIDINE DERIVATIVES AS A JANUS-KINASE INHIBITOR
|
|
NZ572202A
(en)
|
2006-03-27 |
2012-05-25 |
Nerviano Medical Sciences Srl |
Pyridyl- and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors
|
|
PT2201840E
(pt)
|
2006-09-22 |
2012-02-14 |
Pharmacyclics Inc |
Inibidores da tirosina quinase de bruton
|
|
RU2009122670A
(ru)
|
2006-12-21 |
2011-01-27 |
Плекссикон, Инк. (Us) |
Соединения и способы для модуляции киназ и показания к их применению
|
|
PE20081581A1
(es)
|
2006-12-21 |
2008-11-12 |
Plexxikon Inc |
COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
|
|
WO2008079909A1
(en)
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
|
US8338417B2
(en)
|
2007-05-04 |
2012-12-25 |
Irm Llc |
Compounds and compositions as c-kit and PDGFR kinase inhibitors
|
|
DK2740731T3
(en)
|
2007-06-13 |
2016-04-11 |
Incyte Holdings Corp |
CRYSTALLINE SALTS OF JANUSKINASEINHIBITOREN (R) -3- (4- (7H-pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-CYCLOPENTYLPROPANNITRIL
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
EP2074118A2
(en)
|
2007-07-09 |
2009-07-01 |
AstraZeneca AB |
Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
|
|
SG183036A1
(en)
|
2007-07-17 |
2012-08-30 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
CA2693967A1
(en)
|
2007-07-19 |
2009-01-29 |
Schering Corporation |
Heterocyclic amide compounds as protein kinase inhibitors
|
|
PL2176231T3
(pl)
|
2007-07-20 |
2017-04-28 |
Nerviano Medical Sciences S.R.L. |
Podstawione pochodne indazolu aktywne jako inhibitory kinazy
|
|
JP2011501760A
(ja)
|
2007-10-23 |
2011-01-13 |
ノバルティス アーゲー |
呼吸器疾患の処置のためのtrkb抗体の使用
|
|
JP5400791B2
(ja)
|
2007-12-04 |
2014-01-29 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
置換ジヒドロプテリジン−6−オン誘導体、その製造方法及びキナーゼ阻害剤としてのその使用
|
|
CN102015769B
(zh)
|
2008-01-17 |
2014-12-10 |
Irm责任有限公司 |
改进的抗-trkb抗体
|
|
EP2254886B1
(en)
|
2008-03-28 |
2016-05-25 |
Nerviano Medical Sciences S.r.l. |
3,4-dihydro-2h-pyrazino[1,2-a]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
|
US8158636B2
(en)
|
2008-05-19 |
2012-04-17 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
PE20091846A1
(es)
|
2008-05-19 |
2009-12-16 |
Plexxikon Inc |
DERIVADOS DE PIRROLO[2,3-d]-PIRIMIDINA COMO MODULADORES DE CINASAS
|
|
BRPI0913031A2
(pt)
|
2008-05-23 |
2019-11-26 |
Novartis Ag |
derivados de quinolina e quinoxalinas como inibidores de proteína tirosina quinase, seus usos e processo de fabricação, bem como composições farmacêuticas e combinação que os compreende
|
|
EP2313411A1
(en)
|
2008-06-10 |
2011-04-27 |
Plexxikon, Inc. |
5h-pyrr0l0 [2,3-b]pyrazine derivatives for kinase modulation, and indications therefor
|
|
TWI458721B
(zh)
|
2008-06-27 |
2014-11-01 |
Celgene Avilomics Res Inc |
雜芳基化合物及其用途
|
|
CN102105151B
(zh)
|
2008-07-29 |
2013-12-18 |
内尔维阿诺医学科学有限公司 |
Cdk抑制剂在治疗神经胶质瘤中的应用
|
|
JP5746032B2
(ja)
|
2008-09-19 |
2015-07-08 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
3,4−ジヒドロ−2H−ピロロ[1,2−a]ピラジン−1−オン誘導体
|
|
EP2350075B1
(en)
|
2008-09-22 |
2014-03-05 |
Array Biopharma, Inc. |
Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
|
|
KR101853026B1
(ko)
|
2008-10-22 |
2018-04-27 |
어레이 바이오파마 인크. |
TRK 키나아제 억제제로서 치환된 피라졸로[1,5a] 피리미딘 화합물
|
|
WO2010058006A1
(en)
|
2008-11-24 |
2010-05-27 |
Nerviano Medical Sciences S.R.L. |
Cdk inhibitor for the treatment of mesothelioma
|
|
JO3265B1
(ar)
|
2008-12-09 |
2018-09-16 |
Novartis Ag |
مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
|
