JP2016065042A5 - - Google Patents
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- Publication number
- JP2016065042A5 JP2016065042A5 JP2015172636A JP2015172636A JP2016065042A5 JP 2016065042 A5 JP2016065042 A5 JP 2016065042A5 JP 2015172636 A JP2015172636 A JP 2015172636A JP 2015172636 A JP2015172636 A JP 2015172636A JP 2016065042 A5 JP2016065042 A5 JP 2016065042A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline form
- dichlorophenyl
- carboxy
- benzoxazole
- raman
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- TXEIIPDJKFWEEC-UHFFFAOYSA-N tafamidis Chemical compound O1C2=CC(C(=O)O)=CC=C2N=C1C1=CC(Cl)=CC(Cl)=C1 TXEIIPDJKFWEEC-UHFFFAOYSA-N 0.000 claims 9
- 238000001069 Raman spectroscopy Methods 0.000 claims 5
- 238000001237 Raman spectrum Methods 0.000 claims 5
- 238000000634 powder X-ray diffraction Methods 0.000 claims 5
- 238000000371 solid-state nuclear magnetic resonance spectroscopy Methods 0.000 claims 5
- 238000001228 spectrum Methods 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 239000013078 crystal Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 108010071690 Prealbumin Proteins 0.000 claims 1
- 102000009190 Transthyretin Human genes 0.000 claims 1
- 238000002441 X-ray diffraction Methods 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019218244A JP7357525B2 (ja) | 2014-09-08 | 2019-12-02 | ６－カルボキシ－２－（３，５－ジクロロフェニル）－ベンゾオキサゾールの結晶性固体形態 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462047614P | 2014-09-08 | 2014-09-08 | |
| US62/047,614 | 2014-09-08 | ||
| US201562203953P | 2015-08-12 | 2015-08-12 | |
| US62/203,953 | 2015-08-12 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019218244A Division JP7357525B2 (ja) | 2014-09-08 | 2019-12-02 | ６－カルボキシ－２－（３，５－ジクロロフェニル）－ベンゾオキサゾールの結晶性固体形態 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016065042A JP2016065042A (ja) | 2016-04-28 |
| JP2016065042A5 true JP2016065042A5 (enExample) | 2018-08-02 |
Family
ID=54199901
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015172636A Withdrawn JP2016065042A (ja) | 2014-09-08 | 2015-09-02 | ６−カルボキシ−２−（３，５−ジクロロフェニル）−ベンゾオキサゾールの結晶性固体形態 |
| JP2019218244A Active JP7357525B2 (ja) | 2014-09-08 | 2019-12-02 | ６－カルボキシ－２－（３，５－ジクロロフェニル）－ベンゾオキサゾールの結晶性固体形態 |
| JP2021182622A Withdrawn JP2022024014A (ja) | 2014-09-08 | 2021-11-09 | ６－カルボキシ－２－（３，５－ジクロロフェニル）－ベンゾオキサゾールの結晶性固体形態 |
| JP2023115087A Pending JP2023134645A (ja) | 2014-09-08 | 2023-07-13 | ６－カルボキシ－２－（３，５－ジクロロフェニル）－ベンゾオキサゾールの結晶性固体形態 |
| JP2025066606A Pending JP2025108584A (ja) | 2014-09-08 | 2025-04-15 | ６－カルボキシ－２－（３，５－ジクロロフェニル）－ベンゾオキサゾールの結晶性固体形態 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019218244A Active JP7357525B2 (ja) | 2014-09-08 | 2019-12-02 | ６－カルボキシ－２－（３，５－ジクロロフェニル）－ベンゾオキサゾールの結晶性固体形態 |
| JP2021182622A Withdrawn JP2022024014A (ja) | 2014-09-08 | 2021-11-09 | ６－カルボキシ－２－（３，５－ジクロロフェニル）－ベンゾオキサゾールの結晶性固体形態 |
| JP2023115087A Pending JP2023134645A (ja) | 2014-09-08 | 2023-07-13 | ６－カルボキシ－２－（３，５－ジクロロフェニル）－ベンゾオキサゾールの結晶性固体形態 |
| JP2025066606A Pending JP2025108584A (ja) | 2014-09-08 | 2025-04-15 | ６－カルボキシ－２－（３，５－ジクロロフェニル）－ベンゾオキサゾールの結晶性固体形態 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9770441B1 (enExample) |
| EP (3) | EP3191461B1 (enExample) |
| JP (5) | JP2016065042A (enExample) |
| KR (1) | KR102004059B1 (enExample) |
| CN (2) | CN115368313A (enExample) |
| AU (1) | AU2015313875B2 (enExample) |
| BR (1) | BR112017003421B1 (enExample) |
| CA (1) | CA2903194A1 (enExample) |
| CY (1) | CY1124843T1 (enExample) |
| DK (1) | DK3977993T3 (enExample) |
| ES (2) | ES2975633T3 (enExample) |
| FI (1) | FI3977993T3 (enExample) |
| HR (1) | HRP20211834T1 (enExample) |
| HU (2) | HUE065233T2 (enExample) |
