JP2019501863A5 - - Google Patents
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- Publication number
- JP2019501863A5 JP2019501863A5 JP2018516828A JP2018516828A JP2019501863A5 JP 2019501863 A5 JP2019501863 A5 JP 2019501863A5 JP 2018516828 A JP2018516828 A JP 2018516828A JP 2018516828 A JP2018516828 A JP 2018516828A JP 2019501863 A5 JP2019501863 A5 JP 2019501863A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- binding moiety
- substituted
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 15
- 238000004132 cross linking Methods 0.000 claims 13
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 125000004452 carbocyclyl group Chemical group 0.000 claims 12
- 125000005647 linker group Chemical group 0.000 claims 9
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 7
- 108010027179 Tacrolimus Binding Proteins Proteins 0.000 claims 7
- 102000018679 Tacrolimus Binding Proteins Human genes 0.000 claims 7
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 6
- 125000006693 (C2-C9) heterocyclyl group Chemical group 0.000 claims 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 6
- 108010068682 Cyclophilins Proteins 0.000 claims 5
- 102000001493 Cyclophilins Human genes 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 5
- 102000009658 Peptidylprolyl Isomerase Human genes 0.000 claims 4
- 108010020062 Peptidylprolyl Isomerase Proteins 0.000 claims 4
- -1 halogenated alkyl compound Chemical class 0.000 claims 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 102100037827 Peptidyl-prolyl cis-trans isomerase D Human genes 0.000 claims 2
- 102100020739 Peptidyl-prolyl cis-trans isomerase FKBP4 Human genes 0.000 claims 2
- 150000001348 alkyl chlorides Chemical class 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- 101150093441 CYP40 gene Proteins 0.000 claims 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- 102100038912 E3 SUMO-protein ligase RanBP2 Human genes 0.000 claims 1
- 108010069271 FKBP-13 Proteins 0.000 claims 1
- 101000896726 Homo sapiens Lanosterol 14-alpha demethylase Proteins 0.000 claims 1
- 101000979578 Homo sapiens NK-tumor recognition protein Proteins 0.000 claims 1
- 101100137375 Homo sapiens PPID gene Proteins 0.000 claims 1
- 101000611202 Homo sapiens Peptidyl-prolyl cis-trans isomerase B Proteins 0.000 claims 1
- 101000687115 Homo sapiens Peptidyl-prolyl cis-trans isomerase C Proteins 0.000 claims 1
- 101000827313 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP3 Proteins 0.000 claims 1
- 101000932178 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP4 Proteins 0.000 claims 1
- 101000878253 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP5 Proteins 0.000 claims 1
- 101001091194 Homo sapiens Peptidyl-prolyl cis-trans isomerase G Proteins 0.000 claims 1
- 101000741830 Homo sapiens Peptidyl-prolyl cis-trans isomerase-like 1 Proteins 0.000 claims 1
- 101000620711 Homo sapiens Peptidyl-prolyl cis-trans isomerase-like 4 Proteins 0.000 claims 1
- 101001091544 Homo sapiens Peptidylprolyl isomerase domain and WD repeat-containing protein 1 Proteins 0.000 claims 1
- 101001123267 Homo sapiens Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 Proteins 0.000 claims 1
- 101000574242 Homo sapiens RING-type E3 ubiquitin-protein ligase PPIL2 Proteins 0.000 claims 1
- 101000595252 Homo sapiens Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Proteins 0.000 claims 1
- 101000889087 Homo sapiens Spliceosome-associated protein CWC27 homolog Proteins 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 101100061197 Mus musculus Cyp27b1 gene Proteins 0.000 claims 1