|
JOP20190230A1
(ar)
|
2009-01-15 |
2017-06-16 |
Incyte Corp |
طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
|
|
WO2010111527A1
(en)
|
2009-03-26 |
2010-09-30 |
Plexxikon, Inc. |
Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use
|
|
AU2010249443B2
(en)
|
2009-05-22 |
2015-08-13 |
Incyte Holdings Corporation |
3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]octane- or heptane-nitrile as JAK inhibitors
|
|
ES2570756T3
(es)
|
2009-06-15 |
2016-05-20 |
Nerviano Medical Sciences Srl |
Derivados pirimidinilpirrolopiridinona sustituidos, proceso para su preparación y su uso como inhibidores de cinasa
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
KR101921850B1
(ko)
|
2009-10-09 |
2018-11-23 |
인사이트 홀딩스 코포레이션 |
3-(4-(7H-피롤로〔2,3-d〕피리미딘-4-일)-1H-피라졸-1-일)-3-사이클로펜틸프로판니트릴의 하이드록실, 케토 및 글루쿠로나이드 유도체
|
|
WO2011092120A1
(en)
|
2010-01-29 |
2011-08-04 |
Nerviano Medical Sciences S.R.L. |
6,7- dihydroimidazo [1,5-a] pyrazin-8 (5h) - one derivatives as protein kinase modulators
|
|
TWI510487B
(zh)
|
2010-04-21 |
2015-12-01 |
Plexxikon Inc |
用於激酶調節的化合物和方法及其適應症
|
|
CN105693720B
(zh)
|
2010-05-20 |
2019-01-18 |
阵列生物制药公司 |
作为trk激酶抑制剂的大环化合物
|
|
UY33597A
(es)
|
2010-09-09 |
2012-04-30 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
US8916577B2
(en)
|
2011-01-26 |
2014-12-23 |
Nerviano Medical Sciences S.R.L. |
Tricyclic derivatives, process for their preparation and their use as kinase inhibitors
|
|
CN103339134B
(zh)
|
2011-01-26 |
2015-12-23 |
内尔维阿诺医学科学有限公司 |
三环吡咯并衍生物、它们的制备方法和它们作为激酶抑制剂的应用
|
|
JP5941069B2
(ja)
|
2011-02-07 |
2016-06-29 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
キナーゼ調節のための化合物および方法、ならびにそれに対する適応症
|
|
JP6013375B2
(ja)
|
2011-02-24 |
2016-10-25 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
キナーゼ阻害剤としてのチアゾリルフェニル−ベンゼンスルホンアミド誘導体
|
|
JP5959541B2
(ja)
|
2011-02-25 |
2016-08-02 |
ノバルティス アーゲー |
Trk阻害剤としてのピラゾロ[1,5−a]ピリジン
|
|
US9284298B2
(en)
|
2011-04-11 |
2016-03-15 |
Nerviano Medical Sciences S.R.L. |
Pyrazolyl-pyrimidine derivatives as kinase inhibitors
|
|
BR112013026137B1
(pt)
|
2011-04-19 |
2020-12-01 |
Nerviano Medical Sciences S.R.L |
pirimidinil-pirróis substituídos ativos como inibidores da quinase
|
|
CA2835478C
(en)
|
2011-05-12 |
2019-02-05 |
Nerviano Medical Sciences S.R.L. |
Substituted indazole derivatives active as kinase inhibitors
|
|
CN105130967B
(zh)
|
2011-05-13 |
2018-04-17 |
阵列生物制药公司 |
作为trka激酶抑制剂的吡咯烷基脲和吡咯烷基硫脲化合物
|
|
JP6016915B2
(ja)
|
2011-07-28 |
2016-10-26 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
キナーゼ阻害剤として活性なアルキニル置換ピリミジニルピロール
|
|
JP6063945B2
(ja)
|
2011-10-07 |
2017-01-18 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
キナーゼ阻害剤としての4−アルキル置換3,4−ジヒドロピロロ[1,2−a]ピラジン−1(2H)−オン誘導体
|
|
EP2788351B1
(en)
|
2011-10-07 |
2017-06-28 |
Nerviano Medical Sciences S.r.l. |
SUBSTITUTED 3,4-DIHYDROPYRROLO[1,2-a]PYRAZIN-1(2H)-ONE DERIVATIVES AS KINASE INHIBITORS
|
|
BR112014011465A2
(pt)
|
2011-11-14 |
2017-05-09 |
Tesaro Inc |
modulação de determinadas quinases de tirosina
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
CN104254533B
(zh)
|
2012-01-13 |
2017-09-08 |
百时美施贵宝公司 |
用作激酶抑制剂的噻唑或噻二唑取代的吡啶基化合物
|
|
WO2013161919A1
(ja)
|
2012-04-26 |
2013-10-31 |
小野薬品工業株式会社 |
Trk阻害化合物
|
|
MX355409B
(es)
|
2012-05-23 |
2018-04-18 |
Nerviano Medical Sciences Srl |
Proceso para la preparacion de n- [5- (3,5-difluoro-bencil) -1h-indazol-3-il] -4- (4-metil-piperazin-1-il) -2- (tetrahidro-piran-4-ilamino) -benzamida.
