JP2023052201A5 - - Google Patents
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- JP2023052201A5 JP2023052201A5 JP2023000295A JP2023000295A JP2023052201A5 JP 2023052201 A5 JP2023052201 A5 JP 2023052201A5 JP 2023000295 A JP2023000295 A JP 2023000295A JP 2023000295 A JP2023000295 A JP 2023000295A JP 2023052201 A5 JP2023052201 A5 JP 2023052201A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- compound
- alkyl
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562235896P | 2015-10-01 | 2015-10-01 | |
| US62/235,896 | 2015-10-01 | ||
| PCT/US2016/054691 WO2017059207A1 (en) | 2015-10-01 | 2016-09-30 | Methods and reagents for analyzing protein-protein interfaces |
| JP2018516828A JP7411326B2 (ja) | 2015-10-01 | 2016-09-30 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516828A Division JP7411326B2 (ja) | 2015-10-01 | 2016-09-30 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023052201A JP2023052201A (ja) | 2023-04-11 |
| JP2023052201A5 true JP2023052201A5 (enExample) | 2023-06-14 |
Family
ID=58427956
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516828A Active JP7411326B2 (ja) | 2015-10-01 | 2016-09-30 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
| JP2023000295A Pending JP2023052201A (ja) | 2015-10-01 | 2023-01-04 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516828A Active JP7411326B2 (ja) | 2015-10-01 | 2016-09-30 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US9989535B2 (enExample) |
| EP (2) | EP3355930A4 (enExample) |
| JP (2) | JP7411326B2 (enExample) |
| AU (2) | AU2016329064B2 (enExample) |
| CA (1) | CA3000822A1 (enExample) |
| WO (1) | WO2017059207A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
| EP3247378B8 (en) | 2015-01-09 | 2023-08-23 | Revolution Medicines, Inc. | Macrocyclic compounds that participate in cooperative binding and medical uses thereof |
| US9989535B2 (en) | 2015-10-01 | 2018-06-05 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| US11066416B2 (en) * | 2016-02-04 | 2021-07-20 | The Johns Hopkins University | Rapafucin derivative compounds and methods of use thereof |
| JP7104627B2 (ja) | 2016-02-04 | 2022-07-21 | ザ・ジョンズ・ホプキンス・ユニバーシティ | ラパグルチン（ｒａｐａｇｌｕｔｉｎｓ）、ｇｌｕｔの新規阻害剤及びその使用 |
| US10774110B2 (en) | 2016-02-04 | 2020-09-15 | The Johns Hopkins University | Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof |
| KR102359972B1 (ko) | 2016-04-12 | 2022-02-10 | 징코 바이오웍스, 인크. | 화합물의 제조를 위한 조성물 및 방법 |
| CN116478132A (zh) | 2016-07-12 | 2023-07-25 | 锐新医药公司 | 作为变构shp2抑制剂的2,5-双取代型及2,5,6-三取代型3-甲基吡嗪 |
| CN110446709B (zh) | 2017-01-23 | 2023-09-12 | 锐新医药公司 | 作为变构shp2抑制剂的二环化合物 |
| AU2018210196B2 (en) | 2017-01-23 | 2022-06-02 | Revolution Medicines, Inc. | Pyridine compounds as allosteric SHP2 inhibitors |
| WO2018187423A1 (en) * | 2017-04-05 | 2018-10-11 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| EP3606492A4 (en) * | 2017-04-05 | 2020-11-11 | Revolution Medicines, Inc. | LINKS INVOLVED IN A COOPERATIVE BINDING AND USES THEREOF |
| TWI852912B (zh) | 2017-09-07 | 2024-08-21 | 美商銳新醫藥公司 | Shp2抑制劑組合物以及治療癌症的方法 |
| CA3078565A1 (en) | 2017-10-12 | 2019-04-18 | Revolution Medicines, Inc. | Pyridine, pyrazine, and triazine compounds as allosteric shp2 inhibitors |
| BR112020009757A2 (pt) | 2017-12-15 | 2020-11-03 | Revolution Medicines, Inc. | compostos policíclicos como inibidores alostéricos de shp2 |
| US20250388598A1 (en) * | 2019-11-04 | 2025-12-25 | Revolution Medicines, Inc. | Ras inhibitors |
| KR20250175006A (ko) | 2019-11-04 | 2025-12-15 | 레볼루션 메디슨즈, 인크. | Ras 억제제 |
| CN114867735A (zh) | 2019-11-04 | 2022-08-05 | 锐新医药公司 | Ras抑制剂 |
| CA3159559A1 (en) | 2019-11-04 | 2021-05-14 | Revolution Medicines, Inc. | Ras inhibitors |
| EP4055365A1 (en) * | 2019-11-08 | 2022-09-14 | NanoTemper Technologies GmbH | Characterization of particles in solution |
| CN111118046B (zh) * | 2020-01-16 | 2022-02-22 | 中国人民解放军军事科学院军事医学研究院 | 一种能够调控MSCs成脂肪分化能力的基因及其衍生产品 |
| GB202007106D0 (en) * | 2020-05-14 | 2020-07-01 | Ucl Business Plc | Cyclosporine analogues |
| IL301298A (en) | 2020-09-15 | 2023-05-01 | Revolution Medicines Inc | Indole derivatives as RAS inhibitors in cancer therapy |
| CN117616031A (zh) | 2021-05-05 | 2024-02-27 | 锐新医药公司 | 用于治疗癌症的ras抑制剂 |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| CN119661684B (zh) * | 2024-10-21 | 2025-11-25 | 山东大学 | 一种高抗炎活性的脂联素突变体及其制备方法与应用 |