| IL (1) | IL251037B1 (enExample) |
| LT (1) | LT3191461T (enExample) |
| MX (1) | MX374012B (enExample) |
| PL (2) | PL3977993T3 (enExample) |
| PT (2) | PT3191461T (enExample) |
| RS (1) | RS62634B1 (enExample) |
| SG (1) | SG11201700958YA (enExample) |
| SI (2) | SI3977993T1 (enExample) |
| TW (1) | TWI644902B (enExample) |
| WO (1) | WO2016038500A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2571950A (en) | 2018-03-13 | 2019-09-18 | Azad Pharma Ag | New polymorph and new path to synthesize tafamidis |
| WO2020128816A2 (en) | 2018-12-20 | 2020-06-25 | Pfizer Inc. | Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent |
| PL3953339T3 (pl) * | 2019-04-11 | 2025-05-05 | Inke, S.A. | Proces otrzymania 1-deoksy-1-metyloamino-d-glucitolu 2-(3,5-dichlorofenylo)-6-benzoksazolokarboksylanu |
| US12391656B2 (en) | 2019-05-16 | 2025-08-19 | Assia Chemical Industries Ltd. | Solid state forms of Tafamidis and salts thereof |
| WO2021001858A1 (en) * | 2019-07-04 | 2021-01-07 | Msn Laboratories Private Limited, R&D Center | Improved process for the preparation of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid or its pharmaceutically acceptable salts and polymorphs thereof |
| EP4059926A4 (en) | 2019-11-15 | 2022-12-14 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | CRYSTALLINE FORM OF TAFAMIDIS AND PROCESS FOR PRODUCTION AND USE THEREOF |
| EP4077287B1 (en) * | 2019-12-20 | 2025-11-19 | Pfizer Ireland Pharmaceuticals Unlimited Company | Efficient process for making 6-carboxy benzoxazole derivatives |
| WO2021152623A1 (en) * | 2020-01-27 | 2021-08-05 | Dr. Reddy’S Laboratories Limited | Improved processes for the preparation of tafamidis and its meglumine salt |
| WO2021232619A1 (zh) * | 2020-05-19 | 2021-11-25 | 苏州科睿思制药有限公司 | 一种他发米帝司游离酸的晶型及其制备方法和用途 |
| US20230265059A1 (en) * | 2020-07-04 | 2023-08-24 | Nuray Chemicals Private Limited | Solid state forms of 6-carboxy-2-(3, 5-dichlorophenyl)-benzoxazole of formula-i and pharmaceutically acceptable salts thereof |
| WO2022084790A1 (en) * | 2020-10-19 | 2022-04-28 | Glenmark Life Sciences Limited | Process for preparation of tafamidis and salts thereof |
| WO2022107166A1 (en) * | 2020-11-20 | 2022-05-27 | Natco Pharma Limited | Novel crystalline form of tafamidis and its process thereof |
| WO2022112919A1 (en) | 2020-11-25 | 2022-06-02 | Pfizer Inc. | (aza)benzothiazolyl substituted pyrazole compounds |
| CN114907283B (zh) * | 2021-02-07 | 2025-01-28 | 南京正大天晴制药有限公司 | 一种2-(3，5-二氯苯基)-苯并噁唑-6-羧酸的制备方法 |
| CN114989106A (zh) * | 2021-02-09 | 2022-09-02 | 齐鲁制药有限公司 | 氯苯唑酸的新晶型及其制备方法 |
| EP4083027A1 (en) | 2021-04-26 | 2022-11-02 | Química Sintética, S.A. | A solid state form of tafamidis and a process for its preparation |
| WO2023020762A1 (en) | 2021-08-16 | 2023-02-23 | Synthon B.V. | Crystalline forms of tafamidis nicotinamide adduct |
| JP2024541422A (ja) | 2021-11-17 | 2024-11-08 | テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハー | タファミジスの固体状態の形態 |
| KR20250036933A (ko) | 2022-07-28 | 2025-03-14 | 화이자 인코포레이티드 | 타파미디스 약학 조성물 |
| WO2024084362A1 (en) * | 2022-10-17 | 2024-04-25 | Biophore India Pharmaceuticals Pvt. Ltd | A process for the preparation of crystalline form of tafamidis |
| US11878081B1 (en) | 2022-12-23 | 2024-01-23 | Tap Pharmaceuticals Ag | Pharmaceutical formulations of tafamidis |
| US11980685B1 (en) | 2022-12-23 | 2024-05-14 | Tap Pharmaceuticals, Ag | Liquid pharmaceutical formulations of tafamidis |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| DK1587821T6 (da) | 2002-12-19 | 2025-05-26 | Scripps Research Inst | Sammensætninger og fremgangsmåder til stabilisering af trans-thyretin og inhibering af transthyretin-fejlfoldning |