|
|
TWI585088B
(zh)
|
2012-06-04 |
2017-06-01 |
第一三共股份有限公司 |
作爲激酶抑制劑之咪唑并[1,2-b]嗒衍生物
|
|
AR091273A1
(es)
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
|
ES2984771T3
(es)
|
2012-06-13 |
2024-10-31 |
Incyte Holdings Corp |
Compuestos tricíclicos sustituidos como inhibidores de FGFR
|
|
RU2019102203A
(ru)
|
2012-07-11 |
2019-03-05 |
Блюпринт Медсинс Корпорейшн |
Ингибиторы рецептора фактора роста фибробластов
|
|
HK1210696A1
(en)
|
2012-07-11 |
2016-05-06 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
|
RU2666538C2
(ru)
|
2012-08-02 |
2018-09-11 |
НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. |
Замещенные пирролы, активные в качестве ингибиторов киназ
|
|
SMT201900344T1
(it)
|
2012-09-10 |
2019-07-11 |
Principia Biopharma Inc |
Composti di pirazolopirimidina come inibitori di chinasi
|
|
JP6401169B2
(ja)
|
2012-10-04 |
2018-10-03 |
ユニヴァーシティー オブ ユタ リサーチ ファウンデーション |
チロシン受容体キナーゼbtk阻害剤としての置換n−(3−(ピリミジン−4−イル)フェニル)アクリルアミド類似体
|
|
US9604980B2
(en)
|
2012-11-07 |
2017-03-28 |
Nerviano Medical Sciences S.R.L. |
Substituted pyrimidinyl and pyridinyl-pyrrolopyridinones, process for their preparation and their use as kinase inhibitors
|
|
MX2015005805A
(es)
|
2012-11-12 |
2016-04-15 |
Ignyta Inc |
Derivados de bendamustina y métodos para utilizarlos.
|
|
US9822118B2
(en)
|
2012-11-13 |
2017-11-21 |
Array Biopharma Inc. |
Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
|
WO2014078328A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
N-bicyclic aryl,n'-pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
|
WO2014078372A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
|
RU2664541C2
(ru)
|
2012-11-13 |
2018-08-20 |
Эррэй Биофарма Инк. |
Бициклические соединения мочевины, тиомочевины, гуанидина и цианогуанидина, пригодные для лечения боли
|
|
US9809578B2
(en)
|
2012-11-13 |
2017-11-07 |
Array Biopharma Inc. |
Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors
|
|
US9790210B2
(en)
|
2012-11-13 |
2017-10-17 |
Array Biopharma Inc. |
N-(monocyclic aryl),N'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
|
WO2014078378A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
|
WO2014078322A1
(en)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
|
|
MX365733B
(es)
|
2012-11-13 |
2019-06-12 |
Array Biopharma Inc |
Compuestos de n-pirrolidinil, n' -pirazolil-urea, tiourea, guanidina y cianoguanidina como inhibidores de trka cinasa.
