JP2023076606A5 - - Google Patents
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- JP2023076606A5 JP2023076606A5 JP2023060936A JP2023060936A JP2023076606A5 JP 2023076606 A5 JP2023076606 A5 JP 2023076606A5 JP 2023060936 A JP2023060936 A JP 2023060936A JP 2023060936 A JP2023060936 A JP 2023060936A JP 2023076606 A5 JP2023076606 A5 JP 2023076606A5
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- Prior art keywords
- acid sequence
- amino acid
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- region
- aav
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001413 amino acids Chemical group 0.000 claims 63
- 108090000565 Capsid Proteins Proteins 0.000 claims 21
- 102100023321 Ceruloplasmin Human genes 0.000 claims 21
- 239000002245 particle Substances 0.000 claims 18
- 108700019146 Transgenes Proteins 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 241000700605 Viruses Species 0.000 claims 9
- 230000003612 virological effect Effects 0.000 claims 9
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical group 0.000 claims 7
- 241000702421 Dependoparvovirus Species 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 230000001105 regulatory effect Effects 0.000 claims 5
- 108010069013 Phenylalanine Hydroxylase Proteins 0.000 claims 4
- 102100038223 Phenylalanine-4-hydroxylase Human genes 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 102000001039 Dystrophin Human genes 0.000 claims 2
- 108010069091 Dystrophin Proteins 0.000 claims 2
- 108010054218 Factor VIII Proteins 0.000 claims 2
- 102000001690 Factor VIII Human genes 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 229960000301 factor viii Drugs 0.000 claims 2
- 210000000663 muscle cell Anatomy 0.000 claims 2
- 102100026735 Coagulation factor VIII Human genes 0.000 claims 1
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 1
- 201000003542 Factor VIII deficiency Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 1
- 201000011252 Phenylketonuria Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662366838P | 2016-07-26 | 2016-07-26 | |
| US62/366,838 | 2016-07-26 | ||
| JP2019503445A JP6994018B2 (ja) | 2016-07-26 | 2017-07-25 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
| JP2021165270A JP7395550B2 (ja) | 2016-07-26 | 2021-10-07 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021165270A Division JP7395550B2 (ja) | 2016-07-26 | 2021-10-07 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023076606A JP2023076606A (ja) | 2023-06-01 |
| JP2023076606A5 true JP2023076606A5 (enExample) | 2023-07-07 |
Family
ID=59558468
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503445A Expired - Fee Related JP6994018B2 (ja) | 2016-07-26 | 2017-07-25 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
| JP2021165270A Active JP7395550B2 (ja) | 2016-07-26 | 2021-10-07 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
| JP2021215368A Active JP7303287B2 (ja) | 2016-07-26 | 2021-12-29 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
| JP2023060936A Pending JP2023076606A (ja) | 2016-07-26 | 2023-04-04 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503445A Expired - Fee Related JP6994018B2 (ja) | 2016-07-26 | 2017-07-25 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
| JP2021165270A Active JP7395550B2 (ja) | 2016-07-26 | 2021-10-07 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
| JP2021215368A Active JP7303287B2 (ja) | 2016-07-26 | 2021-12-29 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11584780B2 (enExample) |
| EP (1) | EP3491008A2 (enExample) |
| JP (4) | JP6994018B2 (enExample) |
| KR (2) | KR20230161535A (enExample) |
| CN (1) | CN109715650B (enExample) |
| AU (2) | AU2017301600B2 (enExample) |
| BR (1) | BR112019001532A2 (enExample) |
| CA (1) | CA3031026A1 (enExample) |
| CL (6) | CL2019000167A1 (enExample) |
| IL (2) | IL263801B2 (enExample) |
| MX (1) | MX2019000962A (enExample) |
| PE (1) | PE20190401A1 (enExample) |
| PH (1) | PH12019500068A1 (enExample) |
| SG (1) | SG11201811603WA (enExample) |
| WO (1) | WO2018022608A2 (enExample) |
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|---|---|---|---|---|
| GB201508026D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
| JP7064214B2 (ja) | 2015-09-28 | 2022-05-10 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 抗体回避性ウイルスベクターのための方法および組成物 |
| CN110225975A (zh) | 2016-08-23 | 2019-09-10 | 阿库斯股份有限公司 | 用于治疗人受试者中非年龄相关的听力损害的组合物和方法 |
| MX2020008932A (es) * | 2018-02-27 | 2020-10-01 | Univ Pennsylvania | Novedosos vectores de virus adenoasociado (aav), vectores de aav que tienen una desamidacion reducida de la capside y usos de estos. |
| JP7425738B2 (ja) | 2018-04-03 | 2024-01-31 | ギンコ バイオワークス インコーポレイテッド | 眼組織を標的とするウイルスベクター |
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| US12129287B2 (en) | 2020-09-14 | 2024-10-29 | President And Fellows Of Harvard College | Recombinant adeno associated virus encoding clarin-1 and uses thereof |
| US20230383313A1 (en) * | 2020-10-18 | 2023-11-30 | The Trustees Of The University Of Pennsylvania | Improved adeno-associated virus (aav) vector and uses therefor |
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| CN114276419B (zh) * | 2021-12-30 | 2023-11-17 | 上海勉亦生物科技有限公司 | 肌肉高亲和性的新型腺相关病毒衣壳蛋白及其应用 |
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2017
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- 2017-07-25 SG SG11201811603WA patent/SG11201811603WA/en unknown
- 2017-07-25 CN CN201780045741.3A patent/CN109715650B/zh active Active
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- 2017-07-25 MX MX2019000962A patent/MX2019000962A/es unknown
- 2017-07-25 CA CA3031026A patent/CA3031026A1/en active Pending
- 2017-07-25 KR KR1020237039466A patent/KR20230161535A/ko not_active Abandoned
- 2017-07-25 JP JP2019503445A patent/JP6994018B2/ja not_active Expired - Fee Related
- 2017-07-25 KR KR1020197001930A patent/KR102604510B1/ko active Active
- 2017-07-25 BR BR112019001532A patent/BR112019001532A2/pt unknown
- 2017-07-25 AU AU2017301600A patent/AU2017301600B2/en not_active Ceased
- 2017-07-25 WO PCT/US2017/043703 patent/WO2018022608A2/en not_active Ceased
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2019
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2020
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