| CA2669849C (en) * | 2006-12-06 | 2012-01-31 | Pfizer Inc. | Crystalline forms of (3s)-3-[n-(n'-(2-tert-butylphenyl)oxamyl)alaninyl]amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-oxopentanoic acid |
| US8576985B2 (en) | 2009-09-01 | 2013-11-05 | Aptuit (West Lafayette) Llc | Methods for indexing solid forms of compounds |
| SG2014013270A (en) * | 2011-09-16 | 2014-05-29 | Pfizer | Solid forms of a transthyretin dissociation inhibitor |
| US9499527B2 (en) * | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of familial amyloid polyneuropathy |
| GB2571950A (en) | 2018-03-13 | 2019-09-18 | Azad Pharma Ag | New polymorph and new path to synthesize tafamidis |
| US12391656B2 (en) | 2019-05-16 | 2025-08-19 | Assia Chemical Industries Ltd. | Solid state forms of Tafamidis and salts thereof |
| WO2021001858A1 (en) | 2019-07-04 | 2021-01-07 | Msn Laboratories Private Limited, R&D Center | Improved process for the preparation of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid or its pharmaceutically acceptable salts and polymorphs thereof |
| WO2021152623A1 (en) | 2020-01-27 | 2021-08-05 | Dr. Reddy’S Laboratories Limited | Improved processes for the preparation of tafamidis and its meglumine salt |
-
2015
- 2015-08-31 PT PT157712761T patent/PT3191461T/pt unknown
- 2015-08-31 PL PL21203965.5T patent/PL3977993T3/pl unknown
- 2015-08-31 BR BR112017003421-2A patent/BR112017003421B1/pt active IP Right Grant
- 2015-08-31 RS RS20211481A patent/RS62634B1/sr unknown
- 2015-08-31 WO PCT/IB2015/056597 patent/WO2016038500A1/en not_active Ceased
- 2015-08-31 PL PL15771276T patent/PL3191461T3/pl unknown
- 2015-08-31 EP EP15771276.1A patent/EP3191461B1/en active Active
- 2015-08-31 SI SI201532001T patent/SI3977993T1/sl unknown
- 2015-08-31 ES ES21203965T patent/ES2975633T3/es active Active
- 2015-08-31 HU HUE21203965A patent/HUE065233T2/hu unknown
- 2015-08-31 DK DK21203965.5T patent/DK3977993T3/da active
- 2015-08-31 US US15/509,343 patent/US9770441B1/en active Active
- 2015-08-31 FI FIEP21203965.5T patent/FI3977993T3/fi active
- 2015-08-31 SI SI201531753T patent/SI3191461T1/sl unknown
- 2015-08-31 EP EP24152053.5A patent/EP4349406B1/en active Active
- 2015-08-31 AU AU2015313875A patent/AU2015313875B2/en active Active
- 2015-08-31 KR KR1020177006011A patent/KR102004059B1/ko active Active
- 2015-08-31 ES ES15771276T patent/ES2901785T3/es active Active
- 2015-08-31 HU HUE15771276A patent/HUE056583T2/hu unknown
- 2015-08-31 EP EP21203965.5A patent/EP3977993B1/en active Active
- 2015-08-31 SG SG11201700958YA patent/SG11201700958YA/en unknown
- 2015-08-31 CN CN202211071641.7A patent/CN115368313A/zh active Pending
- 2015-08-31 MX MX2017002954A patent/MX374012B/es active IP Right Grant
- 2015-08-31 CN CN201580048168.2A patent/CN106715405A/zh active Pending
- 2015-08-31 LT LTEPPCT/IB2015/056597T patent/LT3191461T/lt unknown
- 2015-08-31 IL IL251037A patent/IL251037B1/en unknown
- 2015-08-31 PT PT212039655T patent/PT3977993T/pt unknown
- 2015-08-31 HR HRP20211834TT patent/HRP20211834T1/hr unknown
- 2015-09-02 JP JP2015172636A patent/JP2016065042A/ja not_active Withdrawn
- 2015-09-03 CA CA2903194A patent/CA2903194A1/en not_active Abandoned
- 2015-09-07 TW TW104129562A patent/TWI644902B/zh active
-
2019
- 2019-12-02 JP JP2019218244A patent/JP7357525B2/ja active Active
-
2021
- 2021-11-09 JP JP2021182622A patent/JP2022024014A/ja not_active Withdrawn
- 2021-12-16 CY CY20211101109T patent/CY1124843T1/el unknown
-
2023
- 2023-07-13 JP JP2023115087A patent/JP2023134645A/ja active Pending
-
2025
- 2025-04-15 JP JP2025066606A patent/JP2025108584A/ja active Pending
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