|
|
US9969694B2
(en)
|
2012-11-13 |
2018-05-15 |
Array Biopharma Inc. |
N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
|
CN103848810A
(zh)
|
2012-11-30 |
2014-06-11 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
|
BR122017003181A2
(pt)
|
2013-02-19 |
2019-09-10 |
Ono Pharmaceutical Co |
composto inibidor de trk, composição farmacêutica e medicamento compreendendo dito composto e seu uso para profilaxia e/ou terapia de doença relacionada à trk e/ou para inibir trk
|
|
EP2970334B1
(en)
|
2013-03-15 |
2018-05-23 |
Biogen MA Inc. |
Macrocyclic compounds as irak4 inhibitors for the treatment of inflammatory diseases
|
|
US9499522B2
(en)
|
2013-03-15 |
2016-11-22 |
Blueprint Medicines Corporation |
Compositions useful for treating disorders related to kit
|
|
ES2646019T3
(es)
|
2013-05-14 |
2017-12-11 |
Nerviano Medical Sciences S.R.L. |
Derivados de 6-amino-7-deaza-purina, proceso para su preparación y su uso como inhibidores de cinasa
|
|
BR112015028845A2
(pt)
|
2013-05-30 |
2017-07-25 |
Plexxikon Inc |
compostos para a modulação da quinase e indicações da mesma
|
|
AR096721A1
(es)
|
2013-06-25 |
2016-01-27 |
Bristol Myers Squibb Co |
Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos
|
|
JP6458018B2
(ja)
|
2013-07-02 |
2019-01-23 |
ファーマサイクリックス エルエルシー |
キナーゼ阻害剤としてのプリノン化合物
|
|
WO2015017533A1
(en)
|
2013-07-30 |
2015-02-05 |
Blueprint Medicines Corporation |
Ntrk2 fusions
|
|
US10875930B2
(en)
|
2013-07-30 |
2020-12-29 |
Blueprint Medicines Corporation |
PIK3C2G fusions
|
|
WO2015017502A1
(en)
|
2013-07-31 |
2015-02-05 |
Merck Patent Gmbh |
Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof
|
|
CA2924362C
(en)
|
2013-09-18 |
2018-12-18 |
Beijing Hanmi Pharmaceutical Co., Ltd. |
Compound inhibiting activities of btk and/or jak3 kinases
|
|
SG11201602070TA
(en)
|
2013-09-30 |
2016-04-28 |
Beijing Synercare Pharma Tech Co Ltd |
Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
|
|
US9334263B2
(en)
|
2013-10-17 |
2016-05-10 |
Blueprint Medicines Corporation |
Compositions useful for treating disorders related to kit
|
|
WO2015057873A1
(en)
|
2013-10-17 |
2015-04-23 |
Blueprint Medicines Corporation |
Compositions useful for treating disorders related to kit
|
|
PT3395814T
(pt)
|
2013-10-25 |
2022-07-27 |
Blueprint Medicines Corp |
Inibidores do recetor do fator de crescimento de fibroblastos
|
|
CA2929316C
(en)
|
2013-11-08 |
2021-12-28 |
Takeda Pharmaceutical Company Limited |
Pyrazole for the treatment autoimmune disorders
|
|
AU2014360446A1
(en)
|
2013-12-05 |
2016-06-09 |
Pharmacyclics, Llc |
Inhibitors of Bruton's tyrosine kinase
|
|
CN109096274B
(zh)
|
2013-12-11 |
2022-07-01 |
比奥根Ma公司 |
可用于治疗人类肿瘤学、神经病学和免疫学疾病的联芳基化合物
|
|
AU2014361798B2
(en)
|
2013-12-13 |
2020-06-11 |
Dana-Farber Cancer Institute, Inc. |
Methods to treat lymphoplasmacytic lymphoma
|
|
AU2014361800B2
(en)
|
2013-12-13 |
2020-05-07 |
Dana-Farber Cancer Institute, Inc. |
Methods to treat lymphoplasmacytic lymphoma
|
|
PL3805233T3
(pl)
|
2014-01-13 |
2024-06-10 |
Aurigene Oncology Limited |
ENANCJOMERY (R) I (S) (S)-N-(5-(3-hydroksypirolidyn-1-ylo)-2-morfolinooksazolo[4,5-b]pirydyn-6-ylo)-2-(2-metylopirydyn-4-ylo)oksazolo-4-karboksyamidu jako inhibitory IRAK4 do leczenia nowotworu złośliwego
