JP2022001064A5 - - Google Patents
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- JP2022001064A5 JP2022001064A5 JP2021165270A JP2021165270A JP2022001064A5 JP 2022001064 A5 JP2022001064 A5 JP 2022001064A5 JP 2021165270 A JP2021165270 A JP 2021165270A JP 2021165270 A JP2021165270 A JP 2021165270A JP 2022001064 A5 JP2022001064 A5 JP 2022001064A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- aav
- capsid protein
- region
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000565 Capsid Proteins Proteins 0.000 claims 70
- 102100023321 Ceruloplasmin Human genes 0.000 claims 70
- 150000001413 amino acids Chemical group 0.000 claims 47
- 239000002245 particle Substances 0.000 claims 45
- 241000700605 Viruses Species 0.000 claims 43
- 108090000623 proteins and genes Proteins 0.000 claims 35
- 239000012634 fragment Substances 0.000 claims 30
- 108700019146 Transgenes Proteins 0.000 claims 29
- 210000004027 cell Anatomy 0.000 claims 23
- 238000000034 method Methods 0.000 claims 22
- 210000000234 capsid Anatomy 0.000 claims 20
- 239000002773 nucleotide Substances 0.000 claims 19
- 125000003729 nucleotide group Chemical group 0.000 claims 19
- 150000007523 nucleic acids Chemical group 0.000 claims 18
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 17
- 241000702421 Dependoparvovirus Species 0.000 claims 15
- 230000001105 regulatory effect Effects 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 238000004113 cell culture Methods 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 108010069013 Phenylalanine Hydroxylase Proteins 0.000 claims 4
- 102100038223 Phenylalanine-4-hydroxylase Human genes 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 102000001039 Dystrophin Human genes 0.000 claims 2
- 108010069091 Dystrophin Proteins 0.000 claims 2
- 108010054218 Factor VIII Proteins 0.000 claims 2
- 102000001690 Factor VIII Human genes 0.000 claims 2
- 229960000301 factor viii Drugs 0.000 claims 2
- 210000005229 liver cell Anatomy 0.000 claims 2
- 210000000663 muscle cell Anatomy 0.000 claims 2
- 102100026735 Coagulation factor VIII Human genes 0.000 claims 1
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 1
- 201000003542 Factor VIII deficiency Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 1
- 201000011252 Phenylketonuria Diseases 0.000 claims 1
- 230000001594 aberrant effect Effects 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021215368A JP7303287B2 (ja) | 2016-07-26 | 2021-12-29 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
| JP2023060936A JP2023076606A (ja) | 2016-07-26 | 2023-04-04 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662366838P | 2016-07-26 | 2016-07-26 | |
| US62/366,838 | 2016-07-26 | ||
| JP2019503445A JP6994018B2 (ja) | 2016-07-26 | 2017-07-25 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503445A Division JP6994018B2 (ja) | 2016-07-26 | 2017-07-25 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021215368A Division JP7303287B2 (ja) | 2016-07-26 | 2021-12-29 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
| JP2023060936A Division JP2023076606A (ja) | 2016-07-26 | 2023-04-04 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022001064A JP2022001064A (ja) | 2022-01-06 |
| JP2022001064A5 true JP2022001064A5 (enExample) | 2022-01-13 |
| JP7395550B2 JP7395550B2 (ja) | 2023-12-11 |
Family
ID=59558468
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503445A Expired - Fee Related JP6994018B2 (ja) | 2016-07-26 | 2017-07-25 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
| JP2021165270A Active JP7395550B2 (ja) | 2016-07-26 | 2021-10-07 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
| JP2021215368A Active JP7303287B2 (ja) | 2016-07-26 | 2021-12-29 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
| JP2023060936A Pending JP2023076606A (ja) | 2016-07-26 | 2023-04-04 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503445A Expired - Fee Related JP6994018B2 (ja) | 2016-07-26 | 2017-07-25 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021215368A Active JP7303287B2 (ja) | 2016-07-26 | 2021-12-29 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
