JP2023078341A5 - - Google Patents
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- JP2023078341A5 JP2023078341A5 JP2023044746A JP2023044746A JP2023078341A5 JP 2023078341 A5 JP2023078341 A5 JP 2023078341A5 JP 2023044746 A JP2023044746 A JP 2023044746A JP 2023044746 A JP2023044746 A JP 2023044746A JP 2023078341 A5 JP2023078341 A5 JP 2023078341A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 46
- 239000002246 antineoplastic agent Substances 0.000 claims 13
- 229940127089 cytotoxic agent Drugs 0.000 claims 13
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 6
- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 claims 3
- 108010069236 Goserelin Proteins 0.000 claims 3
- 229960002932 anastrozole Drugs 0.000 claims 3
- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 3
- 229960002913 goserelin Drugs 0.000 claims 3
- 229960003881 letrozole Drugs 0.000 claims 3
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 3
- 229960001603 tamoxifen Drugs 0.000 claims 3
- 229960005026 toremifene Drugs 0.000 claims 3
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 claims 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 108050002653 Retinoblastoma protein Proteins 0.000 claims 2
- BUROJSBIWGDYCN-GAUTUEMISA-N AP 23573 Chemical compound C1C[C@@H](OP(C)(C)=O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 BUROJSBIWGDYCN-GAUTUEMISA-N 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 101000715943 Caenorhabditis elegans Cyclin-dependent kinase 4 homolog Proteins 0.000 claims 1
- 102000013701 Cyclin-Dependent Kinase 4 Human genes 0.000 claims 1
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims 1
- 102000013698 Cyclin-Dependent Kinase 6 Human genes 0.000 claims 1
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 108010000817 Leuprolide Proteins 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 1
- 229960004562 carboplatin Drugs 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
- 229960001101 ifosfamide Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims 1
- 229960004338 leuprorelin Drugs 0.000 claims 1
- 229960002985 medroxyprogesterone acetate Drugs 0.000 claims 1
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 claims 1
- 229960004296 megestrol acetate Drugs 0.000 claims 1
- RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 102000003998 progesterone receptors Human genes 0.000 claims 1
- 108090000468 progesterone receptors Proteins 0.000 claims 1
- 229960001302 ridaforolimus Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229960000235 temsirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Claims (28)
- それを必要とするヒトにおける網膜芽細胞腫タンパク質ポジティブ（Ｒｂ＋）子宮癌の治療のための医薬組成物であって、
前記医薬組成物が、有効量の、以下の構造：
- 前記医薬組成物が、経口投与される、請求項１に記載の医薬組成物。
- 前記医薬組成物が、連続する２４日以上の間、１日に少なくとも１回、前記ヒトに投与される、請求項１に記載の医薬組成物。