|
|
WO2015108992A1
(en)
|
2014-01-15 |
2015-07-23 |
Blueprint Medicines Corporation |
Heterobicyclic compounds and their use as fgfr4 receptor inhibitors
|
|
WO2015112806A2
(en)
|
2014-01-24 |
2015-07-30 |
Tp Therapeutics, Inc. |
Diaryl macrocycles as modulators of protein kinases
|
|
TWI672141B
(zh)
|
2014-02-20 |
2019-09-21 |
美商醫科泰生技 |
投予ros1突變癌細胞之分子
|
|
WO2015161274A1
(en)
|
2014-04-18 |
2015-10-22 |
Blueprint Medicines Corporation |
Pik3ca fusions
|
|
EP3132054B1
(en)
|
2014-04-18 |
2021-06-30 |
Blueprint Medicines Corporation |
Met fusions
|
|
HUE045340T2
(hu)
|
2014-05-15 |
2019-12-30 |
Array Biopharma Inc |
1-((3S,4R)-4-(3-fluorfenil)-1-(2-metoxietil)pirrolidin-3-il)-3-(4-metil-3-(2- metilpirimidin-5-il)-1-fenil-1H-pirazol-5-il)karbamid mint TrkA kináz inhibitor
|
|
US10378063B2
(en)
|
2014-06-10 |
2019-08-13 |
Blueprint Medicines Corporation |
RAF1 fusions
|
|
WO2015191667A1
(en)
|
2014-06-10 |
2015-12-17 |
Blueprint Medicines Corporation |
Pkn1 fusions
|
|
US9949971B2
(en)
|
2014-06-17 |
2018-04-24 |
Acerta Pharma B.V. |
Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor
|
|
EP3169808B1
(en)
|
2014-07-17 |
2019-05-22 |
Blueprint Medicines Corporation |
Trio:tert fusion in cancer
|
|
US10370724B2
(en)
|
2014-07-17 |
2019-08-06 |
Blueprint Medicines Corporation |
PRKC fusions
|
|
WO2016011141A1
(en)
|
2014-07-17 |
2016-01-21 |
Blueprint Medicines Corporation |
Fgr fusions
|
|
US9688680B2
(en)
|
2014-08-04 |
2017-06-27 |
Blueprint Medicines Corporation |
Compositions useful for treating disorders related to kit
|
|
MX2017001671A
(es)
*
|
2014-08-07 |
2017-07-04 |
Pharmacyclics Llc |
Formulaciones novedosas de un inhibidor de la tirosina cinasa de bruton.
|
|
TWI560185B
(en)
|
2014-08-18 |
2016-12-01 |
Ono Pharmaceutical Co |
Acid addition salt of trk inhibitor compound
|
|
US9969749B2
(en)
|
2014-09-30 |
2018-05-15 |
Merck Sharp & Dohme Corp. |
Inhibitors of IRAK4 activity
|
|
JP6507234B2
(ja)
|
2014-10-02 |
2019-04-24 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
ブルトンチロシンキナーゼ(btk)によって介入される障害の処置における使用のためのピラゾールカルボキサミド化合物
|
|
CN110511209B
(zh)
|
2014-10-24 |
2022-07-05 |
百时美施贵宝公司 |
可用作激酶抑制剂的吲哚甲酰胺化合物
|
|
SG10201903621SA
(en)
|
2014-10-24 |
2019-05-30 |
Bristol Myers Squibb Co |
Tricyclic atropisomer compounds
|
|
CA2967125C
(en)
|
2014-11-14 |
2022-10-25 |
Nerviano Medical Sciences S.R.L. |
6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors
|
|
TWI746426B
(zh)
|
2014-11-16 |
2021-11-21 |
美商亞雷生物製藥股份有限公司 |
(S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型
|
|
EP3221700B1
(en)
|
2014-11-18 |
2022-06-22 |
Blueprint Medicines Corporation |
Prkacb fusions
|
|
WO2016106628A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
|
KR20170109546A
(ko)
|
2015-02-05 |
2017-09-29 |
메르크 파텐트 게엠베하 |
Irak1/4 억제제로서의 매크로시클릭 화합물 및 이들의 용도
|
|
US9717745B2
(en)
*
|
2015-03-19 |
2017-08-01 |
Zhejiang DTRM Biopharma Co. Ltd. |
Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
|
|
WO2016161570A1
(en)
|
2015-04-08 |
2016-10-13 |
Merck Sharp & Dohme Corp. |
Azacarbazole btk inhibitors
|
|
WO2016161571A1
(en)
|
2015-04-08 |
2016-10-13 |
Merck Sharp & Dohme Corp. |
Indazole and azaindazole btk inhibitors
