JP2023058590A5 - - Google Patents
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- Publication number
- JP2023058590A5 JP2023058590A5 JP2023017271A JP2023017271A JP2023058590A5 JP 2023058590 A5 JP2023058590 A5 JP 2023058590A5 JP 2023017271 A JP2023017271 A JP 2023017271A JP 2023017271 A JP2023017271 A JP 2023017271A JP 2023058590 A5 JP2023058590 A5 JP 2023058590A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody
- binding fragment
- poly
- heavy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 5
- 230000003247 decreasing effect Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 206010065687 Bone loss Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 101500025614 Homo sapiens Transforming growth factor beta-1 Proteins 0.000 claims 1
- 101500025624 Homo sapiens Transforming growth factor beta-2 Proteins 0.000 claims 1
- 101500026551 Homo sapiens Transforming growth factor beta-3 Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 229920000805 Polyaspartic acid Polymers 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 230000037182 bone density Effects 0.000 claims 1
- 230000037118 bone strength Effects 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108010064470 polyaspartate Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024205967A JP2025028981A (ja) | 2017-01-20 | 2024-11-27 | 骨標的抗体 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762448763P | 2017-01-20 | 2017-01-20 | |
| US62/448,763 | 2017-01-20 | ||
| PCT/US2018/014350 WO2018136698A2 (en) | 2017-01-20 | 2018-01-19 | Bone-targeting antibodies |
| JP2019539277A JP7227138B2 (ja) | 2017-01-20 | 2018-01-19 | 骨標的抗体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539277A Division JP7227138B2 (ja) | 2017-01-20 | 2018-01-19 | 骨標的抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024205967A Division JP2025028981A (ja) | 2017-01-20 | 2024-11-27 | 骨標的抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023058590A JP2023058590A (ja) | 2023-04-25 |
| JP2023058590A5 true JP2023058590A5 (https=) | 2023-06-13 |
| JP7597836B2 JP7597836B2 (ja) | 2024-12-10 |
Family
ID=61581744
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539277A Active JP7227138B2 (ja) | 2017-01-20 | 2018-01-19 | 骨標的抗体 |
| JP2023017271A Active JP7597836B2 (ja) | 2017-01-20 | 2023-02-08 | 骨標的抗体 |
| JP2024205967A Pending JP2025028981A (ja) | 2017-01-20 | 2024-11-27 | 骨標的抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539277A Active JP7227138B2 (ja) | 2017-01-20 | 2018-01-19 | 骨標的抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024205967A Pending JP2025028981A (ja) | 2017-01-20 | 2024-11-27 | 骨標的抗体 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10844115B2 (https=) |
| EP (1) | EP3571226A2 (https=) |
| JP (3) | JP7227138B2 (https=) |
| KR (3) | KR102755284B1 (https=) |
| CN (2) | CN111032690B (https=) |
| AR (1) | AR110755A1 (https=) |
| AU (1) | AU2018210270A1 (https=) |
| BR (1) | BR112019013986A2 (https=) |
| CA (1) | CA3050884A1 (https=) |
| IL (2) | IL268114B2 (https=) |
| MX (2) | MX2019008549A (https=) |
| MY (2) | MY194819A (https=) |
| SG (1) | SG11201906663VA (https=) |
| TW (3) | TWI788321B (https=) |
| UY (1) | UY37576A (https=) |
| WO (1) | WO2018136698A2 (https=) |
| ZA (1) | ZA201907673B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019533003A (ja) * | 2016-08-11 | 2019-11-14 | プレシセラ，インコーポレイテッド | ＴＧＦ−βアンタゴニストコンジュゲート |
| TW202506185A (zh) | 2017-01-20 | 2025-02-16 | 法商賽諾菲公司 | 抗TGF-β抗體及其用途 |
| TWI788321B (zh) | 2017-01-20 | 2023-01-01 | 美商健臻公司 | 骨靶向抗體 |
| WO2019232285A1 (en) | 2018-05-30 | 2019-12-05 | Purdue Research Foundation | Targeting anabolic drugs for accelerated fracture repair |