- 前記医薬組成物が、連続する２８日以上の間、１日に少なくとも１回、前記ヒトに投与される、請求項１に記載の医薬組成物。
- 前記医薬組成物が、連続する３５日以上の間、１日に少なくとも１回、前記ヒトに投与される、請求項１に記載の医薬組成物。
- 前記医薬組成物が、１日に２回、前記ヒトに投与される、請求項３に記載の医薬組成物。
- 前記医薬組成物が、１日に２回、前記ヒトに投与される、請求項４に記載の医薬組成物。
- 前記医薬組成物が、１日に２回、前記ヒトに投与される、請求項５に記載の医薬組成物。
- 前記医薬組成物が、有効量の少なくとも１つの付加的な化学療法剤をさらに含んでなる、請求項１に記載の医薬組成物。
- 前記付加的な化学療法剤が、アナストロゾール、カルボプラチン、シスプラチン、ドセタキセル、ドキソルビシン、エベロリムス、イホスファミド、ゴセレリン、レトロゾール、酢酸ロイプロリド、メドロキシプロゲステロンアセテート、メゲストロールアセテート、パクリタキセル、リダフォロリムス、タモキシフェン、テムシロリムス、トレミフェン、トラスツズマブ又はこれらの組合せから選択される、請求項９に記載の医薬組成物。
- 前記付加的な化学療法剤が、タモキシフェンである、請求項１０に記載の医薬組成物。
- 前記付加的な化学療法剤が、レトロゾールである、請求項１０に記載の医薬組成物。
- 前記付加的な化学療法剤が、アナストロゾールである、請求項１０に記載の医薬組成物。
- 前記付加的な化学療法剤が、トレミフェンである、請求項１０に記載の医薬組成物。
- 前記付加的な化学療法剤が、ゴセレリンである、請求項１０に記載の医薬組成物。
- ヒトにおける網膜芽細胞腫タンパク質ポジティブ（Ｒｂ＋）プロゲステロンレセプターポジティブ（ＰＲ＋）乳癌の治療のための医薬組成物であって、
前記医薬組成物が、有効量の、以下の構造：
前記医薬組成物が、連続する２４日以上の間、１日に少なくとも１回、前記ヒトに投与される、前記医薬組成物。 - 前記医薬組成物が、経口投与される、請求項１６に記載の医薬組成物。
- 前記医薬組成物が、連続する２８日以上の間、１日に少なくとも１回、前記ヒトに投与される、請求項１６に記載の医薬組成物。
- 前記医薬組成物が、連続する３５日以上の間、１日に少なくとも１回、前記ヒトに投与される、請求項１６に記載の医薬組成物。
- 前記医薬組成物が、１日に２回、前記ヒトに投与される、請求項１６に記載の医薬組成物。
- 前記医薬組成物が、１日に２回、前記ヒトに投与される、請求項１８に記載の医薬組成物。
- 前記医薬組成物が、１日に２回、前記ヒトに投与される、請求項１９に記載の医薬組成物。
- 前記医薬組成物が、有効量の少なくとも１つの付加的な化学療法剤をさらに含んでなる、請求項１６に記載の医薬組成物。
- 前記付加的な化学療法剤が、タモキシフェンである、請求項２３に記載の医薬組成物。
- 前記付加的な化学療法剤が、レトロゾールである、請求項２３に記載の医薬組成物。
- 前記付加的な化学療法剤が、アナストロゾールである、請求項２３に記載の医薬組成物。
- 前記付加的な化学療法剤が、トレミフェンである、請求項２３に記載の医薬組成物。
- 前記付加的な化学療法剤が、ゴセレリンである、請求項２３に記載の医薬組成物。
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361798772P | 2013-03-15 | 2013-03-15 | |
| US61/798,772 | 2013-03-15 | ||
| US201361861374P | 2013-08-01 | 2013-08-01 | |
| US61/861,374 | 2013-08-01 | ||
| US201361911354P | 2013-12-03 | 2013-12-03 | |
| US61/911,354 | 2013-12-03 | ||
| US201461949786P | 2014-03-07 | 2014-03-07 | |
| US61/949,786 | 2014-03-07 | ||
| JP2020123189A JP7250737B2 (ja) | 2013-03-15 | 2020-07-17 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020123189A Division JP7250737B2 (ja) | 2013-03-15 | 2020-07-17 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023078341A JP2023078341A (ja) | 2023-06-06 |
| JP2023078341A5 true JP2023078341A5 (ja) | 2023-08-04 |
Family
ID=51527871
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502870A Active JP6430483B2 (ja) | 2013-03-15 | 2014-03-14 | 化学療法の間の正常細胞の一時的な保護 |
| JP2016503092A Active JP6337083B2 (ja) | 2013-03-15 | 2014-03-14 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2018089382A Active JP6517401B2 (ja) | 2013-03-15 | 2018-05-07 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2018204234A Active JP6767456B2 (ja) | 2013-03-15 | 2018-10-30 | 化学療法の間の正常細胞の一時的な保護 |
| JP2019077828A Active JP6738933B6 (ja) | 2013-03-15 | 2019-04-16 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2020123189A Active JP7250737B2 (ja) | 2013-03-15 | 2020-07-17 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2020155691A Active JP7213854B2 (ja) | 2013-03-15 | 2020-09-16 | 化学療法の間の正常細胞の一時的な保護 |
