CN115368313A - 6-羧基-2-(3,5-二氯苯基)苯并噁唑的结晶固体形式 - Google Patents
6-羧基-2-(3,5-二氯苯基)苯并噁唑的结晶固体形式 Download PDFInfo
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- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
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| US12268669B2 (en) | 2018-12-20 | 2025-04-08 | Pfizer Inc. | Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent |
| PL3953339T3 (pl) * | 2019-04-11 | 2025-05-05 | Inke, S.A. | Proces otrzymania 1-deoksy-1-metyloamino-d-glucitolu 2-(3,5-dichlorofenylo)-6-benzoksazolokarboksylanu |
| HRP20250159T1 (hr) * | 2019-05-16 | 2025-03-28 | Assia Chemical Industries Ltd. | Kruti oblici tafamidisa i njegovih soli |
| WO2021001858A1 (en) * | 2019-07-04 | 2021-01-07 | Msn Laboratories Private Limited, R&D Center | Improved process for the preparation of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid or its pharmaceutically acceptable salts and polymorphs thereof |
| WO2021093809A1 (zh) * | 2019-11-15 | 2021-05-20 | 苏州科睿思制药有限公司 | 他发米帝司的晶型及其制备方法和用途 |
| CA3165298A1 (en) * | 2019-12-20 | 2021-06-24 | Pfizer Ireland Pharmaceuticals | Efficient process for making 6-carboxy benzoxazole derivatives |
| WO2021152623A1 (en) * | 2020-01-27 | 2021-08-05 | Dr. Reddy’S Laboratories Limited | Improved processes for the preparation of tafamidis and its meglumine salt |
| WO2021232619A1 (zh) * | 2020-05-19 | 2021-11-25 | 苏州科睿思制药有限公司 | 一种他发米帝司游离酸的晶型及其制备方法和用途 |
| US20230265059A1 (en) * | 2020-07-04 | 2023-08-24 | Nuray Chemicals Private Limited | Solid state forms of 6-carboxy-2-(3, 5-dichlorophenyl)-benzoxazole of formula-i and pharmaceutically acceptable salts thereof |
| US20230391737A1 (en) * | 2020-10-19 | 2023-12-07 | Glenmark Life Sciences Limited | Process for preparation of tafamidis and salts thereof |
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| CN114907283B (zh) * | 2021-02-07 | 2025-01-28 | 南京正大天晴制药有限公司 | 一种2-(3，5-二氯苯基)-苯并噁唑-6-羧酸的制备方法 |
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| WO2023020762A1 (en) | 2021-08-16 | 2023-02-23 | Synthon B.V. | Crystalline forms of tafamidis nicotinamide adduct |
| WO2023091534A1 (en) | 2021-11-17 | 2023-05-25 | Teva Pharmaceuticals International Gmbh | Solid state form of tafamidis |
| JP2025524085A (ja) | 2022-07-28 | 2025-07-25 | ファイザー・インク | タファミジス医薬組成物 |
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| US11878081B1 (en) | 2022-12-23 | 2024-01-23 | Tap Pharmaceuticals Ag | Pharmaceutical formulations of tafamidis |
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| US20040152140A1 (en) * | 2002-12-19 | 2004-08-05 | Kelly Jeffery W. | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
| WO2013168014A1 (en) * | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of familial amyloid polyneuropathy |
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| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| PL2091910T3 (pl) * | 2006-12-06 | 2015-02-27 | Conatus Pharmaceuticals Inc | Postacie krystaliczne kwasu (3S)-3-[N-(N’-(2-tert-butylofenylo)oksamylo)alaninylo]amino-5-(2’,3’,5’,6’-tetrafluorofenoksy)-4-oksopentanowego |
| US8576985B2 (en) | 2009-09-01 | 2013-11-05 | Aptuit (West Lafayette) Llc | Methods for indexing solid forms of compounds |
| MX2014003043A (es) * | 2011-09-16 | 2015-02-05 | Pfizer | Formas solidas de un inhibidor de disociacion transtiretina. |
| GB2571950A (en) | 2018-03-13 | 2019-09-18 | Azad Pharma Ag | New polymorph and new path to synthesize tafamidis |
| HRP20250159T1 (hr) | 2019-05-16 | 2025-03-28 | Assia Chemical Industries Ltd. | Kruti oblici tafamidisa i njegovih soli |
| WO2021001858A1 (en) | 2019-07-04 | 2021-01-07 | Msn Laboratories Private Limited, R&D Center | Improved process for the preparation of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid or its pharmaceutically acceptable salts and polymorphs thereof |
| WO2021152623A1 (en) | 2020-01-27 | 2021-08-05 | Dr. Reddy’S Laboratories Limited | Improved processes for the preparation of tafamidis and its meglumine salt |
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