- 108010059419 NIMA-Interacting Peptidylprolyl Isomerase Proteins 0.000 claims 1
- 102100023384 NK-tumor recognition protein Human genes 0.000 claims 1
- 102100040283 Peptidyl-prolyl cis-trans isomerase B Human genes 0.000 claims 1
- 102100024968 Peptidyl-prolyl cis-trans isomerase C Human genes 0.000 claims 1
- 102100027913 Peptidyl-prolyl cis-trans isomerase FKBP1A Human genes 0.000 claims 1
- 102100027914 Peptidyl-prolyl cis-trans isomerase FKBP1B Human genes 0.000 claims 1
- 102100026408 Peptidyl-prolyl cis-trans isomerase FKBP2 Human genes 0.000 claims 1
- 102100023846 Peptidyl-prolyl cis-trans isomerase FKBP3 Human genes 0.000 claims 1
- 102100034850 Peptidyl-prolyl cis-trans isomerase G Human genes 0.000 claims 1
- 102100026114 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Human genes 0.000 claims 1
- 102100038802 Peptidyl-prolyl cis-trans isomerase-like 1 Human genes 0.000 claims 1
- 102100022943 Peptidyl-prolyl cis-trans isomerase-like 4 Human genes 0.000 claims 1
- 102100034852 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 Human genes 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 102100029025 Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 Human genes 0.000 claims 1
- 102100025781 RING-type E3 ubiquitin-protein ligase PPIL2 Human genes 0.000 claims 1
- 101100222695 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CPR5 gene Proteins 0.000 claims 1
- 102100036033 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit Human genes 0.000 claims 1
- 102100039430 Spliceosome-associated protein CWC27 homolog Human genes 0.000 claims 1
- 108010006877 Tacrolimus Binding Protein 1A Proteins 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- UCUUFSAXZMGPGH-UHFFFAOYSA-N penta-1,4-dien-3-one Chemical compound C=CC(=O)C=C UCUUFSAXZMGPGH-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 101150108030 ppiD gene Proteins 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 108010062219 ran-binding protein 2 Proteins 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 108010029517 tacrolimus binding protein 1B Proteins 0.000 claims 1
- 108010067247 tacrolimus binding protein 4 Proteins 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023000295A JP2023052201A (ja) | 2015-10-01 | 2023-01-04 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562235896P | 2015-10-01 | 2015-10-01 | |
| US62/235,896 | 2015-10-01 | ||
| PCT/US2016/054691 WO2017059207A1 (en) | 2015-10-01 | 2016-09-30 | Methods and reagents for analyzing protein-protein interfaces |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023000295A Division JP2023052201A (ja) | 2015-10-01 | 2023-01-04 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501863A JP2019501863A (ja) | 2019-01-24 |
| JP2019501863A5 true JP2019501863A5 (enExample) | 2019-11-21 |
| JP7411326B2 JP7411326B2 (ja) | 2024-01-11 |
Family
ID=58427956
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516828A Active JP7411326B2 (ja) | 2015-10-01 | 2016-09-30 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
| JP2023000295A Pending JP2023052201A (ja) | 2015-10-01 | 2023-01-04 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023000295A Pending JP2023052201A (ja) | 2015-10-01 | 2023-01-04 | タンパク質－タンパク質インターフェースを分析するための方法および試薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US9989535B2 (enExample) |
| EP (2) | EP3355930A4 (enExample) |
| JP (2) | JP7411326B2 (enExample) |