| JP2023005413A Ceased JP2023052449A (ja) | 2013-03-15 | 2023-01-17 | 化学療法の間の正常細胞の一時的な保護 |
| JP2023044746A Withdrawn JP2023078341A (ja) | 2013-03-15 | 2023-03-20 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
Family Applications Before (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502870A Active JP6430483B2 (ja) | 2013-03-15 | 2014-03-14 | 化学療法の間の正常細胞の一時的な保護 |
| JP2016503092A Active JP6337083B2 (ja) | 2013-03-15 | 2014-03-14 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2018089382A Active JP6517401B2 (ja) | 2013-03-15 | 2018-05-07 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2018204234A Active JP6767456B2 (ja) | 2013-03-15 | 2018-10-30 | 化学療法の間の正常細胞の一時的な保護 |
| JP2019077828A Active JP6738933B6 (ja) | 2013-03-15 | 2019-04-16 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2020123189A Active JP7250737B2 (ja) | 2013-03-15 | 2020-07-17 | Ｒｂポジティブ異常細胞増殖に対するｈｓｐｃ温存治療 |
| JP2020155691A Active JP7213854B2 (ja) | 2013-03-15 | 2020-09-16 | 化学療法の間の正常細胞の一時的な保護 |
| JP2023005413A Ceased JP2023052449A (ja) | 2013-03-15 | 2023-01-17 | 化学療法の間の正常細胞の一時的な保護 |
Country Status (18)
| Country | Link |
|---|---|
| US (15) | US9527857B2 (ja) |
| EP (3) | EP2968290B1 (ja) |
| JP (9) | JP6430483B2 (ja) |
| CN (4) | CN108434149B (ja) |
| CA (2) | CA2906166C (ja) |
| CY (1) | CY1122434T1 (ja) |
| DK (1) | DK2968290T3 (ja) |
| ES (1) | ES2761406T3 (ja) |
| HK (3) | HK1222792A1 (ja) |
| HR (1) | HRP20192168T1 (ja) |
| HU (1) | HUE046653T2 (ja) |
| LT (1) | LT2968290T (ja) |
| ME (1) | ME03557B (ja) |
| PL (1) | PL2968290T3 (ja) |
| PT (1) | PT2968290T (ja) |
| RS (1) | RS59790B1 (ja) |
| SI (1) | SI2968290T1 (ja) |
| WO (2) | WO2014144326A1 (ja) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9259399B2 (en) | 2007-11-07 | 2016-02-16 | Cornell University | Targeting CDK4 and CDK6 in cancer therapy |
| US8691830B2 (en) | 2010-10-25 | 2014-04-08 | G1 Therapeutics, Inc. | CDK inhibitors |
| EP3216792B1 (en) | 2012-03-29 | 2020-05-27 | G1 Therapeutics, Inc. | Lactam kinase inhibitors |
| CA2870019C (en) | 2012-04-26 | 2020-08-18 | Francis Xavier Tavares | Synthesis of lactams |
| WO2014144740A2 (en) | 2013-03-15 | 2014-09-18 | G1 Therapeutics, Inc. | Highly active anti-neoplastic and anti-proliferative agents |
| JP6430483B2 (ja) * | 2013-03-15 | 2018-11-28 | ジー１、セラピューティクス、インコーポレイテッドＧ１ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 化学療法の間の正常細胞の一時的な保護 |
| WO2015161283A1 (en) | 2014-04-17 | 2015-10-22 | G1 Therapeutics, Inc. | Tricyclic lactams for use in hspc-sparing treatments for rb-positive abnormal cellular proliferation |
| WO2016040858A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
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