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| ATE138807T1 (de) | 1992-03-27 | 1996-06-15 | American Home Prod | 29-demethoxyrapamycin zur induktion der immunosuppression |
| ATE206164T1 (de) | 1993-09-20 | 2001-10-15 | Univ Leland Stanford Junior | Rekombinante herstellung von neuen polyketiden |
| IL112873A (en) | 1994-03-08 | 2005-03-20 | Wyeth Corp | Rapamycin-fkbp12 binding proteins, their isolation and their use |
| GB9410142D0 (en) | 1994-05-20 | 1994-07-06 | Univ Warwick | Carbapenems |
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| EP2342335B1 (en) | 2008-09-24 | 2015-09-16 | Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences | Novel gene cluster |
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| CA2768299C (en) | 2009-07-13 | 2018-03-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
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| CN102712675A (zh) | 2009-09-22 | 2012-10-03 | 爱勒让治疗公司 | 拟肽大环化合物 |
| US20120208720A1 (en) | 2009-10-22 | 2012-08-16 | Kenji Kashiwagi | Rapid display method in translational synthesis of peptide |
| CN106084002A (zh) | 2010-11-30 | 2016-11-09 | 约翰·霍普金斯大学 | 杂交环状文库和其筛选 |
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| AU2012257513B2 (en) | 2011-05-19 | 2017-05-11 | Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) | Macrocyclic compounds as protein kinase inhibitors |
| US9260484B2 (en) | 2011-06-15 | 2016-02-16 | Ohio State Innovation Foundation | Small molecule composite surfaces as inhibitors of protein-protein interactions |
| DE102011111991A1 (de) * | 2011-08-30 | 2013-02-28 | Lead Discovery Center Gmbh | Neue Cyclosporin-Derivate |
| EP2763975B1 (en) * | 2011-10-05 | 2016-04-06 | Merck Sharp & Dohme Corp. | 3-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors |
| AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| PL3210627T3 (pl) | 2012-07-12 | 2023-04-17 | Hangzhou Dac Biotech Co., Ltd | Koniugaty zawierające cząsteczki wiążące się z komórką i środek cytotoksyczny |
| US10131682B2 (en) | 2012-11-24 | 2018-11-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules |
| EP2806274A1 (en) | 2013-05-24 | 2014-11-26 | AIT Austrian Institute of Technology GmbH | Lung cancer diagnostic method and means |
| US10233431B2 (en) | 2014-02-26 | 2019-03-19 | The Regents Of The University Of California | Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases |
| EP3114483A1 (en) | 2014-03-03 | 2017-01-11 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Method and device for detection of pseudomonas aeruginosa |
| TW201629069A (zh) | 2015-01-09 | 2016-08-16 | 霍普驅動生物科技股份有限公司 | 參與協同結合之化合物及其用途 |
| EP3247378B8 (en) | 2015-01-09 | 2023-08-23 | Revolution Medicines, Inc. | Macrocyclic compounds that participate in cooperative binding and medical uses thereof |
| WO2016160362A1 (en) * | 2015-03-31 | 2016-10-06 | Allergan, Inc. | Cyclosporins modified on the mebmt sidechain by heterocyclic rings |
| US9989535B2 (en) | 2015-10-01 | 2018-06-05 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| EP3532633A4 (en) | 2016-10-28 | 2020-09-09 | Ginkgo Bioworks Inc. | COMPOSITIONS AND PROCESSES FOR THE PRODUCTION OF COMPOUNDS |
-
2016
- 2016-09-30 US US15/282,430 patent/US9989535B2/en active Active
- 2016-09-30 WO PCT/US2016/054691 patent/WO2017059207A1/en not_active Ceased
- 2016-09-30 EP EP16852685.3A patent/EP3355930A4/en not_active Withdrawn
- 2016-09-30 CA CA3000822A patent/CA3000822A1/en active Pending
- 2016-09-30 EP EP23172763.7A patent/EP4242304A3/en active Pending
- 2016-09-30 AU AU2016329064A patent/AU2016329064B2/en active Active
- 2016-09-30 JP JP2018516828A patent/JP7411326B2/ja active Active
-
2018
- 2018-05-09 US US15/974,921 patent/US10948495B2/en active Active
- 2018-05-09 US US15/974,923 patent/US10466249B2/en active Active
-
2021
- 2021-01-28 US US17/161,505 patent/US20210405060A1/en not_active Abandoned
-
2023
- 2023-01-04 JP JP2023000295A patent/JP2023052201A/ja active Pending
-
2024
- 2024-01-17 AU AU2024200321A patent/AU2024200321A1/en active Pending
- 2024-03-01 US US18/593,086 patent/US20250085291A1/en active Pending
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