| AU (2) | AU2016329064B2 (enExample) |
| CA (1) | CA3000822A1 (enExample) |
| WO (1) | WO2017059207A1 (enExample) |
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| US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
| EP3247378B8 (en) | 2015-01-09 | 2023-08-23 | Revolution Medicines, Inc. | Macrocyclic compounds that participate in cooperative binding and medical uses thereof |
| US9989535B2 (en) | 2015-10-01 | 2018-06-05 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| US11066416B2 (en) * | 2016-02-04 | 2021-07-20 | The Johns Hopkins University | Rapafucin derivative compounds and methods of use thereof |
| JP7104627B2 (ja) | 2016-02-04 | 2022-07-21 | ザ・ジョンズ・ホプキンス・ユニバーシティ | ラパグルチン（ｒａｐａｇｌｕｔｉｎｓ）、ｇｌｕｔの新規阻害剤及びその使用 |
| US10774110B2 (en) | 2016-02-04 | 2020-09-15 | The Johns Hopkins University | Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof |
| KR102359972B1 (ko) | 2016-04-12 | 2022-02-10 | 징코 바이오웍스, 인크. | 화합물의 제조를 위한 조성물 및 방법 |
| CN116478132A (zh) | 2016-07-12 | 2023-07-25 | 锐新医药公司 | 作为变构shp2抑制剂的2,5-双取代型及2,5,6-三取代型3-甲基吡嗪 |
| CN110446709B (zh) | 2017-01-23 | 2023-09-12 | 锐新医药公司 | 作为变构shp2抑制剂的二环化合物 |
| AU2018210196B2 (en) | 2017-01-23 | 2022-06-02 | Revolution Medicines, Inc. | Pyridine compounds as allosteric SHP2 inhibitors |
| WO2018187423A1 (en) * | 2017-04-05 | 2018-10-11 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
| EP3606492A4 (en) * | 2017-04-05 | 2020-11-11 | Revolution Medicines, Inc. | LINKS INVOLVED IN A COOPERATIVE BINDING AND USES THEREOF |
| TWI852912B (zh) | 2017-09-07 | 2024-08-21 | 美商銳新醫藥公司 | Shp2抑制劑組合物以及治療癌症的方法 |
| CA3078565A1 (en) | 2017-10-12 | 2019-04-18 | Revolution Medicines, Inc. | Pyridine, pyrazine, and triazine compounds as allosteric shp2 inhibitors |
| BR112020009757A2 (pt) | 2017-12-15 | 2020-11-03 | Revolution Medicines, Inc. | compostos policíclicos como inibidores alostéricos de shp2 |
| US20250388598A1 (en) * | 2019-11-04 | 2025-12-25 | Revolution Medicines, Inc. | Ras inhibitors |
| KR20250175006A (ko) | 2019-11-04 | 2025-12-15 | 레볼루션 메디슨즈, 인크. | Ras 억제제 |
| CN114867735A (zh) | 2019-11-04 | 2022-08-05 | 锐新医药公司 | Ras抑制剂 |
| CA3159559A1 (en) | 2019-11-04 | 2021-05-14 | Revolution Medicines, Inc. | Ras inhibitors |
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| CN111118046B (zh) * | 2020-01-16 | 2022-02-22 | 中国人民解放军军事科学院军事医学研究院 | 一种能够调控MSCs成脂肪分化能力的基因及其衍生产品 |
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-
2016
- 2016-09-30 US US15/282,430 patent/US9989535B2/en active Active
- 2016-09-30 WO PCT/US2016/054691 patent/WO2017059207A1/en not_active Ceased
- 2016-09-30 EP EP16852685.3A patent/EP3355930A4/en not_active Withdrawn
- 2016-09-30 CA CA3000822A patent/CA3000822A1/en active Pending
- 2016-09-30 EP EP23172763.7A patent/EP4242304A3/en active Pending
- 2016-09-30 AU AU2016329064A patent/AU2016329064B2/en active Active
- 2016-09-30 JP JP2018516828A patent/JP7411326B2/ja active Active
-
2018
- 2018-05-09 US US15/974,921 patent/US10948495B2/en active Active
- 2018-05-09 US US15/974,923 patent/US10466249B2/en active Active
-
2021
- 2021-01-28 US US17/161,505 patent/US20210405060A1/en not_active Abandoned
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2023
- 2023-01-04 JP JP2023000295A patent/JP2023052201A/ja active Pending
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2024
- 2024-01-17 AU AU2024200321A patent/AU2024200321A1/en active Pending
- 2024-03-01 US US18/593,086 patent/US20250085291A1/en active Pending
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