| JP2023060936A Pending JP2023076606A (ja) | 2016-07-26 | 2023-04-04 | 新規アデノ随伴ウイルスキャプシドタンパク質 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11584780B2 (enExample) |
| EP (1) | EP3491008A2 (enExample) |
| JP (4) | JP6994018B2 (enExample) |
| KR (2) | KR102604510B1 (enExample) |
| CN (1) | CN109715650B (enExample) |
| AU (2) | AU2017301600B2 (enExample) |
| BR (1) | BR112019001532A2 (enExample) |
| CA (1) | CA3031026A1 (enExample) |
| CL (6) | CL2019000167A1 (enExample) |
| IL (2) | IL263801B2 (enExample) |
| MX (1) | MX2019000962A (enExample) |
| PE (1) | PE20190401A1 (enExample) |
| PH (1) | PH12019500068A1 (enExample) |
| SG (1) | SG11201811603WA (enExample) |
| WO (1) | WO2018022608A2 (enExample) |
Families Citing this family (50)
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| GB201508026D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
| CN108137655B (zh) | 2015-09-28 | 2022-04-22 | 北卡罗来纳-查佩尔山大学 | 逃避抗体的病毒载体的方法和组合物 |
| CA3034527A1 (en) | 2016-08-23 | 2018-03-01 | Emmanuel John Simons | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
| EP3768695A4 (en) * | 2018-02-27 | 2022-04-06 | The Trustees of the University of Pennsylvania | NOVEL ADENO-ASSOCIATED VIRUS (AAV) VECTORS, AAV VECTORS WITH REDUCED CAPSIID DEAMIDATION AND USES THEREOF |
| SG11202009451VA (en) | 2018-04-03 | 2020-10-29 | Stridebio Inc | Antibody-evading virus vectors |
| JP7406677B2 (ja) | 2018-04-03 | 2023-12-28 | ギンコ バイオワークス インコーポレイテッド | 抗体を回避するウイルスベクター |
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| JP2023518327A (ja) * | 2020-02-25 | 2023-04-28 | チルドレンズ・メディカル・リサーチ・インスティテュート | アデノ随伴ウイルスカプシドポリペプチドおよびベクター |
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| US20230242905A1 (en) * | 2020-07-03 | 2023-08-03 | Genethon | Method for Engineering Novel Hybrid AAV Capsids Through Hyper Variable Regions Swapping |
| CN116745409A (zh) | 2020-08-19 | 2023-09-12 | 萨雷普塔治疗公司 | 用于治疗雷特综合征的腺相关病毒载体 |
| PT4211231T (pt) * | 2020-09-10 | 2024-07-24 | Univ Devry Val Dessonne | Capsídeo de aav modificado por péptido |
| US12129287B2 (en) | 2020-09-14 | 2024-10-29 | President And Fellows Of Harvard College | Recombinant adeno associated virus encoding clarin-1 and uses thereof |
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| KR20230078805A (ko) | 2020-11-02 | 2023-06-02 | 바이오마린 파머수티컬 인크. | 아데노-연관 바이러스의 농축 공정 |
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| CN114276419B (zh) * | 2021-12-30 | 2023-11-17 | 上海勉亦生物科技有限公司 | 肌肉高亲和性的新型腺相关病毒衣壳蛋白及其应用 |
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| TW202421788A (zh) | 2022-09-22 | 2024-06-01 | 美商拜奧馬林製藥公司 | 用ａａｖ基因療法載體治療致心律不整性心肌病 |
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2017
- 2017-07-25 MX MX2019000962A patent/MX2019000962A/es unknown
- 2017-07-25 PE PE2019000266A patent/PE20190401A1/es unknown
- 2017-07-25 CN CN201780045741.3A patent/CN109715650B/zh active Active
- 2017-07-25 CA CA3031026A patent/CA3031026A1/en active Pending
- 2017-07-25 KR KR1020197001930A patent/KR102604510B1/ko active Active
- 2017-07-25 AU AU2017301600A patent/AU2017301600B2/en active Active
- 2017-07-25 IL IL263801A patent/IL263801B2/en unknown
- 2017-07-25 EP EP17749265.9A patent/EP3491008A2/en active Pending
- 2017-07-25 WO PCT/US2017/043703 patent/WO2018022608A2/en not_active Ceased
- 2017-07-25 JP JP2019503445A patent/JP6994018B2/ja not_active Expired - Fee Related
- 2017-07-25 US US16/319,877 patent/US11584780B2/en active Active
- 2017-07-25 BR BR112019001532A patent/BR112019001532A2/pt unknown
- 2017-07-25 IL IL305149A patent/IL305149A/en unknown
- 2017-07-25 KR KR1020237039466A patent/KR20230161535A/ko not_active Abandoned
- 2017-07-25 SG SG11201811603WA patent/SG11201811603WA/en unknown
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2019
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2020
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- 2021-10-07 JP JP2021165270A patent/JP7395550B2/ja active Active
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2024
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