|
|
ES2861351T3
(es)
|
2015-04-22 |
2021-10-06 |
Rigel Pharmaceuticals Inc |
Compuestos de pirazol y método para fabricar y usar los compuestos
|
|
EP3288558B1
(en)
|
2015-04-30 |
2022-05-11 |
Bayer Pharma Aktiengesellschaft |
Combinations of inhibitors of irak4 with inhibitors of btk
|
|
HK1257555A1
(zh)
|
2015-05-27 |
2019-10-25 |
Gb005, Inc. |
Tec激酶家族之抑制剂
|
|
KR20240070721A
(ko)
|
2015-06-03 |
2024-05-21 |
프린시피아 바이오파마, 인코퍼레이티드 |
티로신 키나제 억제제
|
|
CN108602776B
(zh)
|
2015-09-18 |
2021-12-03 |
默克专利有限公司 |
用作irak抑制剂的杂芳基化合物及其用途
|
|
US20170035881A1
(en)
|
2015-10-19 |
2017-02-09 |
Acerta Pharma B.V. |
Therapeutic Combinations of an IRAK4 Inhibitor and a BTK Inhibitor
|
|
MA55064A
(fr)
*
|
2015-12-16 |
2021-09-29 |
Loxo Oncology Inc |
Composés utilisés comme inhibiteurs de kinase
|
|
US9975882B2
(en)
|
2015-12-16 |
2018-05-22 |
Boehringer Ingelheim International Gmbh |
Heteroaromatic compounds as BTK inhibitors
|
|
WO2017103661A1
(en)
|
2015-12-18 |
2017-06-22 |
Edel-For-Life Sa |
Quality control assay to monitor the completeness of pathogen or targeted cell inactivation treatments in biological, foodstuff, drinks and cosmetics products
|
|
WO2017134685A2
(en)
|
2016-02-02 |
2017-08-10 |
Sun Pharma Advanced Research Company Limited |
Novel hydrazino compounds as btk inhibitors
|
|
WO2017205769A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
CN109715165A
(zh)
|
2016-07-28 |
2019-05-03 |
Tp生物医药公司 |
巨环激酶抑制剂
|
|
EP4011882B1
(en)
|
2016-08-15 |
2025-03-05 |
Purdue Research Foundation |
4-substituted aminoisoquinoline derivatives
|
|
CA3034239A1
(en)
|
2016-08-16 |
2018-02-22 |
Merck Patent Gmbh |
2-oxo-imidazopyridines as reversible btk inhibitors and uses thereof
|
|
CA2939286A1
(en)
|
2016-08-17 |
2018-02-17 |
Pharmascience Inc. |
Spirocyclic containing compounds and pharmaceutical uses thereof
|
|
RU2019108280A
(ru)
|
2016-08-24 |
2020-09-25 |
Аркьюл, Инк. |
Аминопирролопиримидиноновые соединения и способы их применения
|
|
MA46205A
(fr)
|
2016-09-08 |
2019-07-17 |
Sabila Biosciences Llc |
Composés 1,2-dithiolane utiles dans la neuroprotection, les maladies et les états auto-immuns et cancéreux
|
|
KR102686957B1
(ko)
|
2016-11-08 |
2024-07-22 |
주식회사 대웅제약 |
신규한 피롤로피리미딘 유도체 및 이를 포함하는 약학적 조성물
|
|
JOP20190113A1
(ar)
|
2016-11-18 |
2019-05-15 |
Biocad Joint Stock Co |
مثبطات بروتون تيروزين كيناز
|
|
CN108101905A
(zh)
|
2016-11-24 |
2018-06-01 |
中国科学院上海药物研究所 |
嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
|
|
WO2018103060A1
(en)
|
2016-12-09 |
2018-06-14 |
Janssen Pharmaceutica Nv |
Inhibitors of bruton's tyrosine kinase and methods of their use
|
|
CN106831789A
(zh)
|
2016-12-21 |
2017-06-13 |
南京亘泰医药技术有限公司 |
布鲁顿酪氨酸激酶抑制剂
|
|
UY37559A
(es)
|
2017-01-06 |
2018-05-31 |
Pharmacyclics Llc |
Pirazolo[3,4-b]piridina y pirrolo[2,3-b]piridina como inhibidores de la tirosina quinasa de bruton
|
|
US11672800B2
(en)
|
2017-04-21 |
2023-06-13 |
Epizyme, Inc. |
Combination therapies with EHMT2 inhibitors
|
|
KR20220100992A
(ko)
|
2019-12-06 |
2022-07-18 |
록쏘 온콜로지, 인코포레이티드 |
브루톤 티로신 키나제 억제제의 투여
|
|
TW202317099A
(zh)
|
2020-09-10 |
2023-05-01 |
美商絡速藥業公司 |
用於製備(s)-5-胺基-3-(4-((5-氟-2-甲氧基苯甲醯胺基)甲基)苯基)-1-(1,1,1-三氟丙烷-2-基)-1h-吡唑-4-甲醯胺之方法及中間體
|