| TW202019962A (zh) * | 2018-07-10 | 2020-06-01 | 法商賽諾菲公司 | 標靶CD38及TGF-β的組合療法 |
| EP3884066A2 (en) * | 2018-11-19 | 2021-09-29 | Biocartis NV | Enhanced detection of low-copy-number nucleic acids in an integrated workflow |
| IL308175A (en) | 2021-05-07 | 2023-12-01 | Baylor College Medicine | Treatment of moderate to severe defective bone formation |
| EP4373522A4 (en) * | 2021-07-20 | 2025-06-18 | William Marsh Rice University | Engineered compositions for bone-targeted therapy |
| US20230144192A1 (en) | 2021-11-01 | 2023-05-11 | Genzyme Corporation | Treatment of osteogenesis imperfecta |
| CN115403657A (zh) * | 2022-06-23 | 2022-11-29 | 浙江大学 | 一种TGF-β3生长因子的亲和多肽及其应用 |
| AU2024229931A1 (en) | 2023-02-27 | 2025-09-11 | The Trustees Of Columbia University In The City Of New York | Bone-directed therapeutics for the treatment of cancer |
| JP7479537B1 (ja) * | 2023-03-31 | 2024-05-08 | ナガヨシ製薬株式会社 | 咳を止め、痰を減らし、免疫力を向上させるイナゴマメ多糖類およびその調製方法と使用 |
| WO2025184427A1 (en) * | 2024-02-27 | 2025-09-04 | Osteologic Therapeutics, Inc. | Bone-targeted antibodies and methods of use thereof |
| CN120647762B (zh) * | 2025-06-16 | 2026-01-23 | 首都医科大学附属北京友谊医院 | 一种抗β1-AR-ECII抗体及其应用 |
| CN120535618B (zh) * | 2025-07-28 | 2025-09-23 | 成都大熊猫繁育研究基地 | 一种抗大熊猫cdv单克隆抗体、杂交瘤细胞株及用途 |
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| US4867973A (en) | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
| US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
| ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US5824655A (en) | 1995-02-15 | 1998-10-20 | The University Of Utah | Anti-transforming growth factor-β gene therapy |
| GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
| DK0929578T3 (da) | 1996-02-09 | 2003-08-25 | Abbott Lab Bermuda Ltd | Humane antistoffer, der binder human TNFalfa |
| CA2280957A1 (en) | 1997-02-14 | 1998-08-20 | Leslie Orgel | Methods and compositions for delivery of therapeutic agents to bone tissue employing conjugates of negatively charged peptide oligomers with therapeutic agents |
| EP1074563A1 (en) | 1999-08-02 | 2001-02-07 | F. Hoffmann-La Roche Ag | Chimeric polypeptides enhancing dimer formation through electrostatic interactions and disulfide bond, method for production and uses thereof |
| US20030224501A1 (en) | 2000-03-17 | 2003-12-04 | Young Paul E. | Bone morphogenic protein polynucleotides, polypeptides, and antibodies |
| NZ554885A (en) * | 2002-12-31 | 2009-07-31 | Altus Pharmaceuticals Inc | Complexes of hgh crystals and protamine polymers |
| EP1620128A1 (en) | 2003-04-30 | 2006-02-01 | Genzyme Corporation | Tgf-beta antagonists combined with renin-angiotensin-aldosteron-system antagonists for treating renal insufficiency |
| WO2005010049A2 (en) | 2003-07-09 | 2005-02-03 | Eli Lilly And Company | Tgf-beta1 ligands |
| CN1961003B (zh) | 2004-03-31 | 2013-03-27 | 健泰科生物技术公司 | 人源化抗TGF-β抗体 |
| DE602005027461D1 (de) | 2004-04-21 | 2011-05-26 | Enobia Pharma Inc | Konjugate zur zuführung an knochen und verfahren zu deren verwendung beim hinführen von proteinen zum knochen |
| WO2006086469A2 (en) | 2005-02-08 | 2006-08-17 | Genzyme Corporation | Antibodies to tgfbeta |
| TW200714289A (en) * | 2005-02-28 | 2007-04-16 | Genentech Inc | Treatment of bone disorders |
| JP2009521496A (ja) * | 2005-12-23 | 2009-06-04 | イーライ リリー アンド カンパニー | ＴＧＦ−β結合組成物 |
| AU2008255352B2 (en) | 2007-05-31 | 2014-05-22 | Genmab A/S | Stable IgG4 antibodies |
| CA2711256C (en) | 2008-01-03 | 2019-01-15 | The Scripps Research Institute | Antibody targeting through a modular recognition domain |
| US8574577B2 (en) * | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
