JP2018024683A5 - - Google Patents
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- Publication number
- JP2018024683A5 JP2018024683A5 JP2017170788A JP2017170788A JP2018024683A5 JP 2018024683 A5 JP2018024683 A5 JP 2018024683A5 JP 2017170788 A JP2017170788 A JP 2017170788A JP 2017170788 A JP2017170788 A JP 2017170788A JP 2018024683 A5 JP2018024683 A5 JP 2018024683A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- methyl
- peak
- range
- angstroms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 12
- -1 4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl Chemical group 0.000 claims 4
- 150000008064 anhydrides Chemical class 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 230000008018 melting Effects 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- OKTJSMMVPCPJKN-NJFSPNSNSA-N Carbon-14 Chemical compound [14C] OKTJSMMVPCPJKN-NJFSPNSNSA-N 0.000 claims 1
- 238000005481 NMR spectroscopy Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000005384 cross polarization magic-angle spinning Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705780P | 2012-09-26 | 2012-09-26 | |
| US61/705,780 | 2012-09-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534567A Division JP6387349B2 (ja) | 2012-09-26 | 2013-09-20 | 逆転写酵素阻害剤の結晶形態 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018024683A JP2018024683A (ja) | 2018-02-15 |
| JP2018024683A5 true JP2018024683A5 (enExample) | 2018-07-05 |
Family
ID=50388877
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534567A Active JP6387349B2 (ja) | 2012-09-26 | 2013-09-20 | 逆転写酵素阻害剤の結晶形態 |
| JP2017170788A Pending JP2018024683A (ja) | 2012-09-26 | 2017-09-06 | 逆転写酵素阻害剤の結晶形態 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534567A Active JP6387349B2 (ja) | 2012-09-26 | 2013-09-20 | 逆転写酵素阻害剤の結晶形態 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9150539B2 (enExample) |
| EP (1) | EP2900240B1 (enExample) |
| JP (2) | JP6387349B2 (enExample) |
| CN (2) | CN109384765A (enExample) |
| BR (1) | BR112015005997A8 (enExample) |
| CA (1) | CA2882947A1 (enExample) |
| ES (1) | ES2773105T3 (enExample) |
| MX (1) | MX362517B (enExample) |
| WO (1) | WO2014052171A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2977643T3 (es) | 2013-12-04 | 2024-08-28 | Merck Sharp & Dohme Llc | Proceso para fabricar inhibidores de la transcriptasa inversa |
| US11077050B2 (en) | 2017-03-24 | 2021-08-03 | Merck Sharp & Dohme Corp. | Formulation for parenteral administration |
| KR20220130698A (ko) * | 2019-12-20 | 2022-09-27 | 에피자임, 인코포레이티드 | Ezh2 억제제의 결정질 하이드로브로마이드 염, 이의 제조 및 암의 치료에 유용한 약학적 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7309700B2 (en) * | 2004-04-02 | 2007-12-18 | Boehringer Ingelheim International Gmbh | Crystalline forms of 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2′,3′-e] [1,4]diazepin-6-one |
| WO2006010545A1 (en) * | 2004-07-27 | 2006-02-02 | F. Hoffmann-La Roche Ag | Benzyltriazolone compounds as non-nucleoside reverse transcriptase inhibitors |
| KR101541929B1 (ko) * | 2007-05-30 | 2015-08-04 | 에프. 호프만-라 로슈 아게 | 트라이아졸론의 제조방법 |
| MX2010005483A (es) * | 2007-11-20 | 2010-06-11 | Merck Sharp & Dohme | Inhibidores de transcriptasa inversa no nucleosidos. |
| SI2924034T1 (sl) * | 2010-03-30 | 2017-05-31 | Merck Canada Inc. | Farmacevtski sestavek, ki obsega nenukleozidni inhibitor reverzne transkriptaze |
| EP2558093A4 (en) * | 2010-04-08 | 2013-10-02 | Merck Sharp & Dohme | PRODRUGS OF HIV INVERTER TRANSCRIPTASE INHIBITOR |
-
2013
- 2013-09-20 CA CA2882947A patent/CA2882947A1/en not_active Abandoned
- 2013-09-20 CN CN201811295039.5A patent/CN109384765A/zh active Pending
- 2013-09-20 JP JP2015534567A patent/JP6387349B2/ja active Active
- 2013-09-20 MX MX2015003767A patent/MX362517B/es active IP Right Grant
- 2013-09-20 CN CN201380050220.9A patent/CN104684557A/zh active Pending
- 2013-09-20 BR BR112015005997A patent/BR112015005997A8/pt not_active Application Discontinuation
- 2013-09-20 ES ES13840379T patent/ES2773105T3/es active Active
- 2013-09-20 US US14/430,657 patent/US9150539B2/en active Active
- 2013-09-20 WO PCT/US2013/060787 patent/WO2014052171A1/en not_active Ceased
- 2013-09-20 EP EP13840379.5A patent/EP2900240B1/en active Active
-
2017
- 2017-09-06 JP JP2017170788A patent/JP2018024683A/ja active Pending
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