JP2019501863A5 - - Google Patents
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- JP2019501863A5 JP2019501863A5 JP2018516828A JP2018516828A JP2019501863A5 JP 2019501863 A5 JP2019501863 A5 JP 2019501863A5 JP 2018516828 A JP2018516828 A JP 2018516828A JP 2018516828 A JP2018516828 A JP 2018516828A JP 2019501863 A5 JP2019501863 A5 JP 2019501863A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- binding moiety
- substituted
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023000295A JP7812813B2 (ja) | 2015-10-01 | 2023-01-04 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
| JP2026012737A JP2026090316A (ja) | 2015-10-01 | 2026-01-29 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562235896P | 2015-10-01 | 2015-10-01 | |
| US62/235,896 | 2015-10-01 | ||
| PCT/US2016/054691 WO2017059207A1 (en) | 2015-10-01 | 2016-09-30 | Methods and reagents for analyzing protein-protein interfaces |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023000295A Division JP7812813B2 (ja) | 2015-10-01 | 2023-01-04 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501863A JP2019501863A (ja) | 2019-01-24 |
| JP2019501863A5 true JP2019501863A5 (enExample) | 2019-11-21 |
| JP7411326B2 JP7411326B2 (ja) | 2024-01-11 |
Family
ID=58427956
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516828A Active JP7411326B2 (ja) | 2015-10-01 | 2016-09-30 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
| JP2023000295A Active JP7812813B2 (ja) | 2015-10-01 | 2023-01-04 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
| JP2026012737A Pending JP2026090316A (ja) | 2015-10-01 | 2026-01-29 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023000295A Active JP7812813B2 (ja) | 2015-10-01 | 2023-01-04 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
| JP2026012737A Pending JP2026090316A (ja) | 2015-10-01 | 2026-01-29 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US9989535B2 (enExample) |
| EP (2) | EP4242304A3 (enExample) |
| JP (3) | JP7411326B2 (enExample) |
| AU (3) | AU2016329064B2 (enExample) |
| CA (1) | CA3000822A1 (enExample) |
| WO (1) | WO2017059207A1 (enExample) |
Families Citing this family (28)
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| US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
| WO2016112295A1 (en) | 2015-01-09 | 2016-07-14 | Warp Drive Bio, Inc. | Compounds that participate in cooperative binding and uses thereof |
| CA3000822A1 (en) | 2015-10-01 | 2017-04-06 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| CN108697729B (zh) | 2016-02-04 | 2023-05-09 | 约翰霍普金斯大学 | 新型GLUT抑制剂rapaglutin及其用途 |
| AU2017214557B2 (en) | 2016-02-04 | 2022-05-19 | The Johns Hopkins University | Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof |
| US11066416B2 (en) | 2016-02-04 | 2021-07-20 | The Johns Hopkins University | Rapafucin derivative compounds and methods of use thereof |
| CA3020594A1 (en) | 2016-04-12 | 2017-10-19 | Warp Drive Bio, Inc. | Compositions and methods for the production of compounds |
| IL311645B2 (en) | 2016-07-12 | 2025-11-01 | Revolution Medicines Inc | 2,5- disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines asallosteric shp2 inhibitors |
| CN110446709B (zh) | 2017-01-23 | 2023-09-12 | 锐新医药公司 | 作为变构shp2抑制剂的二环化合物 |
| CA3051054A1 (en) | 2017-01-23 | 2018-07-26 | Revolution Medicines, Inc. | Pyridine compounds as allosteric shp2 inhibitors |
| US20200199102A1 (en) * | 2017-04-05 | 2020-06-25 | Revolution Medicines, Inc. | Compounds that participate in cooperative binding and uses thereof |
| WO2018187423A1 (en) * | 2017-04-05 | 2018-10-11 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| TWI852912B (zh) | 2017-09-07 | 2024-08-21 | 美商銳新醫藥公司 | Shp2抑制劑組合物以及治療癌症的方法 |
| BR112020007058A2 (pt) | 2017-10-12 | 2020-10-06 | Revolution Medicines, Inc. | compostos de piridina, pirazina, e triazina como inibidores de shp2 alostéricos |
| BR112020009757A2 (pt) | 2017-12-15 | 2020-11-03 | Revolution Medicines, Inc. | compostos policíclicos como inibidores alostéricos de shp2 |
| JP7472026B2 (ja) * | 2018-02-23 | 2024-04-22 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 選択的なタンパク質分解を誘導するための低分子およびその使用法 |
| US12678067B1 (en) | 2019-03-20 | 2026-07-14 | Biological Art Group, Inc. | Telemetry implants |
| WO2021091956A1 (en) | 2019-11-04 | 2021-05-14 | Revolution Medicines, Inc. | Ras inhibitors |
| MX2022005359A (es) | 2019-11-04 | 2022-06-02 | Revolution Medicines Inc | Inhibidores de ras. |
| CN121471132A (zh) | 2019-11-04 | 2026-02-06 | 锐新医药公司 | Ras抑制剂 |
| US20250388598A1 (en) * | 2019-11-04 | 2025-12-25 | Revolution Medicines, Inc. | Ras inhibitors |
| JP7461078B2 (ja) | 2019-11-08 | 2024-04-03 | ナノテンパー・テクノロジーズ・ゲーエムベーハー | 溶液中の粒子の特徴付け |
| CN111118046B (zh) * | 2020-01-16 | 2022-02-22 | 中国人民解放军军事科学院军事医学研究院 | 一种能够调控MSCs成脂肪分化能力的基因及其衍生产品 |
| GB202007106D0 (en) * | 2020-05-14 | 2020-07-01 | Ucl Business Plc | Cyclosporine analogues |