| CN102203132A (zh) | 2008-08-25 | 2011-09-28 | 安普利穆尼股份有限公司 | Pd-1拮抗剂的组合物和使用方法 |
| EP2379600B2 (en) | 2008-12-22 | 2020-10-14 | Novo Nordisk A/S | Antibodies against tissue factor pathway inhibitor |
| US20120294868A1 (en) | 2009-04-24 | 2012-11-22 | Edwards James R | Anti-tgf-beta induction of bone cell function and bone growth |
| CA3083324A1 (en) | 2010-03-05 | 2011-09-09 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
| SG10201602394QA (en) | 2011-03-29 | 2016-05-30 | Roche Glycart Ag | Antibody FC Variants |
| KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | Ｂ7-ｈ1 및 ｐｄ-1과 결합하는 항체 및 다른 분자들 |
| SG195253A1 (en) | 2011-06-03 | 2013-12-30 | Xoma Technology Ltd | Antibodies specific for tgf-beta |
| MX358447B (es) | 2011-06-13 | 2018-08-21 | Abgenomics Cooeperatief U A Star | Anticuerpos anti-psgl-1 y usos de los mismos. |
| CA2852874A1 (en) | 2011-10-19 | 2013-04-25 | Alexion Pharma Holding | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
| US10052366B2 (en) * | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
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| EP2908913B1 (en) | 2012-10-17 | 2018-10-03 | Cedars-Sinai Medical Center | Molecular signatures of ovarian cancer |
| HUE046702T2 (hu) * | 2013-03-20 | 2020-03-30 | Genzyme Corp | Eljárások üvegcsontbetegség kezelésére |
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| TWI733661B (zh) | 2015-03-04 | 2021-07-21 | 美商健臻公司 | 以高親合性、結合性及特異性結合轉化生長因子－β１的經修飾ＩｇＧ抗體 |
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| TW202506185A (zh) | 2017-01-20 | 2025-02-16 | 法商賽諾菲公司 | 抗TGF-β抗體及其用途 |
| TWI788321B (zh) | 2017-01-20 | 2023-01-01 | 美商健臻公司 | 骨靶向抗體 |
-
2018
- 2018-01-18 TW TW107101790A patent/TWI788321B/zh active
- 2018-01-18 TW TW113101673A patent/TW202421659A/zh unknown
- 2018-01-18 AR ARP180100119A patent/AR110755A1/es unknown
- 2018-01-18 TW TW111146907A patent/TWI832600B/zh active
- 2018-01-19 MY MYPI2019006821A patent/MY194819A/en unknown
- 2018-01-19 AU AU2018210270A patent/AU2018210270A1/en not_active Abandoned
- 2018-01-19 IL IL268114A patent/IL268114B2/en unknown
- 2018-01-19 IL IL317592A patent/IL317592A/en unknown
- 2018-01-19 MY MYPI2022003998A patent/MY207919A/en unknown
- 2018-01-19 EP EP18709437.0A patent/EP3571226A2/en active Pending
- 2018-01-19 UY UY0001037576A patent/UY37576A/es not_active Application Discontinuation
- 2018-01-19 CN CN201880007783.2A patent/CN111032690B/zh active Active
- 2018-01-19 US US15/875,125 patent/US10844115B2/en active Active
- 2018-01-19 WO PCT/US2018/014350 patent/WO2018136698A2/en not_active Ceased
- 2018-01-19 BR BR112019013986-9A patent/BR112019013986A2/pt not_active IP Right Cessation
- 2018-01-19 KR KR1020237042558A patent/KR102755284B1/ko active Active
- 2018-01-19 JP JP2019539277A patent/JP7227138B2/ja active Active
- 2018-01-19 CN CN202410319667.1A patent/CN118121696A/zh active Pending
- 2018-01-19 MX MX2019008549A patent/MX2019008549A/es unknown
- 2018-01-19 KR KR1020197024021A patent/KR102613463B1/ko active Active
- 2018-01-19 SG SG11201906663VA patent/SG11201906663VA/en unknown
- 2018-01-19 KR KR1020257000987A patent/KR20250012197A/ko active Pending
- 2018-01-19 CA CA3050884A patent/CA3050884A1/en active Pending
-
2019
- 2019-07-17 MX MX2022008073A patent/MX2022008073A/es unknown
- 2019-11-20 ZA ZA2019/07673A patent/ZA201907673B/en unknown
-
2020
- 2020-10-23 US US17/079,285 patent/US12098194B2/en active Active
-
2023
- 2023-02-08 JP JP2023017271A patent/JP7597836B2/ja active Active
-
2024
- 2024-08-13 US US18/802,674 patent/US20250074975A1/en active Pending
- 2024-11-27 JP JP2024205967A patent/JP2025028981A/ja active Pending
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