JP2012509281A5 - - Google Patents

Info

Publication number

JP2012509281A5

JP2012509281A5 JP2011536620A JP2011536620A JP2012509281A5 JP 2012509281 A5 JP2012509281 A5 JP 2012509281A5 JP 2011536620 A JP2011536620 A JP 2011536620A JP 2011536620 A JP2011536620 A JP 2011536620A JP 2012509281 A5 JP2012509281 A5 JP 2012509281A5

Authority

JP

Japan

Prior art keywords

diffraction pattern

ray powder

powder diffraction

composition

degrees

Prior art date

2009-11-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 238000000634 powder X-ray diffraction Methods 0.000 claims description 16
• 239000013078 crystal Substances 0.000 claims description 14
• KXGCNMMJRFDFNR-WDRJZQOASA-N linaclotide Chemical compound C([C@H](NC(=O)[C@@H]1CSSC[C@H]2C(=O)N[C@H]3CSSC[C@H](N)C(=O)N[C@H](C(N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N2)=O)CSSC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC3=O)C(=O)N[C@H](C(NCC(=O)N1)=O)[C@H](O)C)C(O)=O)C1=CC=C(O)C=C1 KXGCNMMJRFDFNR-WDRJZQOASA-N 0.000 claims description 13
• 229960000812 linaclotide Drugs 0.000 claims description 13
• 108010024409 linaclotide Proteins 0.000 claims description 13
• 208000018522 Gastrointestinal disease Diseases 0.000 claims description 12
• 208000010643 digestive system disease Diseases 0.000 claims description 10
• 208000018685 gastrointestinal system disease Diseases 0.000 claims description 10
• 206010010774 Constipation Diseases 0.000 claims description 8
• 230000001684 chronic effect Effects 0.000 claims description 4
• 208000002551 irritable bowel syndrome Diseases 0.000 claims description 4
• 239000008194 pharmaceutical composition Substances 0.000 claims description 4
• 238000004519 manufacturing process Methods 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 8
• 238000000034 method Methods 0.000 description 7