| IL301298A (en) | 2020-09-15 | 2023-05-01 | Revolution Medicines Inc | Indole derivatives as RAS inhibitors in cancer therapy |
| IL308195A (en) | 2021-05-05 | 2024-01-01 | Revolution Medicines Inc | RAS inhibitors for cancer treatment |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| CN119661684B (zh) * | 2024-10-21 | 2025-11-25 | 山东大学 | 一种高抗炎活性的脂联素突变体及其制备方法与应用 |
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| ATE92501T1 (de) | 1984-10-04 | 1993-08-15 | Sandoz Ag | Monoklonale antikoerper gegen zyklosporine. |
| EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
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| WO1995008548A1 (en) | 1993-09-20 | 1995-03-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
| IL112873A (en) | 1994-03-08 | 2005-03-20 | Wyeth Corp | Rapamycin-fkbp12 binding proteins, their isolation and their use |
| GB9410142D0 (en) | 1994-05-20 | 1994-07-06 | Univ Warwick | Carbapenems |
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| GB9927191D0 (en) | 1999-11-17 | 2000-01-12 | Angeletti P Ist Richerche Bio | Methods and means for regulation of gene expression |
| AU1776501A (en) | 1999-11-19 | 2001-05-30 | Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and their use in the disruption of protein-protein interactions |
| US7220552B1 (en) * | 1999-11-19 | 2007-05-22 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and their use in the disruption of protein-protein interactions |
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| WO2010031185A1 (en) | 2008-09-19 | 2010-03-25 | Protox Therapeutics Inc. | Treating cancer stem cells using targeted cargo proteins |
| JP5789190B2 (ja) | 2008-09-24 | 2015-10-07 | シャンハイ インスティテュート オブ オーガニック ケミストリー，チャイニーズ アカデミー オブ サイエンシズ | 新規の遺伝子クラスター |
| RU2492181C2 (ru) | 2009-01-30 | 2013-09-10 | Энанта Фармасьютикалс, Инк. | Аналоги циклоспорина для предупреждения или лечения инфекции гепатита с |
| WO2011008260A2 (en) * | 2009-07-13 | 2011-01-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| EP2456777A2 (en) | 2009-07-24 | 2012-05-30 | Université Henri Poincaré - Nancy 1 | Stambomycin and derivatives, their production and their use as drugs |
| CA2774973A1 (en) | 2009-09-22 | 2011-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| JP5174971B2 (ja) | 2009-10-22 | 2013-04-03 | ペプチドリーム株式会社 | ペプチド翻訳合成におけるｒａｐｉｄディスプレイ法 |
| AU2011336727B2 (en) | 2010-11-30 | 2016-11-03 | The Johns Hopkins University | Hybrid cyclic libraries and screens thereof |
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| AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| PL2872157T3 (pl) | 2012-07-12 | 2020-07-13 | Hangzhou Dac Biotech Co., Ltd | Koniugaty wiążących komórkę cząsteczek ze środkami cytotoksycznymi |
| US10131682B2 (en) | 2012-11-24 | 2018-11-20 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules |
| EP2806274A1 (en) | 2013-05-24 | 2014-11-26 | AIT Austrian Institute of Technology GmbH | Lung cancer diagnostic method and means |
| US10233431B2 (en) | 2014-02-26 | 2019-03-19 | The Regents Of The University Of California | Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases |
| CN106255882A (zh) | 2014-03-03 | 2016-12-21 | 耶路撒冷希伯来大学伊森姆研究发展公司 | 用于检测铜绿假单胞菌的方法和装置 |
| WO2016112295A1 (en) | 2015-01-09 | 2016-07-14 | Warp Drive Bio, Inc. | Compounds that participate in cooperative binding and uses thereof |
| TW201629069A (zh) | 2015-01-09 | 2016-08-16 | 霍普驅動生物科技股份有限公司 | 參與協同結合之化合物及其用途 |
| EP3277704A1 (en) * | 2015-03-31 | 2018-02-07 | Allergan, Inc. | Cyclosporins modified on the mebmt sidechain by heterocyclic rings |
| CA3000822A1 (en) | 2015-10-01 | 2017-04-06 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| CN110506120A (zh) | 2016-10-28 | 2019-11-26 | 银杏生物制品公司 | 用于生产化合物的组合物和方法 |
-
2016
- 2016-09-30 CA CA3000822A patent/CA3000822A1/en active Pending
- 2016-09-30 EP EP23172763.7A patent/EP4242304A3/en active Pending
- 2016-09-30 AU AU2016329064A patent/AU2016329064B2/en active Active
- 2016-09-30 EP EP16852685.3A patent/EP3355930A4/en not_active Withdrawn
- 2016-09-30 JP JP2018516828A patent/JP7411326B2/ja active Active
- 2016-09-30 US US15/282,430 patent/US9989535B2/en active Active
- 2016-09-30 WO PCT/US2016/054691 patent/WO2017059207A1/en not_active Ceased
-
2018
- 2018-05-09 US US15/974,923 patent/US10466249B2/en active Active
- 2018-05-09 US US15/974,921 patent/US10948495B2/en active Active
-
2021
- 2021-01-28 US US17/161,505 patent/US20210405060A1/en not_active Abandoned
-
2023
- 2023-01-04 JP JP2023000295A patent/JP7812813B2/ja active Active
-
2024
- 2024-01-17 AU AU2024200321A patent/AU2024200321A1/en not_active Abandoned
- 2024-03-01 US US18/593,086 patent/US20250085291A1/en active Pending
-
2026
- 2026-01-29 JP JP2026012737A patent/JP2026090316A/ja active Pending
- 2026-02-20 AU AU2026201288A patent/AU2026201288A1/en active Pending
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